This report is the fourth in a series summarizing the activities for the period between April 1993 through March 1994 of the US-Japan Cooperative Cancer Research Program during the fourth five-year period of its operation. In this volume, detailed scientific progress reports from each of the four program areas are given along with an administrative summary outlining overall activities.
Since its inception in May 1974, the US-Japan Cooperative Cancer Research Program has been instrumental in establishing a close working relationship between researchers in Japan and the United States and in providing an important means of exchanging scientific information, modern technology, and materials. These activities have significantly contributed to the impressive progress that has marked cancer research and treatment in recent years. In 1994, the Program was renewed for a fifth five-year period beginning April 1, 1994 to March 31, 1999, that has been approved by the National Cancer Institute and Japan Society for the Promotion of Science. We are confident that the Program will continue to grow and bear fruit, thus bringing valuable contributions to scientific communities of both countries. Application of research and technology for cancer control programs will benefit our society to an enormous extent. The dedicated contributions of Ms. Beverly J. Schaff, Ms. Peggy E. Yasem, and Ms. Sanda R. Rife of the National Cancer Institute are greatly acknowledged.

Hitoshi Osaki
Director General
Japan Society for the Promotion of Science

Tsuyoshi Kakefuda, M.D., Ph.D.
Executive Secretary
US-Japan Cooperative Cancer Research Program
National Cancer Institute