17th US-JAPAN JOINT STEERING COMMITTEE MEETING

Fred Hutchinson Cancer Center, Seattle, Washington
June 23–24, 1994

MINUTES
The 17th Joint US-Japan Steering Committee on Cancer Research met on June 23–24, 1994, at the Fred Hutchinson Cancer Center (FHCC) in Seattle, Washington. In attendance were: Drs. T. Hamaoka, S. Miwa, M. Ogawa, H. Sugano, T. Sugimura, and Messrs. H. Kato and Y. Mitsukuri, for Japan; and Drs. R. Adamson, R. Hodes, T. Kakefuda, R. Miller and F. Welsch, for the U.S. The meeting was called to order at 9:00 a.m. by Drs. Miwa and Adamson. Drs. Miwa and Adamson congratulated those present for the success of the joint workshop and scientist exchange programs.
Dr. Welsch introduced Dr. Robert Day, Director of the FHCC. Dr. Day summarized the history of the FHCC—a 100 million dollar plus annual operation—and introduced Drs. Fred Appelbaum, Scott Davis and Paul Nieman, division directors. These scientists respectively summarized the activities of the Clinical Research Division (CRD), Public Health Sciences Division (PHSD) and Basic Science and Molecular Medicine Division (BS&MMD). Close interactions exist between the FHCC and the University of Washington in Seattle (UWS). Thus, for example, 93 faculty at PHS—located at Metropolitan Park—are also faculty at UWS. The 42 BS&MMD laboratories house some 160 postdoctoral fellows and 50 to 60 graduate students at the Lake Union Campus. The CRD involves 55 M.D. and Ph.D. faculty in its intensive care unit at Swedish Hospital and its conventional therapy programs at the UWS Hospital. All FHCC programs will be housed in due time on the Lake Union Campus. Steering Committee members received copies of the 1993 FHCC annual report and the scientific report for 1990–1992.
Drs. Adamson and Sugimura then reviewed progress for the Etiology Program Area, in particular the content of four workshops, three scientist exchanges, and an exchange of a chemical agent during the year. The four workshops were: (1) Oncogene and Tumor Suppressor Genes, (2) Non-Neoplastic Changes Induced by Carcinogens, (3) Natural Substances Including Phytochemicals for Primary Prevention of Cancer, and (4) Xenobiotic-metabolizing Enzymes and their Roles in Cancer Susceptibility. The scientist exchanges involved: (1) Dr. T. Ushijima, NCI-Tokyo, who visited Dr. Housman at MIT; (2) Dr. Y. Ito, Kyoto University, who visited Dr. T. Curran at the Roche Institute; and (3) Dr. T. Ochiya, NCC-Tokyo, who visited Dr. S. Aaronson at the Mt. Sinai Medical Center. Dr. K. Wakabayashi provided Dr. Adamson with 20 gr. of 2-amino-1-methyl-6phenyl-amidazo[4,5-b]pyridine (PhIP).
Drs. Hodes and Hamaoka then reviewed progress for the Biology and Diagnosis Program Area. Three joint workshops were held during the past year: (1) Transmembrane Signal Transduction and Cell Proliferation, (2) Cell Biology of the Host's Antitumor Immune Response, and (3) Gene Manipulation in Malignant Cells. Three scientist exchanges took place during the year: (1) Dr. T. Fujita, the Tokyo Metropolitan Institute of Medical Sciences, visited three American labs; (2) Dr. K. Matsushima, Kanazawa University; visited Dr. J. Oppenheim at the NCI, and (3) Dr. N. Minato, Kyoto University, visited three American labs.
Dr. Ogawa then reviewed progress for the Treatment Area. Three workshops were held during the year: (1) Recent Progress in Drug Resistance, (2) Preclinical and Clinical Studies of New Anticancer Drugs, and (3) Adjuvant Chemotherapy with New Ideas. Three scientific exchanges took place during the year: (1) Dr. M. Ishizuka, Institute for Chemotherapy, Microbial Chemistry Research Foundation, Numazu, visited three American labs; (2) Dr. M. Harada, Kyushu University, visited another three American labs; and (3) Dr. M. Seto, Aichi Cancer Center, visited Dr. R. Dalla-Favera at Columbia University.
Drs. Miller and Sugano then reviewed progress for the Interdisciplinary Area. Two workshops were held during the year: (1) Cancer Clustering, and 2) US-Japan Ethnic Differences in Cancer Occurrence. Two scientist exchanges took place during the year—both to Dr. R. Gallo's lab at the NCI. The visitors were Drs. S. Hino, Tottori University, and N. Tokudome, Nagoya City University.
After an NCI-hosted lunch, the above scientists reviewed the program plans for 1994–95 for each of the program areas. For the Etiology Area, four workshops are planned: (1) Food Carcinogenesis—Heterocyclic Amines, (2) Effects of the administration of multiple carcinogenic and anticarcinogenic compounds, (3) Progression of the Carcinogenic Process in Prostate and Breast Cancer, and (4) Experimental Studies on Genetic Intervention for Cancer Prevention. Drs. R. Hasegawa, N. Morii, and J. Yokota were proposed as exchangees under the JSPS program. Dr. Wakabayashi would provide Dr. Adamson with another 20 gr. of PhIP.
For the Biology and Diagnosis Program Area, workshops on: (1) Transcription Factors in the Regulation of Oncogenesis, (2) Receptor-Ligand Interactions and Signal Transduction in Antigen-Specific T Cell Responses, and (3) Differentiation, Growth and Death of Cells were proposed. Drs. Y. Asano, H. Fujiwara, and S. Taniguchi would be exchange scientists.
For the Treatment Program Area, workshops on: (1) Progress in Radiotherapy, (2) Progress on Treatment of Lung Cancer, and (3) New Anticancer Drugs and MDR Modulators, are planned. Drs. T. Irimura, K. Morita, and T. Takahashi would be exchangees.
For the Interdisciplinary Program Area, workshops on: (1) Cancer Syndromes, and (2) Lymphomas, Leukemia, Autoimmune Disease, and HLA are projected. Drs. S. Sonoda and M. Osame would be exchangees.
Dr. Welsch noted that in addition to the 12 short-term exchanges sponsored each year by the JSPS, many more are sponsored by other agencies under the US-Japan collaborative programs on cancer research. Long-term (one- to three-year) exchanges are sponsored by the NIH Visiting Program (122 Japanese scientists were at the NCI in Bethesda and Frederick during FY 94), the JFCR-NCI program (seven exchanges during the reporting period), the OIA-NCI exchange program (five exchanges during the year) and additional ones as postdoctoral fellows on NCI grants to extramural institutions.
Dr. Adamson announced that he would retire from the NCI next fall, but that he and Dr. Broder had agreed for Dr. Adamson to continue to be active in the US-Japan collaborative program on cancer research, his new responsibilities permitting. He proposed that Dr. Michael Friedman assume the overall coordination of the program for the U.S. side and that Dr. Snorri Thorgeirsson take over the coordination for the U.S. side for the Etiology Area. Both would be assisted, as appropriate, by the OIA. The participants at the meeting thanked Dr. Adamson for his leadership.
The Committee agreed to hold the next Joint Meeting in Kobe in early June of 1995, specific dates to be confirmed after consultation with Drs. Friedman and Thorgeirsson.
The participants agreed that in the future additional annual reports of the US-Japan collaborative program on cancer research be mailed to a list of some 350 Japanese scientists (to be provided by the JSPS), and to the libraries of the NCI-designated cancer centers, National Library of Medicine, and the Library of Congress.
The meeting closed at 5:00 p.m. after remarks by Drs. Adamson, Sugimura, Miwa, and Welsch. The meeting was followed by a working dinner hosted by the JSPS. Discussions between the U.S. and Japan representatives continued on June 24, 1994.

Respectfully submitted,

Federico Welsch, M.D., Ph.D.



FUTURE PLANS
1994–1995

Planned Seminar and Exchange Scientists in the Etiology Program Area:
1. PLANNED SEMINARS

(1) Food Carcinogenesis–Heterocyclic Amines
Hawaii, March 1995
Organizers: Dr. Snorri Thorgeirsson
Dr. Keiji Wakabayashi
Participants: US–7
Japan–7

(2) Coadministration of Multiple Effects of Carcinogenic and Anticarcinogenic Compounds
Hawaii, March 1995
Organizers: Dr. Michael Pariza
Dr. Nobuyuki Ito
Participants: US–7
Japan–7

(3) Topics in Progression of Carcinogenic Processes in Prostate and Breast Cancers
Hawaii, October 1994 or March 1995
Organizers: Dr. William Isaacs or Dr. Carl Barrett
Dr. Ryuichi Yatani
Participants: US–7
Japan–7

(4) Experimental Studies on Genetic Intervention for Cancer Prevention
Hawaii, March 1995
Organizers: Dr. Stuart Aaronson
Dr. Masaaki Terada
Participants: US–7
Japan–7


2. EXCHANGE OF SCIENTISTS

(1) Dr. Ryohei Hasegawa, Nagoya City University
Dates: (2 weeks)
Host: Dr. S .M. Cohen, University of Nebraska

(2) Dr. Narito Morii, Kyoto University
Dates: (3 weeks)
Host: Dr. R.B. Birge, The Rockefeller University

(3) Dr. Jun Yokota, National Cancer Center Research Institute
Dates: (2 weeks)
Host: Dr. R.A. Weinberg, Massachusetts Institute of Technology


3. EXCHANGE OF MATERIALS

From
To
(1) 2-Amin0-1-methyl-6-Phenyl-imidazo [4,5-b]pyridine (PhIP) 20g Dr. K. Wakabayashi Dr. R. Adamson


Planned Seminar and Exchange Scientists in the Biology and Diagnosis Program Area:
1. SEMINARS

(1) Transcription Factors in the Regulation of Oncogenesis
Maui, Hawaii, February 9–11, 1995
Organizers: Dr. Tom Curran
Dr. Tadatsugu Taniguchi
Participants: US–7
Japan–7

(2) Receptor-ligand Interactions and Signal Transduction in Antigen - Specific T Cell Responses
Maui, Hawaii, January 9–11, 1995
Organizers: Dr. Richard Hodes
Dr. Hiromi Fujiwara
Participants: US–10
Japan–7

(3) Differentiation, Growth and Death of the Cells
California, February 16–17, 1995
Organizers: Dr. Dinah Singer
Dr. Takehiko Sasazuki
Participants: US–8
Japan–7


2. EXCHANGE OF SCIENTISTS

(1) Dr. Yoshihiro Asano, University of Tokyo
Dates: March 10–25, 1995
Host: Dr. Alfred Singer, National Cancer Institute
Dr. Richard Hodes, National Institute of Aging

(2) Dr. Hiromi Fujiwara, Osaka University
Dates: September 25–Ocotober 10, 1994
Host: Dr. Alfred Singer, National Cancer Institute
Dr. Steve Burakoff, Dana-Farber Cancer Institute
Dr. Michael Lotze, Pittsburgh University
Dr. Stanley Korsmeyer, Washington University

(3) Shunichiro Taniguchi, Kyushu University
Dates: October 10–24, 1994
Host: Dr. L. Liotta, National Cancer Institute
Dr. G.L. Nicolson, M.D. Anderson


Planned Seminar and Exchange Scientists in the Treatment Program Area:
1. SEMINARS


(1) Progress on Radiotherapy
San Francisco, February 13–15, 1995
Organizers: Dr. Theodore L. Phillips
Dr. Mitsuyuki Abe
Participants: US–7
Japan–7

(2) Progress on Treatment of Lung Cancer
Nagoya, January 1995
Organizers: Dr. Michael A. Friedman
Dr. Yutaka Ariyoshi
Participants: US–6
Japan–10

(3) New Anticancer Drugs and MDR Modulators
Hawaii, February 10–11, 1995
Organizers: Dr. Michael A. Friedman
Dr. Makoto Ogawa, Dr. Takashi Tsuruo
Participants: US–6
Japan–7


2. EXCHANGE Of SCIENTISTS

(1) Tatsuro Irimura, University of Tokyo
Dates: (3 weeks)
Host: Hosts: Dr. B.R. Ze-Her, Harvard University
Dr. O.J. Finn, Pittsuburgh University
Dr. I.J. Fidler, M.D. Anderson Hospital

(2) Kozo Morita, National Institute of Radiological Science
Dates: (3 weeks)
Host: Dr. H. Suit, Harvard University
Dr. L. Peters, M.D. Anderson Cancer Center
Dr. J. Castro, University of California, Davis

(3) Takashi Takahashi, Aichi Cancer Center
Dates: (2 weeks)
Host: Dr. A. Feinberg, Johns Hopkins University
Dr. J. Mulshine, National Cancer Institute
Dr. J. Minna, Simons Cancer Center


Planned Seminar and Exchange Scientists in the Interdisciplinary Program Area:
1. SEMINARS

(1) Cancer Syndromes
Hawaii, Feb. 6–7, 1995
Organizers: Dr. Robert W. Miller
Dr. Haruo Sugano
Participants: US–6–7
Japan–7

(2) Lymphoma, Leukemia, Autoimmune Diseases, and HLA
Hawaii, February 9–10, 1995
Organizers: Dr. Robert W. Miller
Dr. Haruo Sugano
Participants: US–6–7
Japan–7


2. EXCHANGE OF SCIENTISTS

(1) Shunro Sonoda, Kagoshima University
Dates: 31 days
Host: Dr. William A. Blattner, National Cancer Institute
Dr. Robert Gallo, National Cancer Institute

(2) Mitsuhiro Osame, Kagoshima University
Dates: 31 days
Host: Dr. Haase, Minnesota University
Dr. Robert Gallo, National Cancer Institute


PARTICIPANTS

NCI Program Coordinators

Dr. Richard Adamson
Director
Division of Cancer Etiology

Dr. Richard Hodes
Director
National Institute on Aging
Cancer Research Program

Dr. Robert Miller
Scientist Emeritus
Division of Cancer Etiology

NCI Representatives

Dr. Federico Welsch
Associate Director for International Affairs

Tsuyoshi Kakefuda
Executive Secretary for US-Japan Cooperative Cancer Research Program

JSPS Program Coordinators JSPS Representatives

Dr. Takashi Sugimura
President Emeritus
National Cancer Center

Dr. Toshiyuki Hamaoka
Professor
Osaka University

Dr. Makoto Ogawa
Director
Aichi Cancer Center Hospital

Dr. Haruo Sugano
Director
Cancer Chemotherapy Center
Japanese Foundation for Cancer Research

JSPS Representatives

Dr. Shiro Miwa
Director

Mr. Yasushi Mitsukuri
Program Director
Program Department

Mr. Hisashi Kato
JSPS Washington Liaison Office