ADMINISTRATIVE REPORT

This report summarizes activities of the US-Japan Cooperative Cancer Research Program for the Japanese Fiscal Year 1993, the period between April 1, 1993, and March 31, 1994.
The Program consists of the following program areas:

I. Etiology
II. Biology and Diagnosis
III. Treatment
IV. Interdisciplinary

The US-Japan Bilateral Agreement calls for the organization of seminars and workshops, and exchange of scientists, information, and materials. Detailed discussions of these activities will be reported under specific program areas. The tables compiled in this section represent overall summaries for quick review. They should be self-explanatory.
To discuss policy matters and program activities, the Joint Steering Committee of the Program meets once every year. The first meeting of the fifth five-year period (April 1, 1994 to March 31, 1999) was held on June 23-24, 1994, in Seattle, Washington.

Past Meetings
1st 24-25 March 1979 San Francisco, California
2nd 10-11 June 1980 Nara, Japan
3rd 1-2 June 1981 Annapolis, Maryland
4th 31 May-1 June 1982 Tokyo, Japan
5th 9-10 June 1983 Honolulu, Hawaii
6th 13-14 February 1984 Tokyo, Japan
7th 25-26 June 1984 San Francisco
8th 27-28 June 1985 Tokyo, Japan
9th June 26-27, 1986 Anchorage, Alaska
10th June 25-26, 1987 Kyoto, Japan
11th June 23-24, 1988 Anchorage, Alaska
12th June 23-24, 1989 Kashiko-jima, Japan
13th June 28-29, 1990 San Diego, California
14th July 1-2, 1991 Naha, Okinawa, Japan
15th June 22-23,1992 Napa, California
16th June 18-19, 1993 Sapporo, Japan
17th June 23-24, 1994 Seattle, Washington

Activities
Area
Seminar & Symposia
Exchange of Scientists
Exchange of Materials
To Japan
To US
To Japan
To US
Etiology
4
0
3
0
1
Biol & Diag.
3
0
3
0
0
Treatment
3
0
3
0
0
Interdisp.
2
0
2
0
0
Total
12
0
11
0
1


I. ETIOLOGY
1. SEMINARS
(1) Xenobiotic-metabolizing Enzymes and Their Roles in Cancer Susceptibility
Kauai, Hawaii, February 21-22, 1994
Organizers: Dr. Frank J. Gonzalez
Dr. Ryuichi Kato
Participants: US-7
Japan-7

(2) Oncogene and Tumor Suppressor Genes
Maui, Hawaii, March 15-17, 1994
Organizers: Dr. Stuart A. Aaronson
Dr. Masaaki Terada
Participants: US-7
Japan-8

(3) Non-neoplastic Changes Induced by Carcinogens
Honolulu, Hawaii, March 18-19, 1994
Organizers: Dr. Richard H. Adamson
Dr. Nobuyuki Ito
Participants: US-6
Japan-9

(4) Natural Substances Including Phytochemicals for Primary Prevention of Cancer
Honolulu, Hawaii, March 21-22, 1994
Organizers: Dr. Lee W. Wattenberg
Dr. Hoyoku Nishino
Participants: US-7
Japan-7

2. EXCHANGE OF SCIENTISTS
(1) Dr. Toshikazu Ushijima, National Cancer Center Research Institute
Dates: February 25-March 11, 1994
Host Scientist: Dr. David E. Housman, Center for Cancer Research, Massachusetts Institute of Technology

(2) Dr. Yoshiaki Ito, Kyoto University
Dates: September 1-13, 1993
Host Scientist: Dr. Tom Curran, Roche Institute

(3) Dr. Takahiro Ochiya, National Cancer Center Research Institute
Dates: : February 22-March 2, 1994
Host Scientist: Dr. Stuart A. Aaronson, Derald H. Ruttenberg Cancer Center, The Mount Sinai Medical Center

3. EXCHANGE OF MATERIALS
From
To
(1) 2-amino-1-methyl-6- phenyl-imidazo [4,5-b]pyridine (PhIP) 20g Dr. K. Wakabayashi Dr. R. Adamson



II. BIOLOGY AND DIAGNOSIS
1. SEMINARS
(1) Transmembrane Signal Transduction and Cell Proliferation
Maui, Hawaii, January 10-12, 1994
Organizers: Dr. Roger M. Perlmutter
Dr. Tadatsugu Taniguchi
Participants: US - 7
Japan - 8

(2) Cell Biology of the Host's Anti-tumor Immune Response
Rockville, Maryland, January 10-13, 1994
Organizers: Dr. Richard Hodes
Dr, Hiromi Fujiwara
Participants: US - 8
Japan - 8

(3) Gene Manipulation in Malignant Cells
Maui, Hawaii, March 25-26, 1994
Organizers: Dr. Gary J. Nabel
Dr. Takehiko Sasazuki
Participants: US - 8
Japan - 7


2. EXCHANGE OF SCIENTISTS
(1) Dr. Takashi Fujita, The Tokyo Metropolitan Institute of Medical Science
Dates: August 28-September 12, 1993
Host Scientist: Dr. Garry P. Nolan, Stanford University
Dr. David Baltimore, The Rockefeller University
Dr. Paul Andino, Gladstone Institute of Virology and Immunology

(2) Dr. Koji Matsushima, Kanazawa University
Dates: January 1-15, 1994
Host Scientist: Dr. Joost J. Oppenheim, National Cancer Institute

(3) Nagahiro Minato, Kyoto University
Dates: December 4-18, 1993
Host Scientist: Dr. Samuel Strober, Stanford University
Dr. Jack L. Strominger, Harvard University
Dr. Barry R. Bloom, Albert Einstein College of Medicine



III. TREATMENT
1. SEMINARS
(1) Recent Progress in Drug Resistance
Tokyo, November 15-16, 1993
Organizers: Dr. Michael A. Friedman
Dr. Takashi Tsuruo
Participants: US-6
Japan-12

(2) Preclinical and Clinical Studies of New Anticancer Drugs
Kauai, Hawaii, February 25-26, 1994
Organizers: Dr. Michael A. Friedman
Dr. Makoto Ogawa
Participants: US-6
Japan-8

(3) Breast Cancer - Adjuvant and Neoadjuvant Approaches
Oakland, California, March 10-11, 1994
Organizers: Dr. Michael A. Friedman
Dr. Tomoo Tajima
Participants: US-6
Japan-8

2. EXCHANGE OF SCIENTISTS
(1) Masaaki Ishizuka, Institute for Chemotherapy Microbialchemistry Research Foundation
Dates: October 17-30, 1993
Host Scientist: Hosts: Dr. Ronald B. Luftig, Louisiana State University Medical Center
Dr. James E. Talmadge, University of Nebraska Medical Center
Dr. Mary L. Stracke, National Cancer Institute

(2) Mine Harada, Kyushu University
Dates: January 12-February 1, 1994
Host Scientist: Hosts: Dr. Robert P. Gale, Salic Health Care, Inc.
Dr. James O. Armitage, University of Nebraska Medical Center
Dr. Rainer Storb, Fred Hutchinson Cancer Research Center

(3) Masao Seto, Aichi Cancer Center Research Institute
Dates: February 17-March 5, 1994
Host Scientist: Dr. Riccard Dalla-Favera, Columbia University



IV. INTERDISCIPLINARY
1. SEMINARS
(1) Cancer Clustering
Santa Fe, New Mexico, February l4-16, 1994
Organizers: Dr. Robert W. Miller
Dr. Haruo Sugano
Participants: US-7
Japan-7

(2) Ethnic Differences in Cancer Occurrence
Honolulu, Hawaii, March 24-25, 1994
Organizers: Dr. Robert W. Miller
Dr. Kunio Aoki
Participants: US-7
Japan-8


2. EXCHANGE OF SCIENTISTS
(1) Shigeo Hino, Tottori University
Dates: August l0-September 8, 1993
Host: Dr. Robert C. Gallo, National Cancer Institute

(2) Nobuhiro Tokudome, Nagoya City University
Dates: August 1-31, 1993
Host Scientist: Dr. Robert C. Gallo, National Cancer Institute