ADMINISTRATIVE REPORT

This report summarizes activities of the United States-Japan Cooperative Cancer Research Program for the Japanese Fiscal Year 1983, the period between April 1, 1983 and March 31, 1984.
The Program consists of the following program areas:

I. Etiology
II. Biology and Diagnosis
III. Treatment
IV. Interdisciplinary Program and Coordination

The names of the Program Coordinators and Principal Advisors appointed by the implementing agencies appear in pages 126-127.
The types of activities supported under the auspices of the Program are (1) seminars, (2) exchange of scientists, and (3) exchange of materials. The table presented below indicates the activities of each program area during this reporting period, and the following chapter of “Program Area Report” describes in detail the objectives, achievements and future plans for each program area.
To discuss policy matters and program activities, the Joint Steering Committee of the Program meets once every year. Following the first meeting in San Francisco on May 24-25, 1979, the second meeting in Nara on June 10-11, 1980, the third meeting in Annapolis on June 1-2, 1981 and the fourth meeting in Tokyo on May 31-June 1, 1982, the fifth and sixth meetings were held in Honolulu on June 9-10, 1983 and in Tokyo on Feb. 13-1 4, 1 984 (extraordinary), respectively.

Program Areas
Seminars
Exchange of Scientists
Exchange of Materials
From U.S.
From Japan
ETIOLOGY
2
3
7
0
BIOLOGY and DIAGNOSIS
2
1
4
1
TREATMENT
3
3
1
0
INTERDISCIPLINARY PROGRAM and COORDINATION
2
1
4
0
Totals
9
8
16
0


I. ETIOLOGY
1. SEMINARS

(1) Carcinogenicity, Mutagenicity and Metabolism of Heterocyclic Amines
Honolulu. Hawaii. February 17-18, 1984
Organizers: Dr. Snorri S. Thorgeirsson
Dr. Shigeaki Sato
Participants: U.S.-8
Japan-9

(2) Eukaryotic DNA Replication and Repair
San Francisco. March 16-18. 1984
Organizers: Dr. David Korn
Dr. Katsuro Koike
Participants: U.S.- 15
Japan-8

2. EXCHANGE OF SCIENTISTS
(1) Dr. Shaw Watanabe
Pathology Division, National Cancer Center Research Institute, Tokyo
Dates: May 26-July 9, 1983
Host Scientist: Dr. Robert Miller, National Cancer Institute, National Institutes of Health, Bethesda, Maryland

(2) Masanao Miwa
Virology Division, National Cancer Center Research Institute, Tokyo
Dates: June 15 - August 14, 1983
Host Scientist: Frank H. Ruddle, Department of Biology, Yale University, New Haven, Connecticut

(3) Dr. Hirota Fujiki
High-risk Study Division. National Cancer Center Research Institute, Tokyo
Dates: July 4- July 19, 1983
Host Scientist: Dr. Richard E. Moore, Department of Chemistry, University of Hawaii at Manoa, Honolulu, Hawaii

(4) Dr. Kinichiro Oda
Department of Tumor Virus Research, The Institute of Medical Sciences, The University of Tokyo, Tokyo
Dates: July 7 - August 10. 1983
Host Scientists: Dr. Hiroto Okayama. Laboratory of Molecular Genetics, NICHD. National Institutes of Health, Bethesda, Maryland

(5) Dr. Tadashi Yamamoto
Laboratory of Oncology. The Institute of Medical Science, The University of Tokyo, Tokyo
Dates: September 1- November 29. 1983
Host Scientist: Dr. Ira H. Pastan. Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland

(6) Dr. Stuart A. Aaronson
Laboratory of Cellular and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland
Dates: December 4-11, 1983
Host Scientist: Dr. Takashi Sugimura, National Cancer Center Research Institute, Tokyo

(7) Dr. Joseph E. De Larco
Laboratory of Chemoprevention, National Cancer Institute, National Institutes of Health, Bethesda, Maryland
Dates: November 29 - December 11, 1983
Host Scientist: Dr. Takashi Sugimura, National Cancer Center Research Institute, Tokyo

(8) Dr. Motohisa Kaneko
Biophysics Division, National Cancer Center Research Institute, Tokyo
Dates: March 3-20, 1984
Host Scientist: Dr. Philip C. Hanawalt, Department of Biological Science, Stanford University, Stanford, California

(9) Dr. Takeshi Seno
Department of Immunology and Virology, Saitama Cancer Center Research Institute, Saitama
Dates: March 4-31, 1984
Host Scientist: Dr. Mario R. Capecchi, Biology Department, The University of Utah, Salt Lake, Utah

(10) Dr. George Khoury
Laboratory of Molecular Virology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland
Dates: October 19-24, 1983
Host Scientist: Dr. Takashi Sugimura, National Cancer Center Research Institute, Tokyo



II. BIOLOGY AND DIAGNOSIS
1. SEMINARS
(1) Oncogene Products and Neoplastic Cell Growth
Washington, D.C., October 17-19, 1983
Organizers: Dr. Yoji Ikawa
Dr. Benoit de Crombrugghe
Participants: U.S.- 10
Japan-7

(2) Immunogenetic Analysis of the Expression of Tumor Antigens and Responses to Tumors
San Diego, California, October 31 - November 2, 1983
Organizers: Dr. Toshiyuki Hamaoka
Dr. Richard Hodes
Participants: U.S.- 11
Japan-8


2. EXCHANGE OF SCIENTISTS
(1) Dr. Kazuo Moriwaki
Department of Cytogenetics, National Institute of Genetics, Mishima, Shizuoka-ken, Japan
Dates: September 7-29, 1983
Host Scientist: Dr. Igor B. Dawid, Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, NlH, Bethesda, MD.

(2) Kokichi Kikuchi
Department of Pathology, Sapporo Medical College, Sapporo, Japan
Dates: September 28- October 17, 1983
Host Scientist: Dr. Lloyd J. Old. Division of Immunology, Memorial Sloan-Kettering Cancer Center. New York.

(3) Hiromi Fujiwara
Institute for Cancer Research, Osaka University Medical School, Osaka, Japan.
Dates: October 30 - November 21 , 1983
Host Scientist: Dr. Richard Hodes, Immunology Branch, National Cancer Institute, NIH, Bethesda, MD.

(4) Noboru Kuzumaki
Cancer Institute, Hokkaido University School of Medicine, Sapporo, Japan
Dates: March 25, 1983 - April 21 , 1984
Host Scientists: Dr. Stephen J. O’Brien, Section of Genetics, Laboratory of Viral Carcinogenesis, Frederick Cancer Research Facilities, National Cancer Institute, Frederick.

(5) Steven J. Burakoff
Harvard Medical School, Boston, Massachusetts
Dates: August 20 - September 3, 1983
Host Scientist: Scientist: Dr. Toshiyuki Hamaoka, Department of Oncogenesis, Institute for Cancer Research, Osaka University, Osaka, Japan



III. TREATMENT
1. SEMINARS
(1) Anticancer Drug Resistance
Honolulu, Hawaii, May 30 - June 1, 1983
Organizers: Dr. Yoshio Sakurai
Dr. John Driscoll
Participants: U.S.-7
Japan-8

(2) Current Status of Chemotherapy for Curable Cancers
Tokyo, Nagoya, Japan, December 5 - 8, 1983
Organizers: Dr. Makoto Ogawa
Dr. Saul A. Schepartz
Participants: U.S.-3
Japan- 15

(3) Development of New Anticancer Drugs and Biologic Response Modifiers
Tokyo, Japan, February 9-10, 1984
Organizers: Dr. Yoshio Sakurai
Dr. Saul A. Schepartz
Participants: U.S.-7
Japan- 12

2. EXCHANGE OF SCIENTISTS
(1) Dr. Robert Young
National Cancer Institute, NIH, Bethesda, MD.
Dr. Daniel Ihde
National Cancer Institute, NIH, Bethesda, MD.
Dr. Robert Golbey
Memorial Sloan-Kettering Cancer Center, New York
Dates: December 5-9, 1983
Host Scientist: Dr. Yoshio Sakurai, Japanese Foundation for Cancer Research

(2) Dr. Makoto Ogawa
Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Tokyo
Dates: January 17-23, 1984
Host Scientist: Dr. Brian Lyeland-Jones, Drug Evaluation Reporting Section, Investigational Drug Branch, Cancer Therapy Evaluation Program, Division of Cancer Treatment, National Cancer Institute, Bethesda, MD.



IV. INTERDISCIPLlNARY PROGRAM AND COORDINATION
1. SEMINARS
(1) Statistical Methods in Cancer Epidemiology
Hiroshima, Japan, March 1-2, 1984
Organizers: Dr. Takeshi Hirayama
Dr. William J. Blot
Participants: U.S.-9
Japan- 15

(2) The Role of Pathologists in Cancer Epidemiology
San Francisco, March 10-11, 1984
Organizers: Dr. Haruo Sugano
Dr. Robert W. Miller
Participants: U.S.-6
Japan-7


2. EXCHANGE OF SCIENTISTS
(1) Dr. Shigeo Mori
Institute of Medical Science, University of Tokyo
Dates: February 6-26, 1984
Host Scientist: Dr. Marshall E. Kadin, University of Washington,
Dr. Richard E. Slavin, University of Texas, Galveston

(2) Dr. Mitsuaki Yoshida
Department of Viral Oncology, Japanese Foundation for Cancer Research, Tokyo
Dates: May 22 - June 10, 1983
Host Scientist: Dr. Robert C. Gallo, Laboratory of Tumor Cell Biology, National Cancer Institute, NIH, Bethesda, MD.

(3) Dr. Taizan Suchi
Aichi Cancer Center Hospital, Nagoya, Japan
Dates: September 11- October 2, 1983
Host Scientist: Dr. Henry Rappaport, Pathology Panel for Lymphoma Clinical Studies, City of Hope National Medical Center, Duarte, Cal.

(4) Dr. Yasuo Endo
First Department of Medicine, Faculty of Medicine, University of Tokyo
Dates: March 27 - April 18, 1984
Host Scientist: Dr. Robert L. Peters, University of Southern California, Downey

(5) Dr. Robert A. Weinberg
Center for Cancer Research Massachusetts Institute of Technology
Dates: April 6- 17, 1983
Host Scientist: Dr. Kumao Toyoshima, University of Tokyo, Tokyo