Summary of Research Project Results under JSPS FY2001
"Research for the Future Program"



1.Research Institution Osaka University
 
2.Research Area Integrated Fields
 
3.Research Field Biomedical Observation and Control
 
4.Term of Project FY 1997 〜 FY 2001
 
5.Project Number 97I00402
 
6.Title of Project Innovational Basic Technology for Ultrasonic Diagnosis and Treatment

7.Project Leader
Name Institution,Department Title of Position
Masatsugu Hori Osaka University, Graduate School of Medicine Professor

8.Core Members

Names Institution,Department Title of Position
Osamu Oshiro Nara Institute of Science and Technology, Research Center for Advanced Science and Technology Associate Professor
Tohru Masuyama Osaka University, Graduate School of Medicine Lecturer

9.Summary of Research Results

 We have investigated ultrasound utilization for medical filed in this research project. The key words of our research objectives were signal processing, post processing and utilization of ultrasound energy. Although current medical imaging devices using a sequential scanning method to take a cross sectional and a three dimensional image of the body, we achieved to built a non-scanning volume imaging system which enables simultaneous grabbing of multi-directional information and rendering super high-speed volume image which does not have time-spatial distortion that a sequential scanning system has. We also developed an ideal point source of ultrasound for our imaging algorithm under a collaboration of the photonics research group in this "Research for the Future" program. Real-time post-processing of ultrasound image show moving stereo pictures of inside body of us which provide a chance for instant recognition of complicated anomaly of fetus and make a maternal-infant relationship deeper because of its quasi-real face picture of her baby provided a. surface modeling. Non-linear models of signal processing show us further potential of ultrasound diagnosis. Information of tissue character on an ultrasound propagation path could be convoluted on received ultrasound signal. We have tried to utilized analysis of fractal dimension that represented complexity of tissue fibrosis of cardiomyopathy and the Gold'burg number promised to utility of a parametric approach for function of wave distortion that indicates transient tissue elasticity changing. Transient response of biological tissue for ultrasound exposure is quite interesting phenomenon. It was considered as a part of the thermal or a part of cavitational effect for a long time. We showed a biological response of cultured mammalian cell consistent with a mechanical stimulation of ultrasound. Those mechanical effects of ultrasound might be enhanced by pin pointed medication which ultrasonic activation of chemical holding micro capsules.

10.Key Words

(1)ultrasound、(2)point source、(3)three dimensional imaging
(4)LASER、(5)non-linear propagation、(6)tissue characterization
(7)bioeffect、(8)drug delivery system、(9)ring array probe


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