| 1.Research Institution | Tokai University | |
| 2.Research Area | Life Science | |
| 3.Research Field | Cellular Signaling | |
| 4.Term of Project | FY1996〜FY2000 | |
| 5.Project Number | 96L00303 | |
| 6.Title of Project | Elucidation of carbonyl stress pathway and the mechanism of redox regulation to carbonyl atress. |
| Name | Institution,Department | Title of Position |
| Toshio Miyata | Tokai University School of Medicine, Department of Internal Medicine | Associate Professor |
8.Core Members
| Names | Institution,Department | Title of Position |
| Kiyoshi Kurokawa | Tokai University School of Medicine Department of Internal Medicine | Professor |
| Izumi Nakasima | Nagoya University School of Medicine, Department of Medical Internal of Medicine | Professor |
| Charles van Ypersele de Strihou | Universite Catholique de Louvain Service de Nephrologie | Professor |
9.Cooperating Researchers
10.Summary of Research Results
|
Research on the role of advanced glycation end products (AGEs) has brought new insights to non-enzymatic biochemistry. It revealed increased progressive, irreversible protein modifications with reactive carbonyl compounds (RCOs), derived from oxidative and non-oxidative chemistry ("carbonyl stress"). Under carbonyl stress, not only AGEs derived from carbohydrates but also advanced lipoxidation end products (ALEs) derived from lipids modify matrix as well as cellular proteins. Carbonyl stress is augmented by either oxidative stress or impaired detoxification of RCOs. Nitric oxide is also implicated in the atherogenic and inflammatory effects of carbonyl stress. We demonstrated the pathological significance of carbonyl stress in uremia complications (amyloidosis and peritoneal sclerosis), diabetic complications, atherosclerosis, rheumatoid arthritis, age-related macular degeneration, and ling fibrosis. Carbonyl stress mediates intracellular signalings by multiple pathways directly and indirectly, leading to cellular activation or cell death. The indirect pathway involves reaction between RCOs and proteins to produce AGEs, which then bind with RAGE and induce generation of oxygen. In contrast, the direct pathway involves induction of cross-linking or clustering of cell surface receptors by different RCOs to activate receptor (EGFR, Ret etc.) and non-receptor (c-Src, Lck etc.) protein tyrosine kinases (PTKs), and to produce free radicals. The generated free radicals may further accelerate activation of PTKs potentially through a redox reaction-mediated structural modification of the kinase proteins on one hand, and activate ASK1-SEK1-JNK pathway leading to activation of caspases for cell death on the other. The RCOs-mediated activation of PTKs leads to activation of Ras-MAPK pathway. The manipulation of carbonyl stress should provide new therapeutic insights. Among them, these appear promising: thiol repletion, development of novel inhibitors of carbonyl amine chemistry, and acceleration of the glyoxalase detoxification pathway. These therapeutic approaches indeed inhibit the carbonyl modification of proteins with carbohydrates and lipids, prevent the intracellular signaling and cellular responses, and effectively retard the development of tissue damage in vivo in animal models. |
11.Key Words
(1)carbonyl stress、(2)carbonyl stress inhibitor、(3)oxidative stress
(4)reactive carbonyl copound、(5)advanced glycation/lipoxidation end product、(6)diabetes mellitus
(7)chronic renal failure、(8)atherosclerosi、(9)aging
12.References
| Author | Title of Article | |||
| Miyata T et. al | New aspects in the pathogenesis of dialysis-related amyloidosis: Role of β2-microglobulin modified with advanced glycation end products in bone and joint destruction. | |||
| Journal | Volume | Year | Pages Concerned | |
| Nephrol Dial Transplant | 11 [suppl 2] | 1996 | 140-143 | |
| Author | Title of Article | |||
| Miyata T et. al | Monocyte/macrophage response toβ2-microglobulin modified with advanced glycation end products. | |||
| Journal | Volume | Year | Pages Concerned | |
| Kidney Int | 49 | 1996 | 538-550 | |
| Author | Title of Article | |||
| Miyata T et. al | Identification of pentosidine as a native structure for advanced glycation end products in β2-microglobulin forming amyloid fibrils in patients with dialysis-related amyloidosis. | |||
| Journal | Volume | Year | Pages Concerned | |
| Proc Natl Acad Sci USA | 93 | 1996 | 2353-2358 | |
| Author | Title of Article | |||
| Miyata T | Advanced glycation end products and β2-microglobulin in the pathogenesis of bone lesions in dialysis-associated amyloidosis. | |||
| Journal | Volume | Year | Pages Concerned | |
| Nephrol Dial Transplant | 11 | 1996 | 86-90 | |
| Author | Title of Article | |||
| Cai T et. al | β2-Microglobulin modified with advanced glycation end products induces monocyte chemotaxis in vivo. | |||
| Journal | Volume | Year | Pages Concerned | |
| Nephrol Dial Transplant | 11 | 1996 | 1181-1191 | |
| Author | Title of Article | |||
| Miyata T et. al | New aspects in the pathogenesis of dialysis-related amyloidosis: Pathophysiology of advancesglycation end products in renal failure. | |||
| Journal | Volume | Year | Pages Concerned | |
| Jpn J Nephrol | 38 | 1996 | 191-197 | |
| Author | Title of Article | |||
| Miyata T et. al | Alternate repetition of short fore- and backfiltrations reduces convective albumin loss. | |||
| Journal | Volume | Year | Pages Concerned | |
| Kidney Int | 50 | 1996 | 432-435 | |
| Author | Title of Article | |||
| Miyata T et. al | Accmulation of alubumin-linked and free-form pentosidine in the circulation of uremic patients with end-stage renal failure: Renal implications in the pathophysiology of pentosidine. | |||
| Journal | Volume | Year | Pages Concerned | |
| J Am Soc Nephrol | 7 | 1996 | 1198-1206 | |
| Author | Title of Article | |||
| Miyata T et. al | The receptor for advanced glycation end-products(RAGE) is a central mediator of the interaction of AGE-β2microglobulin with human mononuclearphagocytes via an oxidant-sensitive pathway: implications for the pathogenesis of dialysis-related amyloidosis. | |||
| Journal | Volume | Year | Pages Concerned | |
| J Clin Invest | 98 | 1996 | 2353-2358 | |
| Author | Title of Article | |||
| Miyata T et. al | Advanced glycation end products and β2-microglobulin in the pathogenesis of bone lesions in dialysis-associated amyloidosis | |||
| Journal | Volume | Year | Pages Concerned | |
| Nephrol Dial Transplant | 11 | 1996 | 86-90 | |
| Author | Title of Article | |||
| Miyata T et. al | Pathophysiology of advanced glycation end products in renal failure. | |||
| Journal | Volume | Year | Pages Concerned | |
| Nephrol Dial Transplant | 11 [suppl 5] | 1996 | 27-30 | |
| Author | Title of Article | |||
| Sugiyama S et. al | Advanced glycation end products in diabetic nephropathy. | |||
| Journal | Volume | Year | Pages Concerned | |
| Nephrol Dial Transplant | 11 [suppl 5] | 1996 | 91-94 | |
| Author | Title of Article | |||
| Miyata T et. al | Possible involvement of advanced glycation end products in bone resorption. | |||
| Journal | Volume | Year | Pages Concerned | |
| Nephrol Dial Transplant | 11 [suppl 5] | 1996 | 54-57 | |
| Author | Title of Article | |||
| Kimura T et. al, | Identification of advanced glycation end-products of the maillard reaction in pick's disease. | |||
| Journal | Volume | Year | Pages Concerned | |
| Neuroscience Letters | 219 | 1996 | 95-98 | |
| Author | Title of Article | |||
| Takeda A et. al | Immunohistochemical study of advanced glycation end products in aging and alzheimer's disease brain. | |||
| Journal | Volume | Year | Pages Concerned | |
| Neuroscience Letters | 221 | 1996 | 17-20 | |
| Author | Title of Article | |||
| Miyata T et. al | Advanced glycation end products enhance osteoclast-induced bone resorpion in cultured mouse unfractionated bone cells and in rats implanted with devitalized bone particles. | |||
| Journal | Volume | Year | Pages Concerned | |
| J Am Soc Nephrol | 8 | 1997 | 260-270 | |
| Author | Title of Article | |||
| Miyata T et. al | Oxidation conspires with glycation to create noxious advanced glycation end products in renal failure. | |||
| Journal | Volume | Year | Pages Concerned | |
| Nephrol Dial Transplant | 12 | 1997 | 255-258 | |
| Author | Title of Article | |||
| Miyata T et. al | Clearance of pentosidine, an advanced glycation end product, by different modalities of renal replacement therapy. | |||
| Journal | Volume | Year | Pages Concerned | |
| Kidney Int | 51 | 1997 | 880-887 | |
| Author | Title of Article | |||
| Miyata T et. al | Implication of an increased oxidative stress in the formation of advanced glycation end products in patients with end-stage renal failure | |||
| Journal | Volume | Year | Pages Concerned | |
| Kidney Int | 51 | 1997 | 1170-1181 | |
| Author | Title of Article | |||
| Horie K et. al | Immunohistochemical localization of advanced glycation end products, pentosidine and carboxymetyllysine, inlipofuscin pigments of alzheimer's disease and aged neurons. | |||
| Journal | Volume | Year | Pages Concerned | |
| Biochem Biophys Res Commun | 236 | 1997 | 327-332 | |
| Author | Title of Article | |||
| Uchida K et al | Protein modification by a maillard reaction intermediate methylglyoxal immunochemical detection of fluorescent 5-methylimidazolone derivatives in vivo. | |||
| Journal | Volume | Year | Pages Concerned | |
| FEBS Letter | 410 | 1997 | 313-318 | |
| Author | Title of Article | |||
| Satoh H et. al | Advanced glycation endproducts stimulate mitogen-activated protein kinase and proliferation in rabbit vascular smooth muscle cells. | |||
| Journal | Volume | Year | Pages Concerned | |
| Biochem Biophys Res Commun | 239 | 1997 | 111-115 | |
| Author | Title of Article | |||
| Horie K et. al | Immunohistochemical colocalization of glycoxidation products and lipid peroxidation products in diabetic renal glomerular lesions. | |||
| Journal | Volume | Year | Pages Concerned | |
| J Clin Invest | 100 | 1997 | 2995-3004 | |
| Author | Title of Article | |||
| Yasuda Y et. al | Funcional quantiative analysis of the genome in cultured human mesangial cells. | |||
| Journal | Volume | Year | Pages Concerned | |
| Kidney Int | 53 | 1998 | 154-158 | |
| Author | Title of Article | |||
| Yasuda Y et. al | Funcional quantiative analysis of the genome in cultured human mesangial cells. | |||
| Journal | Volume | Year | Pages Concerned | |
| Kidney Int | 53 | 1998 | 154-158 | |
| Author | Title of Article | |||
| Miyata T et. al | Renal catabolism of advanced glycation end products: the fate of pentosidne. | |||
| Journal | Volume | Year | Pages Concerned | |
| Biochem Biophys Res Commun | 244 | 1998 | 45-49 | |
| Author | Title of Article | |||
| Uchida K et. al | Protein-bound acrolein: potential markers for oxidative stress. | |||
| Journal | Volume | Year | Pages Concerned | |
| Proc Natl Acad Sci USA | 95 | 1998 | 4882-4887 | |
| Author | Title of Article | |||
| Ehlerding G et. al | Alteraitions of synovial tissue and their potential role in the deposition of β2-microglobulin-associated amyloid. | |||
| Journal | Volume | Year | Pages Concerned | |
| Nephrol Dial Transplant | 13 | 1998 | 1465-1475 | |
| Author | Title of Article | |||
| Miyata T et. al | β2-Microgloburin in renal disease. | |||
| Journal | Volume | Year | Pages Concerned | |
| J Am Soc Nephrol | 9 | 1998 | 1723-1735 | |
| Author | Title of Article | |||
| Sugiyama S et. al | Implication of the glycoxidation and lipoxidation rections in the pathogenesis of dialysis-related amyloidosis. | |||
| Journal | Volume | Year | Pages Concerned | |
| Int J Mol Med | 2 | 1998 | 561-565 | |
| Author | Title of Article | |||
| Uchida K et. al | Implication of the glycoxidation and lipoxidation rections in the pathogenesis of dialysis-related amyloidosis. | |||
| Journal | Volume | Year | Pages Concerned | |
| Int J Mol Med | 2 | 1998 | 4882-4887 | |
| Author | Title of Article | |||
| Ueda Y et. al | Implication of altered redox regulation by antioxidant enzymes in the increased plasma pentosidine, an advanced glycation end product, in uremia. | |||
| Journal | Volume | Year | Pages Concerned | |
| Biochem Biophys Res Commun | 245 | 1998 | 785-790 | |
| Author | Title of Article | |||
| Miyata T et. al | Autoxidation products of both carbohydrates and lipids are increased in uremic plasma: Is there oxidative stress in uremia? | |||
| Journal | Volume | Year | Pages Concerned | |
| Kidney Int | 54 | 1998 | 1290-1295 | |
| Author | Title of Article | |||
| Miyata T et. al | A mesangium-predominant gene, megsin, is a new serpin up-regulated in IgA nephropathy. | |||
| Journal | Volume | Year | Pages Concerned | |
| J Clin Invest | 102 | 1998 | 828-836 | |
| Author | Title of Article | |||
| Niwa H et. al | Accelerated formation of carboxymethyllysine, an advanced glycation end product, by glyoxal and 3-deoxyglucosone in cultured rat sensory neurons. | |||
| Journal | Volume | Year | Pages Concerned | |
| Biochem Biophys Res Commun | 248 | 1998 | 93-97 | |
| Author | Title of Article | |||
| Takeda A et. al | Advanced glycation end products co-localization with astoricytes and microglial cells in Alzheimer's disease brain. | |||
| Journal | Volume | Year | Pages Concerned | |
| Acta Neuropathol | 98 | 1998 | 555-558 | |
| Author | Title of Article | |||
| Miyata T et. al | Generation of protein carbonyls by glycation and lipoxidation reactions with autoxidation products of ascorbic acid and polyunsaturated fatty acids. | |||
| Journal | Volume | Year | Pages Concerned | |
| FEBS letter | 437 | 1998 | 24-28 | |
| Author | Title of Article | |||
| Kimura T et. al | ocalization of identified advanced glycation end product structure, N-carboxymethyllysine and pentosidine, in age-related inclusions in human brains. | |||
| Journal | Volume | Year | Pages Concerned | |
| Pathology International | 48 | 1998 | 575-579 | |
| Author | Title of Article | |||
| Hangaishi M et. al | Increased aggregation of human platelets produced by advanced glycation end products in vitro. | |||
| Journal | Volume | Year | Pages Concerned | |
| Biochem Biophys Res Commun | 248 | 1998 | 285-292 | |
| Author | Title of Article | |||
| Anwarul AA et. al | Level of HgC12-meditated phosphorylation of intracellular proteins determines death of thymic T-lymphocytes with or without DNA fragmentation. | |||
| Journal | Volume | Year | Pages Concerned | |
| J Cellular Biochemistry | 71 | 1998 | 243-253 | |
| Author | Title of Article | |||
| Miyata T et. al | Carbonyl stress in uremia: Accumulation of carbonyls accelerate the formation of pentosidine, an advanced glycation end product. | |||
| Journal | Volume | Year | Pages Concerned | |
| J Am Soc Nephrol | 9 | 1998 | 2349-2356 | |
| Author | Title of Article | |||
| Anwarul AA et. al | Carbonyl compounds cross-link cellular proteins and activate protein-tyrosine kinase p60c-src | |||
| Journal | Volume | Year | Pages Concerned | |
| J Cellular Biochemistry | 72 | 1999 | 1-7 | |
| Author | Title of Article | |||
| Miyata T et. al | Alterations in non-enzymatic biochemistry in uremia. Origin and significance of carbonyl stress in long-term uremic complications. | |||
| Journal | Volume | Year | Pages Concerned | |
| Kidney Int | 55 | 1999 | 389-399 | |
| Author | Title of Article | |||
| Miyata T et. al | Diagnosis, pathogenesis, and treatment of dialysis-related amyloidosis. | |||
| Journal | Volume | Year | Pages Concerned | |
| Miner Electrolyte Metab | 25 | 1999 | 114-117 | |
| Author | Title of Article | |||
| Wada T et. al | Implication of Carbonyl stress in long-term uremic complications. | |||
| Journal | Volume | Year | Pages Concerned | |
| Nephrol Dial Transplant | 14[Supple 1] | 1999 | 79-81 | |
| Author | Title of Article | |||
| Miyata T et. al | 2-Isopropylidenehydrazono-4-oxo-thiazolidin-5ylacetanilide (OPB-9195) treatment inhibits the development of initial thickening after balloon injury of rat carotid artry proliferation of rat carotid artery following balloon injury: role of glycoxidation and lipoxidation reactions in vascular tissue damage. | |||
| Journal | Volume | Year | Pages Concerned | |
| FEBS Letter | 445 | 1999 | 202-206 | |
| Author | Title of Article | |||
| Miyata T et. al | Carbonyl stress: Increased carbonyl modification of tissue and cellular proteins in uremia. | |||
| Journal | Volume | Year | Pages Concerned | |
| Perit Dial Int | 19 [Supple 2] | 1999 | 58-61 | |
| Author | Title of Article | |||
| Wada T et. al | β2-microglobulin and renal bone disease. | |||
| Journal | Volume | Year | Pages Concerned | |
| Perit Dial Int | 10 [Supple 2] | 1999 | 413-416 | |
| Author | Title of Article | |||
| Izuhara Y et. al | A sensitive and specific ELISA for plasma pentosidine. | |||
| Journal | Volume | Year | Pages Concerned | |
| Nephrol Dial Transplant | 14 | 1999 | 576-580 | |
| Author | Title of Article | |||
| Suzuki D et. al | Immunohistochemical evidence for an increased oxidative stress and carbonyl modification of proteins in diabetic glomerular lesions. | |||
| Journal | Volume | Year | Pages Concerned | |
| J Am Soc Nephrol | 10 | 1999 | 822-832 | |
| Author | Title of Article | |||
| Jadoul M et. al | Influence of hemodialysis membrane type on pentosidine plasma level, a marker of carbonyl stress | |||
| Journal | Volume | Year | Pages Concerned | |
| Kidney Int | 55 | 1999 | 2487-2492 | |
| Author | Title of Article | |||
| Miyata T et. al | Carbonyl stress: increased carbonyl modification of proteins by autoxidation products of carbohydrates and lipids in uremia. | |||
| Journal | Volume | Year | Pages Concerned | |
| Int J Art Org | 22 | 1999 | 195-198 | |
| Author | Title of Article | |||
| Miyata T et. al | Increased carbonyl modification by lipids and carbohydrates in diabetic nephropathy. | |||
| Journal | Volume | Year | Pages Concerned | |
| Kidney Int | 56(Supple71) | 1999 | 54-56 | |
| Author | Title of Article | |||
| Miyata T et. al | Apolipoprotein E2/E5 variants in lipoprotein glomerulopathy recurred in transplanted kidney. | |||
| Journal | Volume | Year | Pages Concerned | |
| J Am Soc Nephrol | 10 | 1999 | 1590-1595 | |
| Author | Title of Article | |||
| Stein G et. al | Decrease in serum pentosidine levels of ESRD patients during polysulfone hemodialysis. | |||
| Journal | Volume | Year | Pages Concerned | |
| Nephrol Dial Transplant | 14 | 1999 | 1606-1608 | |
| Author | Title of Article | |||
| Kikuchi S et. al | Neurotoxicity of methylglyoxal and 3-Deoxyglycose on cultured cortical neurons: Synergism between glycation and oxidative stress, possibly involved in neurodegnerative diseases. | |||
| Journal | Volume | Year | Pages Concerned | |
| J Neurosci Res | 57 | 1999 | 280-289 | |
| Author | Title of Article | |||
| Handa JT et. al | Increase in the advanced glycation end product pentosidine in Bruch's membrane with age. | |||
| Journal | Volume | Year | Pages Concerned | |
| Investigative Ophthalmology Vis Sci. | 40 | 1999 | 775-779 | |
| Author | Title of Article | |||
| Liu W et. al | Hydroxynonenal triggers an epidermal growth factor receptor-linked signal pathway for growth inhibition. | |||
| Journal | Volume | Year | Pages Concerned | |
| J Cell Sci | 112 | 1999 | 2409-2417 | |
| Author | Title of Article | |||
| Farboud B et. al | Development of a polyclonal antibody with broad epitope specificity for advanced glycation end products and localization of these epitpes in Bruch's membrane of the aging eye. | |||
| Journal | Volume | Year | Pages Concerned | |
| Molecular Vision | 5 | 1999 | 11 | |
| Author | Title of Article | |||
| Akhand AA et. al | Nitric oxide controles src kinase activity through a sulfhydryl group modification-mediated Tyr-527-independent and Try-416-linked mechanism. | |||
| Journal | Volume | Year | Pages Concerned | |
| J Biol Chem | 274 | 1999 | 25821-25826 | |
| Author | Title of Article | |||
| Inagi R et. al | oxdative protein damage with carbohydrates and lipids in uremia: carbonyl stress | |||
| Journal | Volume | Year | Pages Concerned | |
| Blood Purification | 17 | 1999 | 95-98 | |
| Author | Title of Article | |||
| Kawada N et. al | Increased oxidative stress in mouse kidneys with unilateral ureteral obstruction. | |||
| Journal | Volume | Year | Pages Concerned | |
| Kidney Int | 56 | 1999 | 1004-1013 | |
| Author | Title of Article | |||
| Nangaku M et. al | Possible involvement of carbonyl stress in the pathogenesis of dialysis-related amyloidosis. | |||
| Journal | Volume | Year | Pages Concerned | |
| Am J Med Sci | 317 | 1999 | 410-415 | |
| Author | Title of Article | |||
| Suzuki D et. al | Carbonyl stress and diabetic nephropathy. | |||
| Journal | Volume | Year | Pages Concerned | |
| Internal Medicine | 38 | 1999 | 309-314 | |
| Author | Title of Article | |||
| Suzuki D et. al | Expression of megsin mRNA, a novel mesangium-predominant gene, in the renal tissues of various glomerular diseases. | |||
| Journal | Volume | Year | Pages Concerned | |
| J Am Soc Nephrol | 10 | 1999 | 2606-2613 | |
| Author | Title of Article | |||
| Hori Y et. al | Crry, a complement regulatory protein, modulates renal interstitial disease induced by proteinuria. | |||
| Journal | Volume | Year | Pages Concerned | |
| Kidney Int | 56 | 1999 | 2096-2106 | |
| Author | Title of Article | |||
| Inagi R et. al | Glucose degradation product methylglyoxal enhances the production of vascular endothelial growth factor in peritoneal cells: role in the functional and morphological alterations of peritoneal membranes in peritoneal dialysis. | |||
| Journal | Volume | Year | Pages Concerned | |
| FEBS Letter | 463 | 1999 | 260-264 | |
| Author | Title of Article | |||
| Miyata T et. al | Carbonyl stress and dialysis-related amyloidosis. | |||
| Journal | Volume | Year | Pages Concerned | |
| Nephrol Dial Transplant | 15(Supple1) | 2000 | 25-28 | |
| Author | Title of Article | |||
| Liu W et. al | 4-hydroxynonenal induces a cellular redox-related activation of the caspase cascade for apoptotic cell death. | |||
| Journal | Volume | Year | Pages Concerned | |
| J Cell Sci | 113 | 2000 | 635-641 | |
| Author | Title of Article | |||
| Combet S et. al | Vascular proliferation and enhanced expression of endothelial nitric oxide synthase in human peritoneum exposed to long-term peritoneal dialysis. | |||
| Journal | Volume | Year | Pages Concerned | |
| J Am Soc Nephrol | 11 | 2000 | 717-728 | |
| Author | Title of Article | |||
| Miyata T et. al | Advanced glycation and lipoxidation of the peritoneal membrane: Respective roles of serum and peritoneal fluid reactive carbonyl compounds | |||
| Journal | Volume | Year | Pages Concerned | |
| Kidney Int | 58 | 2000 | 425-435 | |
| Author | Title of Article | |||
| Miyata T et. al | Role of reactive carbonyl compounds generated during carbohydrate and lipid metabolism. | |||
| Journal | Volume | Year | Pages Concerned | |
| J Am Soc Nephrol | 11 | 2000 | 1719-1725 | |
| Author | Title of Article | |||
| Miyata T et. al, | Mechanism of the inhibitory effect of OPB-9195 [(±)-2-isopropylidenehydrazono-4-oxo-thiazolidin-5ylacetanilide] on advanced lipoxidation end product formation. | |||
| Journal | Volume | Year | Pages Concerned | |
| J Am Soc Nephrol | 11 | 2000 | 1719-1725 | |
| Author | Title of Article | |||
| Miyata T et. al | Relevance of oxidative and carbonyl stress to long-term uremic complications. | |||
| Journal | Volume | Year | Pages Concerned | |
| Kidney Int | 58(Supple1) | 2000 | 120-125 | |
| Author | Title of Article | |||
| Kasper M et. al | Induction of apoptosis by glyoxal in human embryonic lung epithelial cell line L132. | |||
| Journal | Volume | Year | Pages Concerned | |
| Am J Respi Cell Mol Biol | 23 | 2000 | 485-491 | |
| Author | Title of Article | |||
| Du J et. al | Methylglyoxal induces apoptosis in jurkat leukemia T-cells by activating c-Jun N-terminal kinase. | |||
| Journal | Volume | Year | Pages Concerned | |
| J Cell Biochem | 77 | 2000 | 333-344 | |
| Author | Title of Article | |||
| Asahi K et. al | Nitric oxide inhibits the formation of advanced glycation and products. | |||
| Journal | Volume | Year | Pages Concerned | |
| Kidney Int | 58 | 2000 | 1780-1787 | |
| Author | Title of Article | |||
| Ueda Y et. al | Effect of dwell time on carbonyl stress using icodextrin and amino acid peritoneal dialysis fluids | |||
| Journal | Volume | Year | Pages Concerned | |
| Kidney Int | 58 | 2000 | 2158-2524 | |
| Author | Title of Article | |||
| Takeda A et. al | Neuronal and glial advanced glycation end poduct[N ε -(carboxymethyl)lysine] in Alzheimer's disease brains. | |||
| Journal | Volume | Year | Pages Concerned | |
| Acta Neuropathol | 101 | 2001 | 27-35 | |
| Author | Title of Article | |||
| Yamada K et. al | Clusterin is up-regulated in glomerular mesangial cells in complement-mediated injury. | |||
| Journal | Volume | Year | Pages Concerned | |
| Kidney Int | 59 | 2001 | 2518-2524 | |
| Author | Title of Article | |||
| Hou FF et. al | -B2microglobulin modified with advanced glycation end products delaysmonociyte apoptosis | |||
| Journal | Volume | Year | Pages Concerned | |
| Kidney Int | 59 | 2001 | 990-1002 | |
| Author | Title of Article | |||
| Miyata T et. al | Reactive carbonyl compound-related uremic toxicity (carbonyl stress). | |||
| Journal | Volume | Year | Pages Concerned | |
| Kidney Int | in press | |||
| Author | Title of Article | |||
| Miyata T et. al | Innovative approaches to more effective and biomedically more suitable peritoneal dialysis technologies. | |||
| Journal | Volume | Year | Pages Concerned | |
| Kidney Int | in press | |||
| Author | Title of Article | |||
| Combet S et. al | Chronic uremia induces permeability changes, increased nitric oxide synthase expression, and structural modifications in the peritoneum. | |||
| Journal | Volume | Year | Pages Concerned | |
| J Am Soc Nephrol | in press | |||
| Author | Title of Article | |||
| Miyata T et. al | Carbonyl Stress and long-term uremic complications. Advanced in Nephrology | |||
| Journal | Volume | Year | Pages Concerned | |
| Advanced in Nephrology | in press | |||
| Author | Title of Article | |||
| Miyata T et. al | Advanced glycation and lipoxidation end products: reactive carbonyl compounds related uremic toxicity. | |||
| Journal | Volume | Year | Pages Concerned | |
| Nephrol Dial Transplant | in press | |||
| Author | Title of Article | |||
| Chen J et. al | Delayed branching of endothelial capillary cords in glycated collagens is mediated by the early induction of PAI-1. | |||
| Journal | Volume | Year | Pages Concerned | |
| Am J Physiol | in press | |||
| Author | Title of Article | |||
| Kurokawa K et. al | Current issues and future perspectives of chronic renal failure. | |||
| Journal | Volume | Year | Pages Concerned | |
| J Am Soc Nephrol | in press | |||
| Author | Title of Book | ||
| Miyata T et. al | Stress carbonyle et complications a long terme de I ' uremie, in ACTUALITES NEPHROLOGIQUES JEAN HAMBURGER. | ||
| Publisher | Year | Pages | |
| HoPITAL NECKER | 1998 | 247-253 | |
| Author | Title of Book | ||
| Miyata T et. al | Oxdative stress-induced Carbonylstressin uremia. | ||
| Publisher | Year | Pages | |
| Redox Regulation of Cell Signaling and Its Clinical Application. | 1999 | 215-224 | |
| Author | Title of Book | ||
| Nakashima I et. al | Redox-oriented chemical events in signal transduction in cells. | ||
| Publisher | Year | Pages | |
| Redox Regulation of Cell Signaling and Its Clinical Application. | 1999 | 177-204. | |
| Author | Title of Book | ||
| Miyata T et. al | Alterations in nonenzymatic biochemistry of carbohydrates and lipids in uremia. | ||
| Publisher | Year | Pages | |
| Massry and Glassock's Text Book of Nephrology | 2001 | 1275-1278 | |
| Author | Title of Book | ||
| Miyata T et. al | Reactive carbonyl compounds as uremic toxins. | ||
| Publisher | Year | Pages | |
| Dialysis in the 21th Centur | in press | ||