Summary of Research Project Results Under the JSPS FY2000
"Research for the future Program"



1.Research Institution Tokyo Medical and Dental University
 
2.Research Area Life Science
 
3.Research Field Higher Brain Functions
 
4.Term of Project FY1996〜FY2000
 
5.Project Number 96L00208
 
6.Title of Project Brain Mechanisms of Symbol Manipulation

7.Projetct Leader
Name Institution,Department Title of Position
Iriki, Atsushi Tokyo Med. Dent. Univ., Grad. Sch. Professor

8.Core Members

Names Institution,Department Title of Position
Iwamura, Yoshiaki Toho Univ., Sch. Med. Professor
Ojima, Hisayuki Brain Science Institute, RIKEN Senior Res. Assoc.
Tanaka, Michio Toho Univ., Sch. Med. Assist. Prof.

9.Cooperating Researchers

Names Institution,Department Title of Position
Ichinose, Shizuko Tokyo Med. Dent. Univ., Instr. Anal. Ctr. Life Sci. Assist. Prof.
Obayashi, Shigeru Toho Univ., Sch. Med. Assist. Prof.
Ishibashi, Hidetoshi Tokyo Med. Dent. Univ., Grad. Sch. Res. Assoc.

10.Summary of Research Results

Behavioral analyses revealed that Japanese monkeys can insightfully plan a complicated series of combined tool-use acts to accomplish aimed results, and cerebral mechanisms (focused on the intraparietal cortex and related cerebral structures) responsible for this function were studied neurophysiologically. Learning-induced morphological alterations of axon terminals which project from visual cortices onto the intraparietal area were reveal both light-and electron-microscopically. Using H2[15O]-labeled PET, above intraparietal area was confirmed to be activated during the monkeys using tools, together with other brain areas including supplementary- and pre-motor areas, cerebellum and basal ganglia. Also in this intraparietal cortex, area-specific expression pattern of immediate-early-genes was revealed by in sizu hybridization methods, and neurotrophic factors (such as BDNF or NT-3) and their receptor trkB were also shown to be expressed during tool-use learning in above brain area.

11.Key Words

(1)Japanese monkeys、(2)Tool-use、(3)Self-image
(4)Parietal association cortex、(5)Multisensory integration、(6)Single unit recordings
(7)Neurotrophic factors、(8)Cortico-cortical connections、(9)Positron CT

12.References

[Reference Articles]
Author Title of Article
Ishibashi H Acquisition and development of monkey tool-use: behavioral and kinematic analyses.
Journal Volume Year Pages Concerned
Can. J. Physiol. Pharmacol. 78 2000 958-966

Author Title of Article
Obayashi S Subjective image of invisible hand coded by monkey intraparietal neurons.
Journal Volume Year Pages Concerned
Neuroreport 11 2000 3499-3505

Author Title of Article
Taoka M Bilateral receptive field neurons in the hindlimb region of the postcentral somatosensory cortex in awake macaque monkeys.
Journal Volume Year Pages Concerned
Exp. Brain Res. 134 2000 139-146

Author Title of Article
Hiraba H Deficits of masticatory movement caused by lesions in the orofacial somatosensory cortex of the awake cat.
Journal Volume Year Pages Concerned
Somatosensory and Motor Res. 17 2000 361-372

Author Title of Article
Ishibashi H Tool-use learning selectively induces expression of brain-derived neurotrophic factor, its receptor trkB, and neurotrophin 3 in the intraparietal cortex of monkeys.
Journal Volume Year Pages Concerned
Cogn. Brain Res.   2001 in press

Author Title of Article
Iriki A Self-images in the video monitor coded by monkey intraparietal neurons.
Journal Volume Year Pages Concerned
Neurosci. Res.   2001 in press

Author Title of Article
Obayashi S Monkey PET imaging of brain activation subserving tool-use.
Journal Volume Year Pages Concerned
Neurosci. Res., Suppl. 24 2000 S78

Author Title of Article
Toda T The callosal connections in the forelimb region of the monkey postcentral somatsensory cortex.
Journal Volume Year Pages Concerned
Neurosci Res., Suppl. 24 2000 S112

Author Title of Article
Taoka M Integration of somatic information from different body parts in the second somatosensory cortex.
Journal Volume Year Pages Concerned
Neurosci Res., Suppl. 24 2000 S112

Author Title of Article
Iriki A Coding self-image by parietal neurons.
Journal Volume Year Pages Concerned
Proc. 26th SEIRIKEN Int. Symp.   2000 24-25

Author Title of Article
Obayashi S PET imaging of the monkey brain during tool-use.
Journal Volume Year Pages Concerned
Soc. Neurosci. Abst. 226 2000 1500

Author Title of Article
Ishibashi H Increased gene expression in the monkey intraparietal cortex underlying alteration of somatosensory-visual integration accompanysing tool-use learning.
Journal Volume Year Pages Concerned
Proc. 2nd. Multisens. Res. Conf.   2000 4

[Reference Books]
Author Title of Book
Iwamura Y Bilateral activity and callosal connections in the somatosensory cortex.
Publisher Year Pages
Neuroscientist 2001 in press

Author Title of Book
Obayashi S Functinal brain mapping of monkey tool use.
Publisher Year Pages
  2001 submitted

Author Title of Book
Iwamura Y The Corsini Encyclopedia of Psychology and Behavioral Science.
Publisher Year Pages
John Wiley 2000 1247-1248

Author Title of Book
Iwamura Y Somatosensory Processing-from single neuron to brain imaging.
Publisher Year Pages
Harwood Academic 2001 101-112


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