| 1.Research Institution | Tokyo Medical and Dental University | |
| 2.Research Area | Life Science | |
| 3.Research Field | Higher Brain Functions | |
| 4.Term of Project | FY1996〜FY2000 | |
| 5.Project Number | 96L00208 | |
| 6.Title of Project | Brain Mechanisms of Symbol Manipulation |
| Name | Institution,Department | Title of Position |
| Iriki, Atsushi | Tokyo Med. Dent. Univ., Grad. Sch. | Professor |
8.Core Members
| Names | Institution,Department | Title of Position |
| Iwamura, Yoshiaki | Toho Univ., Sch. Med. | Professor |
| Ojima, Hisayuki | Brain Science Institute, RIKEN | Senior Res. Assoc. |
| Tanaka, Michio | Toho Univ., Sch. Med. | Assist. Prof. |
9.Cooperating Researchers
| Names | Institution,Department | Title of Position |
| Ichinose, Shizuko | Tokyo Med. Dent. Univ., Instr. Anal. Ctr. Life Sci. | Assist. Prof. |
| Obayashi, Shigeru | Toho Univ., Sch. Med. | Assist. Prof. |
| Ishibashi, Hidetoshi | Tokyo Med. Dent. Univ., Grad. Sch. | Res. Assoc. |
10.Summary of Research Results
|
Behavioral analyses revealed that Japanese monkeys can insightfully plan a complicated series of combined tool-use acts to accomplish aimed results, and cerebral mechanisms (focused on the intraparietal cortex and related cerebral structures) responsible for this function were studied neurophysiologically. Learning-induced morphological alterations of axon terminals which project from visual cortices onto the intraparietal area were reveal both light-and electron-microscopically. Using H2[15O]-labeled PET, above intraparietal area was confirmed to be activated during the monkeys using tools, together with other brain areas including supplementary- and pre-motor areas, cerebellum and basal ganglia. Also in this intraparietal cortex, area-specific expression pattern of immediate-early-genes was revealed by in sizu hybridization methods, and neurotrophic factors (such as BDNF or NT-3) and their receptor trkB were also shown to be expressed during tool-use learning in above brain area. |
11.Key Words
(1)Japanese monkeys、(2)Tool-use、(3)Self-image
(4)Parietal association cortex、(5)Multisensory integration、(6)Single unit recordings
(7)Neurotrophic factors、(8)Cortico-cortical connections、(9)Positron CT
12.References
| Author | Title of Article | |||
| Ishibashi H | Acquisition and development of monkey tool-use: behavioral and kinematic analyses. | |||
| Journal | Volume | Year | Pages Concerned | |
| Can. J. Physiol. Pharmacol. | 78 | 2000 | 958-966 | |
| Author | Title of Article | |||
| Obayashi S | Subjective image of invisible hand coded by monkey intraparietal neurons. | |||
| Journal | Volume | Year | Pages Concerned | |
| Neuroreport | 11 | 2000 | 3499-3505 | |
| Author | Title of Article | |||
| Taoka M | Bilateral receptive field neurons in the hindlimb region of the postcentral somatosensory cortex in awake macaque monkeys. | |||
| Journal | Volume | Year | Pages Concerned | |
| Exp. Brain Res. | 134 | 2000 | 139-146 | |
| Author | Title of Article | |||
| Hiraba H | Deficits of masticatory movement caused by lesions in the orofacial somatosensory cortex of the awake cat. | |||
| Journal | Volume | Year | Pages Concerned | |
| Somatosensory and Motor Res. | 17 | 2000 | 361-372 | |
| Author | Title of Article | |||
| Ishibashi H | Tool-use learning selectively induces expression of brain-derived neurotrophic factor, its receptor trkB, and neurotrophin 3 in the intraparietal cortex of monkeys. | |||
| Journal | Volume | Year | Pages Concerned | |
| Cogn. Brain Res. | 2001 | in press | ||
| Author | Title of Article | |||
| Iriki A | Self-images in the video monitor coded by monkey intraparietal neurons. | |||
| Journal | Volume | Year | Pages Concerned | |
| Neurosci. Res. | 2001 | in press | ||
| Author | Title of Article | |||
| Obayashi S | Monkey PET imaging of brain activation subserving tool-use. | |||
| Journal | Volume | Year | Pages Concerned | |
| Neurosci. Res., Suppl. | 24 | 2000 | S78 | |
| Author | Title of Article | |||
| Toda T | The callosal connections in the forelimb region of the monkey postcentral somatsensory cortex. | |||
| Journal | Volume | Year | Pages Concerned | |
| Neurosci Res., Suppl. | 24 | 2000 | S112 | |
| Author | Title of Article | |||
| Taoka M | Integration of somatic information from different body parts in the second somatosensory cortex. | |||
| Journal | Volume | Year | Pages Concerned | |
| Neurosci Res., Suppl. | 24 | 2000 | S112 | |
| Author | Title of Article | |||
| Iriki A | Coding self-image by parietal neurons. | |||
| Journal | Volume | Year | Pages Concerned | |
| Proc. 26th SEIRIKEN Int. Symp. | 2000 | 24-25 | ||
| Author | Title of Article | |||
| Obayashi S | PET imaging of the monkey brain during tool-use. | |||
| Journal | Volume | Year | Pages Concerned | |
| Soc. Neurosci. Abst. | 226 | 2000 | 1500 | |
| Author | Title of Article | |||
| Ishibashi H | Increased gene expression in the monkey intraparietal cortex underlying alteration of somatosensory-visual integration accompanysing tool-use learning. | |||
| Journal | Volume | Year | Pages Concerned | |
| Proc. 2nd. Multisens. Res. Conf. | 2000 | 4 | ||
| Author | Title of Book | ||
| Iwamura Y | Bilateral activity and callosal connections in the somatosensory cortex. | ||
| Publisher | Year | Pages | |
| Neuroscientist | 2001 | in press | |
| Author | Title of Book | ||
| Obayashi S | Functinal brain mapping of monkey tool use. | ||
| Publisher | Year | Pages | |
| 2001 | submitted | ||
| Author | Title of Book | ||
| Iwamura Y | The Corsini Encyclopedia of Psychology and Behavioral Science. | ||
| Publisher | Year | Pages | |
| John Wiley | 2000 | 1247-1248 | |
| Author | Title of Book | ||
| Iwamura Y | Somatosensory Processing-from single neuron to brain imaging. | ||
| Publisher | Year | Pages | |
| Harwood Academic | 2001 | 101-112 | |