Summary of Research Project Results Under the JSPS FY2000
"Research for the future Program"



1.Research Institution Kyoto University
 
2.Research Area Life Science
 
3.Research Field Higher Brain Functions
 
4.Term of Project FY1996〜FY2000
 
5.Project Number 96L00206
 
6.Title of Project Search for Dynamic Neuronal Assemblies Underlying Information Processing of Memory

7.Projetct Leader
Name Institution,Department Title of Position
Yoshio Sakurai Kyoto University Graduate School of Letters, Psychology Professor

8.Core Members

Names Institution,Department Title of Position
Kiyoshi Kurata Hirosaki University School of Medicine, Physiology Professor
Tetsuo Yamamori Okazaki National Institutes, Institute for Basic Biology Professor

9.Cooperating Researchers

Names Institution,Department Title of Position
Masato Inoue Kyoto University, Primate Research Institute Research Associate
Masumi Wakita Kyoto University, Primate Research Institute Instructor
Takashi Kitsukawa Okazaki National Institutes, Institute for Basic Biology Instructor

10.Summary of Research Results

1. Studies with rats, i.e., multiple-task comparison of multiple neuronal activities recorded simultaneously, showed that hippocampal cell-assemblies encoded difference of tasks (context or situation). They also showed that the cell assembly encoding the task for processing of temporal events was completely included in the cell assembly encoding the task for processing of stimulus properties.
2. A study with monkeys succeeded training of a behavioral task suitable for investigating neuronal activity and their correlations underlying short-term retention of temporal information of stimuli. Multi-neuronal activities and their correlations in the prefrontal cortex during performance of the tasks are being analyzed by a newly developed system with software which made use of Independent Component Analysis (ICA).
3. A study with monkeys showed different roles in different motor-related areas for memory of new motor-visual association (prism adaptation). It also showed that functional relations among neurons in the premotor area changed dynamically in the process of learning of the prism adaptation.
4. A study with rats showed that c-Fos expression, an indicator of activated groups of neurons, in the neocortical areas changed dynamically among different memory tasks the rats were performing. The changed c-Fos were in the excitatory neurons only.
5. A study with mice are developing new transgenic mice to see the dendrites and axons of neuronal assemblies being activated during performance of memory tasks.

11.Key Words

(1)Memory、(2)Neuronal Circuit、(3)Cell Assembly
(4)Hippocampus、(5)Neocortex、(6)Gene Expression

12.References

[Reference Articles]
Author Title of Article
Sakurai, Y. Hippocampal and neocortical cell assemblies ...
Journal Volume Year Pages Concerned
Journal of Neuroscience 16 1996 2807-2814

Author Title of Article
Sakurai, Y. Population coding by cell assemblies ...
Journal Volume Year Pages Concerned
Neuroscience Research 26 1996 1-16

Author Title of Article
Sakurai, Y. Is cell-assembly coding a general principle ...
Journal Volume Year Pages Concerned
Proceedings of the 2nd RIEC International Symposium   1997 67-72

Author Title of Article
Sakurai, Y. Cell-assembly coding for several information ....
Journal Volume Year Pages Concerned
Proceedings of the 3rd Riken-Tamagawa ...   1998 19

Author Title of Article
Sakurai, Y. The search for cell assemblies in the working ...
Journal Volume Year Pages Concerned
Behavioural Brain Research 91 1998 1-13

Author Title of Article
Sakurai, Y. Cell-assembly coding in several memory processes.
Journal Volume Year Pages Concerned
Neurobiology of Learning and Memory 70 1998 212-225

Author Title of Article
Sakurai, Y. How do cell assemblies encode information ...
Journal Volume Year Pages Concerned
Neuroscience and Biobehavioral Reviews 23 1999 785-796

Author Title of Article
Sakurai, Y. Elemental, configural, and sequential memory ...
Journal Volume Year Pages Concerned
Psychobiology 27 2000 486-490

Author Title of Article
Takahashi, S. Classification of neuronal activities from ...
Journal Volume Year Pages Concerned
Neurocomputing   2001 In press

Author Title of Article
Wang, Y. Quantitative analyses of thalamic and cortical ...
Journal Volume Year Pages Concerned
Brain Research 781 1998 59-67

Author Title of Article
Kurata, K. Reacquisition deficits in prism adaptation after ...
Journal Volume Year Pages Concerned
Journal of Neurophysiology 81 1999 1927-1938

Author Title of Article
Kurata, K. Sensorimotor transformations in the dorsal ...
Journal Volume Year Pages Concerned
Hirosaki Medical Journal 5.51 1999 75-80

Author Title of Article
Kurata, K. Activation of the dorsal premotor cortex and ...
Journal Volume Year Pages Concerned
Journal of Neurophysiology 84 2000 1667-1672

Author Title of Article
Yamamori, T. Immediately early gene expression.
Journal Volume Year Pages Concerned
Report of a workshop; Human Frontiers ...   1996 28-38

Author Title of Article
Yano, R. Cerebellar long-term plasticity and gene expression
Journal Volume Year Pages Concerned
Proceding of the Uehara Memorial ...   1996 35-44

Author Title of Article
Fujiwara, T. Interaction of HPC-1/syntaxin 1A with ...
Journal Volume Year Pages Concerned
Biochemical and Biophysical Research ... 231 1999 352-355

Author Title of Article
Matsuzawa, M. Novel activities of midkine were examined on ...
Journal Volume Year Pages Concerned
Cellular and Molecular Neurobiology 19 1999 209-220

Author Title of Article
Komine, Y. A novel type of non-coding RNA expressed ...
Journal Volume Year Pages Concerned
Molecular Brain Research 66 1999 1-13

Author Title of Article
Onishi, A. Dichromatism in macaque monkeys
Journal Volume Year Pages Concerned
Nature 422 1999 140-141

Author Title of Article
Karachot, L. Rapidly turned over protein maintains metabotropic ...
Journal Volume Year Pages Concerned
NeuroReport 11 2000 2903-2906

Author Title of Article
Serizawa S. Mutually exclusive expression of odorant receptor ...
Journal Volume Year Pages Concerned
Nature Neuroscience 3 2000 687-693

Author Title of Article
Liang, F. Differential expression of gamma-aminobutyric ...
Journal Volume Year Pages Concerned
Journal of Comparative Neurology 416 2001 475-495

Author Title of Article
Tochiani, S. occl is preferentially expressed in the primary ...
Journal Volume Year Pages Concerned
European Journal of Neuroscience 13 2001 297-307

Author Title of Article
Watakabe, A. GDF7, a BMP/TGF beta family member, is ...
Journal Volume Year Pages Concerned
Journal of Neurochemistry 76 2001 1455-1464

Author Title of Article
Liang, F. Differential expression of gamma-aminobutyric ...
Journal Volume Year Pages Concerned
Journal of Comparative Neurology   2001 In press

Author Title of Article
Karachot, L. Induction of long-term depression in cerebellar ...
Journal Volume Year Pages Concerned
Journal of Neurophysiology   2001 In press

Author Title of Article
Vigot, R. Synaptic LTD in vivo recorded on the rat ...
Journal Volume Year Pages Concerned
Archives of Italian Biology   2001 In press

Author Title of Article
Watakabe A. Similarity and variation in gene expression ...
Journal Volume Year Pages Concerned
Molecular Brain Research   2001 In press

Author Title of Article
Mikami, A. Memory of object identity
Journal Volume Year Pages Concerned
Brain Processes and Memory   1996 369-376

Author Title of Article
Mikami, A. Neural representation of visual object in ...
Journal Volume Year Pages Concerned
Proceedings of the 2nd RIEC International Symposium   1997 107-112

Author Title of Article
Koyama, T. Nociceptive neurons in the macaque anterior ...
Journal Volume Year Pages Concerned
NeuroReport 9 1998 2663-2667

[Reference Books]
Author Title of Book
Sakurai, Y. Brain Processes and Memory
Publisher Year Pages
Elsevier 1996 414

Author Title of Book
Sakurai, Y. The Hippocampus: Functions and Clinical Relevance
Publisher Year Pages
Elsevier 1996 474

Author Title of Book
Sakurai, Y. Neuronal Ensembles
Publisher Year Pages
Springer 2001 In press

Author Title of Book
Yamamori, T. Chemical Factors in Neural Growth ...
Publisher Year Pages
Elsevier 1996 414

Author Title of Book
Mikami, A. The association cortices: structure and function.
Publisher Year Pages
Hawood Academic Pub. 1997 317


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