Summary of Research Project Results Under the JSPS FY2000
"Research for the future Program"



1.Research Institution Kyoto Prefectural University of Medicine
 
2.Research Area Life Science
 
3.Research Field Higher Brain Functions
 
4.Term of Project FY1996〜FY2000
 
5.Project Number 96L00201
 
6.Title of Project Functions of the Basal Ganglia in Behavioral Learning and Memory

7.Projetct Leader
Name Institution,Department Title of Position
Minoru, Kimura Kyoto Prefectural University of Medicine Professor

8.Core Members

Names Institution,Department Title of Position
Hiromichi, Sato Osaka University, Faculty of Health and Sport Sciences Professor
Yoshio, Imahori Kyoto Prefectural University of Medicine Associate Professor
Keisuke, Toyama Kyoto Prefectural University of Medicine Emeritus Professor

9.Cooperating Researchers

Names Institution,Department Title of Position
Naoyuki, Matsumoto Kyoto Prefectural University of Medicine Instructor
Yoshio, Ohmori Kyoto Prefectural University of Medicine Instructor
Satoshi, Shimegi Osaka University, Faculty of Health and Sport Sciences Assistant Professor

10.Summary of Research Results

We have obtained large volume of new findings on the mechanisms of learning and memory in the basal ganglia and on the cortico-basal ganglia relations through 3 major projects.
(1) Mechanisms of learning and memory in the basal ganglia: Major findings obtained in this study are: Discharge properties of striate interneurons (TANs) acquired through learning are maintained by D2 type dopamine receptor mechanisms; The striate neurons adaptively change their activity to achieve goal-directed serial activation of motor elements; The nigrostrriate dopamine system plays a crucial role in learning to acquire tactics for goal-directed motor sequence.
(2) Functional roles of thalamo-striate projections: We found that information related to attention and orienting is transferred from the primate CM/Pf thalamus to the striatum during behavioral tasks.
(3) Involvement of human basal ganglia in sequence motor learning: We established a new PET imaging method to visualize dopamine turnover and postsynaptic activation in the human striatum.
(4) Contextual modulation of primary visual cortical activity: Responses of V1 neurons to visual stimuli covering large visual field are suppressed by a group of neurons in terms of collateral axons of pyramidal neurons located in layers II/III.
(5) Development of high resolution magnetoencephalography (MEG): We newly developed a MEG system with both high spatial and time resolutions to non-invasively measure human brain activity.
(6) Information representation and interaction between functional modules in the primary somatosensory cortex: We found a new aspect of somatosensory information representation in the rat Barrel cortex which is primarily involved in somatosensory feature extractions.

11.Key Words

(1)Learning、(2)Memory、(3)Basal ganglia
(4)Motor sequence、(5)Reinforcement learning、(6)Thalamus
(7)PET、(8)Dopamine、(9)Contexual modulation

12.References

[Reference Articles]
Author Title of Article
Kimura, M., Kato, M., Shimazaki, H., Watanabe, K., Matsumoto, N. Neural information transferred from the putamen to the globus pallidus during learned movement in the monkey.
Journal Volume Year Pages Concerned
J Neurophysiol. 76 1996 3771-3786

Author Title of Article
Yamaki, T., Yoshino, E., Fujimoto, M., Ohmori, Y., Imahori, Y., Ueda, S. Chronological positron emission tomographic study of severe diffuse brain injury in the chronic stage.
Journal Volume Year Pages Concerned
J Trauma. 40 1996 50-56

Author Title of Article
Ohmori, Y., Imahori, Y., Ueda, S., Fujii, R., Wakita, K., Inoue, M., Tazawa, S. Radioiodinated diacylglycerol analogue: a potential imaging agent for single-photon emission tomographic investigations of cerebral ischaemia.
Journal Volume Year Pages Concerned
Eur J Nucl Med. 23 1996 280-289

Author Title of Article
Yamaki, T., Imahori, Y., Ohmori, Y., Yoshino, E., Hohri, T., Ebisu, T., Ueda, S. Cerebral hemodynamics and metabolism of severe diffuse brain injury measured by PET.
Journal Volume Year Pages Concerned
J Nucl Med. 37 1996 1166-1170

Author Title of Article
Ohmori, Y., Maekawa, M., Imahori, Y., Yoshino, E., Ueda, S. Spontaneous regression of intracranial arteriovenous malformation on PET.
Journal Volume Year Pages Concerned
J Nucl Med. 37 1996 1673-1676

Author Title of Article
木村 實 大脳基底核のはたらき
Journal Volume Year Pages Concerned
生体の科学 47 1996 44-49

Author Title of Article
今堀良夫、井戸達雄、岩田練、舟木善仁、籏野健太郎 セカンドメッセンジャー画像化(PET)によるヒト脳機能解析法の開発
Journal Volume Year Pages Concerned
Innervision. 11 1996 14

Author Title of Article
Kimura, M., Matsumoto, N. Neural activity in the basal ganglia: functional implications.
Journal Volume Year Pages Concerned
Adv Neurol. 74 1997 111-118

Author Title of Article
Kimura, M., Matsumoto, N. Nigrostriatal dopamine system may contribute to behavioral learning through providing reinforcement signals to the striatum.
Journal Volume Year Pages Concerned
Euro Neurol. 38 1997 11-17

Author Title of Article
Mishima, Y., Imahori, Y., Honda, C., Hiratsuka, J., Ueda, S., Ido, T. In vivo diagnosis of human malignant melanoma with positron emission tomography using specific melanoma-seeking 18F-DOPA analogue.
Journal Volume Year Pages Concerned
J Neurooncol. 33 1997 163-169

Author Title of Article
Kusuki, T., Imahori, Y., Ueda, S., Inokuchi, K. Dopaminergic modulation of LTP induction in the dentate gyrus of intact brain.
Journal Volume Year Pages Concerned
Neuroreport. 8 1997 2037-2040

Author Title of Article
Yamamoto, N., Higashi, S., Toyama, K. Stop and branch behaviors of Geniculocortical Axons: A Time-lapse study in organotypic cocultures.
Journal Volume Year Pages Concerned
J Neurosci. 17 1997 3653-3663

Author Title of Article
木村 實 大脳基底核と強化学習
Journal Volume Year Pages Concerned
医学のあゆみ 181 1997 1058-1060

Author Title of Article
今堀良夫、藤井 亮、上田 聖 脳の世紀を拓く:ポジトロンCTによる脳機能解析
Journal Volume Year Pages Concerned
新医療 265 1997 92-96

Author Title of Article
藤井亮、今堀良夫、木村寛、外山敬介、湯浅光秋、熊倉豊、堀井均、脇田員男、柳生武彦、中村隆一、上田聖、井戸達雄、金綱隆弘 フッ素18標識フルオロドーパ合成システムとその有用性の検討
Journal Volume Year Pages Concerned
核医学 34 1997 1055-1061

Author Title of Article
Watanabe, K., Kimura, M. Dopamine-receptor mediated mechanisms involved in the expression of learned activity of primate striatal neurons.
Journal Volume Year Pages Concerned
J Neurophysiol. 79 1998 2568-2580

Author Title of Article
Kusuki, T., Imahori, Y., Fujii, R, Inokuchi, K., Kimura, M., Ueda, S. Potentiation of phosphoinositide-derived signals induced during LTP in rat intact brain.
Journal Volume Year Pages Concerned
NeuroReport. 9 1998 2085-2088

Author Title of Article
Imahori, Y., Ueda, S., Ohmori, Y., Kusuki, T., Ono, K., Fujii, R., Ido, T. Fluorine-18-labeled fluoroboronophenylalanine PET in patients with glioma.
Journal Volume Year Pages Concerned
J Nucl Med. 39 1998 325-333

Author Title of Article
Imahori, Y., Ueda, S., Ohmori, Y., Sakae, K., Kusuki, T., Kobayashi, T., Takagaki, M., Ono, K., Ido, T., Fujii, R. Positron emission tomography-based boron neutron capture therapy using boronophenylalanine for high-grade gliomas: Part-I.
Journal Volume Year Pages Concerned
Clinical Cancer Res. 4 1998 1825-1832

Author Title of Article
Imahori, Y., Ueda, S., Ohmori, Y., Sakae, K., Kusuki, T., Kobayashi, T., Takagaki, M., Ono, K., Ido, T., Fujii, R. Positron emission tomography-based boron neutron capture therapy using boronophenylalanine for high-grade gliomas: Part-II.
Journal Volume Year Pages Concerned
Clinical Cancer Res. 4 1998 1833-1841

Author Title of Article
Watanabe, D., Inokawa, H., Hashimoto., K., Suzuki, N. Kano, M. Shigemoto, R. Hirano,. T., Toyama, K., Kaneko, S., Yokoi, M., Moriyoshi, K., Suzuki, M., Kobayashi, K., Nagatsu, T., Kreitman, R. Pastan, I., Nakanishi, S. Ablation of cerebellar Golgi cells disrupts synaptic integration involving GABA inhibition and NMDA receptor activation in motor coordiantion.
Journal Volume Year Pages Concerned
Cell. 95 1998 17-27

Author Title of Article
Akase, E., Inokawa, H., Toyama, K. Neuronal responsiveness to three-dimensional motion in cat postero-medial lateral suprasylvian cortex.
Journal Volume Year Pages Concerned
Exp Brain Res. 122 1998 214-226

Author Title of Article
木村 實 大脳基底核と手の運動の強化学習
Journal Volume Year Pages Concerned
神経研究の進歩 42 1998 117-123

Author Title of Article
木村 實 運動のplanningと調節における基底核の役割
Journal Volume Year Pages Concerned
CLINICAL NEUROSCIENCE. 16 1998 500-503

Author Title of Article
木村 實 運動計画と大脳基底核
Journal Volume Year Pages Concerned
科学 68 1998 970-979

Author Title of Article
渡辺克茂、木村 實 記憶と基底核
Journal Volume Year Pages Concerned
CLINICAL NEUROSCIENCE. 16 1998 504-505

Author Title of Article
天神博志、今堀良夫 PETによる脳循環調節研究.
Journal Volume Year Pages Concerned
血管と内皮 8 1998 386-389

Author Title of Article
今堀良夫 PET(positron emission tomography)を用いたアニラセタムの神経伝達改善作用の検討
Journal Volume Year Pages Concerned
診療と新薬 35 1998 1066-1072

Author Title of Article
中瀬泰然、水野敏樹、高梨芳彰、中島健二、今堀良夫、古谷誠一、成瀬昭二 Proton magnetic resonance spectroscopy(1H-MRS)によりNAAの低下を認めたcorticobasal degeneration(CBD)の1例.
Journal Volume Year Pages Concerned
脳神経 50 1998 421-425

Author Title of Article
矢野ひとみ、今堀良夫、天神博志、上田 聖 音楽療法に関するポジトロンCTを用いたシグナル伝達画像による評価.
Journal Volume Year Pages Concerned
音楽療法研究 3 1998 57-62

Author Title of Article
天神博志、大森義男、今堀良夫、上田 聖、中島健二. 虚血性脳血管障害に対する浅側頭動脈・中大脳動脈吻合術 (STA-MCA anastomosis) の適応との転帰.
Journal Volume Year Pages Concerned
脳卒中 20 1998 351-355

Author Title of Article
Matsumoto, N., Hanakawa, T., Maki, S., Graybiel, AM., Kimura, M. Nigrostriatal dopamine system in learning to perform sequential motor tasks in a predictive manner.
Journal Volume Year Pages Concerned
J Neurophysiol. 82 1999 978-998

Author Title of Article
Sato, H., Hata, Y., Tsumoto, T. Effects of blocking non-NMDA receptors on visual responses in the cat visual cortex.
Journal Volume Year Pages Concerned
Neuroscience. 94 1999 697-703

Author Title of Article
Shimegi, S., Ichikawa, T., Akasaki, T., Sato, H. Temporal characteristics of response integration evoked by multiple whisker stimulations in the barrel cortex of rats.
Journal Volume Year Pages Concerned
J Neurosci. 19 1999 10164-10175

Author Title of Article
Imahori, Y., Fujii, R., Kondo, M., Ohmori, Y., Nakajima, K. Neural features of recovery from CNS injury revealed by PET in human brain.
Journal Volume Year Pages Concerned
Neuroreport. 10 1999 117-121

Author Title of Article
Kondo, M., Imahori, Y., Mori, S., Ueda, Y., Fujii, R., Nakajima, K. Aberrant plasticity in Alzheimer's disease.
Journal Volume Year Pages Concerned
Neuroreport. 10 1999 1481-1484

Author Title of Article
Kobori, N., Imahori, Y., Mineura, K., Ueda, S., Fujii, R. Visualization of mRNA expression in CNS using 11C-labeled phosphorothioate oligodeoxynucleotide.
Journal Volume Year Pages Concerned
Neuroreport. 10 1999 2971-2974

Author Title of Article
Matsumoto, K., Imahori, Y., Fujii, R., Ohmori, Y., Sekimoto, T., Ueda, S., Mineura, K. Evaluation of phosphoinositides turnover on ischemic human brain with 11C-diacylglycerol using positron emission tomography.
Journal Volume Year Pages Concerned
J Nucl Med. 40 1999 1590-1594

Author Title of Article
Mizuno, T., Takanashi, Y., Nakase, T., Makino, M., Iwamoto, K., Nakajima, K., Furuya, S., Naruse, S., Imahori, Y., Yoshida, Y. Clinical application of magnetoencephalography in a patient with corticobasal degeneration.
Journal Volume Year Pages Concerned
J Neuroimaging. 9 1999 45-47

Author Title of Article
Toyama, K., Yoshikawa, K., Yoshida, Y., Kondo, S., Tomita, Y., Takanashi, Y., Ejima, Y., Yoshizawa, S. A new method for magnetoencephalography (MEG) : Three dimensional magnetometer-spatial filter system.
Journal Volume Year Pages Concerned
Neuroscience. 91 1999 405-415

Author Title of Article
Higashi, S., Crair, M., Kurotani, T., Inokawa, H., Toyama, K. Altered spatial patterns of functional thalamocortical connections in barrel cortex after neonatal infraorbital nerve cut revealed by optical recording.
Journal Volume Year Pages Concerned
Neuroscience.   1999 439-452

Author Title of Article
Yamada, K., Yamamoto, N., Toyama, K. Development of membrane properties of rat neocortical neurons studies in organotypic cocultures.
Journal Volume Year Pages Concerned
Neuroscience Letters. 275 1999 65-68

Author Title of Article
Yoshimura, Y., Sato, H., Imamura, K., Watanabe, Y. Properties of horizontal and vertical inputs to pyramidal cells in the superficial layers of the cat visual cortex.
Journal Volume Year Pages Concerned
J Neurosci. 20 2000 1931-1940

Author Title of Article
Shimegi, S., Akasaki, T., Ichikawa, T., Sato, H. Physiological and anatomical organization of multiwhisker response interaction in the barrel cortex of rats.
Journal Volume Year Pages Concerned
J Neurosci. 20 2000 6241-6248

Author Title of Article
Kawano, H., Takeuchi, Y., Misawa, A., Sawada, T., Imahori, Y. Putaminal necrosis presenting with hemidystonia.
Journal Volume Year Pages Concerned
Pediatric Neurology. 22 2000 222-224

Author Title of Article
Wakita, K., Imahori, Y., Ido, T., Fujii, R., Horii, H., Shimizu, M., Nakajima, S., Mineura, K., Nakamura, T., Kanatsuna, T. Simplification for measuring the input function for 18FDG-PET:Investigation of one-point blood sampling method.
Journal Volume Year Pages Concerned
J Nucl Med. 41 2000 1484-1490

Author Title of Article
Chida, M., Kagaya, Y., Imahori, Y., Namiuchi, S., Fujii, R., Fukuchi, M., Takahashi, C., Tezuka, F., Ido, T., Shirato, K. Visualization of myocardial phosphoinositide turnover with 1-[1-11C]-butyry1-2-palmitoyl-rac-glycerol in rats with myocardial infarction.
Journal Volume Year Pages Concerned
J Nucl Med. 41 2000 2063-2068

Author Title of Article
Toyama, K., Yoshikawa, K. Tomita, S., Kajihara, S. A new technique in magnetoencephalography and its application to visual neuroscience.
Journal Volume Year Pages Concerned
Integrated Human Brain Science Theory, Method Application (Music)   2000  

Author Title of Article
Imamura, Y., Inokawa H., Ito A., Kadotani H., Toyama K., Noda M., Nakanishi S., Hirano T. Roles of GABAergic inhibition and NMDA receptor subunits in the spatio-temporal integration in the cerebellar cortex of mice.
Journal Volume Year Pages Concerned
Neuroscience Research. 38 2000 289-301

Author Title of Article
Ikeda S., Toyama K. Independent component analysis for noisy data - MEG data analysis.
Journal Volume Year Pages Concerned
Neural Networks. 13 2000 1063-1074

Author Title of Article
Yamada, K., Yamamoto, N., Toyama, K. Development of NMDA and non-NMDA receptor-mediated excitatory synaptic transmission in geniculocortical and corticocortical in organotypic coculture preparations.
Journal Volume Year Pages Concerned
European Journal of Neuroscience. 12 2000 3854-3862

Author Title of Article
木村 實 大脳基底核の機能はどこまでわかったか
Journal Volume Year Pages Concerned
脳21 13 2000 9-14

Author Title of Article
松本直幸、木村 實 大脳基底核の学習機能
Journal Volume Year Pages Concerned
脳21 13 2000 23-28

Author Title of Article
木村 實 運動動作の学習における大脳基底核の役割
Journal Volume Year Pages Concerned
脳の科学 22 2000 1067-1073

Author Title of Article
木村 實、今井寿正 Practical Talk: 大脳基底核の機能について
Journal Volume Year Pages Concerned
KINESIS Advances in Movement Neuroscience. 5 2000 3-9

Author Title of Article
Matsumoto, N, Minamimoto, T., Graybiel, AM., Kimura, M. Neurons in the thalamic CM/Pf complex supply neurons in the striatum with information about behaviorally significant events.
Journal Volume Year Pages Concerned
J Neurophysiol. 85 2001 960-976

Author Title of Article
Ueda, Y., Kimura, M. Neuronal activity of the primate putamen during performance of instructed and remembered motor sequence tasks.
Journal Volume Year Pages Concerned
J Neurophysiol (sub-mitted)    

Author Title of Article
Kondo M., Imahori Y., Mineura K., Kimura M., Nakajima, K. Altered neuronal interaction in the basal ganglia-thalamocortical circuit of corticobasal degeneration: A positron emission tomographic study.
Journal Volume Year Pages Concerned
Neuroreport (sub-mitted)    

Author Title of Article
木村 實 大脳皮質基底核系の機能研究 -現状と展望-
Journal Volume Year Pages Concerned
京都府立医科大学雑誌 110 2001 89-103

[Reference Books]
Author Title of Book
Matsumoto, N., Hanakawa, T., Maki, S., Kimura, M. THE BASAL GANGLIA V.
Publisher Year Pages
Plenum press, New York. 1996 201-208

Author Title of Book
Matsumoto, N., Hanakawa, T., Maki, S., Kimura, M. Brain Processes and Memory.
Publisher Year Pages
Elsevier. 1996 307-315

Author Title of Book
佐藤宏道、吉村由美子 Molecular Medicine.
Publisher Year Pages
中山書店、東京 1996 706-713

Author Title of Book
Imahori, Y., Fujii, R., Ueda, S. Recent Advances in Biomedical Imaging.
Publisher Year Pages
Elsevier Science B. V., Amsterdam 1997 109-112

Author Title of Book
木村 實 最新内科学大系
Publisher Year Pages
中山書店 1997 33-41

Author Title of Book
吉村由美子、佐藤宏道 臨床科学
Publisher Year Pages
エースアート、大阪 1997 211-218

Author Title of Book
佐藤宏道 Bio Science 用語ライブラリー「脳・神経」
Publisher Year Pages
羊土社、東京 1997 200-201

Author Title of Book
吉村由美子、佐藤宏道 Bio Science 用語ライブラリー「脳・神経」
Publisher Year Pages
羊土社、東京 1997 202-203

Author Title of Book
外山敬介 生体の科学
Publisher Year Pages
医学書院 1997 12-19

Author Title of Book
外山敬介、黒谷 亨、東 秀二、山本亘彦 CLINICAL NEUROSCIENCE.
Publisher Year Pages
中外医学社 1997 43-48

Author Title of Book
外山敬介、黒谷 亨、山本亘彦 小児科診療
Publisher Year Pages
(株)診断と治療社 1997 39-47

Author Title of Book
外山敬介、黒谷 亨 CLINICAL NEUROSCIENCE
Publisher Year Pages
中外医学社 1997 14-17

Author Title of Book
外山敬介 神経精神薬理
Publisher Year Pages
星和書店 1997 959-966

Author Title of Book
外山敬介、甘利俊一 科学
Publisher Year Pages
岩波書店 1997 429-437

Author Title of Book
外山敬介、黒谷 亨、山本亘彦 脳と計算論
Publisher Year Pages
朝倉書店 1997 90-105

Author Title of Book
外山敬介 頭脳学のみかた AERA MOOK
Publisher Year Pages
朝日新聞社 1997 10-11

Author Title of Book
佐藤宏道、吉村由美子 神経伝達物質 update
Publisher Year Pages
中外医学社、東京 1998 98-105

Author Title of Book
佐藤宏道、今村一之 平成10年度近畿地区大学放送公開講座「健康を科学する-ウェルネスを求めて-」
Publisher Year Pages
大阪大学 1998 135-157

Author Title of Book
外山敬介、黒谷 亨、山本亘彦 CLINICAL NEUROSCIENCE.
Publisher Year Pages
中外医学社 1998 1236-1244

Author Title of Book
外山敬介 21世紀に向けて産官学連携戦略-ネットワーク社会における科学と産業
Publisher Year Pages
奈良先端科学技術大学 AGIP21 編 1998 165-188

Author Title of Book
外山敬介 あうろーら
Publisher Year Pages
21世紀の関西を考える会事務局 1998 123-130

Author Title of Book
佐藤宏道、赤崎孝文、吉村由美子 脳の科学 特集「視覚皮質の構造と機能-一次視覚野を中心に-」
Publisher Year Pages
星和書店、東京 1999 519-525

Author Title of Book
外山敬介 脳・神経の科学II-脳の高次機能 現代医学の基礎7
Publisher Year Pages
岩波書店 1999 19-53

Author Title of Book
外山敬介 脳と行動 臨床精神医学講座21
Publisher Year Pages
中山書店 1999 89-102

Author Title of Book
外山敬介 脳と行動 臨床精神医学講座1 (別刷り)
Publisher Year Pages
中山書店 1999 89-102

Author Title of Book
木村 實 運動の神経科学
Publisher Year Pages
NAP 2000 50-59

Author Title of Book
佐藤宏道 脳科学大事典
Publisher Year Pages
朝倉書店 2000 104-108

Author Title of Book
佐藤宏道 視覚情報処理ハンドブック
Publisher Year Pages
朝倉書店 2000 53-63

Author Title of Book
外山敬介 21世紀耳鼻咽喉科 領域の臨床10.
Publisher Year Pages
中山書店 2000 459-490

Author Title of Book
外山敬介 21世紀医学フォーラム・京都 心を医学する
Publisher Year Pages
21世紀医学フォーラム編集委員会編 2000 12-21

Author Title of Book
外山敬介 生体の科学
Publisher Year Pages
(財)金原一郎記念医学医療振興財団/医学書院 2000 153-163

Author Title of Book
外山敬介、小松由紀夫 脳の科学
Publisher Year Pages
星和書店 2000 347-357

Author Title of Book
外山敬介 脳科学大辞典
Publisher Year Pages
朝倉書店 2000 2-12,29-34,62-66,80-84

Author Title of Book
外山敬介 Client21. (別刷り)
Publisher Year Pages
中山書店 2000 459-490

Author Title of Book
外山敬介 生体の科学 (別刷り)
Publisher Year Pages
(財)金原一郎記念医学医療振興財団/医学書院 2000 153-163

Author Title of Book
外山敬介、小松由紀夫 脳の科学 (別刷り)
Publisher Year Pages
星和書店 2000 347-357

Author Title of Book
木村 實(分担執筆) 高次脳機能への挑戦 (印刷中)
Publisher Year Pages
朝倉書店    

Author Title of Book
尾関宏文、赤崎孝文、佐藤宏道 脳の情報表現ニューロン ネットワークと数理モデル (印刷中)
Publisher Year Pages
朝倉書店    

Author Title of Book
佐藤宏道 眼の事典(印刷中)
Publisher Year Pages
朝倉書店    


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