Summary of Research Project Results Under the JSPS FY2000
"Research for the future Program"



1.Research Institution University of Tsukuba
 
2.Research Area Integrated Fields
 
3.Research Field Tissue Engineering
 
4.Term of Project FY1996〜FY2000
 
5.Project Number 96I00202
 
6.Title of Project Bioprocess engineering of functional regeneration of cultured cells

7.Projetct Leader
Name Institution,Department Title of Position
Norio Ohshima Inst Basic Med Sci, Dept Biomed Eng, Univ. Tsukuba Professor

8.Core Members

Names Institution,Department Title of Position
Kennichi Yanagi Inst Basic Med Sci, Dept Biomed Eng, Univ. Tsukuba Assist Prof
Hirotoshi Miyoshi Inst Basic Med Sci, Dept Biomed Eng, Univ. Tsukuba Assist Prof
Keiko Ookawa Inst Basic Med Sci, Dept Biomed Eng, Univ. Tsukuba Assist Prof

9.Cooperating Researchers

Names Institution,Department Title of Position
Katsutoshi Goto Inst Basic Med Sci, Dept Pharmacol, Univ. Tsukuba Professor
Masayuki Yamamoto Inst Basic Med Sci, Dept Dev. Mol. Biol., Univ. Tsukuba Professor
Teruo Watanabe Saga Medical School Vice President

10.Summary of Research Results

This project if constructed from 3 main research fields, i.e., 1) reconstruction of hepatic functions, 2) reconstruction of bone and joint functions, and 3) reconstruction of neo-vascular functions. Results obtained in each fields are described below.
In the research for the reconstruction of hepatic functions, development of a novel bioartificial liver (BAL), packed-bed type BAL, was attempted. This series of research included scaling up of the BAL, optimization of culture conditions, establishment of a hepatic failure model pig, determination of the conditions of extracorporeal circuit, and application of fetal liver cells as a cell source of the BAL. Moreover, to the purpose of the establishment of new treatment of liver failure by cell transplantation or of clarifying the mechanism of liver regeneration, identification of hepatic stem cells were performed by use of FACS analysis.
In the reconstruction of bone and joint functions, bone formation by osteoblast and chondro-induction from bone marrow cells were investigated. To reconstruct the hematopoietic functions in bone marrow, ex vivo expansion and proliferation of hematopoietic stem cells as well as basic studies clarifying mechanisms of differentiation and proliferation of hematopietic cells were performed.
In the reconstruction of neo-vascular functions, mechanism of recovery of endothelial cells after vascular injury were investigated. Moreover, a new PTCA device which can prevent vascular damage after PTCA treatment, was developed. Establishment of transgenic rabbits which are effective models to clarify the mechanism of atherogenesis, investigations of vascularization during tumor growth and of functions in blood-brain barrier, were also attempted.

11.Key Words

(1)Bioartificial Liver、(2)Fetal Liver Cells、(3)Hepatic Stem Cell
(4)Osteoblast、(5)Chondrocyte、(6)Hematopoietic Stem Cells
(7)Endothelial Cell、(8)Atherosclerosis、(9)Angiogenesis

12.References

[Reference Articles]
Author Title of Article
N. Ohshima, K. Yanagi and H. Miyoshi Packed-bed type reactor to attine high density culture of hepatocytes for use as a bioartificial liver
Journal Volume Year Pages Concerned
Artif. Organs Vol.21 1997 1169-1176

Author Title of Article
N. Ohshima Advantages of mass transfer modeling for development of hybrid artificial liver support system
Journal Volume Year Pages Concerned
Proc JSME Meeting Thermal Engineering Division No.97-25 1997 231-232

Author Title of Article
K. Yannagi, H. Miyoshi, N. Ohshima High density culture of hepatocyte for development an artificial liver support system: studies on culture conditions
Journal Volume Year Pages Concerned
Proc JSME Meeting Thermal Engineering Division No.97-25 1997 233-235

Author Title of Article
N. Ohshima Tissue engineering aspects of development of bioartificial livers (invited review)
Journal Volume Year Pages Concerned
J. Chin. Inst. Chem. Engrs.   1997 441-453

Author Title of Article
K. Yanagi, H. Miyoshi and N. Ohshima Improvement of metabolic performance of hepatocytes cultured in vitro in a packed-bed reactor for use as a bioartificial liver
Journal Volume Year Pages Concerned
ASAIO J. Vol.44 1998 M436-M440

Author Title of Article
N. Ohshima, K. Yanagi, H. Miyoshi, P. Kan Bio-process engineering for development of artificial liver support system by use of cultured hepatocytes
Journal Volume Year Pages Concerned
J. Jpn Soc Biosci Biotechnol Agrochem 72 1998 528

Author Title of Article
N. Ohshima Regenerative medicine: development of bio-artificial liver supposrt system through tissue engineering methods
Journal Volume Year Pages Concerned
J Chem Eng Jpn Vol.62 1998 133-135

Author Title of Article
K. Yanagi, N. Ohshima Hepatocyte culture system for use as an bioartificial liver
Journal Volume Year Pages Concerned
Clinic-All-Round 48 1999 244-245

Author Title of Article
K. Yanagi, H. Miyoshi, N. Ohshima High density culture of hepatocytes for development of bio-artificial liver
Journal Volume Year Pages Concerned
Jpn J Artif Organs 28 1999 152-155

Author Title of Article
K. Yanagi, H. Miyoshi, N. Ohshima High density culture of hepatocytes for development of bio-artificial liver
Journal Volume Year Pages Concerned
Acta Hepatologica Japanica 40 1999 187-189

Author Title of Article
N. Ohshima, K. Yanagi and H. Miyoshi Development of a packed-bed type bioartificial liver: Tissue engineering approach
Journal Volume Year Pages Concerned
Transplant. Proc. 31 1999 2016-2017

Author Title of Article
N. Ohshima, K. Yanagi, H. Miyoshi Tissue engineering approach to develop a bioartificial liver support system
Journal Volume Year Pages Concerned
Proc JSME Meeting Bioengineering Division 99-3 1999 16-17

Author Title of Article
K. Yanagi, H. Miyoshi, N. Ohshima High density culture of hepatocytes for development of bio-artificial liver suppost system: effects of dissolved oxygen tension on reactor performance
Journal Volume Year Pages Concerned
Proc JSME Meeting Bioengineering Division 99-3 1999 244-245

Author Title of Article
K. Yanagi, H. Miyoshi and N. Ohshima A high-density culture of hepatocytes using porous substrate for use as a bioartificial liver
Journal Volume Year Pages Concerned
J. Artif. Organs 2 1999 124-128

Author Title of Article
K. Yanagi, Thein. Tun, H. Miyoshi, H. Taniguchi, Y. Takada, K. Fukao, N. Ohshima Packed-bed type reactor to develop a bio-artificial liver: scale-up and improvement of reactor
Journal Volume Year Pages Concerned
Acta Hepatologica Japnoica 41 2000 76-77

Author Title of Article
N. Ohshima Development of bioartificial liver through tissue engineerng approach
Journal Volume Year Pages Concerned
Clinical Engineering 11 2000 338-344

Author Title of Article
K. Yanagi and N. Ohshima Improvement of metabolic performance of cultured hepatocytes by high oxygen tension in the atmosphere
Journal Volume Year Pages Concerned
Artif. Organs Vol.1 2001 1-6

Author Title of Article
H. Miyoshi, K. Ookawa and N. Ohshima Hepatocyte culture utilizing porous polyvinyl formal resin maintains long-term stable albumin secretion activity
Journal Volume Year Pages Concerned
J. Biomater. Sci. Polymer Edn. Vol.9 1998 227-237

Author Title of Article
H. Miyoshi, N. Ohshima Development of bioartificial livers from the tissue engineering viewpoint
Journal Volume Year Pages Concerned
Jpn J Artif Organs 27 1998 724-732

Author Title of Article
H. Miyoshi, T. Ehashi, H. Ema, H-C. Hsu, H. Nakauchi, N. Ohshima Culture of fetal liver cells utilizing porous ;olymer substrate
Journal Volume Year Pages Concerned
Proc JSME Meeting Bioengineering Division 99-3 1999 246-247

Author Title of Article
H. Miyoshi, N. Ohshima Reconstruction of hepatocytes and liver
Journal Volume Year Pages Concerned
Gendai Iryo 31(12) 1999 3035-3040

Author Title of Article
H. Miyoshi, N. Ohshima Application of tissue engineering technology to bioartificial liver
Journal Volume Year Pages Concerned
Pharma Medica 18 2000 49-55

Author Title of Article
H. Miyoshi, T. Ehashi, H. Ema, H. C. Hsu, H. Nakauchi and N. Ohshima Long-term culture of fetal liver cells using three-dimensional porous polymer substrate
Journal Volume Year Pages Concerned
ASAIO J. 46 2000 397-402

Author Title of Article
T. H. Yang, H. Miyoshi and N. Ohshima A novel cell immobilization method utilizing centrifugal force to achieve high-density hepatocyte culture in a porous scaffold.
Journal Volume Year Pages Concerned
J. Biomed. Mater. Res.   2001 379-386

Author Title of Article
H. Taniguchi, K. Fukao and H. Nakauchi Constant delivery of proinsulin by encapsulation transfected cells
Journal Volume Year Pages Concerned
J. Surg. Res. 70 1997 41-45

Author Title of Article
H. Taniguchi, Y. Takeda, K. Fukanaga, K. Yuzawa, M. Ohtsuka, K. Todoroki and K. Fukao Establishment of a swine model for auxiliart partial orthotopic liver transplantation
Journal Volume Year Pages Concerned
Transplant. Proc. Vol.30 1998 3232-3236

Author Title of Article
H. Taniguchi, A. Sugioka, M. Morita, A. Hasumi, Y. Takada, K. Fukunaga, K. Yuzawa, M. Ohtsuka, K. Fukao and H. Nakauchi Is donor-derived long-term and multilineage hematopoiesis established after liver transplantation?
Journal Volume Year Pages Concerned
Transplant. Proc. Vol.30 1998 3865-3866

Author Title of Article
H. Taniguchi, R. Kondo, A. Suzuki, S. Ito, Y. Takada, K. Fukunaga, et al. Evidence for the presence of hepatic stem cells in the murine fetal liver
Journal Volume Year Pages Concerned
Transplant. Proc. 31 1999 454

Author Title of Article
H. Taniguchi, R. Kondo, A. Suzuki, Y. Zheng, S. Ito, Y. Takada, et al. Identification and characterization of hepatic stem cells in the murine fetal liver
Journal Volume Year Pages Concerned
Cell Transplant. 8 1999 197

Author Title of Article
R. Kondo, H. Taniguchi, A. Suzuki, Y. Zheng, S. Ito, K. Fukunaga, et al. Establishment of a flowcytometrical method for the enrichment of hepatic stem cells
Journal Volume Year Pages Concerned
Cell Transplant. 8 1999 189

Author Title of Article
H. Taniguchi Stem cell system in liver and its application of regenerative medicine
Journal Volume Year Pages Concerned
Saishin Igaku 54 1999 2793-2798

Author Title of Article
H. Taniguchi Bone marrow chimerism and immunotolerance in organ transplantation
Journal Volume Year Pages Concerned
Jpn J Clin Immunol 22 1999 428-430

Author Title of Article
H. Taniguchi, K. Fukao, H. Nakauchi Advances in regenerative medicine in hepatology
Journal Volume Year Pages Concerned
Transplantation Today 13 2000 228-232

Author Title of Article
H. Taniguchi, A. Suzuki From organ replacement to organ regeneration
Journal Volume Year Pages Concerned
Cell Technology 19 2000 869-873

Author Title of Article
H. Taniguchi Hepatic stem cells and "organ regeneration"
Journal Volume Year Pages Concerned
Igaku no Ayumi 192 2000 849

Author Title of Article
A. Suzuki, Y. W. Zheng, R. Kondo, M. Kusakabe, Y. Takada, K. Fukao, H. Nakauchi and H. Taniguchi Flowcytometric separation and enrichment of multipotent hepatic progenitor cells in mouse developing liver
Journal Volume Year Pages Concerned
Hepatology 32 2000 1230-1239

Author Title of Article
H. Taniguchi, R. Kondo, A. Suzuki, Y. Zheng, Y. Takada, K. Fukunaga, K. Seino, K. Yuzawa, et al. Clonogenic colony forming ability of flowcytometrically isolated hepatic stem/progenitor cells in the murine fetal liver.
Journal Volume Year Pages Concerned
Cell Transplant. 9 2000 697-700

Author Title of Article
H. Taniguchi, K. Fukao From organ transplantation to organ regeneration: overview of regenerative medicine
Journal Volume Year Pages Concerned
Transplantation Today 13 2000 11-18

Author Title of Article
H. Taniguchi Therapeutic application of stem cell system in hepatology
Journal Volume Year Pages Concerned
BIO Clinica 15 2000 32-35

Author Title of Article
H. Taniguchi and A. Suzuki Identification and enrichment of hepatic stem cells by flowcytometric cell sorting
Journal Volume Year Pages Concerned
PNE Protein Nucleic Acid and Enzyme 45(13) 2000 2250-2256

Author Title of Article
H. Taniguchi, A. Suzuki, Y. W. Zheng, Y. Takada, K. Fukunaga, K. Seino, et al. Usefulness of flowcytometric cell sorting for enrichment of hepatic stem cells in the liver
Journal Volume Year Pages Concerned
Transplant. Proc.   in press  

Author Title of Article
Y. W. Zheng, H. Taniguchi, A. Suzuki, Y. Takada, K. Fukunaga, K. Seino, et al. Effects of four different extracellular matrixes on clonal culture of murine fetal hepatocyte
Journal Volume Year Pages Concerned
Transplant. Proc.   in press  

Author Title of Article
Y. W. Zheng, H. Taniguchi, A. Suzuki, Y. Takada, K. Fukunaga, K. Seino, et al. Clonal culture of the murine fetal hepatocyte at extremely low density and the effects of growth factors
Journal Volume Year Pages Concerned
Transplant. Proc.   in press  

Author Title of Article
A. Suzuki, H. Taniguchi, Y. W. Zheng, Y. Takada, K. Fukunaga, et al. Clonal colony formation of hepatic stem/progenitor cells were enhanced by embryonic fibroblast conditioned medium (EFCM)
Journal Volume Year Pages Concerned
Transplant. Proc.   in press  

Author Title of Article
A. Suzuki, H. Taniguchi, Y. W. Zheng, Y. Takada, K. Fukunaga, et al. Proliferative and functional ability of transplanted murine neonatal hepatocytes in adult liver
Journal Volume Year Pages Concerned
Transplant. Proc.   in press  

Author Title of Article
Y. Kino, M. Sawa, S. Kasai and M. Mito Multiporous celluose microcarrier for the development of a hybrid artificial liver using isolated hepatocytes.
Journal Volume Year Pages Concerned
J. Surg. Res. Vol.79 1998 71-76

Author Title of Article
S. Kasai, M. Sawa Present and future of artificial liver
Journal Volume Year Pages Concerned
Igaku no Ayumi 188 1998 665-670

Author Title of Article
S. Kasai, M. Sawa Therapeutic use of hepatocyte transplantation for hepatic insufficiency
Journal Volume Year Pages Concerned
PNE Protein Nucleic Acid and Enzyme 45(13) 2000 2301-2306

Author Title of Article
K. Fukunaga, Y. Takada, G. Mei, H. Taniguchi, M. Otsuka, K. Goto and K. Fukao Protective effects of endothelin antagonist on hepatic allografts procured from non-heart-beating donors in porcine liver transplantation.
Journal Volume Year Pages Concerned
Low Tempreture Medicine 24 1998 105-109

Author Title of Article
K. Fukunaga, Y. Takada, H. Taniguchi, K. Yuzawa, M. Otsuka, T. Todoroki, K. Goto and K. Fukao. Protecting the viability of hepatic allografts procured from non-heart-beating donors by blockade of endothelin and platelet activating factor in porcine liver transplantation
Journal Volume Year Pages Concerned
Int. Surg. 83 1998 226-231

Author Title of Article
K. Fukunaga. Y. Takada, H. Taniguchi, M. Otsuka, K. Goto and K. Fukao. Successful liver transplantation from non-heart-beating donors by blockade of endothelin and PAF.
Journal Volume Year Pages Concerned
Transplant. Proc. 30 1998 3797

Author Title of Article
Y. Takada, K. Fukunaga, H. Taniguchi, K. Yuzawa, M. Otsuka and K. Fukao. Energy metabolism of hepatic allografts subjected to prolonged warm ischemia and its pharmacologic modulation.
Journal Volume Year Pages Concerned
Transplant. Proc. 30 1998 3694-3695

Author Title of Article
K. Fukunaga, Y. Takada, H. Taniguchi, M. Otsuka and k. Fukao Endothelin antagonist improves viability of graft liver from non-heart-beating donor
Journal Volume Year Pages Concerned
Transplant. Proc. 31 1999 460-461

Author Title of Article
K. Fukunaga, Y. Takada, G. Mei, H. Taniguchi, K. Seino, K. Yuzawa, M. Otsuka, T. Todoroki, K. goto, K. Fukao An endothelin receptor antagonist ameliorates injuries of sinusoid lining cells in porcine liver transplantation
Journal Volume Year Pages Concerned
Am. J. Surg. 178 1999 64-68

Author Title of Article
K. Seino, N. Kayagaki, N. Yamaguchi, Y. Takada, S. Uyama, K. Kiuchi, K. Tanaka, H. Yagita, K. Okumura, K. Fukao Soluble forms of CD95 and CD95 ligand after living related liver transplantation
Journal Volume Year Pages Concerned
Transplantation 67 1999 634-636

Author Title of Article
T. Todoroki, T. Kawamoto, H. Takahashi, Y. Takada, N. Koike, M. Otsuka, K. Fukao Treatment of gallbladder cancer by radical resection
Journal Volume Year Pages Concerned
Br. J. Surg. 86 1999 622-627

Author Title of Article
T. Todoroki, T. Kawamoto, M. Otsuka, N. Koike, S. Yoshida, Y. Takada, S. Adachi, H. Kashiwagi, K. Fukao, K. Ohara Benefits of combining radiotherapy with aggressive resection for Stage IV gallbladder cancer
Journal Volume Year Pages Concerned
Hepato-Gastroenterology 46 1999 1585-1591

Author Title of Article
K. Fukunaga, T. Todoroki, Y. Takada, M. Otsuka, T. Kawamoto, K. Fukao Hepatic functional reserve in patients with biliary malignancies: an assessment by technetium 99m galactosyl human serum albumin hepatic scintigraphy
Journal Volume Year Pages Concerned
Int. Surg. 84 1999 199-203

Author Title of Article
Y. Takada, S. Adachi, N. Kanazawa, T. Enomoto, S. Ishiguro, H. Taniguchi, et al. ? Simultaneous resections of liver and stomach to multiple cancer
Journal Volume Year Pages Concerned
J. Jpn. Coll. Surgeons 24 1999 852-855

Author Title of Article
K. Fukunaga, Y. Takada, H. Taniguchi, M. Gu, K. Seino, K. Yuzawa, M. Otsuka, T. Todoroki, K. Goto and K. Fukao Endothelin antagonist treatment for successful liver transplantation from non-heart-beating donors
Journal Volume Year Pages Concerned
Transplantation 67 1999 328-332

Author Title of Article
Y. Takada, K. Fukunaga, M. Gu, S. Ishiguro, H. Taniguchi, K. Seino, K. Yuzawa, M. Otsuka and K. Fukao Improvement of allograft viability with organs procured from non-heart-beating donors in porcine liver transplantation
Journal Volume Year Pages Concerned
Transplant. Proc. 32 2000 277-278

Author Title of Article
Y. Takada, K. Fukunaga, G. Mei, S. Ishiguro, H. Taniguchi, K. Seino, K. Yuzawa, M. Otsuka and K. Fukao Porcine model of fulminant hepatic failure treated by liver transplantation.
Journal Volume Year Pages Concerned
Transplant. Proc. 32 2000 2243-2244

Author Title of Article
M.. Gu, Y. Takada, K.. Fukunaga, S. Ishiguro, H. Taniguchi, K. Seino, K. Yuzawa, M. Otsuka, T. Todoroki and K. Fukao Pharmacologic graft protection withut donor pretreatment in liver transplantation from non-heart-beating donors.
Journal Volume Year Pages Concerned
Transplantation 70 2000 1021-1025

Author Title of Article
K. Fukunaga, Y. Takada, G. Mei, S. Ishiguro, K. Seino, H. Taniguchi, K. Yuzawa, M. Otsuka, K. Goto and K. Fukao Peri-and postoperative kinetics of endothelin-1/big endothelin-1 and effects of endothelin antagonist in porcine liver transplantation from non-heart-beating donors.
Journal Volume Year Pages Concerned
Transplant. Proc. 32 2000 1647-1649

Author Title of Article
Y. Takada, K. Fukunaga, M. Gu, S. Ishiguro, H. Taniguchi, K. Seino, K. Yuzawa, M. Otsuka, K. Fukao Improvement of allograft viability with organs procured from non-heart-beating donors in porcine liver transplantation
Journal Volume Year Pages Concerned
Transplant. Proc.   2000 277-278

Author Title of Article
Y. Takada, S. Ishiguro, K. Fukunaga, M. Gu, H. Taniguchi, K. Seino, K. Yuzawa, M. Otsuka, T. Todoroki and K. Fukao Increased intracranial pressure in a porcine model of fulminant hepatic failure using amatoxin and endotoxin.
Journal Volume Year Pages Concerned
J. Hepatol.   in press  

Author Title of Article
M.. Gu, Y. Takada, K. Fukunaga, S. Ishiguro, K. Seino, H. Taniguchi, K. Yuzawa, M. Otsuka and K. Fukao Improvement of graft function without donor pretreatment in liver transplantation from non-heart-beating donors.
Journal Volume Year Pages Concerned
Transplant. Proc.   in press  

Author Title of Article
M.. Gu, Y. Takada, K.. Fukunaga, S. Ishiguro, H. Taniguchi, K. Seino, K. Yuzawa, M. Otsuka, T. Todoroki and K. Fukao Role of platelet activating factor in hepatectomy with Pringle's maneuver.
Journal Volume Year Pages Concerned
J. Surg. Res.   in press  

Author Title of Article
K. Seino.. T. Ogino, K. Fukunaga, H. taniguchi, Y. Takada, K. Yuzawa, M. Otsuka, H. Yagita, K. Okumura and K. Fukao Attempts to reveal the mechanism of CD95 ligand-mediated inflammation
Journal Volume Year Pages Concerned
Transplant. Proc.   in press  

Author Title of Article
M. Otsuka, K. Yuzawa, Y. Takada, H. Taniguchi, K. Fukunaga, K. Seino, T. Todoroki and K. Fukao Long term graft survival of living related kidney transplantation after donor specific transfusion
Journal Volume Year Pages Concerned
Transplant. Proc.   in press  

Author Title of Article
Y. Takada, M. Otsuka, K. Seino, H. Taniguchi, N. Koike, T. Kawamoto, K. Koda, S. Adachi, K. Yuzawa, M. Nozue, T. Todoroki, K. Fukao Hepatic resection for metastatic tumors from non colorectal carcinoma
Journal Volume Year Pages Concerned
Hepato-Gastroenterology   in press  

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T. Kanamori, T. Habu, T. Shinbo and K. Sakai Difference in solute diffusivity in cross-linked collagen gels prepared under various conditions
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Mater. Sci. Eng. C13 2000 85-89

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ASAIO J. 46 2000 612-619

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J. Membr. Sci.   in press  

Author Title of Article
P. Kan, H. Miyoshi, K. Yanagi and N. Ohshima Effects of shear stress on metabolic function of the co-culture system of hepatocyte/nonparenchymal cells for a biortificial liver
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ASAIO J. Vol.44 1998 M441-M444

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D. -K. Kim, M. Kojima, T. Fukushima, M. Miyasaka and H. Nakauchi. Engraftment of human myelodysplastic syndrome derived cell line in transgenic severe combined immunodeficient(TG-SCID)mice expressing human GM-CSF and IL-3.
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Eur. J. Hematol. 61 1998 93-99

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Oncogene Vol.14 1997 1901-1910

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Blood Vol.91 1998 798-805

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T. Kuroha, S. Takahashi, T. Komeno, K. Itoh, T. Nagasawa and M. Yamamoto Ablation of Nrf2 function does not increase the erythroid or megakaryocytic cell lineage dysfunction caused by p45 NF-E2 gene distupion
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J. Biochem. 123 1998 376-379

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K. Igarashi, H. Hoshino, A. Muto, N. Suwabe, S. Nishikawa, H. Nakauchi and M. Yamamoto Multivalent DNA binding complex generated by small maf and bachl as a passible biochemical basis for Eβ-globin locus control region complex
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J. Biol. Chem. Vol.273 1998 11783-11790

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Blood Vol.92 1998 434-442

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EMBO J. 17 1998 6689-6700

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EMBO J. 17 1998 5734-5743

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K. Itoh, N. Wakabayashi, Y. Katoh, T. Ishii, K. Igarashi, J. D. Engel and M. Yamamoto Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain
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Genes Dev. 13 1999 76-86

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J. Biol. Chem. 274 1999 6443-6452

Author Title of Article
O. Nakajima, S. Takahashi, H. Harigae, K. Furuyama, N. Hayashi, et al. Heme deficiency in erythroid lineage causes differentiation arrest and cytoplasmic iron overload
Journal Volume Year Pages Concerned
EMBO J. 18 1999 6282-6289

Author Title of Article
N. Minegishi, J. Ohta, H. Yamagiwa, N. Suzuki, S. Kawauchi, Y. Zhou, et al. The mouse GATA-2 gene is expressed in the para-aortic splanchnopleura and aorta-gonads and mesonephros region
Journal Volume Year Pages Concerned
Blood 93 1999 4196-4207

Author Title of Article
C. Yoshida, F. Tokumasa, K. Hohmura, J. Bungert, N. Hayashi, T. Nagasawa, J. D. Engel, M. Yamamoto, K Takeyasu, K. Igarashi Long range interaction of cis-DNA elements mediaterd by architectural transcription factor Bach1
Journal Volume Year Pages Concerned
Genes to Cells 4 1999 643-655

Author Title of Article
X. Pan, N. Minegishi, H. Harigae, H. Yamagiwa, M. Minegishi, Y. Akine and M. Yamamoto Identification of human GATA-2 gene distal IS exon and its expression in hematopoietic stem cell fractions
Journal Volume Year Pages Concerned
J. Biochem. 127 2000 105-112

Author Title of Article
   
Journal Volume Year Pages Concerned
    2000 59-67

Author Title of Article
S. Nishimura, S. Takahashi, T. Kuroha, N. Suwabe, T. Nagasawa, et al. A GATA box in the GATA-1 gene hematopoietic enhancer is critical element in the network of GATA factors and sites that regulate this gene
Journal Volume Year Pages Concerned
Mol. Cell. Biol. 20 2000 713-723

Author Title of Article
A. Kobayashi, H. Yamagiwa, H. Hoshino, A. Muto, K. Sato, et al. A combinatorial code for gene expression generated by transcription factor Bach2 and MAZR (MAZ-related factor) through BTB/POZ domain
Journal Volume Year Pages Concerned
Mol. Cell. Biol. 20 2000 1733-1746

Author Title of Article
H. Hoshino, A. Kobayashi, M. Yoshida, N. Kudo, T. Oyake, H. Motohashi, N. Hayashi, M. Yamamoto and K. Igarashi Oxidative stress abolishes leptomycin B-sensitive nuclear export of transcription repressor Bach2 that counteracts activation of Maf recognition element.
Journal Volume Year Pages Concerned
J. Biol. Chem. 275 2000 15370-15376

Author Title of Article
I. Matsumura, A. Kawasaki, H. Tanaka, J. Sonoyama, S. Ezoe, N. Minegishi, K. Nakajima, M. Yamamoto and Y. Kanakura Biologic significance of GATA-1 activities in Ras-mediated megakaryocytic differentiation of hematopoietic cell lines.
Journal Volume Year Pages Concerned
Blood 96 2000 2440-2450

Author Title of Article
T. Ishii, K. Itoh, S. Takahashi, H. Sato, T. Yanagawa, Y. Kato, S. Bannai and M. Yamamoto Transcription factor Nrf2 coordinately regulates oxidative stress-inducible genes responsible for the electropile counterattack response.
Journal Volume Year Pages Concerned
J. Biol. Chem.   2000 16023-16029

Author Title of Article
N. Minegishi and M. Yamamoto Transcriptinal factors and angiogenesis
Journal Volume Year Pages Concerned
Frontier of Vascular Biology   in press  

Author Title of Article
N. Minegishi Hematopoiesis by GATA-2
Journal Volume Year Pages Concerned
Hematooncology   in press  

Author Title of Article
T. Ushida, T. Murata and T. Tateishi Initial response of cultured bovine chondrocytes to hydrostatic pressure
Journal Volume Year Pages Concerned
Jpn. J Clin. Biomech. 19 1998 263-266

Author Title of Article
T. Murata, T. Ushida, S. Mizuno and T. Tateishi Proteoglycan synthesis by chondrocytes cultured under hydrostatic pressure and perfusion
Journal Volume Year Pages Concerned
Mater. Sci. Eng. Vol.C6 1998 297-300

Author Title of Article
S. Mizuno, T. Ushida, T. Tateishi and J. Glowacki Effects of physical stimulation on chondrogenesis in vitro
Journal Volume Year Pages Concerned
Mater. Sci. Eng. Vol.C6 1998 301-306

Author Title of Article
T. Ushida Artificial organs from tissue engineering: cartilage
Journal Volume Year Pages Concerned
Jpn. J Artif. Organs 27 1998 787-792

Author Title of Article
T. Murata, T. Ushida and T. Tateishi Effects of continuous hydrostatic pressure on extracellular matrix synthesis of cultured chondeocytes
Journal Volume Year Pages Concerned
Jpn. J. Clin. Biomech. 19 1998 267-271

Author Title of Article
T. Ushida Development of regenerated cartilage: artificial organs with living cells
Journal Volume Year Pages Concerned
Exp. Med. 17(1) 1999 42-47

Author Title of Article
G. Chen, T. Ushida and T. Tateishi Fabrication of PLGA-collagen hybrid sponge
Journal Volume Year Pages Concerned
Chem. Lett.   1999 561-562

Author Title of Article
G. Chen, T. Murata, T. Ushida, T. Tateishi Development of biodegradable composite sponge material
Journal Volume Year Pages Concerned
Proc JSME Meeting Bioengineering Division 99-3 1999 380-381

Author Title of Article
T. Ushida Artificial joints: annual review
Journal Volume Year Pages Concerned
Jpn. J Artif. Organs 28 1999 662-663

Author Title of Article
T. Tateishi and T. Ushida Tissue engieering and mechanical stimuli
Journal Volume Year Pages Concerned
Materials Integration 13(2) 2000 27-31

Author Title of Article
T. Tateishi, T. Ushida and G. Chen Tissue regeneration and polymer material: frontier of tissue engineering
Journal Volume Year Pages Concerned
Jpn. J. Polymer Sci. 49 2000 121-124

Author Title of Article
G. Chen, T. Ushida and T. Tateishi Hybrid biomaterials for tissue engineering: a preparative method for PLA or PLGA-collagen.
Journal Volume Year Pages Concerned
Adv. Mater. 12 2000 455-457

Author Title of Article
G. Chen, T. Ushida and T. Tateishi A biodegradable hybrid sponge nested with collagen microsponges.
Journal Volume Year Pages Concerned
J. Biomed. Mater. Res. 51 2000 273-279

Author Title of Article
G. Chen, T. Ushida, T. Tateishi Development of biodegradable composite sponge material and its application to 3-D culture of chondrocytes
Journal Volume Year Pages Concerned
Jpn. J. Artif. Organs 29 2000 463-467

Author Title of Article
G. Chen, T. Ushida and T. Tateishi A hybrid network of synthetic polymer mesh and collagen sponge
Journal Volume Year Pages Concerned
J. Chem. Soc. Chem. Comm. 16 2000 1505-1506

Author Title of Article
G. Chen, T. Ushida and T. Tateishi A hybrid sponge of poly (DL-lactic-co-glycolic acid), collagen and apatite
Journal Volume Year Pages Concerned
Bioceramics 13 in press  

Author Title of Article
G. Chen, T. Ushida and T. Tateishi Preparation of poly(L-lactic acid)and poly(DL-lactic-co-glycolic acid)foams by use of ice microparticulates
Journal Volume Year Pages Concerned
Biomaterials   in press  

Author Title of Article
T. Ushida, G. Chen, T. Tamaki, Y. Umezu and T. Tateishi A three-dimensional porous scaffold of biodegradable synthetic polymers and porous hydroxyapatite beads for bone tissuee engineering
Journal Volume Year Pages Concerned
Bioceramics 13 in press  

Author Title of Article
T. Uemura, A. Nemoto, J. Yamamoto, T. Ushida and T. Tateishi Cultured osteoblasts and osteoclasts studied by AFM and CLSM
Journal Volume Year Pages Concerned
BME 11 1997 21-28

Author Title of Article
Y. K. Liu, T. Uemura, A. Nemoto, T. Yabe, N. Fujii, T. Ushida and T. Tateishi Osteopontin involvement in integrin-mediated cell signaling and regulation of expression of alkaline phosphatase during early differentiation of UMR cells
Journal Volume Year Pages Concerned
FEBS Lett. 420 1997 112-116

Author Title of Article
Y. Liu, A. Nemoto, Y. Feng and T. Uemura The binding ability to matrix proteins and the inhibitory. effects on cell adhesion of synthetic peptides derived from a conserved sequence of integrins
Journal Volume Year Pages Concerned
J. Biochem. Vol.121 1997 961-968

Author Title of Article
T. Uemura, Y. Liu, Y. Feng, A. Nemoto, T. Yabe, T. Ushida, H. Miyamoto and T. Tateishi The role of sialopproteins in recognition of bone surface by osteoblasts via integrin
Journal Volume Year Pages Concerned
Mat. Sci. Eng. C 4 1997 303-309

Author Title of Article
T. Yabe, A. Nemoto and T. Uemura Recognition of osteopontin by rat bone marrow derived osteoblastic primary cells
Journal Volume Year Pages Concerned
Biosci. Biotech. Biochem. Vol.61 1997 754-756

Author Title of Article
Y. Feng, G. Gao, S. Cheng, T. Uemura and T. Yang Molecular recognition mechanism between mesohemin and antibody 11D1
Journal Volume Year Pages Concerned
Chem. Lett. No.4 1997 327-328

Author Title of Article
N. Fujii, Y. Momose, Y. Ishibashi, T. Uemura, M. Takita and M. Takehana Specific racemization and isomerization of the aspartyl residue of EφA-crystallin due to UV-8 irradiation
Journal Volume Year Pages Concerned
Exp. Eye Res. Vol.65 1997 99-104

Author Title of Article
N. Fujii, Y. Momose, M. Yamasaki, T. Yamagaki, H. Nakanishi, T. Uemura, M. Takita and N. Ishii The conformation formed by the domain after alanine-155 induces inversion of aspartic acid-151 in alpha A-cryatallin from aged human lenses
Journal Volume Year Pages Concerned
Biochem. Biophys. Res. Commun. Vol.239 1997 918-923

Author Title of Article
T. Uemura, B. W. Callen, Z. Yu, X. Shen and J. E. Davies AFM study of calcified accretions secreted from osteoblastic primary cells
Journal Volume Year Pages Concerned
JBMBB Vol.1 1998 283-286

Author Title of Article
T. Uemura, Z. Yu, S. Yamamoto, T. Ushida and T. Tateishi Localization of osteopontin-GFP fusion proteins in osteoblastic cells: Dual-channel confocal imaging of GFP fusion proteins and organelles
Journal Volume Year Pages Concerned
Bioimages Vol.6 1998 127-129

Author Title of Article
T. Uemura and T. Tateishi Observation of cultured cells by AFM
Journal Volume Year Pages Concerned
Igaku no Ayumi 184 1998 204-205

Author Title of Article
A. Nemoto and T. Uemura FAK-mediated signal transduction within osteoblasts: initial differentiation by osteopontin
Journal Volume Year Pages Concerned
Jpn. J. Biochemistry 71 1999 140-145

Author Title of Article
T. Uemura, A. Nemoto, J. An, Y. -K. Liu, T. Yoshikawa, et al. Osteopontin involvement in osteoblast differentiation and its effect on in vivo osteogenic potential of bone marrow derived osteoblasts
Journal Volume Year Pages Concerned
Bioceramics 12 1999 265-268

Author Title of Article
A. Nemoto, T. Uemura, T. Ushida and T. Tateishi Gravity effects on mRNA expression of marker enzymes in osteoblasts
Journal Volume Year Pages Concerned
Bioceramics 12 1999 269-272

Author Title of Article
R. Honma, W. Chen, Y. -K. Liu, H. -Y. Deng, A. Nemoto and T. Uemura Complete sealing zone formation needs multiple gene participation
Journal Volume Year Pages Concerned
Bioceramics 12 1999 273-276

Author Title of Article
A. Nemoto and T. Uemura Hypergravity effects on osteoclast activity
Journal Volume Year Pages Concerned
Journal of Gravitational Physiology 7 2000 127-128

Author Title of Article
T. Uemura, Y. -k. Liu and Y. Kuboki. mRNA expression of MT1-MMP, MMP-9, cathepsin K and TRAP in highly enriched osteoclasts cultured on several matrix proteins and ivory surfaces.
Journal Volume Year Pages Concerned
Biosci. Biotechnol. Biochem. Vol.64 2000 1771-1773

Author Title of Article
K. Kurata, T. Uemura, A. Nemoto, T. Tateishi, T. Murakami, H. Higaki, H. Miura and Y. Iwamoto Highly enriched osteoclasts on ivory slices upregulate bone-resorbing activities and mRNA expressions of osteoclast marker enzymes in responce to mechanical strain
Journal Volume Year Pages Concerned
J. Bone Miner. Res. 16 in press  

Author Title of Article
H. Kojima, A. Nemoto, T. Uemura, R. Honma, M. Ogura and Y-K. Liu DRAK1, death associated protein kinase-related apoptosis-inducing protein kinase, is expressed in active osteoclast strongly and induces apoptosis
Journal Volume Year Pages Concerned
J. Biol. Chem.   in press  

Author Title of Article
K. Kurata, T. Uemura, A. Nemoto, T. Tateishi, T. Murakami, H. Higaki, H. Miura and Y. Iwamoto Mechanical syrain effect on bone-resorbing activity and mRNA expressions of marker enzymes in isolated osteoclast culture
Journal Volume Year Pages Concerned
J. Bone Miner. Res.   in press  

Author Title of Article
R. Honma, Y-K. Liu, A. Nemoto and T. Uemura DRAK1, death-associated protein kinase-related apoptosis-inducing protein kinase, is expressed in active osteoclast strongly and induces apoptosis
Journal Volume Year Pages Concerned
J. Biol. Chem.   in press  

Author Title of Article
J. Dong, H. Kojima, T. Uemura, M. Kikuchi, T. Tateishi and J. Tanaka In vivo evaluation of a novel porous hydroxyapatite to sustain osteogenesis of transplanted bone marrow derived osteoblastic cells
Journal Volume Year Pages Concerned
J. Biomed. Mat. Res.   in press  

Author Title of Article
Thein Tun, H. Miyoshi, H. Ema, H. Nakauchi and N. Oushima New type of matrix support for bone marrow cell cultures: In vitro culture and in vivo transplantation experiments
Journal Volume Year Pages Concerned
ASAIO J. 46 2000 522-526

Author Title of Article
M. Sugahara, K. Ookawa, and N. Ohshima In. vitro perfusion culture system to evaluate the endothelial injury with balloon catheter
Journal Volume Year Pages Concerned
Jpn. J. Artif. Organs 27 1998 514-518

Author Title of Article
M. Seto, K. Ookawa and N. Ohshima Analysis of the leukocyte adhesiveness onto endothelial cells under flow conditions
Journal Volume Year Pages Concerned
Microcirculation annual Vol.14 1998 59-60

Author Title of Article
H. Uyama, S. Haraoka, T. Shimokawa, K. Goto, K. Dohi, T. Watanabe Diet-induced hypercholesterolemia increases endothelin-1 release by aortic endothelial cells
Journal Volume Year Pages Concerned
Pathobiology 64 1996 328-332

Author Title of Article
Y. V. Bobryshev and T. Watanabe Ultrastructural evidence for association of vascular dendritic cells with T-lymphocytes and with B-cells in human atherosclerosis
Journal Volume Year Pages Concerned
J. Submicrosc. Cytol. Pathol. Vol.29 1997 209-221

Author Title of Article
Y. V. Bpbryshev, T. Ikezawa and T. Watanabe Formation of Birbeck granule-like structures in vascular dendritic cells in human atherosclerotic aorta Lag-antibody to epidermal Langerhans cells recognizes cells in the arotic wall
Journal Volume Year Pages Concerned
Atherosclerosis 133 1997 193-202

Author Title of Article
Y. V. Bobryshev and T. Watanabe Subset of vascular dendritic cells transforming into foam cells in human atherosclerotic lesions
Journal Volume Year Pages Concerned
Cardiovascular Pathology Vol.6 1997 321-331

Author Title of Article
O. Nie, J. Fan, S. Haraoka and T. Watanabe Inhibition of mononuclear cell recruitment in aortic intima by treatment with anti-ICAM-1 and anti-LAF-1 monoclonal antibodies in hypercholesterolemic rats:implications of the ICAM-1 and LFA-1 pathway in atherogenesis
Journal Volume Year Pages Concerned
Lab Invest Vol.77 1997 469-482

Author Title of Article
S. Haraoka, T. Shimokama, T. Watanabe Role of T lympocytes in the pathogenesis of atherosclerosis. Animal studies using athymic rats
Journal Volume Year Pages Concerned
Ann NY Acad Sci. Vol.811 1997 515-518

Author Title of Article
S. Matsumoto, M. Katoh, S. Saito, T. Watanabe, Y. Masuho Identification of soluble type of membrane type matrix metalloproteinase 3 formed by alternative spliced mRNA
Journal Volume Year Pages Concerned
Biochem Biophys Acta Vol.1354 1997 159-170

Author Title of Article
F. Sugiyama, S. Haraoka, T. Watanabe, N. Shiota, K. Taniguchi, Y. Ueno, K. Tanimoto, K. Murakami, A. Fukamizu, K. Yagami Accerelation of atherosclerotic lesions in transgenic mice with hypertension by the activated renin-angiotensin system
Journal Volume Year Pages Concerned
Lab Invest 76 1997 835-842

Author Title of Article
YV. Bobryshev, RSA. Lord, T. Watanabe Structural peculiarities of vascular dendric cell tubulovesicular system in human athero sclerotic aorta
Journal Volume Year Pages Concerned
J Submicrosc Cytol Pathol Vol.29 1997 553-561

Author Title of Article
YV Bobryshev, VR. Babaev, RSA. Lord, T. Watanabe Cell death in atheromatous plaque of the carotid artery occurs through necrosis rather than apotosis
Journal Volume Year Pages Concerned
In Vivo Vol.11 1997 441-452

Author Title of Article
T. Watanabe Transgenic rabbit for atherosclerosis research: develpment of disease model animal
Journal Volume Year Pages Concerned
Igaku no Ayumi 182 1997 396-400

Author Title of Article
S. Matsumoto, T. Kobayashi, M. Katoh, S. Saito, Y. Ikeda, M. Kobori, Y. Masuho and T. Watanabe Expression and localization of matrix metalloproteinase-12 in the aorta of choleserol-fed rabbit
Journal Volume Year Pages Concerned
Am J Pathol Vol.153 1998 109-119

Author Title of Article
T. Watanabe, J. Fan Atherosclerosis and inflammation Mononuclear cell recruitment and adhesion molecules with reference to the implication of ICAM-1/LFA-1 pathway in atherogenesis
Journal Volume Year Pages Concerned
International Journal of Cardiology 66 1998 S45-S53

Author Title of Article
M. Araki, J. Fan and T. Watanabe Immunohistochemical localization of lipoprotein lipase and apolipoprotein E in human atherosclerotic lesions
Journal Volume Year Pages Concerned
Acta Histochem. Cytochem. Vol.31 1998 485-492

Author Title of Article
J. Fan and T. Watanabe Hepatic lipase
Journal Volume Year Pages Concerned
J. Atheroscler Thromb Vol.5 1998 41-45

Author Title of Article
Watanabe, T. and Fan, J. Inflammation and atherosclerosis.
Journal Volume Year Pages Concerned
J Internal Cardiol. 66(Suppl): 1998 S45-S53

Author Title of Article
J. Fan, M. Araki, L. Wu, M. Challah, H. Shimoyamada, R. M. Lawn, et al. Assembly of lipoprotein (a) in transgenic rabbits expressing human apolipoprotein (a)
Journal Volume Year Pages Concerned
Biochem. Biophys. Res. Comm. 255 1999 639-644

Author Title of Article
H. Unoki, J. Fan, T. Watanabe Low density lipoproteins modulate endothelial cells to secrete endothelin-1 in a polarized pattern: A study using a culture model system simulating arterial intima
Journal Volume Year Pages Concerned
Cell Tissue Res. 295 1999 89-99

Author Title of Article
J. Fan, M. Challah and T. Watanabe Transgenic rabbit models for biomedical research : Current status, basic methods and future perspectives
Journal Volume Year Pages Concerned
Pathol. Int. 49 1999 583-594

Author Title of Article
* C. M. Barbagallo, J. Fan, P. J. Blanche, M. Rizzo, M. J. Taylor, R. M. Krauss Overexpression of human hepatic lipase and apoprotein E in transgenic rabbits attenuates response to dietary cholesterol and alters lipoprotein subclass distributions
Journal Volume Year Pages Concerned
Arterioscl. Thromb. Vascul. Biol. 19 1999 625-632

Author Title of Article
S. Iwasa, J. Fan, M. Nagata, T. Watanabe Increased expression of endothelin-1 and endothelin B receptors in human atherosclerotic lesions. A possible role in atherogenesis
Journal Volume Year Pages Concerned
Atherosclerosis 146 1999 93-100

Author Title of Article
J. Fan and T. Watanabe Disease model animal for hyperlipidemia: transgenic rabbits
Journal Volume Year Pages Concerned
Gendai Iryo 31 1999 97-101

Author Title of Article
J. Fan and T. Watanabe Development of clone transgenic rabbit
Journal Volume Year Pages Concerned
Pathol. Clin. Med. Suppl. 1999 324

Author Title of Article
J. Fan and T. Watanabe Development of transgenic rabbit model
Journal Volume Year Pages Concerned
Anitex 12 2000 147-152

Author Title of Article
M. Araki, J. Fan, M. Challah, A. Bensadoun, N. Yamada, K. Honda, T. Watanabe Transgenic rabbits expressing human lipoprotein lipase
Journal Volume Year Pages Concerned
Cytotechnology Vol.33 2000 93-99

Author Title of Article
J. Fan and T. Watanabe Development and application of transgenic rabbit models
Journal Volume Year Pages Concerned
Igaku no Ayumi 193 2000 474-478

Author Title of Article
J. Fan, S. Matsumoto and T. Watanabe Induction and regulation of matrix metalloproteinase-12 by cytokines and CD40 signalig in monocyte/macrophages
Journal Volume Year Pages Concerned
Biochemical and Biophysical Research Communications 269 2000 808-815

Author Title of Article
J. Fan, H. Unoki, S. Iwasa and T. Watanabe Role of Endothelin-1 in atherosclerosisa
Journal Volume Year Pages Concerned
Ann NY Acad Sci Vol.902 2000 84-94

Author Title of Article
J. Fan, M. Challah, H. Shimoyamada and T. Watanabe Transgenic rabbits expressing human apolipoprotein (a) as a useful model for the study of lipoprotein (a)
Journal Volume Year Pages Concerned
Ann NY Acad Sci Vol.902 2000 347-351

Author Title of Article
J. Fan, M. Challah, H. Shimoyamada, M. Shiomi, S. Marcovina, T. Watanabe Defects of the LDL receptor in WHHL transgenic rabbits lead to a marked accumulation of plasma lipoprotein(a)
Journal Volume Year Pages Concerned
J Lipid Res Vol.41 2000 1004-1012

Author Title of Article
T. Kobayashi, T. Miyauchi, S. Iwasa, S. Sakai, J. Fan, M. Nagata, K. Goto and T. Watanabe Corresponding distribution of increased endothelin-B receptor expression and increased endothelin- 1 expression in the aorta of apolipoprotein E-deficient mice with advanced atherosclerosis
Journal Volume Year Pages Concerned
Pathology International 50 2000 929-936

Author Title of Article
M Araki, J Fan, T Watanabe. Human lipoprotein lipase transgenic rabbits.
Journal Volume Year Pages Concerned
Cytotechnology Vol.33 2000 93-99

Author Title of Article
J Fan, T Watanabe Human apolipoprotein(a) transgenic rabbits: cholesterol-fed and transgenic rabbit models for the study of atherosclerosis.
Journal Volume Year Pages Concerned
J Arterioscl Thromb   2000 26-32

Author Title of Article
J Fan, T Watanabe. Transgenic rabbits expressing human apolipoprotein(a).
Journal Volume Year Pages Concerned
J Arterioscl Thromb   2000 8-13

Author Title of Article
J. Fan and T. Watanabe Introduction to dysfunction of lipid metabolism: transgenic rabbits
Journal Volume Year Pages Concerned
Nippon Rinsho 59 2001 621-625

Author Title of Article
J. Fan, H. Shimotamada. M. Challah, H. Sun, S. Marcovina, K. Honda, T. Watanabe Transgenic rabbits expressing human apolipoprotein(a) develop more extensive atherosclerotic lesions in response to a cholesterol-rich diet.
Journal Volume Year Pages Concerned
Arterioscl. Thromb. Vascul. Biol. Vol.21 2001 88-94

Author Title of Article
J. Fan, T. Watanabe Human apo(a) transgenic rabbits, as a useful model for the study of human Lp(a)
Journal Volume Year Pages Concerned
Ann. NY Acad. Sci.   in press  

Author Title of Article
J. Fan, H. Shimoyamada, M. Challah, S. Marcovina, K. Honda, T. Watanabe Transgenic rabbits expressing human apolipoprotein(a) develop enhanced atherosclerotic lesions in response to a cholesterol-rich diet
Journal Volume Year Pages Concerned
Circulation   in press  

Author Title of Article
M Nagai, T. Nagai, M. Yamamoto, K. Goto, I. R. Bishop, N. Hayashi, H. Kondo, Y. Seyama, K. Kano, H. Fujita and S. Sassa Novel regulation of 6-aminolevulinate synthase in the rat Harderian gland
Journal Volume Year Pages Concerned
Biochem. Pharmacol. 53 1997 643-650

Author Title of Article
T. Miyauchi, K. Goto Heart failure endothelin receptor antagonist.
Journal Volume Year Pages Concerned
Trends Pharmacol. Sci.   1997 210-217

Author Title of Article
M. Uesugi, Y. Kasuya, K. Hayashi and K. Goto SB209670. a potent endothelin receptor antagonist, prevents or delays axonal degeneration after spinal cord injury.
Journal Volume Year Pages Concerned
Brain Res. 786: 1998 235-239

Author Title of Article
H. Le-Niculescu, E. Bonfuco, Y. Kasuya, F.-X. Claret, D. R.Green, et al. Withdrawal of survival factors results in activation of the JNK pathway in neuronal cells leading to Fas ligand induction and cell death
Journal Volume Year Pages Concerned
Mol. Cell. Biol. 19 1999 751-763

Author Title of Article
J. Ishida, S. Asada, H. Daitoku, K. Fujiwara, Y. Kon, K. Murakami, et al. Expression and characterization of mouse angiotensin II type 1a receptor tagging hemagglutinin epitope in culture cells
Journal Volume Year Pages Concerned
Int. J. Mol. Med. 3 1999 263-270

Author Title of Article
S. Namiki, F. Kaneda, M. Ikegami, T. Arai, K. Fujimori, S. Asada, et al. Bis-N-nitroso-caged nitric oxides: Photochemistry and biological performance test by rat aorta vasorelaxation
Journal Volume Year Pages Concerned
Bioorganic Medic. Chem. 7 1999 1695-1702

Author Title of Article
S. Asada, Y. Kasuya, H. Hama, T. Masaki, K. Goto Cytodifferentiation potentiates aFGF-induced p21ras/Erk signaling pathway in rat cultured astrocytes
Journal Volume Year Pages Concerned
Biochem. Biophys. Res. Comm. 260 1999 441-445

Author Title of Article
Y. Kakinuma, H. Hama, Y. Kasuya, A. Fukamizu A new aspect of renin-angiotensin system (RAS) in central nervous system -RAS indispensable for maintaining function of astrocytes-
Journal Volume Year Pages Concerned
Recent Res. Devel. Neurochem. 2 1999 473-493

Author Title of Article
K. Onodera, S. Takahashi, S. Nishimura, J. Ohta, H. Motohashi, K. Yomogida, N. Hayashi, J. D. Engle and M. Yamamoto GATA-1 transcription is controlled by distinct regulatory mechanisms during primitive and definitive erythropoiesis
Journal Volume Year Pages Concerned
Proc. Natl. Acad. Sci. USA Vol.94 1997 4487-4492

Author Title of Article
S. Takahashi, K. Onodera, H. Motohashi, N. Suwabe, N. Hayashi, N. Yanai, Y. Nabeshima and M. Yamamoto Arrest in primitive erythroid cell development caused by promoter-specific disruption of the GATA-1 gene
Journal Volume Year Pages Concerned
J. Biol. Chem. Vol.272 1997 12611-12615

Author Title of Article
M. Yamamoto, S. Takahashi, K. Onodera, Y. Muraosa and J. D. Engel Upstream and downstream of erythroid transcription factor GATA-1 (invited review)
Journal Volume Year Pages Concerned
Genes to Cells 2 1997 107-115

Author Title of Article
K. Onodera, K. Yomogida, N. Suwabe, S. Takahashi, Y. Muraosa, et al. Conserved structure, regulatory elements, and transcriptional regulation from the GATA-1 gene testis promoter
Journal Volume Year Pages Concerned
J. Biochem. 121 1997 251-263

Author Title of Article
S. Imagawa, M. Yamamoto and Y. Miura Negative regulation of the erythropoietin gene expression by the GATA transcription factors
Journal Volume Year Pages Concerned
Blood Vol.89 1997 1430-1439

Author Title of Article
A. Tanabe, T. Furukawa, Y. Ogawa, M. Yamamoto, N. Hayashi, et al. Involvement of the Transcriptional Factor GATA-1 in Regulation of Expression of Coproporphyrinogen Oxidase in Mouse Erythroleukemia Cells
Journal Volume Year Pages Concerned
Biochem. Biol. Res. Commun. 233 1997 729-736

Author Title of Article
H. Harigae, S. Takahashi, N. Suwabe, H. Ohtsu, L. Gu, Z. Yang, et al. Differential roles of GATA-1 and GATA-2 in growth and differentiation of mast cellsÅ@
Journal Volume Year Pages Concerned
Genes to Cells 3 1998 39-50

Author Title of Article
H. Motohashi, J. Ohta, J. D. Engel and M. Yamamoto A core region of the mafK gene IN promoter directs neurone-specific transcription in vivo
Journal Volume Year Pages Concerned
Genes to Cells Vol.3 1998 671-684

Author Title of Article
N. Suwabe, S. Takahashi, T. Å@Nakano and M. Yamamoto. GATA-1 regulates growth and differentiation of deffinitive erythroid lineage cells during in vitro ES cell differentiation.
Journal Volume Year Pages Concerned
Blood Vol.92 1998 4108-4118

Author Title of Article
S. Kawauchi, S. Takahashi, O. Nakajima. H. Ogino, M. Morita, et al. Regulation of lens fiber cell differentiation by transcriptional factor c-Maf
Journal Volume Year Pages Concerned
J. Biol. Chem. 274 1999 19254-19260

Author Title of Article
S. Takahashi, R. Shimizu, T. Kuroha, K. Yoh, N. Suwabe, J. Ohta, et al. GATA factor transgenes under GATA-1 locus control rescue germ line GATA-1 mutant deficiencies
Journal Volume Year Pages Concerned
Blood 96 2000 910-916

Author Title of Article
K. Furukawa, K. Ookawa, T. Ushida, T. Tateishi and N. Ohshima Development of a new shear flow apparatus to evaluate platelet-biomaterial interactions
Journal Volume Year Pages Concerned
Advances in Polymeric Biomaterials Science   1997 137-144

Author Title of Article
K. Furukawa, T. Ushida, T. Tateishi Reorganization of vascular wall cells in vitro-effect of VEGF gradient-
Journal Volume Year Pages Concerned
Jpn. J. of Artif. Organs Vol.26 1997 492-497

Author Title of Article
K. Furukawa, T. Ushida, H. Sugano, N. Ohshima, And T. Tateishi New method for material screening of antithrombogenic materials
Journal Volume Year Pages Concerned
Jpn. J. Artif. Organs 27 1998 507-513

Author Title of Article
K. Furukawa, T. Ushida, H. Sugano, N. Ohshima, T. Tateishi Real time observation of platelet adhesion to opaque biomaterial surface under shear flow conditions
Journal Volume Year Pages Concerned
J. Biomed. Mater. Res. 46 1999 93-102

Author Title of Article
K. Furukawa, T. Ushida, H. Sugano, N. Oshima, and T. Tateishi Effects of shear stress on the platelet adhesion to materials
Journal Volume Year Pages Concerned
Proc JSME Meeting Bioengineering Division 99-3 1999 262-263

Author Title of Article
K. Furukawa, T. Tateishi, and T. Ushida Development of evasluation system for blood compatible materials: real-time observation under dynamic contidions
Journal Volume Year Pages Concerned
Image Lab. Jan. 2000 6-10

Author Title of Article
K. Furukawa, T. Ushida, T. Nagase, T. Noguchi, H. Nakamigawa et al. Effects of 3-D sturucture on adhesion strength of endothelial cells in reconstructed artificial vessels
Journal Volume Year Pages Concerned
Jpn. J. Artif. Organs 29 2000 9-10

Author Title of Article
K. Furukawa, T. Ushida, T. Tateishi Development of evaluation system for blood compatible materials
Journal Volume Year Pages Concerned
MEL News 7 2000 4-7

Author Title of Article
Katsuko FURUKAWA,. Takashi USHIDA, Hirohito SUGANO, Norio OHSHIMA, Tettsuya TATEISHI. Effect of shear stress on platelet adhesion to expanded polytetrafluoroethylene, a silicone sheet, and an endothelial cell monolayer.
Journal Volume Year Pages Concerned
ASAIO J 46 2000 696-701

Author Title of Article
Y. Sakai, K. Furukawa, K. Naruse, T. Ushida, Y. Harihara et al. Hepatocyte aggregate by tissue engineering methodology
Journal Volume Year Pages Concerned
Jpn. J. Artif. Organs 29 2000 426-432

Author Title of Article
Katsuko S FURUKAWA, Takashi USHIDA, Yasuyuki SAKAI, Motoyuki SUZUKI, Tetsuya TATEISHI. Formation of human fibroblasts-aggregates (spheroids) by rotational culture for tissue-engineered skin.
Journal Volume Year Pages Concerned
Cell Transplantation   in press  

Author Title of Article
Yasuyuki SAKAI, Katsuko FURUKAWA, Takashi USHIDA, Tetsuya TATEISHI, Motoyuki SUZUKI In vitro organization of biohybrid rat liver tissue incorporating growth-factor- and hormone-releasing biodegradable-polymer microcapsules
Journal Volume Year Pages Concerned
Cell Transplantation   in press  

Author Title of Article
N. Ohshima, K. Yanagi, T. Suzuki and K. Ookawa Analyses of the branching pattern vascular architecture and microhemodynamics in the tumor microcirculation
Journal Volume Year Pages Concerned
Microcirculation annual 13 1997 15-16

Author Title of Article
H. Natsui, K. Yanagi, Y. Nakayama. and N. Ohshima Effects of intra-arterial administration of prostaglandin E1 on intramuscular microcirculation
Journal Volume Year Pages Concerned
Microcirculation annual Vol.13 1997 79-80

Author Title of Article
T. Suzuki, K. Yanagi, K. Ookawa, K. Hatakeyama and N. Ohshima Stimulation by chemoattractants affects the adhesiveness of leukocytes in the neovasculature of the solid tumor tissue
Journal Volume Year Pages Concerned
Vol. 13 Vol.13 1997 47-48

Author Title of Article
K. Yanagi, T. Suzuki, K. Ookawa and N. Ohshima Hemodynamics in a microvasculature of a peritoneal disseminated tumor model of a rat
Journal Volume Year Pages Concerned
Microcirculation annual Vol.13 1997 45-46

Author Title of Article
D. Ma, K. Yanagi, K. Ookawa, N. Ohshima Antithrombotic effect of Xue-sai-tong injection in mesenteric microvessels of rats
Journal Volume Year Pages Concerned
Microcirculation annual Vol.13 1997 121-122

Author Title of Article
N. Ohshima Biomechanics of blood formed elements: visualization by selective fluorescent imaging
Journal Volume Year Pages Concerned
B&R 11 1997 172-181

Author Title of Article
K, Yanagi, T. Suzuki, K. Ookawa and N. Ohshima Analysis of angiogenic process and hemodynamics in the peritoneal disseminated tumor model of rats
Journal Volume Year Pages Concerned
Proc. 3rd Asian Congress for Microcirculation   1997 67-72

Author Title of Article
N. Ohshima Organ microcirculation from basics to clinical applications: CLSM application
Journal Volume Year Pages Concerned
Igaku no Ayumi 184 1998 835-840

Author Title of Article
H. Natsui, K. Yanagi, Y. Nakayama and N. Ohshima Effects of prostaglandin E1 on muscle microcirculation
Journal Volume Year Pages Concerned
Hemorheology: Connection between Biorheology and Clinical Medicine   1998 17-23

Author Title of Article
H. Natsui, K. Yanagi, Y. Nakayama and N. Ohshima Effects of intra-arterial administration of prostaglandin E1 on muscle capillary
Journal Volume Year Pages Concerned
Microcirculation annual Vol.14 1998 121-122

Author Title of Article
T. Suzuki, K. Yanagi, K. Hatakeyama and N. Ohshima Blood flow and leukocyte adhesiveness are reduced in the microcirculation of a peritoneal disseminated colon carcinoma
Journal Volume Year Pages Concerned
Annals of Biomedical Engineering Vol.26 1998 803-811

Author Title of Article
N. Ohshima, K. Yanagi, K. Ookawa, T. Suzuki and K. Hatakeyama Biomechanical aspects of leukocyte behavior in tumor microcirculation
Journal Volume Year Pages Concerned
The Fifth Japan-USA-Singapore-China Conference on Biomechanics   1998 72-73

Author Title of Article
N. Ohshima Characteristics of venation from the viewpoint of microcirculation
Journal Volume Year Pages Concerned
Jpn. J. Phlebology 10 1999 1-9

Author Title of Article
J. Wang and N. Ohshima Development of flow visualization method of microcirculation in diabetes rats: Flow visualization of mailfold skin microcrrculation by selective fluorescent tracer labelling technique and analysis of hemodynamic and hemorheological parameters
Journal Volume Year Pages Concerned
J. Jpn. Coll. Angiolog. 39 1999 429-439

Author Title of Article
C. Ito and N. Ohshima Quantitative analysis of angiogenic process in the rat peritoneal disseminated tumor model under intravital microscopic observation
Journal Volume Year Pages Concerned
Microcirculation annual 15 1999 83-84

Author Title of Article
J. Wang, N. Ohshima Visualization of microvascular blood flow in the nailfold of diabetic model rats
Journal Volume Year Pages Concerned
Microcirculation annual 15 1999 103-104

Author Title of Article
C. Miyoshi and N. Ohshima In vivo observation of microvasculature by intravital TV-microscope system
Journal Volume Year Pages Concerned
Surgery Frontier 6 1999 85-90

Author Title of Article
S. Yamaguchi, M. Ito, K. Yanagi and N. Ohshima Somatosensory modulation of hemodynamics in the mesenteric arteriole of anesthetized rats
Journal Volume Year Pages Concerned
Microcirculation annual 15 1999 95-96

Author Title of Article
N. Funakoshi, M. Onizuka, S. Iizuka, K. Yanagi, N. Ohshima, S. Ishikawa, K. Mitsui, T. Mitsui A new model of lung metastasis for intravital studies
Journal Volume Year Pages Concerned
Microvasc. Res. Vol.59 2000 361-367

Author Title of Article
S. Iwashita, K. Yanagi, N. Ohshima and M. Suzuki Insulin increases blood flow rate in the microvasculature of the cremaster muscle of rats
Journal Volume Year Pages Concerned
in vivo 26 2000 51-52

Author Title of Article
S. Yamaguchi, M. Ito and N. Ohshima Somatosensory inputts modulate blood pressure heart rate, and microvascular blood flow velocity in mesenteric arteriole in the anesthetized rats
Journal Volume Year Pages Concerned
Microcirculation annual   2000 77-78

Author Title of Article
C. Miyoshi and N. Ohshima Time-course changes in expression of vascular endothelial growth factor(VEGF)in the peritoneal disseminated tumor model of the rat
Journal Volume Year Pages Concerned
Microcirculation annual 16 2000 137-138

Author Title of Article
S. Iwashita, K. Yanagi, N. Ohshima and M. Suzuki Insulin Increases Blood Flow Rate in the Microvasculature of Cremaster Muscle of the Anesthetized Rats
Journal Volume Year Pages Concerned
in vivo   in press  

Author Title of Article
S. Yamaguchi, M. Ito, and N. Ohshima Somatosensory nociceptive mechanical stimulation modulates systemic and mesenteric microvascular hemodynamics in anesthetized rats
Journal Volume Year Pages Concerned
J. Autonom. Nerv. Sys.   in press  

[Reference Books]
Author Title of Book
N. Ohshima Bioprocess engineering of functional regeneration of cultured animal cells: Project report
Publisher Year Pages
Tissue Engineering for Therapeutic Use 2, Elsevier Science 1998 113-118

Author Title of Book
N. Ohshima, K. Yanagi, H. Miyoshi and P. Kan Improvement of the performance of a packed-bed type bioartificial liver
Publisher Year Pages
Tissue Engineering for Therapeutic Use 3, Elsevier Science 1999 53-63

Author Title of Book
S. Kasai and M. Sawa Present status of an artificial liver support system for hepatic failure
Publisher Year Pages
Tissue Engineering for Therapeutic Use 1, Elsevier Science 1998 71-85

Author Title of Book
S. Kasai and M. Sawa Hepatocyte transplantation
Publisher Year Pages
Annual Review Gastroenterology 2000, Chugai Medical Press, Tokyo 2000 58-64

Author Title of Book
N. Minegishi and M. Yamamoto Erythrocyte differentiation and transcriptional factors
Publisher Year Pages
Annual Review Hematology 2000, Chugai Medical Press, Tokyo 2000 47-57

Author Title of Book
N. Minegishi and M. Yamamoto Analysis of expression of GFP by flowcytometry
Publisher Year Pages
GFP and Bioimaging, Yodo-sha, Tokyo 2000 197-206

Author Title of Book
T. Murata, T. Ushida, S. Mizuno and T. Tateishi Effects of hydrostatic pressure on extracellular matrix synthesis of cultured chondrocytes
Publisher Year Pages
Biomedical Materials Research in the Far East (III), Kobunshi Kankoukai 1997 42-43

Author Title of Book
T. Ushida and T. Tateishi Incorporation of physical factors into tissue engineering for therapeutic use
Publisher Year Pages
Tissue Engineering for Therapeutic Use 1, Elsevier Science 1998 139-148

Author Title of Book
T. Uemura, Y. K. Liu, A. Nemoto, T. Yabe, T. Ushida and T. Tateishi Biomedical Materials Research in the Far East (III), Kobunshi Kankoukai
Publisher Year Pages
The role of osteopontin in bone remodeling 1997 38-39

Author Title of Book
J. Fan, M. Araki, L. Wu, M. Challah, H. Shimoyamada, R. M. Lawn, H. Kakuta, H. Shikama and T. Watanabe Animal Cell Technology: Challenge for the 21st Century, Kluwar Academic Publishers, Dordrecht
Publisher Year Pages
Transgenic rabbits: a novel model for the study of atherosclerosis 1999 203-207

Author Title of Book
S. Takahashi, N. Minegishi, K. Igarashi and M. Yamamoto Generation of molecular probes for hematopoietic cell purification
Publisher Year Pages
Tissue Engineering for Therapeutic Use 4, Elsevier Science 2000 131-140

Author Title of Book
K. Furukawa, T. Ushida, H. Sugano, N. Ohshima and T. Tateishi Real-time observation of platelet-biomaterial interaction by modifying a cone-plate type viscometer
Publisher Year Pages
Biomedical Materials Research in the Far East (III), Kobunshi Kankoukai 1997 78-79

Author Title of Book
K. S. Furukawa, T. Ushida, T. Nagase, T. Noguchi, H. Nakamigawa, T. Tamaki and T. Tateishi Effects of existence of smooth muscle cells and fibroblasts on adhesive force of endothelial cells
Publisher Year Pages
Biomedical Materials Research in the Far East (IV), Kobunshi Kankoukai 2000 45-46


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