Summary of Research Project Results Under the JSPS FY2000
"Research for the future Program"



1.Research Institution Okayama University of Science
 
2.Research Area Physical and Engineering Science
 
3.Research Field Advanced Processes
 
4.Term of Project FY1996〜FY2000
 
5.Project Number 96P00303
 
6.Title of Project Integrated Chemical Process

7.Projetct Leader
Name Institution,Department Title of Position
Junzo Otera Okayama University of Science, Faculty of Engineering Professor

8.Core Members

Names Institution,Department Title of Position
Hideki Sakurai Science University of Tokyo, Faculty of Science and technology Professor
Susumu Ohira Okayama University of Science, Faculty of Science Professor
Akihiro Orita Okayama University of Science, Faculty of Engineering Assistant Professor

9.Cooperating Researchers

Names Institution,Department Title of Position
Takashi Hoshi Science University of Tokyo, Faculty of Science and technology postdoctoral fellow
Jayamma Yaruva Okayama University of Science, Faculty of Engineering postdoctoral fellow
Hiroshi Ikeda Okayama University of Science, Faculty of Engineering postdoctoral fellow

10.Summary of Research Results

The development of environmentally benign chemical processes is one of the most important issues to be solved in the near future. A challenge to such problem was made on the basis of process chemistry by two groups.
The Otera group at Okayama University of Science advanced new concepts for compaction of multi-step chemical processes. "Integrated Chemical Process" enables successive reactions to proceed in one-pot by sttling the reaction conditions compatible with all relevant reactions. This treatment results in not only compaction of the process but also increase of the overall yield. On the other hand, substrates with multifold reaction sites undergo different reactions simultaneously with perfect selectivity in "Parallel Recognition". "Shotgun Process" allows similar substrates to be transformed by treatment with multifold reagents in one shot. In these treatments, the protection-deprotection procedures are no more necessary. In the meantime, a new automated synthesizer was developed which can reproduce normal bench work. Air- and water-sensitive materials were employable without difficulty and various one-pot processes were successfully run on this machine.
The Sakurai group at Science University of Tokyo was engaged in improving synthetic processes of organosilicon compounds. A new polymerization process for polysilanes was developed by use of masked disilenes. This protocol controls the polymerization much more effectively than the conventional one that employs chorosilanes as starting materials. During this project, a new procedure for reduction of polychloroarenes was devised, which is of great significance in terms of the environmental technology of dioxins. The production of silicones is the most important process in organosilicon chemistry. The conventional process involves conversion of Si-O bond in silica to Si-Cl and re-conversion of Si-Cl to Si-O. The direct conversion of silica to silicones was also investigated with recourse to hypervalent organosilicon chemistry.

11.Key Words

(1)one-pot reaction、(2)integrated chemical process、(3)parallel recognition
(4)shotgun process、(5)automated synthesis、(6)polysilane
(7)silicone、(8)polychloroarene、(9)reduction

12.References

[Reference Articles]
Author Title of Article
J. Chen Parallel recognition by virtue of differentiation between carbonyls, acetals and ennes
Journal Volume Year Pages Concerned
Tetrahedron 54 1998 8411-8420

Author Title of Article
A. Orita Integrated Chemical Process:One-Pot Double Elimination Method for Acetylenes
Journal Volume Year Pages Concerned
Chem. Eur. J. 5 1999 1355-1367

Author Title of Article
A. Orita Automated synthesis: Development of a new apparatus friendly to synthetic chemists
Journal Volume Year Pages Concerned
Org. Process Res. Dev. 4 2000 333-336

Author Title of Article
T. Sanji Self-Assembled Micelles of Amphiphilic Polysilane Block Copolymers
Journal Volume Year Pages Concerned
Macromolecules 32 1999 5718

Author Title of Article
T. Sanji Encapsulation of polysilane into shell-cross-linked micelles
Journal Volume Year Pages Concerned
Chem. Commun.   1999 2201

Author Title of Article
T. Sanji Preparation of nanometer-sizedhollow particles by photochemical degradation of polysilane shell cross-linked micelles and reversible encapsulation of guest molecules
Journal Volume Year Pages Concerned
Macromolecules 33 2000 8524-8526

[Reference Books]
Author Title of Book
J. Otera. Ed. Modern Carbonyl Chemistry
Publisher Year Pages
Wiley-VCH, Weinheim 2000 613

Author Title of Book
M. J. Went Silicon-Containing Polymers.
Publisher Year Pages
R. G. Jones et al. 2000 419-437


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