| 1.Research Institution | Okayama University of Science | |
| 2.Research Area | Physical and Engineering Science | |
| 3.Research Field | Advanced Processes | |
| 4.Term of Project | FY1996〜FY2000 | |
| 5.Project Number | 96P00303 | |
| 6.Title of Project | Integrated Chemical Process |
| Name | Institution,Department | Title of Position |
| Junzo Otera | Okayama University of Science, Faculty of Engineering | Professor |
8.Core Members
| Names | Institution,Department | Title of Position |
| Hideki Sakurai | Science University of Tokyo, Faculty of Science and technology | Professor |
| Susumu Ohira | Okayama University of Science, Faculty of Science | Professor |
| Akihiro Orita | Okayama University of Science, Faculty of Engineering | Assistant Professor |
9.Cooperating Researchers
| Names | Institution,Department | Title of Position |
| Takashi Hoshi | Science University of Tokyo, Faculty of Science and technology | postdoctoral fellow |
| Jayamma Yaruva | Okayama University of Science, Faculty of Engineering | postdoctoral fellow |
| Hiroshi Ikeda | Okayama University of Science, Faculty of Engineering | postdoctoral fellow |
10.Summary of Research Results
|
The development of environmentally benign chemical processes is one of the most important issues to be solved in the near future. A challenge to such problem was made on the basis of process chemistry by two groups. The Otera group at Okayama University of Science advanced new concepts for compaction of multi-step chemical processes. "Integrated Chemical Process" enables successive reactions to proceed in one-pot by sttling the reaction conditions compatible with all relevant reactions. This treatment results in not only compaction of the process but also increase of the overall yield. On the other hand, substrates with multifold reaction sites undergo different reactions simultaneously with perfect selectivity in "Parallel Recognition". "Shotgun Process" allows similar substrates to be transformed by treatment with multifold reagents in one shot. In these treatments, the protection-deprotection procedures are no more necessary. In the meantime, a new automated synthesizer was developed which can reproduce normal bench work. Air- and water-sensitive materials were employable without difficulty and various one-pot processes were successfully run on this machine. The Sakurai group at Science University of Tokyo was engaged in improving synthetic processes of organosilicon compounds. A new polymerization process for polysilanes was developed by use of masked disilenes. This protocol controls the polymerization much more effectively than the conventional one that employs chorosilanes as starting materials. During this project, a new procedure for reduction of polychloroarenes was devised, which is of great significance in terms of the environmental technology of dioxins. The production of silicones is the most important process in organosilicon chemistry. The conventional process involves conversion of Si-O bond in silica to Si-Cl and re-conversion of Si-Cl to Si-O. The direct conversion of silica to silicones was also investigated with recourse to hypervalent organosilicon chemistry. |
11.Key Words
(1)one-pot reaction、(2)integrated chemical process、(3)parallel recognition
(4)shotgun process、(5)automated synthesis、(6)polysilane
(7)silicone、(8)polychloroarene、(9)reduction
12.References
| Author | Title of Article | |||
| J. Chen | Parallel recognition by virtue of differentiation between carbonyls, acetals and ennes | |||
| Journal | Volume | Year | Pages Concerned | |
| Tetrahedron | 54 | 1998 | 8411-8420 | |
| Author | Title of Article | |||
| A. Orita | Integrated Chemical Process:One-Pot Double Elimination Method for Acetylenes | |||
| Journal | Volume | Year | Pages Concerned | |
| Chem. Eur. J. | 5 | 1999 | 1355-1367 | |
| Author | Title of Article | |||
| A. Orita | Automated synthesis: Development of a new apparatus friendly to synthetic chemists | |||
| Journal | Volume | Year | Pages Concerned | |
| Org. Process Res. Dev. | 4 | 2000 | 333-336 | |
| Author | Title of Article | |||
| T. Sanji | Self-Assembled Micelles of Amphiphilic Polysilane Block Copolymers | |||
| Journal | Volume | Year | Pages Concerned | |
| Macromolecules | 32 | 1999 | 5718 | |
| Author | Title of Article | |||
| T. Sanji | Encapsulation of polysilane into shell-cross-linked micelles | |||
| Journal | Volume | Year | Pages Concerned | |
| Chem. Commun. | 1999 | 2201 | ||
| Author | Title of Article | |||
| T. Sanji | Preparation of nanometer-sizedhollow particles by photochemical degradation of polysilane shell cross-linked micelles and reversible encapsulation of guest molecules | |||
| Journal | Volume | Year | Pages Concerned | |
| Macromolecules | 33 | 2000 | 8524-8526 | |
| Author | Title of Book | ||
| J. Otera. Ed. | Modern Carbonyl Chemistry | ||
| Publisher | Year | Pages | |
| Wiley-VCH, Weinheim | 2000 | 613 | |
| Author | Title of Book | ||
| M. J. Went | Silicon-Containing Polymers. | ||
| Publisher | Year | Pages | |
| R. G. Jones et al. | 2000 | 419-437 | |