MOLECULAR CANCER THERAPEUTICS

A Symposium Celebrating 30 years in Cancer Research
Sponsored by the Japan Society for the Promotion of Science (JSPS)and the National Cancer Institute (NCI)

AGENDA

March 1-2, 2004
Natcher Conference Center on the NIH Campus

March 1

8:00 — 9:00 AM   Registration
9:00 — 9:45 AM Session #1 — Welcome and Introductory Remarks

Dr. Joe Harford, NCI
Mr. Koji Nakanishi, JSPS
Dr. M. Terada (Coordinator)

9:45 — 10:30 AM Coffee break and cake to celebrate 30 years of US-Japan Cooperation on Cancer Research

Keynote Speakers —

10:30 — 11:15 AM Dr. Robert Weinberg (Whitehead Inst./MIT, Cambridge, MA): Cellular Mechanisms Leading to Human Tumor Formation
11:15 — 12:00 PM Dr. Julie Buring (Brigham and Women’s Hospital, Boston, MA): Discrepancies between observational studies and randomized trials: What lessons can we learn—
12:00 — 1:30 PM Lunch
 
Session #2 — Molecular Cancer Therapeutics: Epidemiology and Population Science
Chairs: Dr. Ed Trapido and Dr. Tomoyuki Kitagawa
1:30 — 2:00 PM   Dr. Naoko Sueoka (Saga Univ., Faculty of Medicine): Heterogeneous nuclear ribonucleoprotein B1 as a new parameter for early detection and chemoprevention of human lung cancer
2:00 — 2:30 PM Dr. Mark Shriver (Penn State Univ., University Park, PA): Measuring and using ancestry to study the genetics of complex diseases
3:00 — 3:30 PM Dr. Tetsuya Kamataki (Graduate Sch. of Pharmaceutical Science, Hokkaido Univ.): CYD2A6 genetic polymorphism as an important factor determining the risk of tobacco-related cancer
3:30 — 3:45 PM Coffee break
3:45 — 4:15 PM Dr. Michael Antoni (Univ. of Miami, Coral Gables, FL): Effects of Stress Management Intervention on Quality of Life and Physiological Functioning in Women with Breast Cancer
4:15 — 4:45 PM Dr. Shunro Sonoda (Kagoshima Univ., Faculty of Medicine): HLA-A*26, HLA-B*4002, HLA-B*4006,m and HLA-B*4801 alleles predispose to adult T cell leukemia: the limited recognition of HTLV type 1 tax peptide anchor motifs and epitopies to generate anti-HTLVtype 1 tax CD8(+) cytotoxic T lymphocytes
4:45 — 5:15 PM Dr. Gary Schwartz (Comprehensive Ca. Ctr. At Wake Forest Univ., Winston-Salem, NC): Looking on the sunny side: Prostate cancer chemoprevention with vitamin D

March 2

Session #3 - Molecular cancer Therapeutics: Clinical Science
Chairs: Dr. Michaele Christian and Dr. Takashi Tsuruo
8:30 — 9:00 AM   Dr. Peter Jones (Norris Comprehensive Can. Ctr., USC, Los Angeles, CA): Epigenetic therapy
9:00 — 9:30 AM Dr. Yoichi Furukawa (Inst. of Medical Science, Univ. of Tokyo): Identification and characterization of novel molecular targets for treatment of human cancer
9:30 — 10:00 AM Dr. Hiroyuki Seimiya (Cancer Chemotherapy Ctr., JFCR): Mechanisms for telomere length regulation as anticancer molecular target
10:00 — 10:15 AM Coffee break
10:15 — 10:45 AM Dr. Neal Rosen (MSKCC, New York, NY): Hsp90: Development of an unexpected therapeutic target
10:45 — 11:15 AM Dr. Yoshiro Niitsu (Sapporo Med. Univ., Sapporo): A novel AML therapy targeting VLA4/fibronectin interaction
11:15 — 11:45 AM Dr. Gregg Semenza (Johns Hopkins Univ., Baltimore, MD): HIF-1alpha as a therapeutic target
11:45 — 1:00 PM LUNCH
 
Session #4 — Molecular cancer Therapeutics: Basic Science
Chairs: Dr. Snorri Thorgeirsson and Dr. Masaaki Terada
1:00 — 1:30 PM   Dr. Michiyuki Matsuda (Res. Inst. for Microbial Diseases, Osaka): Growth stimulating pathways visualized by probes based on the principle of fluorescence resonance energy transfer
1:30 — 2:00 PM Dr. Anita Roberts (NCI, Bethesda, MD): The two faces of TGF-beta in carcinogenesis
2:00 — 2:30 PM Dr. Keiji Wakabayashi (Natl. Cancer Ctr. Res. Inst.): Mono (ADP-ribosyl)action of N2 position of guanine in DNA by an apoptosis-inducing protein, pierisin-1, from cabbage butterfly
2:30 — 2:45 PM Coffee break
2:45 — 3:15 PM Dr. Jeffrey M. Rosen (Baylor College of Medicine, Houston, TX): Stem cells and cancer
3:15 — 3:45 PM Dr. Yukiko Gotch (Univ. of Tokyo): Regulation of cell death by phosphorylation
3:45 — 4:15 PM Dr. Steven Rosenberg (NCI, Bethesda, MD): Adoptive-cell-therapy for the treatment of patients with cancer
4:15 — 4:30 PM Closing Remarks and Adjournment