SECOND U.S.-JAPAN COOPERATIVE CANCER RESEARCH PROGRAM SYMPOSIUM
National Cancer Institute and Japan Society for the Promotion of Science

International Lecture Hall
National Cancer Center, Tokyo

March 8 (Thu) 9:00-17:05
Chairperson: M. Terada
9:00-9:05 Welcome Remarks S. Miwa
9:05-9:10 Introductory Remarks T. Kitagawa
I. Genetic Instability and Cancer
9:10-10:00 Genetic instability and carcinogenesis (Special Lecture) M. Sekiguchi
10:00-10:25 Cancer therapeutics: the role of telomeres and telomerase in cell cycle checkpoint responses J. Shay
(Coffee break)
Chairperson: Y. Ito
10:45-11:10 Xeroderma pigmentosum variant: gene and protein F. Hanaoka
11:10-11:35 Genetic instability and the BRCA genes M. Moynahan
11:35-12:00 Function of NBSI for genetic stability after irradiation K. Komatsu
(Lunch)
Chairperson: L. Loeb
13:00-13:25 Chromatin silencing and tumorigenesis by polycomb group genes M. Kanno
13:25-13:50 Phosphorylation of Ser46 regulates apoptosis-inducing ability of p53 Y. Taya
13:50-14:15 Patterns and mechanisms of chromosomal aberrations in cancer cells T. Ried
14:15-14:40 Methylation and chromatin assembly in RUNX-related cancer Y. Ito
(Coffee break)
Chairperson: M. Christian
15:00-15:25 Chromosomal instability in oral cancer cells S. Gollin
15:25-15:50 Molecular mechanisms of chromosome maintenance F. Ishikawa
15:50-16:15 Mutator phenotype and cancer L. Loeb
Chairperson: T. Tsuruo
16:15-17:05 Genetic instability and cancer treatment (Special Lecture) T. Tlsty

March 9 (Fri) 9:00-14:00
II. Factors Associated with Sensitivity to Cancer-related Infection

Chairperson: R. Hiatt
9:00-9:25 Factors influencing H. Pylori-induced gastritis and cancer risk M. Asaka
9:25-9:50 H. Pylori and cancer: why some and not others? J. Parsonnet
9:50-10:15 Dietary factors affecting H. Pylori-associated gastritis in Mongolian gerbils K. Wakabayashi
(Coffee break)
Chairperson: S. Thorgeirssol
10:35-11:00 Cytokine gene polymorphisms in gastric cancer and AIDS-related malignancies C. Rabkin
11:00-11:25 Identification of a single nucleotide polymorphism in the MXA gene promoter related with the response to hepatitis C patient to interferon S. Mishiro
11:25-11:50 Traub The role of Epstein-Barr virus in the development of nasopharyngeal carcinoma N. Raab-
(Lunch)
Chairperson: T. Kitagawa
13:00-13:50 The Human Genes that Limit AIDS (Special Lecture) C. Winkler
13:50-14:00 Closing Remarks J. Harford

VENUE:International Lecture Hall
National Cancer Center, Tokyo

INQUIRY: Japan Society for the Promotion of Science
Tel: +81-3-3263-1725, Fax: +81-3-3263-1673
Homepage: http://www.jsps.go.jp