ADMINISTRATIVE REPORT

This report summarizes activities of the US-Japan Cooperative Cancer Research Program for the Japanese Fiscal Year 1997, the period between April 1, 1 997, and March 31, 1998.
The Program consists of the following program areas:

I. Etiology
II. Biology and Diagnosis
III. Treatment
IV. Interdisciplinary

The US-Japan Bilateral Agreement calls for the organization of seminars and workshops, exchange of scientists for information exchange and materials. Detailed discussions of these activities will be reported under specific program areas. The tables compiled in this section represent overall summaries for quick review. They should be self-explanatory.
To discuss policy matters and program activities, the Joint Steering Committee of the Program meets once every year. (The fifth meeting of the fifth five-year period (April 1, 1994 to March 31, 1999) was held on March 11 - 12, 1999, in Tokyo, Japan.

Past Meetings
1st 24-25 March 1979 San Francisco, California
2nd 10-11 June 1980 Nara, Japan
3rd 1-2 June 1981 Annapolis, Maryland
4th 31 May-1 June 1982 Tokyo, Japan
5th 9-10 June 1983 Honolulu, Hawaii
6th 13-14 February 1984 Tokyo, Japan
7th 25-26 June 1984 San Francisco
8th 27-28 June 1985 Tokyo, Japan
9th June 26-27, 1986 Anchorage, Alaska
10th June 25-26, 1987 Kyoto, Japan
11th June 23-24, 1988 Anchorage, Alaska
12th June 23-24, 1989 Kashiko-jima, Japan
13th June 28-29, 1990 San Diego, California
14th July 1-2, 1991 Naha, Okinawa, Japan
15th June 22-23,1992 Napa, California
16th June 18-19, 1993 Sapporo, Japan
17th June 23-24, 1994 Seattle, Washington
18th June 30-July, 1995 Osaka, Japan
19th March 27, 1997 Bethesda, Maryland
20th March 11-12, 1999 Tokyo, Japan

Activities
Area
Seminar & Symposia
Exchange of Scientists
Exchange of Materials
To Japan
To US
To Japan
To US
Etiology
3
0
3
0
0
Biol & Diag.
1
0
2
0
0
Treatment
1
0
4
0
0
Interdisp.
1
0
2
0
0
Total
6
0
11
0
0


I. ETIOLOGY
1. SEMINARS
(1) Preneoplastic Lesions / Precancerous Lesions
Kauai, Hawaii, February 14-16, 1998
Organizers: Dr. David Sidransky
Dr. Setsuo Hirohashi
Participants: US - 8
Japan - 8

(2) Angiogenesis and Cancer
Maui, Hawaii, February 22-24, 1998
Organizers: Dr. Napoleone Ferrara
Dr. Masabumi Shibuya
Participants: US - 8
Japan - 7

(3) Cell Cycle Control and Cancer
Maui, Hawaii, February 20-21, 1998
Organizers: Dr. Snorri Thorgeirsson
Dr. Hiroto Okayama
Participants: US - 7
Japan - 8

2. EXCHANGE OF SCIENTISTS
(1) Dr. Tomoyuki Shirai
Nagoya City University Medical School
Dates: March 1-8, 1998
Host: Dr. Maartin C. Bosland
Nelson Institute of Environmental Medicine
New York University Medical Center

(2) Dr. Motoharu Seiki
Institute of Medical Science, Tokyo University
Dates: July 10-20, 1997
Host: Dr. Henning Birkedal-Hansen
Dental Research Institute, NIH

(3) Dr. Hiroyuki Tsuda Chemotherapy Division
National Cancer Center Research Institute
Dates: Januaru 21 - February 1, 1998
Host Scientist: Dr. Henry Pitot, McArdle Laboratory for Cancer Research
Dr. Jerrold M. Ward, NCI Veterinary Pathology
Dr. Snorri Thorgeirsson, NCI
Dr. Glenn T. Merlino NCI


II. BIOLOGY AND DIAGNOSIS
1. SEMINARS
(1) Genetic Diagnosis of Cancer
Bethesda, Maryland February 13-15, 1998
Organizers: Dr. Lance A. Liotta
Dr. Takashi Takahashi
Participants: US - 12
Japan - 7


2. EXCHANGE OF SCIENTISTS
(1) Dr. Takashi Tokino Sapporo Medical University
Cancer Research Institute
Dates: October 27 - November 3, 1997
Host: Dr. Bert Vogelstein
Howard Hughes Medical Institute, Johns Hopkins Oncology Center

(2) Dr. Tetsu Akiyama Research Institute for Microbial Diseases
Osaka University
Dates: March 2-8, 1998
Host: Dr. Ichiro Maruyama
The Scripps Research Institute of Molecular Genetics



III. TREATMENT
1. SEMINARS
(1) New Anticancer Drugs and Antimetastatic Drugs
Los Angeles May 20-21, 1998
Organizers: Dr. Makoto Ogawa
Dr. Michaele C. Christian
Participants: US - 6
Japan - 7

2. EXCHANGE OF SCIENTISTS
(1) Noriyuki Sato Sapporo Medical University School of Medicine
Dates: February 15-21, 1998
Host: Dr. Franco Marincola, NCI
Dr. Promod Stivastava, Univ. Connecticut School of Medicine

(2) Chihiro Shimazaki Kyoto Prefectural University of Medicine
Dates: September 4-21, 1 997
Host: Dr. Bayard Clarkson, Memorial Sloan-Kettering Cancer Center
Dr. Riehard Champlin, MD Anderson Cancer Center
Dr. Karl Blume, Stanford University Medical Center
Dr. William Bensinger, Fred Hutchinson Cancer Research Center

(3) Toshitada Takahashi Aichi Cancer Center, Research Institute
Dates: October 15-26, 1997
Host: Dr. Lloyd J. Old
Ludwig Institute for Cancer Research, New York Branch

(4) Hirohiko Tsujii Research Center of Heavy Particle Therapy
National Institute of Radiological Sciences
Dates: November 30 - December 13, 1997
Host: Dr. George E. Laramore, University of Washington Medical Center
Dr. Michael J. Zelefsky, Memorial Sloan-Kettering Cancer Center
Dr. Herman D. Suit, Massachusetts General Hospital



IV. INTERDISCIPLINARY
1. SEMINARS
(1) Molecular Carcinogenesis and Molecular Epidemiology of Cancer
Hawaii: Hawaii February 14-15, 1998
Organizers: Dr. Curtis Harris
Dr. Tomoyuki Kitagawa
Participants: US - 9
Japan - 7

2. EXCHANGE OF SCIENTISTS
(1) Gang-Hong Lee Asahikawa Medical College
Dates: January 16 - February 1, 1998
Host: Dr. Allan Balmain, ONYX Pharrnaceuticals
Dr. Norman R. Drinkwater, McArdle Laboratory for Cancer Research
University of Wisconsin
Dr. Takashi Kojima, Albert Einstein College of Medicine

(2) Kei Nakachi Saitama Cancer Center Research Institute
Dates: March 24 - April 13, 1998
Host: Dr. Waun Ki Hong MD Anderson Cancer Center
The University of Texas