ADMINISTRATIVE REPORT

This report summarizes activities of the US-Japan Cooperative Cancer Research Program for the Japanese Fiscal Year 1994, the period between April 1, 1994 and March 31, 1995.
The Program consists of the following program areas:

I. Etiology
II. Biology and Diagnosis
III. Treatment
IV. Interdisciplinary

The US-Japan Bilateral Agreement calls for the organization of seminars and workshops, exchange of scientists for information exchange, and materials. Detailed discussions of these activities will be reported under specific program areas. The tables compiled in this section represent overall summaries for quick review. They should be self-explanatory.
To discuss policy matters and program activities, the Joint Steering Committee of the Program meets once every year. The second meeting of the fifth five-year period (April 1, 1994 to March 31, 1999) was held on June 29-30, 1995, in Osaka, Japan.

Past Meetings
1st 24-25 March 1979 San Francisco, California
2nd 10-11 June 1980 Nara, Japan
3rd 1-2 June 1981 Annapolis, Maryland
4th 31 May-1 June 1982 Tokyo, Japan
5th 9-10 June 1983 Honolulu, Hawaii
6th 13-14 February 1984 Tokyo, Japan
7th 25-26 June 1984 San Francisco
8th 27-28 June 1985 Tokyo, Japan
9th June 26-27, 1986 Anchorage, Alaska
10th June 25-26, 1987 Kyoto, Japan
11th June 23-24, 1988 Anchorage, Alaska
12th June 23-24, 1989 Kashiko-jima, Japan
13th June 28-29, 1990 San Diego, California
14th July 1-2, 1991 Naha, Okinawa, Japan
15th June 22-23,1992 Napa, California
16th June 18-19, 1993 Sapporo, Japan
17th June 23-24, 1994 Seattle, Washington
18th June 30-July 1, 1995 Osaka, Japan

Activities
Area
Seminar & Symposia
Exchange of Scientists
Exchange of Materials
To Japan
To US
To Japan
To US
Etiology
4
0
3
0
1
Biol & Diag.
3
0
3
0
0
Treatment
3
0
3
0
0
Interdisp.
2
0
2
0
0
Total
12
0
11
0
1


I. ETIOLOGY
1. SEMINARS
(1) Heterocyclic Amines: New Insights into Risk for Humans
Hawaii: March 15-16, 1995
Organizers: Dr. Snorri Thorgeirsson
Dr. Keiji Wakabayashi
Participants: US - 7
Japan - 7

(2) Coadministration and Multiple Effects of Carcinogenic and Anticarcinogenic Compounds
Hawaii: March 13-14, 1995
Organizers: Dr. Michael Pariza
Dr. Nobuyuki Ito
Participants: US - 7
Japan - 7

(3) Breast and Prostate Cancers: Molecular Carcinogenesis in Relation to Life Style
Hawaii: March 28-29, 1995
Organizers: Dr. J. Carl Barrett
Dr. Ryuichi Yatani
Participants: US - 7
Japan - 7

(4) Experimental Studies on Genetic Intervention for Cancer Prevention
Hawaii: March 23-25, 1995
Organizers: Dr. Stuart Aaronson
Dr. Masaaki Terada
Participants: US - 7
Japan – 7

2. EXCHANGE OF SCIENTISTS
(1) Dr. Ryohei Hasegawa, Nagoya City University
Dates: November 6-16, 1994
Host: Dr. S M. Cohen, University of Nebraska

(2) Dr. Narito Morii, Kyoto University
Dates: November 6-16, 1994
Host: Dr. R B Birge, The Rockefeller Universi

(3) Dr. Jun Yokota, National Cancer Center Research Institute
Dates: November 24 - December 14, 1994
Host: Dr. R A Weinberg, Massachusetts Institute of Technology

3. EXCHANGE OF MATERIALS
From
To
(1) 2-Amino-1-methyl-6-Phenyl-imidazo[4,5-b] pyridine (PhJP) 20g Dr. K Wakabayashi Dr.R Adamson



II. BIOLOGY AND DIAGNOSIS
1. SEMINARS
(1) Transcription Factors in the Regulation of Oncogenesis
Maui, Hawaii: February 9-11, 1995
Organizers: Dr. Tom Curran
Dr. Tadatsugu Taniguchi
Participants: US - 8
Japan - 7

(2) Receptor-ligand Interactions and Signal Transduction in Antigen - specific Immune Responses
Maui, Hawaii: January 9-11, 1995
Organizers: Dr. Richard Hodes
Dr. Hiromi Fujiwara
Participants: US - 5
Japan - 7

(3) Differentiation, Growth, and Death of the Cells
California: February 20-21, 1995
Organizers: Dr. Dinah Singer
Dr. Takehiko Sasazuki
Participants: US - 8
Japan - 7


2. EXCHANGE OF SCIENTISTS
(1) Dr. Yoshihiro Asano, University of Tokyo
Dates: March 16-29, 1995
Host: Dr. Alfred Singer, National Cancer Institute
Dr. Richard Hodes, National Institute of Aging

(2) Dr. Hiromi Fujiwara, Osaka University
Dates: September 25-Ocotober 9, 1994
Host: Dr. Alfred Singer, National Cancer Institute
Dr. Steve Burakoff, Dana-Farber Cancer Institute
Dr. Michael Lotze, Pittsburgh University
Dr. Stanley Korsmeyer, Washington University



III. TREATMENT
1. SEMINARS
(1) Progress in Radiotherapy
San Francisco: February 13-15, 1995
Organizers: Dr. Theodore L Phillips
Dr. Mitsuyuki Abe
Participants: US - 7
Japan - 7

(2) Progress in Treatment of Lung Cancer
Nagoya, Japan, January 17-18, 1995
Organizers: Dr. Michael A. Friedman
Dr. Yutaka Ariyoshi
Participants: US - 6
Japan - 10

(3) New Anticancer Drugs and MDR Modulators
Hawaii: February 10-11, 1995
Organizers: Dr. Michael A Friedman
Dr. Makoto Ogawa, Dr. Takashi Tsuruo
Participants: US - 6
Japan - 7

2. EXCHANGE OF SCIENTISTS
(1) Tatsuro Irimura, University of Tokyo
Dates: November 7-19, 1994
Host: Dr. B.R. Ze-Her, Harvard University
Dr. O. J. Finn, Pittsburgh University
Dr. I.J. Fidler, M.D. Anderson Hospital

(2) Kozo Morita, National Institute of Radiological Science
Dates: December 2-21, 1994
Host: Dr. H. Suit, Harvard University
Dr. L. Peters, M.D. Anderson Hospital
Dr. J Castro, University of California, Davis

(3) Takashi Takahashi, Aichi Cancer Center
Dates: February 6-7, 1995
Host: Dr. A. Feinberg, Johns Hopkins University
Dr. J. Mulshine, National Cancer Institute
Dr. J Minna, Simons Cancer Center



IV. INTERDISCIPLINARY
1. SEMINARS
(1) Genetic Disorders with High Risk of Cancer
Hawaii: February 6-7, 1995
Organizers: Dr. Robert W, Miller
Dr. Haruo Sugano
Participants: US - 6
Japan - 7

(2) Lymphoproliferative and Autoimmunal Diseases Their Reciprocal Relationship
Hawaii, February 9-10, 1995
Organizers: Dr. Robert W Miller
Dr. Haruo Sugano
Participants: US - 6
Japan - 7


2. EXCHANGE OF SCIENTISTS
(1) Shunro Sonoda, Kagoshima University
Dates: September 24 - October 18, 1994
Host: Dr. William A Blattner, National Cancer Institute
Dr. Robert Gallo, National Cancer Institute

(2) Mitsuhiro Osame, Kagoshima University
Dates: September 10 - October 1, 1994
Host: Dr. Haase, Minnesota University
Dr. Robert Gallo, National Cancer Institute