PREFACE

This report summarizes the activities of the US-Japan Cooperative Cancer Research Program from April 1992 through March 1993. This is the last year of the fourth five-year period of the Program's operation. In this volume are detailed scientific progress reports from each of the four program areas including an administrative summary outlining overall activities for each area.

Since its inception in May 1974, the US-Japan Cooperative Cancer Research Program has been instrumental in establishing a close working relationship between researchers in Japan and the United States. The Program provides an important means of exchanging scientific information, modern technology, and materials - significantly contributing to the marked progress which has been made in recent years in cancer research and treatment.

This year the Program was renewed by the National Cancer Institute and the Japan Society for the Promotion of Science for another five-year period extending from April 1, 1994 to March 31, 1999. We are confident that the Program will continue to grow and bear fruit, in the form of bringing valuable contributions to scientific communities of both countries.

The dedicated contributions to the Ms. Beverly J. Schaff, Ms. Jean L. Cross and Ms. Peggy E. Yasem of the National Cancer Institute are greatly appreciated.