ADMINISTRATIVE REPORT

This report summarizes activities of the US-Japan Cooperative Cancer Research Program for the Japanese Fiscal Year 1992, the period between April 1, 1992, and March 31, 1993.
The Program consists of the following program areas:

I. Etiology
II. Biology and Diagnosis
III. Treatment
IV. Interdisciplinary

The US-Japan Bilateral Agreement calls for the organization of seminars and workshops, exchange of scientists for information exchange and materials. Detailed discussions of these activities will be reported under specific program areas. The tables compiled in this section represent overall summaries for quick review. They should be self-explanatory.
To discuss policy matters and program activities, the Joint Steering Committee of the Program meets once every year. The fifth meeting of the fourth five-year period (April 1, 1989 to March 31, 1994) was held on June 18, 1993, in Sapporo, Japan.

Past Meetings
1st 24-25 March 1979 San Francisco, California
2nd 10-11 June 1980 Nara, Japan
3rd 1-2 June 1981 Annapolis, Maryland
4th 31 May-1 June 1982 Tokyo, Japan
5th 9-10 June 1983 Honolulu, Hawaii
6th 13-14 February 1984 Tokyo, Japan
7th 25-26 June 1984 San Francisco
8th 27-28 June 1985 Tokyo, Japan
9th June 26-27, 1986 Anchorage, Alaska
10th June 25-26, 1987 Kyoto, Japan
11th June 23-24, 1988 Anchorage, Alaska
12th June 23-24, 1989 Kashiko-jima, Japan
13th June 28-29, 1990 San Diego, California
14th July 1-2, 1991 Naha, Okinawa, Japan
15th June 22-23,1992 Napa, California
16th June 18-19, 1993 Sapporo, Japan

Activities
Area
Seminar & Symposia
Exchange of Scientists
Exchange of Materials
from US to Japan
from Japan to US
from US to Japan
from Japan to US
Etiology
3
0
3
0
1
Biol & Diag.
3
0
3
0
0
Treatment
3
0
3
0
0
Interdisp.
2
0
1
0
0
Total
11
0
10
0
0


I. ETIOLOGY
1. SEMINARS
(1) Nitric Oxide and Cancer
Williamsburg, Virginia, January 19-20, 1993
Organizers: Dr. Steven R. Tannenbaum
Dr. Hiroyasu Esumi
Participants: US - 8
Japan - 9

(2) Viral Regulatory Proteins and Host Factors Regulating the Gene Expression
Maui, Hawaii, January 26-27, 1993
Organizers: Dr. Peter Howley
Dr. Mitsuaki Yoshida
Participants: US - 6
Japan - 7

(3) Topics in Carcinogenesis: Malignant Neoplasms Occurring Under Particular Circumstances
Maui, Hawaii, March 3-5, 1993
Organizers: Dr. Richard H. Adamson
Dr. Yoichi Konishi
Participants: US - 7
Japan - 7

2. EXCHANGE OF SCIENTISTS
(1) Dr. Michinari Hamaguchi, Nagoya University School of Medicine
Dates: August 10 - September 3, 1992
Host Scientist: Dr. Hidesaburo Hanafusa, The Rockefeller University

(2) Dr. Hiroyasu Esumi, National Cancer Center Research Institute
Dates: January 16 - January 24, 1993
Host Scientist: Dr. Richard A. Adamson, National Cancer Institute
Dr. Kenneth Olden, National Institute of Environmental Health Science
Dr. Zeev A. Ronai, American Health Foundation

(3) Dr. Kazuo Tajima, Aichi Cancer Center Research Institute
Dates: January 5 - January 17, 1993
Host Scientist: Dr. Robert W. Miller, National Cancer Institute
Dr. Dimitrios Trichopoulos, Harvard School of Public Health
Dr. Ronald K. Ross, University of Southern California

3. EXCHANGE OF MATERIALS
From
To
(1) 2-amino-1-methyl-6-phenylimidazo [4,5-b] pyridine (PhIP) 18g Dr. K. Wakabayashi Dr. R. Adamson



II. BIOLOGY AND DIAGNOSIS
1. SEMINARS
(1) Self-non-self Discrimination in the Immune System
Kona, Hawaii, January 11-13, 1993
Organizers: Dr. Richard Hodes
Dr. Hiromi Fujiwara
Participants: US - 10
Japan - 7

(2) Signal Transduction from Plasma Membrane to Nucleus
Maui, Hawaii, January 25-27, 1993
Organizers: Dr. Benoit de Crombrugghe
Dr. Tadatsugu Taniguchi
Participants: US - 7
Japan – 9

(3) Transcription Factors in Lymphocyte Differentiation and Transformation
Napa Valley, California, February 15-16, 1993
Organizers: Dr. Stanley J. Korsmeyer
Dr. Takehiko Sasazuki
Participants: US - 6
Japan - 6


2. EXCHANGE OF SCIENTISTS
(1) Dr. Shigeo Ohno, Yokohama City University School of Medicine
Dates: January 16 - February 1, 1993
Host Scientist: Dr. Richard M. Niles, Marshall University

(2) Dr. Masaynki Miyasaka, Tokyo Metropolitan Institute of Medical Research
Dates: February 28 - March 14, 1993
Host Scientist: Dr. Steven D. Rosen, University of California San Francisco
Dr. Nicholas L. Tilney, Brigham & Women's Hospital

(3) Nobuo Sakaguchi, Faculty of Medicine, Tottori University
Dates: October 19 - October 26, 1992
Host Scientist: Dr, Paul W. Kincade, Oklahoma Medical Research Foundation



III. TREATMENT
1. SEMINARS
(1) Gastrointestinal Cancer - Biochemical Modulation and Monoclonal Antibody
Tokyo, November 7-8, 1992
Organizers: Dr. Michael A. Friedman
Dr. Makoto Ogawa
Participants: US - 6
Japan - 22

(2) New Drugs - Novel Structure and Tubulin Binder
Maui, Hawaii, February 15-16, 1993
Organizers: Dr. Michael A. Friedman
Dr. Makoto Ogawa
Participants: US - 6
Japan - 9

(3) Breast Cancer - New Therapies
Oakland, California, March 8-9, 1993
Organizers: Dr. Michael A. Friedman
Dr. Makoto Ogawa
Participants: US - 7
Japan - 7

2. EXCHANGE OF SCIENTISTS
(1) Toshiwo Andoh, Aichi Cancer Center Research Institute
Dates: October 18 - November 3, 1992
Host Scientist: Dr. J.L. Nitiss, University of Southern California
Dr. J.C. Wang, Harvard University
Dr. M. Potmesil, New York University School of Medicine

(2) Shosuke Kawanishi, Faculty of Medicine, Kyoto University
Dates: November 16 - December 6, 1992
Host Scientist: Dr. Lawrence A. Loeb, University of Washington
Dr. W. David Wilson, Georgia State University
Dr. Arthur P. Grollman, State University of New York

(3) Yoshiro Niitsu, Sapporo Medical College
Dates: October 23 - November 12, 1992
Host Scientist: Dr. Jayanta Roy Chowhnury, Albert Einstein College of Medicine



IV. INTERDISCIPLINARY
1. SEMINARS
(1) Retroviruses and Cancer: US-Japan Clinical Epidemiological Experiences
Bethesda, Maryland, January 6-8, 1993
Organizers: Dr. William A. Blattner
Dr. Shigeo Hino
Participants: US - 8
Japan - 13

(2) The Fourth Japan-US Biostatistics Conference in the Study of Human Cancer
Tokyo, November 9-11, 1992
Organizers: Dr. David G. Hoel
Dr. Takashi Yanagawa
Participants: US - 8
Japan - 10


2. EXCHANGE OF SCIENTISTS
(1) Hiroyuki Shimizu, Gifu University, School of Medicine
Dates: November 1 - November 30, 1992
Host Scientist: Dr. Ross Prentice, Fred Hutchinson Cancer Research Center
Dr. Walter C. Willet, Harvard School of Public Health
Dr. William J. Blot, National Cancer Institute
Dr. Pelayo Correa, Louisiana State University Medical Center
Dr. Brian E. Henderson, University of Southern California School of Medicine
Dr. Laurence N. Kolonel, University of Hawaii at Manoa