ADMINISTRATIVE REPORT

This report summarizes activities of the US-Japan Cooperative Cancer Research Program for the Japanese Fiscal Year 1991, the period between April 1, 1991, and March 31, 1992.
The Program consists of the following program areas:

I. Etiology
II. Biology and Diagnosis
III. Treatment
IV. Interdisciplinary

The US-Japan Bilateral Agreement calls for the exchange of scientists, the exchange of materials, and the organization of seminars and workshops. Detailed discussions of these activities will be reported under specific program areas. The tables compiled in this section represent overall summaries for quick review. They should be self-explanatory.
To discuss policy matters and program activities, the Joint Steering Committee of the Program meets once every year. The third meeting of the fourth five-year period of its operation (April 1990 to March 1995) was held on June 22-23, 1992, in the Silverado, Napa Valley, California.

Past Meetings
1st 24-25 March 1979 San Francisco, California
2nd 10-11 June 1980 Nara, Japan
3rd 1-2 June 1981 Annapolis, Maryland
4th 31 May-1 June 1982 Tokyo, Japan
5th 9-10 June 1983 Honolulu, Hawaii
6th 13-14 February 1984 Tokyo, Japan
7th 25-26 June 1984 San Francisco
8th 27-28 June 1985 Tokyo, Japan
9th June 26-27, 1986 Anchorage, Alaska
10th June 25-26, 1987 Kyoto, Japan
11th June 23-24, 1988 Anchorage, Alaska
12th June 23-24, 1989 Kashiko-jima, Japan
13th June 28-29, 1990 San Diego, California
14th July 1-2, 1991 Naha, Okinawa, Japan
15th June 22-23, 1 992 Napa, California

Activities
Area
Seminar & Symposia
Exchange of Scientists
Exchange of Materials
from US to Japan
from Japan to US
from US to Japan
from Japan to US
Etiology
4
0
3
1
2
Biol & Diag.
3
0
3
0
0
Treatment
3
0
3
0
0
Interdisp.
2
1
3
0
0
Total
12
1
12
1
2


I. ETIOLOGY
1. SEMINARS
(1) Involvement of Growth Regulatory Genes in Cancer
Maui, Hawaii, February 15-17, 1992
Organizers: Dr. Stuart Aaronson
Dr. Masaaki Terada
Participants: US - 7
Japan – 8

(2) Genomic Instability in Carcinogenesis and Tumor Progression
Kauai, Hawaii, February 15-17, 1992
Organizers: Dr. Curtis Harris
Dr. Setsuo Hirohashi
Participants: US - 7
Japan - 7

(3) Transgenic Animals for Cancer Research
Oiso, February 23-26, 1992
Organizers: Dr. George Vande Woude
Dr. Motoya Katsuki
Participants: US - 5
Japan - 11

(4) Seminar on Cancer Prevention
Maui, Hawaii, March 9-10, 1992
Organizers: Dr. Richard Adamson
Dr. Suketami Tominega
Participants: US-7
Japan- 7

2. EXCHANGE OF SCIENTISTS
(1) Dr. Masae Tatematsu
Aichi Cancer Center Research Institute
Dates: October 24 - November 6, 1991
Host Scientist: Dr. Lawrence Werther, Mt. Sinai Medical Center
Dr. Michael Samloff, Veterans Administration Medical Center
Dr. Teresa Pretlow, Case Western Reserve University

(2) Dr. Hiroyasu Esumi
National Cancer Center Research Institute
Dates: March 12-22, 1992
Host Scientist: Dr. Richard Adamson, National Cancer Institute
Dr. Ken Olden, National Institute of Environmental Health
Dr. Tim Bowden, University of Arizona
Dr. Sarawachi Sukumar, Salk Institute
Dr. Lawrence Loeb, University of Washington

(3) Dr. Tadatsugu Taniguchi
Osaka University
Dates: January 16-30, 1992
Host Scientist: Dr. Roger M. Perlmutter, University of Washington

3. EXCHANGE OF MATERIALS
From
To
1. MeIQx 3g Dr. R. Adamson Dr. S. Takayama
2. 4,8-DiMeIQx 2g Dr. S. Takayama Dr. R. Adamson
3. Benzo(a)pyrene derivative Dr. R. Adamson Dr. S. Takayama



II. BIOLOGY AND DIAGNOSIS
1. SEMINARS
(1) Receptor-mediated Modulation of Lymphocyte Growth and Activation
San Diego, January 13-15, 1992
Organizers: Dr. Richard Hodes
Dr. Hiromi Fujiwara
Participants: US - 12
Japan - 8

(2) Programmed Cell Death in Cancer & T Cell Repertoire Selection
Fukuoka, Japan, February 18-19, 1992
Organizers: Dr. Stanley Korsmeyer
Dr. Takehiko Sasazuki
Participants: US - 5
Japan - 10

(3) Mucin Structure and Other Cancer Associated Carbohydrate Antigens
Hawaii, February 2l-26, 1992
Organizers: Dr. Young S. Kim
Dr. Ikuo Yamahsina
Participants: US - 10
Japan - 14
Canada - 1


2. EXCHANGE OF SCIENTISTS
(1) Dr. Nobumoto Watanabe
Tsukuba Life Science Center
Dates: June 22 - July 23, 1991
Host Scientist: r. George Vande Woude, NCI-FrederickCancer Research and Development Center

(2) Dr. Takashi Saito
Chiba University Medical School
Dates: September 25 - October 12, 1991
Host Scientist: Dr. Ronald Germain, National Institute of Allergy and Infectious Diseases

(3) Dr. Jun-ichi Miyazaki
Kumamoto University Medical School
Dates: December 2 -15, 1991
Host Scientist: Dr. Keiko Ozato, National Institute of Child Health and Human Development



III. TREATMENT
1. SEMINARS
(1) Current Progress in Radiation Oncology
Ann Arbor, November 21-23, 1991
Organizers: Dr. Theodore Phillips
Dr. Mitsuyuki Abe
Participants: US - 20
Japan - 12

(2) New Agents and Differentiating Agents
Hawaii, February 1992
Organizers: Dr. Michael Friedman
Dr. Funimaro Takaku and Dr. Makoto Ogawa
Participants: US - 6
Japan - 7

(3) High Dose Chemotherapy and Hematopoietic Growth Factors
Tokyo, March 13 - 14, 1992
Organizers: Dr. Michael Friedman
Dr. Makoto Ogawa
Participants: US - 4
Japan - 17


2. EXCHANGE OF SCIENTISTS
(1) Dr. Hamo Seto
Institute of Applied Microbiology, University of Tokyo
Dates: November 11 - 28, 1991
Host Scientist: Dr. B.I. Sikic, Stanford University
Dr. M. Raber, M.D. Anderson Cancer Center
Dr. L. Chen, Dana-Farber Cancer Institute
Dr. M. Tanabe, SRI International
Dr. V. Narayanan, National Cancer Institute

(2) Dr. Yasuo Morishima
Nagoya University
Dates: October 4 - 23, 1991
Host Scientist: Dr. B. Dupont Memorial Sloan-Kettering Cancer Center
Dr. John A. Hansen, University of Washington
Dr. P. McGlave, Minnesota University

(3) Dr. Takao Yamori
Cancer Chemotherapy Center
Dates: October 5 - 25, 1991
Host Scientist: Dr. Robert Shoemaker, National Cancer Institute



IV. INTERDISCIPLlNARY
1. SEMINARS
(1) The US-Japan Difference in Cancer Experience
Hawaii, March 12 - 13, 1992
Organizers: Dr. Robert Miller
Dr. Hamo Sugano
Participants: US - 9
Japan - 9

(2) Genetic Analysis of Hepatocarcinogenesis
Hawaii, February 8 - 9, 1992
Organizers: Dr. Henry Pitot
Dr. Tomoyuki Kitagawa
Participants: US - 6
Japan - 7


2. EXCHANGE OF SCIENTISTS
(1) Dr. Takuro Nakamura
Department of Pathology, University of Tokyo Medical School
Dates: November 11 - December 11, 1991
Hosts: Dr. Francis Collins, Howard Hughes Medical Institute
Dr. Neal Copeland, Basic Research Program, FCRDC

(2) Dr. Hideaki Toyoshima
Niigata University School of Medicine
Dates: September 8 - October 8, 1991
Hosts: Dr. Mark Skolnick, University of Utah
Dr. Robert Haile, University of California, Los Angeles
Dr. Joseph Fraumeni, National Cancer Institute
Dr. David Thomas, Fred Hutchinson Cancer Research Center

(3) Dr. Katsuro Koike
Cancer Institute
Dates: June 15-22, 1991
Hosts: Dr. Stuart Aaronson, National Cancer Institute
Dr. George Vande Woude, Frederick Cancer Research and Development Center