14th NCI-JSPS JOINT STEERING COMMITTEE MEETING
Okinawa Miyako Hotel, Naha, Okinawa, Japan, July 1-2, 1991
The 14th meeting of the Steering Committee of the US-Japan Cooperative Cancer Research Program was held at the Miyako Hotel in Okinawa on July 1 and 2, 1991. Those attending for Japan were: Drs. Shiro Miwa, Takashi Sugimura, Haruo Sugano, Toshiyuki Hamaoka, and Makoto Ogawa, and Messrs. Nagahide Onozawa and Sho Hagio. Those attending for the U.S. were Drs. Richard Adamson, Richard Hodes, Michael Friedman, Robert Miller, Tsuyoshi Kakefuda, and Federico Welsch.
Dr. Miwa, a Director of JSPS and Director of the Okinaka Memorial Institute for Medical Research in Tokyo, opened the meeting at 9:00 a.m., welcoming all participants. Dr. Adamson responded calling the US-Japan Cooperative Cancer Research Program the foremost bilateral program of the NCI. Dr. Adamson noted that the cancer incidence in Okinawa was different from mainland Japan and more like that in Alaska and the Aleutian Islands. Dr. Ogawa expressed his satisfaction with the advances in chemotherapy which have resulted from the US-Japan collaboration. The group reviewed, in detail, the scientific activities of the 1990-1991 areas: Cancer Etiology, Cancer Biology and Diagnosis, Cancer Treatment, and Interdisciplinary.
There were three US-Japan workshops in the Etiology area: Prostate cancer, Cancer risk assessment of environmental chemicals, and Prevalence and structure of the hepatitis C virus. The three workshops in the Biology and Diagnosis area were: Signal transduction and gene regulation in cancer, Lymphocyte adhesion and its related signal transduction, and Molecular mechanisms in oncogenesis and tumor progression. In the Treatment area the joint workshops were: Current treatment strategy of lung cancer, New drugs and antimetastatic drugs, and The role of growth factors in cancer treatment. The workshops in the Interdisciplinary area were entitled: Transplacental and transgeneration carcinogenesis and pathophysiology of renal cancer. A summary of each workshop, including a listing of the participants, has been included in this Progress Report.
Eleven Japanese scientists visited U.S. laboratories under the NCI-JSPS Scientist Exchange Program (see each Program Area report).
Three grams of 2-Amino-3,4-dimethylimidazo [4,5-f]quinoline(MeIQ) and 2 grams of 2-Amino-3,4,8-trimethylimidazo [4,5-f]quinoxaline were exchanged between the NCI and National Cancer Center (NCC), Japan.
The group then discussed the workshops proposed and scientist exchanges for 1991-1992 (Appendix: Future Plans). It is expected that NCC will send NCI 18 grams of 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP).
Dr. Welsch then presented a request by the Korean Academy of Medical Sciences asking that they be allowed to send an observer to the next US-Japan Steering Committee Meeting. The committee will deliberate on this issue anew before the next committee meeting.
Dr. Welsch then offered to have his office pay for three intramural and three extramural scientists' airfare and per diem costs in Japan if such scientists would like to spend 10 to 15 days in the laboratory of a Japanese scientist to either learn a technique or work out a collaborative project.
The participants agreed that the next meeting will be held in Silverado, Napa Valley on June 22-23, 1992
The meeting adjourned at 5:30 p.m.
On July 2 at 6:00 p.m. the group met with Drs. Akira Osawa (Dean and Professor of Urology), Kunio Ibaraki (Professor of Orthopaedic Surgery and Director of the University Hospital), Masao Nakano (Professor of Radiology), Yoshihiro Muto (Professor of Surgery), and Teruo Iwamasa (Professor of Pathology) of the Ryukyo University Medical School. They expressed interest in participating in the US-Japan bilateral agreements in cancer research. Dean Osawa received a description of OIA programs and the guidelines for short-term scientist exchanges.
After lectures by Drs. Adamson and Ogawa, the group participated in a reception jointly organized by the JSPS and the University of Ryukyus.
| Respectfully submitted, Federico Welsch, M.D., Ph.D. |
FUTURE PLANS
Twelve future seminars or symposia are envisioned, nine in the U.S. and three in Japan. Twelve Japanese scientists will be visiting U.S. laboratories in the Exchange Scientists Program financially supported by the JSPS. Research materials will continued to be exchanged reciprocally as did during past years for collaborative research between the U.S. and Japan.
Planned Seminars and Exchange Scientists in the Etiology Program Area for FY92:
1. PLANNED SEMINARS
| (1) Growth Factors and Their Receptors Hawaii, February 15-17, 1992 |
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| Organizers: | Dr. Stuart Aaronson Dr. Masaaki Terada |
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| Participants: | US-7 Japan-7 |
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(2) Genomic Instability Hawaii, February 16-17, 1992 |
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| Organizers: | Dr. Curtis Harris Dr. Setsuo Hirohashi |
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| Participants: | US-7 Japan-7 |
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(3) Transgenic Animals in Cancer Research Tokyo, February 23-26, 1992 |
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| Organizers: | Dr. George Vande Woude Dr. Motoya Katsuki |
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| Participants: | US - 6 Japan - 7 |
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(4) Fundamentals in Cancer Prevention Hawaii, March 9-10, 1992 |
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| Organizers: | Dr. Richard Adamson Dr. Suketami Tominaga |
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| Participants: | US-7 Japan-7 |
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2. EXCHANGE OF SCIENTISTS
| (1) Dr. Masuo Tatematsu, Aichi Cancer Center Research Institute | ||
| Dates: | October 1-14, 1991 | |
| Host: | Dr. Lawrence Werther, Mt. Sinai Medical Center Dr. Michael Sanloff, Veterans Administration Medical Center Dr. Teresa Pretlow, Case Western Reserve University |
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(2) Dr. Hiroyasu Esumi, National Cancer Center Research Institute |
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| Dates: | November 30 - December 11, 1991 | |
| Host: | Dr. Frank Gonzalez, National Cancer Institute | |
(3) Dr. Tadatsugu Taniguchi, Osaka University |
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| Dates: | January 1992 | |
| Hosts: | Dr. Jan Vilcek, New York University Medical Center | |
Planned Seminars and Exchange Scientists in the Biology and Diagnosis Program Area for FY92:
1. PLANNED SEMINARS
| (1) Significance of Mucin and Other Cancer-associated Carbohydrate Antigens in Cell Biology Hawaii, February 24-26, 1992 |
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| Organizers: | Dr. Young S. Kim Dr. Ikuo Yamahsina |
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| Participants: | US - 7 Japan - 8 |
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(2) Lymphocyte Growth and Activation and Its Receptor-mediated Modulation San Diego, January 13-15, 1992 |
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| Organizers: | Dr. Richard Hodes Dr. Hiromi Fujiwara |
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| Participants: | US - 10 Japan – 7 |
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(3) Molecular Mechanism of Progammed Cell Death Kyushu, February 18-19, 1992 |
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| Organizers: | Dr. Stanley Korsmeyer Dr. Takehiko Sasazuki |
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| Participants: | US - 6 Japan - 7 |
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2. EXCHANGE OF SCIENTISTS
| (1) Dr. Nobumoto Watanabe, Tsukuba Life Science Center | ||
| Dates: | June 22 - 23, 1991 | |
| Host: | Dr. George Vande Woude | |
(2) Dr. Takashi Saito, Chiba University Medical School |
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| Dates: | September - October 1991 | |
| Host: | Dr. Ronald Germain, National Institute of Allergy and Infectious Diseases | |
(3) Dr. Jun-ichi Miyazaki, Kumenoto University Medical School |
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| Dates: | October 1991 | |
| Hosts: | Dr. Keizo Ozato, National Institute of Child Health and Human Development | |
Planned Seminars and Exchange Scientists in the Treatment Program Area for FY92:
1. PLANNED SEMINARS
| (1) Current Progress in Radiation Oncology Ann Arbor, November 21-25, 1991 |
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| Organizers: | Dr. Theodore Philips Dr. Mitsuyuki Abe |
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| Participants: | US - 7 Japan - 7 |
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(2) New Anticancer Drugs and Differentiation Hawaii, February 15-16, 1992 |
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| Organizers: | Dr. Michael Friedman Dr. Funimaro Takaku and Dr. Makoto Ogawa |
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| Participants: | US - 7 Japan – 7 |
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(3) High Dose Chemotherapy with Autologous Stem Cell Transplantation Tokyo, March 13-14, 1992 |
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| Organizers: | Dr. Michael Friedman Dr. Makoto Ogawa |
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| Participants: | US - 6 Japan 10 |
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2. EXCHANGE Of SCIENTISTS
| (1) Dr. Haruo Seto, Institute of Applied Microbiology | ||
| Dates: | September 19 - October 6, 1991 | |
| Host: | Dr. B.I. Sikic, Stanford University Dr. M. Raber, M.D. Anderson Cancer Center Dr. L. Chen, Dana-Farber Cancer Institute |
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(2) Dr. Yasuo Morishima, Nagoya University |
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| Dates: | September 16 - October 6 | |
| Host: | Dr. B. Dupont, Memorial Sloan-Kettering Cancer Center Dr. G. Rivera, Wister Institute Dr. P. McGlave, Minnesota University |
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(3) Dr. Takao Yamori, Cancer Chemotherapy Center |
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| Dates: | September 1991 | |
| Hosts: | Dr. Robert Shoemaker, National Cancer Institute | |
Planned Seminars and Exchange Scientists in the Interdisciplinary Program Area for FY92:
1. PLANNED SEMINARS
| (1) The US-Japan Difference in Cancer Epidemiology and Etiology Hawaii, March 12-13, 1992 |
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| Organizers: | Dr. Robert Miller Dr. Haruo Sugano |
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| Participants: | US - 6 Japan – 7 |
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(2) Genetic Analysis of Hepatocarcinogenesis Hawaii, February 8-9, 1992 |
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| Organizers: | Dr. Henry Pitot Dr. Tomoyuki Kitagawa |
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| Participants: | US - 6 Japan - 7 |
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2. EXCHANGE OF SCIENTISTS
| (1) Dr. Takuro Nakamura, University of Tokyo | ||
| Dates: | November 11 - December 10, 1991 | |
| Host: | Dr. Francis Collins, Howard Hughes Medical Institute Dr. Neal Copeland, Basic Research Program FCRDC |
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(2) Dr. Hideaki Toyoshima, Niigata University School of Medicine |
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| Dates: | September 9 - October 9, 1991 | |
| Hosts: | Dr. Mark Skolnick, University of Utah Dr. Robert Haile, University of California, Los Angeles Dr. Joseph Fraumeni, National Cancer Institute Dr. David Thomas, Fred Hutchinson Cancer Research Center |
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(3) Dr. Katsuro Koike, Cancer Institute |
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| Dates: | June 15-26, 1991 | |
| Host: | Dr. Stuart Aaronson, National Cancer Institute | |
14TH JOINT US-JAPAN STEERING COMMITTEE MEETING
Okinawa Miyako Hotel, Okinawa, Japan, July 1-2, 1991
AGENDA
| July 1, Monday | ||
| 9:00a.m. | Welcoming Remarks | Dr. Miwa Dr. Adamson |
| Annual Report for the Etiology Program Area | Dr. Adamson Dr. Sugimura |
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| Annual Report for the Biology and Diagnosis Program Area | Dr. Hodes Dr. Hamaoka |
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| 10:15-10:30 | Coffee Break | |
| 11:00 a.m. | Annual Report for the Treatment Program Area | Dr. Friedman Dr. Ogawa |
| Annual Report for the Interdisciplinary Area | Dr. Miller Dr. Sugano |
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| 12:00 noon | Lunch hosted by NCI | |
| 1:30p.m. | Program Plans for 1991-92 | |
| Etiology Program Area | Dr. Sugimura Dr. Adamson |
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| 3:30-3:45 p.m. | Coffee Break | |
| Biology and Diagnosis Program Area | Dr. Hamaoka Dr. Hodes |
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| Treatment Program Area | Dr. Ogawa Dr. Friedman |
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| Interdisciplinary Program Area | Dr. Sugano Dr. Miller |
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| General Discussion | ||
| Closing Remarks | Dr. Miwa Dr. Adamson |
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| 6:30 p.m. | Dinner hosted by JSPS | |
| July 2, Tuesday | ||
| 9:00 a.m. | Local Tour (Southern Area of Okinawa Island) | |
| 12:00-1:30 p.m. | Lunch | |
| 1:30 p.m.-4:00 p.m. | Local Tour (Central Area of the Island) | |
| 6:00 p.m. | Lecture by Dr. Adamson, Discussion and Reception, jointly organized by JSPS and University of the Ryukyus | |
| 6:00 p.m.-7:00 p.m. | Lecture and Discussion with Faculty members of the University of the Ryukyu Medical School | |
| 7:00-8:00 p.m. | Reception | |
PARTICIPANTS
NSI Program Coordinators
Dr. Richard Adamson
Director
Division of Cancer Etiology
Dr. Richard Hodes
Experimental Immunology Branch
Division of Cancer Biology and Diagnosis
Dr. Michael Friedman
Associate Director for Cancer Therapy Evaluation Program
Division of Cancer Treatment
Dr. Robert Miller
Chief, Clinical Epidemiology
Branch Division of Cancer Etiology
NCI Representatives
Dr. Federico Welsch
Associate Director for International Affairs
Dr. Tsuyoshi Kakefuda
Executive Secretary
US-Japan Cooperative Cancer Research Program
JSPS Program Coordinators
Dr. Takashi Sugimura
President
National Cancer Center
Dr. Toshiyuki Hamaoka
Professor
Osaka University Medical School
Makoto Ogawa
Chief
Division of Clinical Chemotherapy
Japanese Foundation for Cancer Research
Dr. Haruo Sugano
Director
Cancer Institute
Japanese Foundation for Cancer Research
JSPS Representative
Dr. Shiro Miwa
Director
Mr. Nagahide Onozawa
Head
Research Cooperation Division
Mr. Sho Hagio
Research Cooperation Division
Lecture by Dr. Richard Adamson
Discussion and Reception jointly organized by JSPS and University of the Ryukyus
Okinawa Miyako Hotel, Okinawa, July 2, 1991
List of Participants
NCI Program Coordinators
Dr. Richard Adamson
Director, Division of Cancer Etiology
Dr. Michael Friedman
Associate Director, Cancer Therapy Evaluation Program
Division of Cancer Treatment
Dr. Robert Miller
Chief, Clinical Epidemiology Branch, Division of Cancer Etiology
NCI Representatives
Dr. Federico Welsch
Associate Director for International Affairs
Dr. Tsuyoshi Kakefuda
Executive Secretary
US-Japan Cooperative Cancer Research Program
JSPS Program Coordinators
Dr. Takashi Sugimura
President, National Cancer Center
Dr. Toshiyuki Hamaoka
Professor, Osaka University Medical School
Dr. Makoto Ogawa
Chief, Division of Clinical Chemotherapy
Cancer Chemotherapy Center
Japan Foundation for Cancer Research
University of the Ryukyus
Dr. Akira Ohsawa
Dean of the Faculty of Medicine
Dr. Kunio Ibaraki
Director of University Hospital
Dr. Hajime Naganori
Professor of Legal Medicine
Dr. Teruo Iwamasa
Professor of Pathology II
Dr. Masao Nakano
Professor of Radiology
Dr. Yoshihiro Muto
Professor of Surgery I
Mr. Yasuhiro Mori
Chief of General Affairs Division
Mr. Tadayoshi Numata
Chief of Administration
JSPS Representatives
Mr. Nagahide Onozawa
Head Research Cooperation Division
Mr. Sho Hagio
Staff Research Cooperation Division