ADMINISTRATIVE REPORT

This report summarizes activities of the US-Japan Cooperative Cancer Research Program for the Japanese Fiscal Year 1990, the period between April 1, 1990, and March 31, 1991.
The Program consists of the following program areas:

I. Etiology
II. Biology and Diagnosis
III. Treatment
IV. Interdisciplinary

The US-Japan Bilateral Agreement calls for the exchange of scientists, the exchange of materials, and the organization of seminars and workshops. Detailed discussions of these activities will be reported under specific program areas. The tables compiled in this section represent overall summaries for quick review. They should be self-explanatory.
To discuss policy matters and program activities, the Joint Steering Committee of the Program meets once every year. The second meeting of the fourth five-year period of its operation (April 1990 to March 1995) was held on July 1-2, 1991, in the Miyako Hotel, Okinawa, Japan.

Past Meetings
1st 24-25 March 1979 San Francisco, California
2nd 10-11 June 1980 Nara, Japan
3rd 1-2 June 1981 Annapolis, Maryland
4th 31 May-1 June 1982 Tokyo, Japan
5th 9-10 June 1983 Honolulu, Hawaii
6th 13-14 February 1984 Tokyo, Japan
7th 25-26 June 1984 San Francisco
8th 27-28 June 1985 Tokyo, Japan
9th June 26-27, 1986 Anchorage, Alaska
10th June 25-26, 1987 Kyoto, Japan
11th June 23-24, 1988 Anchorage, Alaska
12th June 23-24, 1989 Kashiko-jima, Japan
13th June 28-29, 1990 San Diego, California
14th July 1-2, 1991 Naha, Okinawa, Japan

Activities
Area
Seminar & Symposia
Exchange of Scientists
Exchange of Materials
from US to Japan
from Japan to US
from US to Japan
from Japan to US
Etiology
3
0
3
1
2
Biol & Diag.
3
0
3
0
0
Treatment
3
0
3
0
0
Interdisp.
2
0
2
0
0
Total
11
0
11
1
2


I. ETIOLOGY
1. SEMINARS
(1) Manifestation of Prostatic Carcinoma
San Francisco, February 18-20, 1991
Organizers: Dr. David Longfellow
Dr. Nobuyuki Ito
Participants: US - 8
Japan - 6

(2) Hepatitis C Virus, a Causative Infectious Agent of Non A. Non B Hepatitis: Prevalence and Its Structure
Kauai, Hawaii, March 11-12, 1991
Organizers: Dr. Edward Tabor
Dr. Ken-ichi Kobayashi
Participants: US - 8
Japan - 9

(3) Scientific Basis for Cancer Risk Assessment of Environmental Chemicals
Kauai, Hawaii, March 14-15, 1991
Organizers: Dr. E.L. Anderson
Dr. Richard Adamson
Dr. Yuzo Hayashi
Participants: US-7
Japan- 7

2. EXCHANGE OF SCIENTISTS
(1) Dr. Hiroshi Handa, University of Tokyo
Dates: August 27 - September 14, 1990
Host Scientist: Dr. J. Menley, Columbia University
Dr. P.A. Sharp, Massachusetts Institute of Technology
Dr. M.R. Green, Harvard University
Dr. A.J. Berk, University of California Los Angeles

(2) Dr. Hiroyuki Tsuda, Fujita-Gakuen Health University
Dates: October 16-28, 1990
Host Scientist: Dr. J.E. Klaunig, Medical College of Ohio
Dr. Curtis Harris, National Cancer Institute
Dr. G.K. Michalopoulos, Duke University Medical Center

(3) Dr. Masao Yamada, National Children's Medical Research Center
Dates: December 1-14, 1990
Host Scientist: Drs. T. Grodzicker, E. Harlow and W. Herr Cold Spring Harbor Laboratory
Dr. F.W. Alt, Columbia University
Dr. J. Silver, North Shore University Hospital
Dr. T.A Look, St. Jude Children's Research Hospital



II. BIOLOGY AND DIAGNOSIS
1. SEMINARS
(1) Signal Transduction and Gene Regulation in Cancer
Bethesda, Maryland, October 10-12, 1990
Organizers: Dr. Ira Pastan and Dr. Glenn Merlino
Dr. Yoji Ikawa
Participants: US - 9
Japan - 7

(2) Lymphocyte Adhesion and Its Related Signal Transduction
Osaka, Japan, November 8-10, 1990
Organizers: Dr. Richard Hodes
Dr. Hiromi Fujiwara
Participants: US - 6
Japan - 11

(3) Molecular Mechanisms in Oncogenesis and Tumor Progression
Kauai, Hawaii, January 17-18, 1991
Organizers: Dr. Stanley Korsmeyer
Dr. Takehiko Sasazuki
Participants: US - 8
Japan - 6


2. EXCHANGE OF SCIENTISTS
(1) Dr. Hiroshi Hamada, University of Tokyo
Dates: March 25 - April 4, 1991
Host Scientist: Dr. Rudolf Jaenish, White Head Institute and Massachusetts Institute of Technology

(2) Dr. Hideo Yamagishi, Kyoto University
Dates: September 29 - October 21, 1990
Host Scientist: Dr. Michael Brenner, Dana-Farber Cancer Institute

(3) Dr. Yasunobu Yoshikai, Kyushu University
Dates: October 16-22, 1990
Host Scientist: Dr. J.A. Bluestone, University of Chicago



III. TREATMENT
1. SEMINARS
(1) Lung Cancer - Current Treatment Strategy
Okayama, Japan, November 12-13, 1990
Organizers: Dr. Mark Green
Dr. Ikuro Kimura
Participants: US - 6
Japan - 17

(2) New Drugs and Antimetastatic Drugs
Hilo, Hawaii, February 9-10, 1991
Organizers: Dr. John Glick
Dr. Takashi Tsuruo
Participants: US - 5
Japan - 7

(3) The Role of Growth Factors in Cancer Treatment
Napa Valley, California, March 18-19, 1991
Organizers: Dr. David Parkinson
Dr. Makoto Ogawa
Participants: US - 6
Japan – 7

2. EXCHANGE OF SCIENTISTS
(1) Dr. Takao Yamori, Cancer Chemotherapy Center
Dates: October 15 - November 2, 1990
Host Scientist: Dr. Robert Shoemaker, National Cancer Institute
Dr. G.L. Nicolson, M.D. Anderson Cancer Center
Dr. B. Vogelstein, Johns Hopkins University School of Medicine

(2) Dr. Kazuo Umezawa, Keio University
Dates: September 15 - October 3, 1990
Host Scientist: Dr. T. Hunter, Salk Institute
Dr. I.H. Krakoff, M.D. Anderson Cancer Center
Dr. H. Hanaftisa, Rockfellow University

(3) Dr. Michihiko Kuwano, Medical College of Oita
Dates: December 1-20, 1990
Host Scientist: Dr. Kenneth Cowan, National Cancer Institute
Dr. M. Beck, St. Jude Children's Research Hospital
Dr. D. Schlessinger, Washington University, St. Louis



IV. INTERDISCIPLINARY
1. SEMINARS
(1) Transplacental and Transgeneration Carcinogenesis
Volcano House, Hawaii, November 13-14, 1990
Organizers: Dr. Jerry Rice
Dr. Taisei Nomura
Participants: US - 9
Japan - 9

(2) Pathophysiology of Renal Cancer
Honolulu, Hawaii, February 18-19, 1991
Organizers: Dr. Frederick Li
Dr. Yusuke Nakamura
Participants: US – 8
Japan – 9


2. EXCHANGE OF SCIENTISTS
(1) Dr. Atsuhiko Sakamoto, University of Tokyo, Faculty of Medicine
Dates: October 4 - November 2, 1990
Hosts: Dr. Joan Rosai, Yale University Medical School
Dr. Austin Vickery, Jr., Harvard Medical School
Dr. George Wied, University of Chicago

(2) Dr. Ryuichiro Sasaki, Nagoya University School of Medicine
Dates: November 5-25, 1990
Hosts: Dr. Robert Miller, National Cancer Institute
Dr. Walter Willet, Harvard University School of Medicine
Dr. Brian Henderson, Southern California School of Medicine


3. EXCHANGE OF MATERIALS
From
To
1. MeIQx 3g Dr. S. Takayama Dr. R.H. Adamson
2. 4-8-DiMeIQx 2g Dr. S. Takayama Dr. R.H. Adamson
3. Benzo(a)pyrene Derivative Dr. R.H. Adamson Dr. S. Takayama