13th NCI-JSPS JOINT STEERING COMMITTEE MEETING
Radisson Hotel, San Diego, June 28, 1990
The 13th meeting of the Steering Committee of the US-Japan. Cooperative Cancer Research Program was held at the Radisson Hotel in San Diego, California on June 28, 1990. Those attending for Japan were: Drs. Shozo Takayama, Takehiko Sasazuki, Makoto Ogawa, Haruo Sugano, and Mr. Satoru Endo, and for the U.S.: Drs. Richard Adamson, Richard Hodes, Michael Friedman, Robert Miller, Tsuyoshi Kakefuda, and Federico Welsch.
Dr. Adamson opened the meeting at 9 a.m., welcoming all participants. He congratulated both sides on the success of the program over the last 16 years. He explained the absence of Dr. Sugimura and asked for a moment of silence in honor of the late Dr. Yamamura. He then predicted a small but significant budget increase for the NCI for FY 1991, but also warned about the uncertainties if the Gramm-Rudman-Hollings deficit reduction act were to take hold of the 1991 budget.
Dr. Sugano expressed the Japanese side satisfaction on how the bilateral program has been progressing. He explained that Dr. Sakai retired this March and therefore was not at the meeting.
Dr. Welsch informed the group of pr. Kakefudas request to return to the laboratory and of Dr. Adamsons and his agreement to him dedicating 80 percent of his time to bench work. The remaining 20 percent of his time will be dedicated to advising on the US-Japan bilateral cancer research program and related activities. Dr. Welsch also mentioned that he had discussed with Dr. Sugimura the desirability of publishing in a scientific journal (perhaps in the Japanese Journal of Cancer Research, and/or Journal) meeting reports concerning all of the US-Japan workshops. The meeting participants agreed to encourage scientists participating in the US-Japan workshops to publish the achievement of the seminars in scientific journals. Dr. Welsch proposed that the annual progress report could then be simplified. This could make it more timely and would limit it to a summary of progress during the year, copies of the agenda, and published meeting reports of individual workshops. However, some other participants strongly expressed that the report should be published in the same style as before. Dr. Ogawa handed out a list of papers and books resulting from the treatment area workshops over the years and copies of published meeting reports. Dr. Takayama also handed out copies of meeting reports of the workshops published in Canccer Research and Japanese Journal of Cancer Research.
The group then reviewed the workshops, exchange scientists and exchanged materials during 1989-1990, and those planned for 1990-1991 (Attachment; Future Plans). Dr. Adamson committed additional Division of Cancer Etiology funds to pay for the extra U.S. participants at the Etiology meeting in Japan, for extra participants at the Etiology meetings in Hawaii (if any), and for Dr. Susan Sieber to perhaps attend the Cancer After Prenatal Exposure meeting. Dr. Welsch related to the group that some American reviewers had complained that they could not peer review the nominations by our Japanese colleagues due to the fact that there was little research plan or statement of what was supposed to be accomplished by the Japanese exchange scientist during his/her visit to the U.S. He proposed that the JSPS increase the length of item No. 17 entitled Research Plan in their application to up to three pages. It was agreed that both sides would examine the form at the next meeting. Dr. Adamson suggested that the NCI members of the joint steering committee should meet twice a year in Bethesda to be updated on the status of the workshops and of the scientific exchange.
Those present at the meeting agreed to make any necessary corrections to the annual progress reports by August 1, 1990. During the coming fiscal year both an annual report and meeting reports for rapid publication will be prepared. It was agreed that the progress report for 1989-1990 would be edited by NCI and printed by JSPS.
The participants agreed that the next meeting will be held either in Okinawa (first preference), Tokyo area (second preference), or Sapporo (third preference) on June 20-21 (first preference) or July 1-2 (second preference), 1991.
The meeting closed at 5:30 p.m.
| Respectfully submitted, Federico Welsch, M.D., Ph.D. |
FUTURE PLANS
Twelve future seminars or symposia are envisioned, nine in the U.S. and three in Japan. Eleven Japanese scientists will be visiting U.S. laboratories in the Exchange Scientist Program. Muta-carcinogenic heterocyclic amines will be sent to the NCI for collaborative studies between the NCI and other institutions in the U.S. and the National Cancer Center, Japan. Fecapentaene will be shipped to Japan for other international collaborative studies.
Planned Seminars and Exchange Scientists in the Etiology Area for FY 90:
1. PLANNED SEMINARS
| (1) Viral Regulatory Proteins and Their Effect on Host Cell Proliferation and Differentiation Tokyo or Kyoto January or February, 1991 (3 days) |
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| Organizers: | Dr. Mitsuaki Yoshida Dr. Peter M. Howley |
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| Participants: | U.S.: 7 Japan: 7 |
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(2) Manifestation of Prostatic Cancers Hawaii December, 1990 (3 days) |
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| Organizers: | Dr. Nobuyuki Ito and Dr. Tadao Kakizoe Dr. R. Nagel, Dr. Michael Brower and/or Dr. Maarten Bosland (candidates) |
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| Participants: | US-7 Japan-7 |
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(3) Scientific Basis for Cancer Risk Assessment of Environmental Chemicals Hawaii February or March 1991 (3 days) |
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| Organizers: | Dr. Yuzo Hayashi Dr. E. L. Anderson |
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| Participants: | US - 7 Japan - 7 |
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(4) Hepatitis C Virus, a Causative Infectious Agent of Non A Non B Hepatitis: Prevalence and Its Structure Hawaii February or March, 1991 (3 days) |
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| Organizers: | Dr. Ken-ichi Kobayashi Dr. P. H. Purcell |
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| Participants: | US-7 Japan-7 |
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2. EXCHANGE OF SCIENTISTS
| (1) Dr. Hiroshi Handa University of Tokyo, School of Medicine | ||
| Dates: | July 20 - August 9, 1990 (21 days) | |
| Host Scientist(s): | Dr. J. Manley, Columbia University Dr. P. A. Sharp, Massachusetts Institute of Technology Dr. M. R. Green, Harvard University Dr. A. J. Berk, University of California at Los Angeles |
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(2) Dr. Hiroyuki Tsuda Fujita Gakuen Health University |
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| Dates: | September 10-24, 1990 (15 days) | |
| Host Scientist(s): | Dr. J.E. Klaunig, Medical College of Ohio Dr. C. Harris, NCI Dr. G. K. Michalopoulos, Duke University Medical Center |
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(3) Dr. Masao Yamada National Childrens Medical Research Center |
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| Dates: | September 17 - October 1, 1990 (15 days) | |
| Host Scientist(s): | Drs. Grodzicker, E. Harlow and W. Herr Cold Spring Harbor Laboratory Dr. F. W. Alt, Columbia University Dr. J. Silver, North Shore University Hospital Dr. T. A. Look, St. Jude Childrens Research Hospital |
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Planned Seminars and Exchange Scientists in the Biology and Diagnosis Program Area for FY90:
1. PLANNED SEMINARS
| (1) Gene Activation and Signal Transduction Washington D.C., October, 1990 (3 days) |
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| Organizers: | Dr. Ira Pastan Dr. Yoji Ikawa |
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| Participants: | U.S.: 7 Japan: 7 |
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(2) Molecular Mechanisms Involved in Cellular Interactions Osaka, November, 1990 (3 days) |
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| Organizers: | Dr. Hiromi Fujiwara Dr. Richard Hodes |
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| Participants: | U.S.: 6 Japan: 10 |
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(3) Molecular Mechanisms in Oncogenesis and Tumor Progression Hawaii, January 14-15, 1991 |
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| Organizers: | Dr. Takehiko Sasazuki Dr. Stanley J. Korsmeyer |
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| Participants: | U.S.: 7 Japan: 6 |
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2. EXCHANGE OF SCIENTISTS
| (1) Dr. Hiroshi Hamada University of Tokyo, School of Medicine |
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| Dates: | (31 days) | |
| Host Scientist(s): | Dr. Rudolf Jaenish, White Head Institute, MIT | |
(2) Dr. Hideo Yamagishi Kyoto University |
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| Dates: | (21 days) | |
| Host Scientist(s): | Dr. Michael Brenner, Dana-Farber Cancer Institute | |
(3) Dr. Yasunobu Yoshikai Medical Institute of Bioregulation, Kyushu University |
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| Dates: | (10 days) | |
| Host Scientist(s): | Dr. J.A. Bluestone, University of Chicago | |
Planned Seminars and Exchange Scientists in the Treatment Program Area for FY90:
1. PLANNED SEMINARS
| (1) Lung Cancer: Current Treatment Strategies Okayama, November 12-13, 1990 |
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| Organizers: | Drs. Ikuro Kimura and Makoto Ogawa Drs. Mark R. Green and Michael A. Friedman |
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| Participants: | U.S. - 7 Japan - 10 |
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(2) New Drugs and Antimetastatic Drugs Hawaii, February 9-10, 1991 |
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| Organizers: | Dr. Takashi Tsuruo Dr. John H. Glick Dr. Michael A. Friedman |
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| Participants: | US - 7 Japan 7 |
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(3) The Role of Growth Factors in Cancer Treatment San Francisco, March 18-19, 1991 |
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| Organizers: | Dr. Makoto Ogawa Dr. David R. Parkinson and Dr. Michael A. Friedman |
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| Participants: | US -7 Japan - 7 |
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2. EXCHANGE Of SCIENTISTS
| (1) Dr. Takao Yamori Cancer Chemotherapy Center Japanese Foundation for Cancer Research |
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| Dates: | September 20 - October 10, 1990 | |
| Host Scientist(s): | Dr. R. Shoemaker, FCRDC, NCI Dr. G.L. Nicolson, M.D. Anderson Cancer Center Dr. B. Vogelstein, Johns Hopkins University School of Medicine and Hospital |
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(2) Dr. Kazuo Umezawa Keio University |
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| Dates: | September 1-21, 1990 | |
| Host Scientist(s): | Dr. T. Hunter, Salk Institute San Diego Dr. I.H. Krakoff, M.D. Anderson Cancer Center Dr. H. Hanafusa, Rockfeller University |
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(3) Dr. Nobuhiko Kuwano Medical college of Oita |
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| Dates: | January, 1991 (21 days) | |
| Host Scientist(s): | Dr. K. Cowan, NCI Dr. W. Beck, St. Jude Hospital Dr. D. Schlessinger, Washington University |
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Planned Seminars and Exchange Scientists in the Interdisciplinary Program Area for FY90:
1. PLANNED SEMINARS
| (1) Transplacental and Transgeneration Carcinogenesis Hawaii, November 13-14, 1990 |
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| Organizers: | Dr. Taisei Nomura Dr. Jerry M. Rice |
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| Participants: | US - 6 Japan 7 |
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(2) Pathophysiology of Renal Cancer Hawaii, February, 1991 |
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| Organizers: | Dr. Yusuke Nakamura, Cancer Institute Japanese Foundation for Cancer Research Dr. Frederick P. Li, NCI, Dana-Farber Cancer Institute |
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| Participants: | US - 6 Japan - 7 |
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2. EXCHANGE OF SCIENTISTS
| (1) Dr. Atsuhiko Sakamoto, University of Tokyo, School of Medicine | ||
| Dates: | (31 days) | |
| Host Scientist(s): | Juan Rosai, Yale University Medical School | |
(2) Dr. Ryuichiro Sasaki, Nagoya University School of Medicine |
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| Dates: | (21 days) | |
| Host Scientist(s): | Dr. Robert W. Miller, NCI Dr. Walker Willet, Harvard University School of Medicine Dr. Brian E. Henderson, University of Southern California School of Medicine |
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| From | To | |
| 1. MeIQx,3g | Dr. Shozo Takayama | Dr. Richard H. Adamson |
| 2. 4-8-DiMeIQx 2g | Dr. Shozo Takayama | Dr. Richard H. Adamson |
| 3. Fecapentaene | Dr. Richard H. Adamson | Dr. Shozo Takayama |
The proposed activities for all Program Areas were Approved by the Joint Steering Committee.
13TH JOINT US-JAPAN STEERING COMMITTEE MEETING
Radisson Hotel, San Diego, June 28, 1990
AGENDA
| Thursday, June 28 | ||
| 9:00a.m. | Welcoming Remarks | Dr. Adamson Dr. Sugano |
| Annual Report for the Etiology Program Area | Dr. Adamson Dr. Takayama |
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| Annual Report for the Biology and Diagnosis Program Area | Dr. Hodes Dr. Sasazuki |
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| Coffee Break | ||
| 11:00 a.m. | Annual Report for the Treatment Program Area | Dr. Friedman Dr. Ogawa |
| Annual Report for the Interdisciplinary Area | Dr. Miller Dr. Sugano |
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| 12:00 noon | Lunch hosted by JSPS | |
| 1:30p.m. | Program Plans for 1990-91 | |
| Etiology Program Area | Dr. Takayama Dr. Adamson |
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| 3:30 p.m. | Coffee Break | |
| Biology and Diagnosis Program Area | Dr. Sasazuki Dr. Hodes |
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| Treatment Program Area | Dr. Ogawa Dr. Friedman |
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| Interdisciplinary Program Area | Dr. Sugano Dr. Miller |
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| General Discussion | ||
| Closing Remarks | Dr. Adamson | |
| 6:30 p.m. | Dinner hosted by NCI | |
PARTICIPANTS
UNITED STATES
NCI Program Coordinators
Dr. Richard Adamson
Director
Division of Cancer Etiology
Dr. Richard Hodes
Experimental Immunology Branch
Division of Cancer Biology and Diagnosis
Dr. Michael Friedman
Associate Director for Cancer Therapy Evaluation
Division of Cancer Treatment
Dr. Robert Miller
Chief, Clinical Epidemiology Branch
Division of Cancer Etiology
NCI Representatives
Dr. Federico Welsch
Associate Director for International Affairs
Dr. Tsuyoshi Kakefuda
Executive Secretary
US-Japan Cooperative
Cancer Research Program
JAPAN
JSPS Program Coordinators
Dr. Shozo Takayama
Director
National Cancer Center
Research Institute
Dr. Takehiko Sasazuki
Medical Institute of Bioregulation
Kyushu University
Dr. Makoto Ogawa
Chief, Division of Clinical Chemotherapy
Japanese Foundation for Cancer Research
Dr. Haruo Sugano
Director, Cancer Institute
Japanese Foundation for Cancer Research
JSPS Representatives
Mr. Satoru Endo
Research Cooperation Division
JSPS