ADMINISTRATIVE REPORT

This report summarizes activities of the US-Japan Cooperative Cancer Research Program for the Japanese Fiscal Year 1987, the period between April 1, 1987, and March 31, 1988.
The program consists of the following program areas:

I. Etiology
II. Biology and Diagnosis
III. Treatment
IV. Interdisciplinary

The US-Japan Bilateral Agreement calls for the exchange of scientists, the exchange of materials, and the organization of seminars and workshops. Detailed discussions of these activities will be reported under specific program areas. The tables compiled in this section represent overall summaries for quick review. They should be self-explanatory.
To discuss policy matters and program activities, the Joint Steering Committee of the Program meets once every year. The fourth meeting of the third five-year period of its operation (April 1984 to March 1989) was held on June 23-24, 1988, in Anchorage, Alaska.

Past Meetings
1st 24-25 March 1979 San Francisco, California
2nd 10-11 June 1980 Nara, Japan
3rd 1-2 June 1981 Annapolis, Maryland
4th 31 May-1 June 1982 Tokyo, Japan
5th 9-10 June 1983 Honolulu, Hawaii
6th 13-14 February 1984 Tokyo, Japan
7th 25-26 June 1984 San Francisco
8th 27-28 June 1985 Tokyo, Japan
9th June 25-26, 1986 Anchorage, Alaska
10th June 25-26, 1987 Kyoto, Japan

Activities
Program Areas
Seminars
Exchange of Scientists
Exchange of Materials
From U.S.
From Japan
ETIOLOGY
4
1
4
8
BIOLOGY and DIAGNOSIS
3
0
4
0
TREATMENT
3
0
3
0
INTERDISCIPLINARY PROGRAM and COORDINATION
2
0
3
0
Totals
12
1
14
8


I. ETIOLOGY
1. SEMINARS
(1) Cancer cell membrane: aberrant glycosylationand othercritical molecularevents, Hawaii, February 15-18, 1988
Organizers: Dr. Sen-itiroh Hakomori
Dr. Setsuo Hirohashi
Participants: U.S.-8
Japan-8

(2) Glutathione S-transferases and carcinogenesis, Hawaii, March 23-24, 1988
Organizers: Dr. Henry C. Pitot
Dr. Kiyoshi Sato
Participants: U.S.-6
Japan-6

(3) Development of new medium-term bioassay for carcinogenesis, Hawaii, December 15-17, 1987
Organizers: Dr. Jerrold M, Ward
Dr. Nobuyuki Ito
Participants: U.S.-7
Japan-7

(4) Biology of oncogenes, Hawaii, February 17-18, 1988
Organizers: Dr. Stuart A. Aaronson
Dr. Masaaki Terada
Participants: U.S.-7
Japan-8

2. EXCHANGE OF SCIENTISTS
(1) Dr. Katsuyuki Yaginuma Cancer Institute, Tokyo
Dates: September 27 - October 30, 1987
Host Scientist: Dr. Jesse W. Summers Fox Chase Cancer Center Philadelphia

(2) Dr. Masao Hirose Nagoya City university
Dates: November 4 - 13, 1987
Host Scientist: Dr. H. Witschi, University of California, Davis

(3) Dr. Nam-ho Huh University of Tokyo
Dates: August 12 - September 3, 1987
Host Scientist: Dr. Eliezer Huberman, Argonne National Laboratory
Dr. Curtis C. Harris, National Cancer Institute
Dr. Anthony E. Pegg, Milton S. Hershey Medical Center

(4) Dr. Yukihito Ishizaka National Cancer Center Research Institute
Dates: March 1 - April 4, 1988
Host Scientists: Dr. Anthony V. Carrano, Lawrence Livermore National Laboratory

(5) Dr.Wolfgang Zacharias University of Alabama
Dates: September 5-26, 1981
Host Scientist: Dr. Hikoya Hayatsu, Okayama University



II. BIOLOGY AND DIAGNOSIS
1. SEMINARS
(1) Molecular biology of cancer cells, Kyoto, Japan, April 4-6, 1988
Organizers: Dr. Ira Pastan
Dr. Shigetaka Nakanishi
Participants: U.S.-6
Japan- 10

(2) Molecular mechanisms of lymphoid cell activation and application to tumor immunology, Hawaii, February 8-11, 1988
Organizers: Dr. Richard Hodes
Dr. Toshiyuki Hamaoka
Participants: U.S.-7
Japan-8

(3) Molecular diagnosis of cancer, Hawaii, February 8-11, 1988
Organizers: Dr. Stanley Korsmeyer
Dr. Tadamitsu Kishimoto
Participants: U.S.-7
Japan-8


2. EXCHANGE OF SCIENTISTS
(1) Dr. Mitsuaki Yoshida The Cancer Institute
Dates:
Host Scientist:

(2) Dr. Takashi Nishimura Tohoku University
Dates: March 28, 1986 - August 31, 1987
Host Scientist: Dr. Steven Burakoff, Harvard Medical School

(3) Dr. Masao Kimoto Saga Medical School
Dates: January 31 - February 13, 1988
Host Scientist: Dr. Alfred Singer, National Cancer Institute

(4) Dr. Hiromi Fujiwara Osaka University Medical School
Dates: September 14 - October 4, 1987
Host Scientist: Dr. Mark I. Greene, Pennsylvania University School of Medicine

(5) Dr. Kenichi Matsubara Osaka University
Dates: January 30 - February 14, 1988
Host Scientist: (Please see Exchange Scientist Summary Report)



III. TREATMENT
1. SEMINARS
(1) The role of cytokines in cancer treatment, Tokyo, November 4-5, 1987
Organizers: Dr. Michael Friedman
Dr. Makoto Ogawa
Participants: U.S.-6
Japan-8

(2) New screening systems and new drugs, Hawaii, February 5-6, 1988
Organizers: Dr. Michael Friedman
Dr. Makoto Ogawa
Participants: U.S.-6
Japan-7

(3) Current progress of combined modality of radiotherapy, San Francisco, March 13-16, 1988
Organizers: Dr. Theodore Phillips
Dr. Mitsuyuki Abe
Participants: U.S.-27
Japan-21

2. EXCHANGE OF SCIENTISTS
(1) Dr. Ohtsura Niwa Research Institute for Nuclear Medicine and Biology, Hiroshima
Dates: September 27 - October 10, 1987
Host Scientist: Dr. Isaiah Fidler, University of Texas

(2) Dr. Shuichi Fujimoto Chiba Cancer Center Research Institute
Dates: November 5-25, 1987
Host Scientist: Dr. Lloyd Old, Memorial Sloan-Kettering Cancer Center



IV. INTERDISCIPLlNARY PROGRAM
1. SEMINARS
(1) Melanoma and skin cancer: biology and comparative features in the U.S. and Japan, Tokyo, November 13-15, 1988
Organizers: Dr. Thomas Fitzpatrick
Dr. Jun Kukita
Participants: U.S.- 10
Japan- 10

(2) The family syndrome of sarcoma, breast cancer, and other neoplasms, Hawaii, March 21-23, 1988
Organizers: Dr. Robert Miller
Dr. Frederick Li
Dr. Haruo Sugano
Participants: U.S.-7
Japan-9


2. EXCHANGE OF SCIENTISTS
(1) Dr. Eiichi Tahara Hiroshima University
Dates: November 1-24, 1987
Host Scientist: Dr. M. Ryoji, Research Institute of Scripps Clinic
Dr. Jeffrey Schlom, National Cancer Institute

(2) Dr. Katsuhiro Fukuda Kurume University
Dates: July 13 - August 11, 1987
Host Scientist: Dr. Brian E. Henderson, Univ. of South California
Dr. R.B. Hayes, National Cancer Institute
Dr. L.N. Kolonel, Univ. of Hawaii

(3) Dr. Mitsuru Takanami Kyoto University
Dates: January 26 - February 6, 1988
Host Scientist: (Please see Exchange Scientist Summary Report)