ADMINISTRATIVE REPORT

This report summarizes activities of the U.S.-Japan Cooperative Cancer Research Program for the Japanese Fiscal Year 1986, the period between April 1, 1986 and March 31, 1987.
The Program consists of the following program areas:

I. Etiology
II. Biology and Diagnosis
III. Treatment
IV. Interdisciplinary

The U.S.-Japan Bilateral Agreement calls for the exchange of scientists, the exchange of materials, and the organization of seminars and workshops. Detailed discussions of these activities will be reported under specific program areas. The tables compiled in this section represent overall summaries for quick review. They should be self-explanatory.
To discuss policy matters and program activities, the Joint Steering Committee of the Program meets once every year. The third meeting of the third five-year period of its operation (April 1984 to March 1989) was held on June 25-26, 1987, in Kyoto, Japan.

Past Meetings
1st 24-25 March 1979 San Francisco, California
2nd 10-11 June 1980 Nara, Japan
3rd 1-2 June 1981 Annapolis, Maryland
4th 31 May-1 June 1982 Tokyo, Japan
5th 9-10 June 1983 Honolulu, Hawaii
6th 13-14 February 1984 Tokyo, Japan
7th 25-26 June 1984 San Francisco
8th 27-28 June 1985 Tokyo, Japan
9th 25-26 June 1986 Anchorage, Alaska

Activities
Program Areas
Seminars
Exchange of Scientists
Exchange of Materials
From U.S.
From Japan
ETIOLOGY
3
1
3
2
BIOLOGY and DIAGNOSIS
3
0
4
0
TREATMENT
3
0
3
0
INTERDISCIPLINARY PROGRAM and COORDINATION
2
0
3
0
Totals
11
1
13
2


I. ETIOLOGY
1. SEMINARS
(1) Marine Natural Products and Chemoprevention
Hawaii, February 11-13, 1987
Organizers: Dr. Richard Moore
Dr. Hirota Fujiki
Participants: U.S.-9
Japan-7

(2) Transacting Factors in Viral Carcinogenesis
Kyoto, Japan, March 11-13, 1987
Organizers: Dr. Peter Howley
Dr. Mitsuaki Yoshida
Participants: U.S.-6
Japan-10

(3) Risk assessment of Chemical Carcinogenesis
Hawaii, March 12-13, 1987
Organizers: Dr. Richard Adamson
Dr. Shigeaki Sato
Participants: U.S.-6
Japan-7

2. EXCHANGE OF SCIENTISTS
(1) Dr. Jun Yokota National Cancer Center Research Institute, Tokyo
Dates: February 16-March 6, 1987
Host Scientist: Dr. Mortimer L. Mendelsohn, University of California, Livermore
Dr. Raymond L. White, University of Utah
Dr. William F. Benedict, Children’s Hospital of Los Angeles, California

(2) Dr. Yusuke Wataya Okayama University
Dates: January 20-March 5, 1987
Host Scientist: Dr. Daniel Santi, University of California at San Francisco, California

(3) Dr. Katsumi Yamashita National Cancer Center Research Institute, Tokyo
Dates: February 20-March 19, 1987
Host Scientist: Dr. Kurt Randerath, Baylor College of Medicine, Houston, Texas


II. BIOLOGY AND DIAGNOSIS
1. SEMINARS
(1) Immunogenic Analysis of Host Response to Tumor
Seattle, Washington, November 10-12, 1986
Organizers: Dr. Richard Hodes
Dr. Toshiyuki Hamaoka
Participants: U.S.-15
Japan-15

(2) Oncogenes and Tumor Antigens
Seattle, Washington, November 10-12, 1986
Organizers: Dr. Stanley Korsmeyer
Dr. Tadamitsu Kishimoto
Participants: U.S.-15
Japan-15

(3) Regulatory Element in Normal and Transformed Cells
Hawaii, February 12-14, 1987
Organizers: Dr. James Darnell
Dr. Masami Muramatsu
Participants: U.S.-6
Japan-7


2. EXCHANGE OF SCIENTISTS
(1) Dr. Masharu Sakai University of Tokyo, Tokyo
Dates: September 7 - October 10, 1986
Host Scientist: Dr. M.R. Liberman and Dr. R.P. Perry, Fox Chase Cancer Center, Philadelphia.
Dr. H. Okayama, NIMR, NIH

(2) Dr. Masaru Taniguchi Chiba University School of Medicine
Dates: October 26 - November 16, 1986
Host Scientist: Dr. Ronald Germain, NIAID, NIH
Dr. S. Hakomori, Fred Hutchinson Cancer Center, Seattle, Washington

(3) Dr. Takashi Nishimura Tohoku University
Dates: January 7-21, 1987
Host Scientist: Dr. Steven Burakoff, Dana-Farber Cancer Institute, Boston, Massachusetts

(4) Dr. Tadamitsu Kishimoto Osaka University, Osaka
Dates: January 7-21, 1987
Host Scientists: Dr. William E. Paul, NIAID, NIH



III. TREATMENT
1. SEMINARS
(1) Bone Marrow Transplantation
Tokyo, Japan, November 7-8, 1986
Organizers: Dr. Michael Friedman
Dr. Makoto Ogawa
Participants: U.S.-6
Japan-11

(2) Neoadjuvant and Adjuvant Therapy
Hawaii, February 3-4, 1987
Organizers: Dr. Michael Friedman
Dr. Makoto Ogawa
Participants: U.S.-6
Japan-6

(3) Biochemical Pharmacology of Treatment Failure
Washington, D.C., March 26-27, 1987
Organizers: Dr. Michael Friedman
Dr. Makoto Ogawa
Participants: U.S.-11
Japan-7

2. EXCHANGE OF SCIENTISTS
(1) Dr. Keisuke Aiba Jikei University Medical School
Dates: January 5 - July 3, 1987
Host Scientist: Dr. Bruce Chabner, Division of Cancer Treatment, NCI

(2) Dr. Yukihiko Naruki Toho University School of Medicine
Dates: April 1 - September 30, 1986
Host Scientist: Dr. Paul Strudler, NCI

(3) Dr. Taisuke Ohnishi Okayma University of School of Medicine
Dates: March 9-29, 1987
Host Scientist: Dr. J.F. Holland, Mount Sinai School of Medicine, New York



IV. INTERDISCIPLlNARY PROGRAM AND COORDINATION
1. SEMINARS
(1) Hepatitis B and Primary Hepatocellular Carcinoma
Hawaii, January 29-30, 1987
Organizers: Dr. W. Thomas London
Dr. Tomoyuki Kitagawa
Participants: U.S.-6
Japan-7

(2) Genetics of Human Cancer
Los Angeles, California, March 23-25, 1987
Organizers: Dr. Frederick P. Li
Dr. Hiraku Takabe
Participants: U.S.-10
Japan-11

2. EXCHANGE OF SCIENTISTS
(1)Dr. Mitsuru Mori Sapporo Medical College, Sapporo
Dates: October 24 - December 23, 1986
Host Scientist: Dr. Brian Henderson, University of Southern California

(2) Dr. Okio Hino Cancer Institute, Tokyo
Dates: August 13 - September 27, 1986
Host Scientist: Dr, Charles Rogler, Albert Einstein College of Medicine, New York

(3) Dr. Isamu Kino University Hamamatsu School of Medicine
Dates: November 25 - December 24, 1986
Host Scientist: Dr. Leslie Sobin, Armed Forces Institute of Pathology Washington, D.C.