ADMINISTRATIVE REPORT

This report summarizes the activities for the period between 1 April 1985 and 31 March 1986. It is the 2nd report in the series.
The Program consists of four program areas:

I. Etiology
II. Biology and Diagnosis
III. Treatment
IV. Interdisciplinary Program and Coordination

The US-Japan Bilateral Agreement calls for exchange of scientists, exchange of materials, and organization of seminars and workshops. Detailed discussion of these activities will be reported under specific program areas. The tables compiled in this section re-present overall summaries for quick review. They should be self-explanatory.
To discuss policy matters and program activities, the Joint Steering Committee of the Program meets once every year. The second meeting of the third five-year period of its operation (from April 1984 to March 1989) was held on June 26-27, 1986 in Anchorage, Alaska.

Past Meetings
1st 24-25 March 1979 San Francisco, California
2nd 10-11 June 1980 Nara, Japan
3rd 1-2 June 1 981 Annapolis, Maryland
4th 31 May-1 June 1982 Tokyo, Japan
5th 9-10 June 1983 Honolulu, Hawaii
6th 13-14 February 1984 Tokyo, Japan
7th 25-26 June 1984 San Francisco
8th 27-28 June 1985 Tokyo, Japan

Activities
Program Areas
Seminars
Exchange of Scientists
Exchange of Materials
From U.S.
From Japan
ETIOLOGY
3
0
6
1
BIOLOGY and DIAGNOSIS
3
1
4
0
TREATMENT
3
0
4
0
INTERDISCIPLINARY PROGRAM and COORDINATION
2
1
4
0
Totals
11
2
18
1


I. ETIOLOGY
1. SEMINARS
(1) Oncogenes and Experimental Carcinogenesis, Molokai, Hawaii, March 12-14, 1986
Organizers: Dr. Stuart A. Aaronson
Dr. Masaaki Terada
Participants: U. S.-6
Japan-6

(2) Modifying Factors in Gastrointestinal Carcinogenesis, Tokyo, March 12-14, 1986
Organizers: Dr. Shigeaki Sato
Dr. Gary M. Williams
Participants: U.S.-6
Japan-7

(3) Oxygen Radicals in Cancer, Waianae, Hawaii, March 26-29, 1986
Organizers: Dr. Bruce N. Ames
Dr. Susumu Nishimura
Participants: U.S.-8
Japan-7

2. EXCHANGE OF SCIENTISTS
(1) Dr. Shun Nakamura
Institute of Medical Science, The University of Tokyo
Dates: July 9- October 10, 1985
Host Scientist: Dr. G. Vande Woude, Litton-Bionetics, Inc.
Dr. E. Gilboa, Prinston University
Dr. K. Arai, DNAX Research Institute

(2) Dr. Masuo Yutsudo
Department of Tumor Virology, Research Institute for Microbial Diseases, Osaka University, Osaka
Dates: November 2- December 1, 1985
Host Scientist: Dr. Peter M. Howley, Laboratory of Tumor Virus Biology
National Cancer Institute

(3) Dr. Tada-aki Hori
Division of Genetics, National Institute of Radiological Sciences, Chiba
Dates: November 25- December 25, 1985
Host Scientist: Dr. Thomas W. Glover, University of Michigan, Ann Arbor

(4) Dr. Yuji Kurokawa
National Institute of Hygienic Sciences, Tokyo
Dates: December 8- December 19, 1985
Host Scientists: Dr. Thomas J. Slaga, The University of Texas System Cancer Center, Texas

(5) Dr. Kazuo Negishi
Okayama University, Okayama
Dates: January 10- March 9, 1986
Host Scientist: Dr. Robert D. Wells, The University of Alabama at Birmingham

(6) Dr. Koichi Yoshida
Department of Molecular Biology, Cancer Research Institute, Sapporo Medical College, Sapporo
Dates: March 8, 1985- March 7, 1986
Host Scientist: Dr. G. Chinnadurai, Institute for Molecular Virology, St. Louis
University Medical Center, St. Louis



II. BIOLOGY AND DIAGNOSIS
1. SEMINARS
(1) Analysis of Host's Immune Responses Involved in Anti-tumor Immune Resistance, Kyoto, November 11- 13, 1986
Organizers: Dr. Toshiyuki Hamaoka
Dr. Richard J. Hodes
Participants: U.S.-8
Japan-13

(2) Cell Surface Markers and Genes, Sapporo, Hokkaido, January 31- February 3, 1986
Organizers: Dr. Tadamitsu Kishimoto
Dr. Frederick W. Alt
Participants: U.S.-6
Japan-6

(3) Regulation of Expression and Function of Transformation-related Genes, Honolulu, Hawaii, February 17-1 9, 1986
Organizers: Dr. Stephen Oroszlan
Dr. Yoji Ikawa
Participants: U.S.-8
Japan-7


2. EXCHANGE OF SCIENTISTS
(1) Dr. William Benedict
Children Hospital of Los Angeles
Dates: September 11- October 2, 1985
Host Scientist: Dr. Yoji Ikawa Institute of Physical and Chemical Research

(2) Dr. Takeshi Watanabe Medical Institute of Bioregulation, Kyushu University
Dates: March 18- March 30, 1986
Host Scientist: Dr. Paul W. Kincade, Oklahoma Medical Research Foundation

(3) Dr. Toshiyuki Hamaoka
Institute for Cancer Research, Osaka University Medical School
Dates: January 12- January 26, 1986
Host Scientist: Dr. Mark I, Greene, Department of Immunology, School of Medicine, University of Pennsylvania
Dr. Richard Hodes, National Cancer Institute

(4) Dr. Kazuo Todokoro
Tsukuba Life Science Center, The Institute of Physical and Chemical Research
Dates: March 7- March 26, 1986
Host Scientists: Kenichi Arai, DNAX Research Institute of Molecular and Cellular Biology



III. TREATMENT
1. SEMINARS
(1) Progress of Combined Modality of Chemotherapy and Radiotherapy, Tokyo, October 10- 11, 1985
Organizers: Dr. Makoto Ogawa
Dr. Michael A. Friedman
Participants: U.S.-9
Japan-13

(2) Clinical Trials Methodology- Chemotherapy and BRM, Hawaii, January 30- 31, 1986
Organizers: Dr. Michael A. Friedman
Dr. Makoto Ogawa
Participants: U.S.-7
Japan-7

(3) New Drugs under Development and Regional Chemotherapy Bethesda, March 24-25, 1986
Organizers: Dr. Michael A. Friedman
Dr. Makoto Ogawa
Participants: U.S.-11
Japan-7

2. EXCHANGE OF SCIENTISTS
(1) Dr. Hiroki Koyama
The Center of Adult Diseases
Dates: November 16- November 30, 1985
Host Scientist: Dr. William L. McGuire, Division of Medical Oncology, The University of Texas Health Science Center.

(2) Dr. Takashi Tsuruo
Cancer Chemotherapy Center, Japanese Foundation for Cancer Research
Dates: April 23, 1984- May 31, 1985
Host Scientist: Dr. Robert F. Ozols, National Cancer Institute

(3) Dr. Katsuhiro Inoue
Japanese Foundation for Cancer Research
Dates: October 8, 1985- October 7, 1986
Host Scientist: Dr. Robert Ozols, National Cancer Institute

(4) Dr. Toshio Kitagawa
Particle Radiation Medical Science Center of Tsukuba University
Dates: September 21- October 2, 1985
Host Scientist: Dr. Herman D. Suit, Dept. of Radiation Medicine, Massachusetts General Hospital



IV. INTERDISCIPLlNARY PROGRAM AND COORDINATION
1. SEMINARS
(1) Cancer Epidemiology in Southeast Asia, Hawaii, December 12- 13, 1985
Organizers: Dr. Kunio Aoki
Dr. Robert W. Miller
Participants: U.S.-7
Japan-7

(2) Recent Advances in Bladder Cancer Research, Nagoya, Japan, March 24- 25, 1986
Organizers: Dr. Nobuyuki Ito
Dr. Samuel M. Cohen
Participants: U.S.-9
Japan- 11


2. EXCHANGE OF SCIENTISTS
(1)Dr. Koji Namba
Hiroshima University
Dates: February 8- March 9, 1986
Host Scientist: Dr. Eugene Yanagihara, Kuakini Medical Center, Honolulu
Dr. Bharat N. Nathwani, University of Southern California

(2) Dr. Aya Hanai
Center for Adult Diseases, Osaka
Dates: October 20- December 19, 1985
Host Scientist: Dr. John L. Young Jr., National Cancer Institute

(3) Dr. Motoharu Seiki
Japanese Foundation for Cancer Research
Dates: December 25- January 12, 1986
Host Scientist: Kenichi Arai, DNAX Research Institute of Molecular and |Cellular Biology

(4) Dr. Charles E. Rogler
Albert Einstein College of Medicine
Dates: November 2- 18, 1986
Host Scientist: Dr. Okio Hino, Cancer Institute, Tokyo