ADMINISTRATIVE REPORT
This report summarizes activities of the U.S.-Japan Cooperative Cancer Research Program for the Japanese Fiscal Year 1982, the period between April 1982 and March 1983.
The Program consists of the following program areas:
| I. | Etiology |
|
| II. | Biology and Diagnosis |
|
| III. | Treatment |
|
| IV. | Interdisciplinary Program and Coordination |
|
The types of activities supported under the auspices of the Program are seminars and exchange of scientists. The table presented below indicates the activities of each program area during this reporting period, and the following chapters of program area reports describe in detail the objectives, achievements, and future plans for each program area.
|
Program Areas
|
Seminars
|
Exchange of Scientists
|
|
|
From U.S.
|
From Japan
|
||
| ETIOLOGY |
3
|
0
|
6
|
| BIOLOGY and DIAGNOSIS |
3
|
0
|
2
|
| TREATMENT |
2
|
1
|
2
|
| INTERDISCIPLINARY PROGRAM and COORDINATION |
2
|
1
|
4
|
| Totals |
10
|
2
|
14
|
I. ETIOLOGY
1. SEMINARS
| (1) Multiple Primary Neoplasms |
||
| Oiso, Japan, February 17-18, 1983 |
||
| Organizers: | Dr. Curtis C. Harris Dr. Keiichi Suemasu |
|
| Participants: | U.S.-7 Japan-11 |
|
| (2) New Etiology of Lung Cancer | ||
| Honolulu, Hawaii, March 21-23, 1983 | ||
| Organizers: | Dr. Herbert S. Rosenkranz Dr. Ernst Wynder Dr. Takeshi Hirayama |
|
| Participants: | U.S.-12 Japan-7 |
|
| (3) Carcinogenesis and Environmental Factors | ||
| Dedham, Massachusetts, March 28-29, 1983 | ||
| Organizers: | Dr. Steven R. Tannenbaum Dr. Gerald N. Wogan Dr. Takashi Sugimura Dr. Shigeaki Sato |
|
| Participants: | U.S.-11 Japan-8 |
|
| (1) Dr. Hiroyasu Esumi Virology Division, National Cancer Center Research Institute, Tokyo |
||
| Dates: | May 1-25, 1982 | |
| Host Scientist: | Dr. James D. Watson, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York | |
| (2) Dr. Hiroshi Handa Institute of Medical Science University of Tokyo, Tokyo |
||
| Dates: | June 12-September 2, 1982 | |
| Host Scientist: | Dr. Phillip A. Sharp, Massachusetts Institute of Technology, Cambridge, Massachusetts | |
| (3) Dr. Ohtsura Niwa Department of Experimental Radiology, Faculty of Medicine, Kyoto University, Kyoto |
||
| Dates: | August 2-September 16, 1982 | |
| Host Scientist: | Dr. James W. Gautsch, Department of Cellular and Developmental Immunology, Scripps Clinic and, Research Foundation, La Jolla, California | |
| (4) Dr. Kunito Yoshiike Department of Enteroviruses, National Institute of Health, Tokyo |
||
| Dates: | August 10-October 19, 1982 | |
| Host Scientist: | Dr. Kenneth K. Takemoto, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland |
|
| (5) Dr. Tetsuya Kamataki Department of Pharmacology, School of Medicine, Keio University, Tokyo |
||
| Dates: | February 28-March 26, 1983 | |
| Host Scientist: | Dr. F. P. Guengerich, Vanderbilt University Medical School, Nashville, Tennessee | |
| (6) Dr. Yuzo Hayashi Division of Pathology, National Institute of Hygienic Sciences, Tokyo |
||
| Dates: | March 28-April l, 1983 | |
| Host Scientist: | Dr. Ronald W. Moch, Division of Pathology, Bureau of Food, Food and Drug Administration, Washington, DC | |
| (1) Immunogenetic Analyses of the Expression of Tumor Antigens and Responses to Tumors | ||
| Osaka, Japan, November 29-December l, 1982 | ||
| Organizers: | Dr. Toshiyuki Hamaoka Dr. Richard J. Hodes |
|
| Participants: | U.S.-5 Japan-14 |
|
| (2) Gene Transfer in Animal Cells and Activation of Cellular Oncogenes | ||
| Honolulu, Hawaii, January 17-19, 1983 | ||
| Organizers: | Dr. Yoshio Okada Dr. George F. Vande Woude |
|
| Participants: | U.S.-6 Japan-7 |
|
| (3) Cytology Automation | ||
| New York, New York, February 20-22, 1983 | ||
| Organizers: | Dr. Yoshio Tenjin Dr. Myron Melamed |
|
| Participants: | U.S.-16 Japan-7 Netherlands-1 |
|
| (1) Dr. Hideko Urushihara Department of Viral Oncology, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo |
||
| Dates: | August 28-September 15, 1982 | |
| Host Scientist: | Dr. Peter C. Hoppe, Jackson Laboratory, Bar Harbor, Maine | |
| (2) Dr. Mikio Yamashita Electrotechnical Laboratory, Ministry of International Trade and Industry, Tsakuba, Ibraki-Ken, Japan |
||
| Dates: | November 1-30, 1982 | |
| Host Scientist: | Dr. Marvin A. vanDilla, Lawrence Livermore National Laboratory, Livermore, California | |
| (1) High-LET Particle Irradiation and Other Approaches to Increasing Effectiveness of Radiation Therapy for Cancer | ||
| Chiba, Osaka, Japan, October 2-5, 1982 | ||
| Organizers: | Dr. Mitsuyuki Abe Dr. Glenn E. Sheline |
|
| Participants: | U.S.-9 Japan-19 |
|
| (2) Eighth Annual Treatment Area Review Meeting | ||
| Bethesda, Maryland, November 22-24, 1982 | ||
| Organizers: | Dr. Yoshio Sakurai Dr. Bruce A. Chabner Dr. Stephen A. Sherwin |
|
| Participants: | U.S.-22 Japan-8 |
|
| (1) Dr. Makoto Ogawa Cancer Chemotherapy Center, Tokyo, Japan |
||
| Dates: | July 9-July 22, 1982 | |
| Host Scientist: | Dr. Bruce A. Chabner, Division of Cancer Treatment, National Cancer Institute, Bethesda, Maryland | |
| (2) Dr. Hisashi Majima Chiba Cancer Center, Chiba, Japan |
||
| Dates: | December 1-December 14, 1982 | |
| Host Scientist: | Dr. Bruce A. Chabner, Division of Cancer Treatment, National Cancer Institute, Bethesda, Maryland | |
| (3) Dr. Joel E. Tepper Department of Radiation Medicine, General Hospital, Boston, Massachusetts |
||
| Dates: | September 29-October 13, 1982 | |
| Host Scientist: | Dr. Mitsuyuki Abe, Department of Radiology, Faculty of Medicine, Kyoto University, Kyoto, Japan | |
| (1) Differences in Lymphocytic Disease in the U.S. and Japan |
||
| Fred Hutchinson Cancer Research Center, Seattle, Washington September 6-7, 1982 | ||
| Organizers: | Dr. Mizu Kojima Dr. Marshall E. Kadin |
|
| Participants: | U.S.-15 Japan-13 Germany-1 United Kingdom-1 |
|
| (2) Human Hepatocarcinogenesis | ||
| Honolulu, Hawaii, January 20-22, 1983 | ||
| Organizers: | Dr. Wataru Mori Dr. Hans Popper |
|
| Participants: | U.S.-6 Japan-7 Canada-1 |
|
| (1) Dr. Teruyo Sakakura Department of Experimental Pathology, Aichi Cancer Center, Nagoya, Japan |
||
| Dates: | February 13-March 27, 1983 | |
| Host Scientist: | Dr. Takami Oka, Laboratory of Biochemistry and Metabolism, National Institute of Arthritis, Diabetes, and Digestive and Kidney Diseases, Bethesda, Maryland | |
| (2) Dr. Yasuo Takano Department of Pathology, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan |
||
| Dates: | March 28-May 28, 1983 | |
| Host Scientist: | Dr. Marshall E. Kadin, Department of Laboratory Medicine, University of Washington, Seattle, Washington | |
| (3) Dr. Nobuo Nemoto Department of Experimental Pathology, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan |
||
| Dates: | March 28-April 10, 1983 | |
| Host Scientist: | Dr. Tsuyoshi Kakefuda, Laboratory of Molecular Carcinogenesis, National Cancer Institute, Bethesda, Maryland | |
| (4) Dr. Tadashi Utakoji Cytogeneticist, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan |
||
| Dates: | March 27-April 10, 1983 | |
| Host Scientists: | Dr. E. H. Blackburn, Department of Molecular Biology, University of California, Berkeley, and Dr. John Carbon, Department of Biological Sciences, University of California, Santa Barbara, California |
|
| (5) Dr. Marshall Kadin Department of Laboratory Medicine, University of Washington, Seattle, Washington |
||
| Dates: | April 11-May 2, 1983 | |
| Host Scientist: | Dr. M. Hanaoka, Institute for Virus Research, Kyoto University, Kyoto, Japan | |
|
Year
|
Investigator
|
Material
|
| 1979 | P. Marks (New York) | Dihydroteleocidin B |
| I. B. Weinstein (New York) | Dihydroteleocidin B | |
| T. Slaga (Oak Ridge) | Dihydroteleocidin B | |
| 1980 | W. Troll (New York) | Teleocidin |
| I. B. Weinstein (New York) | Teleocidin | |
| T. Kakunaga (Bethesda) | Teleocidin Hydrolized Teleocidin Dihydroteleocidin B |
|
| S. H. Yuspa (Bethesda) | Teleocidin | |
| R. B. Heberman (Bethesda) | Teleocidin | |
| 1981 | I.B. Weinstein (New York) | Lyngbyatoxin A Tetrahydrolyngbyatoxin A Teleocidin Teleocidin B Debromoaplysiatoxin Aplysiatoxin |
| T. Kakunaga (Bethesda) | Teleocidin Aplysiatoxin Debromoaplysiatoxin |
|
| S.H. Yuspa (Bethesda) | Teleocidin | |
| W. Troll (New York) | Teleocidin | |
| F.P. Becker (Houston) | Teleocidin | |
| M. Shoyab (Bethesda) | Teleocidin | |
| C. Heidelberger (LOS Angeles) | Teleocidin | |
| H. Huberman (Oak Ridge) | Teleocidin | |
| C. Borek (New York) | Teleocidin | |
| M. Vale (San Diego) | Teleocidin | |
| C.H. Kwong (Madison) | Teleocidin | |
| N. Mukai (Boston) | Teleocidin | |
| N. Shimizu (Tucson) | Teleocidin and other compounds | |
| D.W. Golde (LOS Angeles) | Teleocidin | |
| S.R. Tannenbaum (Boston) | Teleocidin | |
| C.C. Harris (Bethesda) | Teleocidin | |
| T. Slaga (Oak Ridge) | Teleocidin | |
| L. Levine (Waltham) | Teleocidin B Dihydroteleocidin B |
|
| J.E. Trosko (Michigan) | Teleocidin | |
| V.E. Steele (North Carolina) | Teleocidin Hydrolyzed teleocidin |
|
| M. Rosner (Boston) | Hydrolyzed teleocidin | |
| J.S. Pagano (North Carolina) | Teleocidin | |
| 1982 | J.E. Trosko (Michigan) | Hydrolyzed teleocidin Teleocidin B |
| G.R. Gunther (Memphis) | Teleocidin | |
| L. Kopelowich (New York) | Teleocidin | |
| M. Mukai (Boston) | Teleocidin | |
| S. Nesnow (North Carolina) | Teleocidin | |
| H.R. Herschman (Los Angeles) | Teleocidin | |
| L. Diamond (Philadelphia) | Teleocidin | |
| W. Troll (New York) | Teleocidin Lyngbyatoxin A Aplysiatoxin Debromoaplysiatoxin |
|
| T. Kakunaga (Bethesda) | Lyngbyatoxin A Aplysiatoxin Debromoaplysiatoxin |
|
| C.R. Geard (New York) | Teleocidin | |
| R.E. Moore (Honolulu) | Teleocidin | |
| N. Colburn (Bethesda) | Dihydroteleocidin B | |
| A.H. Tashjian (Boston) | Dihydroteleocidin B | |
| R.N. Mascardo (Connecticut) | Teleocidin Dihydroteleocidin B |
|
| D. Kabelitz (New York) | Dihydroteleocidin | |
| J.L. Seltzer (St. Louis) | Dihydroteleocidin B | |
| S.M. Camiolo (New York) | Dihydroteleocidin B | |
| M. Mukai (Boston) | Teleocidin | |
| R.K. Boutwell (Madison) | Teleocidin | |
| L.A. Loeb (Seattle) | Teleocidin | |
| 1983 | B.I. Carr (California) | Teleocidin |
| M. Mukai (Boston) | Teleocidin | |
| H.P. Koeffler (Los Angeles) | Teleocidin | |
| M. Rosner (Boston) | Teleocidin | |
| D. Benjamin (Bethesda) | Teleocidin | |
| C.E. Wenner (New York) | Dihydroteleocidin B | |
| M. Lipkin (New York) | Teleocidin | |
| C.C. Harris (Bethesda) | Teleocidin Aplysiatoxin Debromoaplysiatoxin |