I. ETIOLOGY
Fujiki, H., Mori, M. Nakayasu, M., Terada, M., Sugimura, T., and Moore, R.E.: Indole alkaloids: Dihydroteleocidin B, teleocidin, and lyngbyatoxin A as members of a new class of tumor promoters. Proc. Natl. Acad. Sci., 78: 3872-3876, 1981.
Nakayasu, M., Fujiki, H., Mori, M., Sugimura, T., and Moore, R.E.: Teleocidin, Lyngbyatoxin A and Their Hydrogenated Derivatives, Possible Tumor Promoters, Induce Terminal Differentiation in HL-60 Cells. Cancer Lett., 12: 271-277, 1981.
Oppermann, H., Levinson, A.D., Levintow, L., Varmus, H.E., Bishop, J.M., and Kawai, S.: Two Cellular Proteins that Immunoprecipitate with the Transforming Protein of Rous Sarcoma Virus. Virology, 113: 736-751, 1981.
Sakamoto, H., Terada, M., Fujiki, H., Mori, M., Nakayasu, M., Sugimura, T., and Weinstein, I.B.: Stimulation of Prostaglandin Production and Choline Turnover in HeLa Cells by Lyngbyatoxin A and Dihydroteleocidin B. Biochem. and Biophys. Res. Comm., 102: 100-107, 1981.
Umezawa, K., Weinstein, I.B., Horowitz, A., Fujiki, H., Matsushima, T., and Sugimura, T.: Similarity of teleocidin B and phorbol ester tumour promoters in effects on membrane receptors. Nature, 290: 411-413, 1981.
Gray, G.E., Pike, M.C., Hirayama T., Tellez, J., Gerkins, V., Brown, J.B., Casagrande, J.T., and Henderson, B.E.: Diet and Hormone Profiles in Teenage Girls in Four Countries at Different Risk for Breast Cancer - Short Report. Preventive Medicine, 11: 108-113, 1982.
Hirakawa, T., Kakunaga, T., Fujiki, H., and Sugimura, T.: A New Tumor-Promoting Agent, Dihydroteleocidin B, Markedly Enhances Chemically Induced Malignant Cell Transformation. Science, 216: 527-529, 1982.
Huberman, E., Blaslawsky, G.R., Callaham, M., and Fujiki, H.: Induction of differentiation of human promyelocytic leukemia (HL-60) cells by teleocidin and phorbol-12-myristate-13-acetate. Carcinogenesis, vol. 3, pp. 111-114, 1982.
Mathey-Prevot, B., Hanafusa, H., and Kawai, S.: A Cellular Protein Is Immunologically Crossreactive with and Functionally Homologous to the Fujinami Sarcoma Virus Transforming Protein. Cell, 28: 897-906, 1982.
Richards, W.L., Tsukada, Y., and Potter, V.R.: Phenotypic Diversity of gammaglutamyl-transpeptidase Activity and Protein Secretion in Hepatoma Cell Lines. Cancer Research, 42: 1374-1383, 1982.
Sugimura, T., Fujiki, H., Mori, M., Nakayasu, M., Terada, M., Umezawa, K., and Moore, R.E.: Teleocidin: New Naturally Occurring Tumor Promoter. Carcinogenesis, Volume 7, Edited by E. Hecker et al., Raven Press, New York, 1982, pp.69-73.
Nonoyama, M. and Hirai, K.: Organization and expression of the DNAs of Marek's disease virus and herpesvirus of turkeys. In: "HERPES VIRUS DNA-Recent Studies on the Internal Organization and Replication of the Viral Genome- , " Edited by Y. Becker, Martinus Nijhoff Publishers, Hague, (1982), pp. 437-461 .
Troll, W., Witz, G., Goldstein, B., Stone, D., and Sugimura, T.: The Role of Free Oxygen Radicals in Tumor Promotion and Carcinogenesis. Carcinogenesis, Volume 7, Edited by E. Hecker et al., Raven Press, New York, 1982, pp. 593-597.
Troll, W.: Free Oxygen Radicals - Modulator of Carcinogens, (to be published).
II. BIOLOGY AND DIAGNOSIS
Tasaka, M. and Takeuchi, I.: Role of cell sorting in pattern formation in Dictyostelium discoideum. Differentiation, 18: 191-196, 1981.
Takeuchi, I., Tasaka, M. Oyama, M. Yamamoto, A., and Amagai, A. : Pattern formation in the development of Dictyostelium discoideum. In "Proceedings of IX Congress of the Inter-national Society of Developmental Biologists" (M. M. Burger, ed.) Alan R. Liss, Inc., New York.
Barondes, S. H.: Lectins: Their multiple endogenous cellular functions. In Annual Review of Biochemistry, 50: 207-231, 1981.
Cooper, D. N. and Barondes, S.H.: Isolectins from Dictyostelium purpureum: Purification and characterization of seven functionally distinct forms. J. Biol. Chem., 256: 5046-5051, 1981.
Lieberman, M. A., Raben, D., and Glaser, L.: Cell Surface Associated Growth Inhibitory Proteins. Expt. Cell. Res., 133: 413-419, 1981.
Takeichi, M., Atsumi, T., Yoshida, C., Uno, K., and Okada, T.S.: Selective adhesion of embryonal carcinoma cells and differentiated cells by Ca2+ dependent sites. Develop. Biol., 87: 340-350, 1981.
Fujisawa, H. et al.,: Retinotopic analysis of fiber pathway in amphibians. I. The adult newt Cynops pyrrhogaster. Brain Res., 206: 9-20, 1981.
Fujisawa, H.: Retinotopic analysis of fiber pathways in the regenerating retinotectal system of the adult newt Cynops pyrrhogaster. Brain Res., 206: 27-37, 1981.
Fujisawa, H. et al.: Branching of regenerating retinal axons and preferential selection of appropriate branches for specific neuronal connection in the newt. Develop. Biol., (in press).
Coffman, R. and Weissman, I. J. Exp. Med. 153: 269, 1981.
Nottenburg, C. and Weissman, I. Proc. Natl. Acad. Sci., 1981.
Butcher, E., Stevens, S. K., Reichert, R. and Weissman, I. L.: Recent advances in mucosal immunity, K. Sell, ed., Raven Press, New York, (in press).
Kitamura, Y. et al. : Spleen colony-forming cell as common precursor for tissue mast cells and granulocytes. Nature, 291, 159, 1981.
Hiai, H., Nishi, Y. Miyazawa, T. et al. : Mouse lymphoid leukemias: Symbiotic complexes of neoplastic lymphocytes and their microenvironments. J. Natl. Cancer Inst., 66: 713-722, 1981.
Hiai, H., Nishizuka, Y.: Growth stimulation of microenvironment-dependent mouse leukemias by tumorpromoting phorbol esters. J. Natl. Cancer Inst., 67, 1981.
Okayama, M., Oguri, K., Sato, C. and Kimura, K.: In Proc. 6th Int. Symp. on Glycoconju-gates (T. Yamakawa, T. Osawa and S. Handa, eds.) pp. 371-372, Japan Science Society Press, Tokyo, 1981.
De Crombrugghe, B. and Pastan, I.: Structure and Regulation of a Collagen Gene. TIBS, 1981.
Avvedimento, E., Yamada, Y., Lovelace, E., de Crombrugghe, B. and Pastan, I.: Decrease in the levels of nuclear RNA precursors for!!
!2-collagen in Rous sarcoma virus transformed fibroblasts. Nucl. Acids. Res., 9: 1123-1131, 1981. Sobel, M. E., Yamamoto, T. de Crombrugghe, B. and Pastan, I.: Regulation of procellagen mRNA levels in Rous sarcoma virus-transformed chick embryo fibroblasts. Biochem., 30: 2678-2684, 1981.
Vogeli, G., Ohkubo, H., Sobel, M., Yamada, Y., Pastan, I. and de Crombrugghe, B.: Structure of the promoter for chicken!!
!2 type I collagen gene. Proc. Natl. Acad. Sci. U.S.A., 78: 5334-5338, 1981. Hayashi, H. and Ishimaru Y.: International Review of Cytology, 70: 139-215, 1981.
Ikawa, Y., Imai, N., Sagata, N., Urushihara, H., Soma, G-1., Amanuma, H., and Obinata, M.: Erythroid Differentiation in Embryonal Teratocarcinoma Cells, in "Teratocarcinoma and Embryonic Cell Interactions" (Muramatsu, T., Ikawa, Y., Gachelin, G., and Moscona, A.A. eds.), Japan Scientific Societies Press, Tokyo and Academic Press, Inc., New York, (in press).
Obinata, M., Uchiyama, Y., Kameji, R., and Ikawa, Y.: Analysis on the Molecular Mechanism of Globin Gene Expression in Phenotypic Variants of Cultured Friend Leukemia Cells, Leukemia Research, 5: 129-140, 1981.
Fischer, D.G., Hubbard, W.J., and Koren, H.S.: Tumor cell killing by freshly isolated peripheral blood monocytes. Cell. Immunol., 58: 426-435, 1981.
Weston, P.A., Jensen, P.J., Levy, N.L., and Koren, H.S.: Spontaneous cytotoxicity against virus-infected cells: Relationship to NK against uninfected cell lines and to ADCC. J. Immunol., 126: 1220-1224, 1981.
Copeland, S.C., Koren, H.S., and Jensen, P.J.: The involvement of endogenous interferon in natural killing assays. Cell. Immunol., (in press).
Koren, H.S., Anderson, S.J., and Adams, D.O.: Studies on the antibody dependent cellular cytotoxicity (ADCC) of thioglycollate-stimulated and BCG-activated peritoneal macro-phages in vitro. Cell. Immunol., 57: 51-61, 1981.
Koren, H.S., Meltzer, M.S., and Adams, D.O.: The ADCC capacity of macrophages from C3H/HeJ and A/J mice can be augmented by BCG. J. Immunol., 126: 1013-1015, 1981.
Singer, A., Hathcock, K.S., and Hodes, R.J.: Self-recognition in allogeneic radiation bone marrow chimeras. A radiation-resistant host element dictates the self specificity and immune response gene phenotype of T-helper cells. J. Exp. Med. 153: 1286-1301, 1981.
Singer, A., Morrissey, P.J., Hathcock, K.S., Ahmed, A., Scher, I., and Hodes, R.J.: Role of the major histocompatibility complex (MHC) in T cell activation of B cell subpopulations. Lyb5 and Lyb5 B cell subpopulations differ in their requirement for MHC restricted T cell recognition. J. Exp. Med. 154: 501-516, 1981.
Gress, R.E., Wesley, M., and Hodes, R.J.: The role of H-2 in T cell recognition. J. Immunol. 127: 1763-1766, 1981.
Kruisbeek, A.M., Hodes, R.J., and Singer, A.: Cytotoxic T lymphocyte responses by chimeric thymocytes: Self-recognition is determined early in T cell development. J. Exp. Med. 153: 13-29, 1981.
Koyama, S., Fujimoto, S., Tada, T., and Sakita, T.: Effect of bacillus Calmette-Guerin cell wall skeleton on the induction of the cytotoxic and suppressor T cells against syngeneic tumor in the mouse. Int. J. Cancer. 27: 829-835, 1981.
Vitetta, E.S., Krolick, K.A., and Uhr, J.W.: Neoplastic B cells as targets for antibody-ricin A chain. Immunological Reviews, 1981, (in press).
Forman, J., Ciavarra, R., and Vitetta, E.S.: Cytotoxic T cells specific for antigens expressed on surface immunoglobulin positive cells. J. Exp. Med., 1981 (in press).
Pure, E., Isakson, P.C., Takatsu, K., Hamaoka, T., Swain, S.L., Dutton, R.W., Dennert, G., Uhr, J.W., and Vitetta, E.S.: Induction of B cell differentiation by T cell factors.:
I. Stimulation of lgM secretion by products of a T cell hybridoma and a T cell line. J. of Immunol., 1981, (in press).
Isakson, P.C., Pure, E., Uhr, J.W., and Vitetta, E.S.: Induction of proliferation and differentiation of neoplastic B cells. In B lymphocytes in the immune response (Scottsdale Symposium) Elsevier North/Holland, New York, Vol. 15, pp. 501 -506, 1981.
Muirhead, M., Vitetta, E.S., Isakson, P., Krolick, K., Dees, J., and Uhr, J.W.: Increased susceptibility to the lethal effects of bacterial lipopolysaccharide in mice with a B-cell leukemia (BCL). J. Natl. Cancer Inst. 66: 745-753, 1981.
Anderson, S.A., Isakson, P.C., Pure, E., Muirhead, M., Uhr, J.W., and Vitetta, E.S.: Immuno-suppression in the murine B cell leukemia (BCL): Role of an adherent cell in the suppression of primary in vitro antibody responses. J. Immunol., 126: 1603-1607, 1981.
Black, P.L., Vitetta, E.S., Porman, J., Kang, C.Y., May, P., and Uhr, J.W.: Role of glycosylation in the H-2 restricted cytolysis of virus infected cells. Eur. J. Immunol., 11 : 48-55, 1981.
Muraguchi, A., Kishimoto, T., Miki, T., Kuritani, T., Kaieda, K., and Yamamura, Y.: T cell replacing factor (TRF)-induced IgG-section in a human B blastoid cell line and demonstration of acceptors for TRF. Journal of Immunology, 127: 412, 1981.
Okada, M., Yoshimura, N., Kaieda, T., Yamamura, Y., and Kishimoto, T.: Establishment and characterization of human T hybrid cells secreting immunoregulatory molecules. Proc. Natl. Acad. Sci., U.S.A., 1981, (in press).
Kishimoto, T., Yoshizaki, K., Kuritani, T., Muraguchi, A., Miki, T., Nakagawa, T., and Yamamura, Y.: Induction of proliferation and Ig-secretion in human monoclonal B cells with anti-immunoglobulin and T cell products. In B lymphocytes in the immune response, edt. by Klinman, Mosier, Scher and Vitetta. pp. 515, 1981.
Hashimoto, Y., and Masuko, T.: Hybridoma established from spleen cells of a rat immune to syngeneic bladder tumor; its secretion of monoclonal antibody specific for a tumor cell clone in a long-term transplanted bladder tumor line. Gann, 72: 329-330, 1981.
Endoh, H., Suzuki, Y., and Hashimoto, Y.: Antibody coating of liposomes with l-ethyl-3-(3-dimethylaminopropyl) carbodimide and the effect on target specificity. J. Immunol. Metho., 44: 79-85, 1981.
Masuko, T., and Hashimoto, Y.: Cell surface antigens in normal and neoplastic urinary bladder epithelial cells of the rat. JNCI, 67: 423-429, 1981 .
Masuko, T., and Hashimoto, Y.: Emergence of an epidermis-associated cell surface antigen in epithelial cells of the rat urinary bladder in carcinogenesis. JNCI, 67: 431-436, 1981.
Abo, T., Kawate, T., Itoh, K., and Kumagai, K.: Studies on the bioperiodicity of the immune response. I. Circadian rhythms of human T, B and K cell traffic in the peripheral blood. J. Immunol., 126: 1360-1363, 1981.
Kawate, T., Abo, T., Hinuma, S., and Kumagai, K.: Studies on the bioperiodicity of the immune response. II. Co-variations of murine T and B cells and a role of corticosterioid. J. Immunol., 126: 1364-1367, 1981.
Takatsu, K., Tominaga, A., and Hamaoka, T.: X-linked recessive inheritance of a defective responsiveness to T cell-replacing factor in DBA/2Ha mice. Immunology Letters, 3: 137-143, 1981.
Tsuchida, T., Fujiwara, H., Tsuji, Y., and Hamaoka, T.: Studies on metastasis in syngeneic murine tumor systems. 111. Inhibitory effect of propionibacterium acnes-activated macro-phages on the tumor metastasis enhanced by tumor-specific immunosuppression. GANN, 72: 205-212, 1981.
Fujiwara, H., Tsuchida, T., Mizuochi, T., Kohmo, T., and Hamaoka, T.: Suppressive effect of X-irradiated tumor cell-presensitization on the induction of syngeneic tumor immunity. III. The mechanism of specific suppression in effector T cell clones against tumor-associated transplantation antigens. GANN, 73, 1981, (in press).
Hamaoka T., Takatsu, K., Okuno, K., and Tsuchida, T. : Functional characterization of the killer helper factor responsible for the induction of cytotoxic T lymphocytes from thymocytes, and evidence for the nature of this factor as distinct from T cell-replacing factor (TRF) in regards to B cell triggering. J. Immunol., 127: 659-665, 1981.
Fujimoto, J., Ishii, Y., Koshiba, H., Matsuura, A., Ogasawara, M., and Kikuchi, K.: Human thymus antigen: Characterization and its expression on human leukemias. Am. J. Hematol., 10: 145-156, 1981.
Ishii, Y., Fujimoto, J., Koshiba, H., and Kikuchi, K.: Isolation and partial characterization of a 72,000-dalton glycoprotein (Tgp 72) on human thymus and T cells: Possible relation-ship to mouse Ly-1 antigens. J. Immunol., 126: 2171-2182, 1981.
Nishio, C., Ishii, Y., Jimbo, K., and Kikuchi, K.: Immunochemical characterization of murine B16 melanoma associated antigens and their detections in sera of tumor-bearing hosts by radioimmunoassay. GANN, 72: 213-219, 1981.
Yamanaka, N., Ishii, Y., Koshiba, H., Mikuni, C., Ogasawara, M., and Kikuchi, K.: A study of surface markers in non-Hodgkin's lymphoma by using anti-T and anti-B lymphocyte sera. Cancer, 47: 311-318, 1981.
Yamamoto, S., and Tokunaga, T.: D-Mannose as a component of the macrophage surface receptor for macrophage-activating factor (MAF) in mice. Cell. Immunol., 61 : 319-331 , 1981.
Akagawa, K.S., Momoi, T., Nagai, Y., and Tokunaga, T.: Appearance of asialo GM1 glycosphingolipid on the cell surfaces during lymphokine-induced differentiation of M1 cells. FEBS Letters, 130: 80-84, 1981.
Kasai, M., Yoneda, T., Habu, S., Maruyama, Y., Okumura, K., and Tokunaga, T.: In vivo effect of anti-asialo GM1 antibody on natural killer activity. Nature, 291 : 334-335, 1981.
Tokuhisa, T., and Taniguchi, M.: Two distinct allotypic determinants on the antigen-specific suppressor and enhancing T cell factors that are encoded by genes linked to the immunoglobulin heavy chain locus. J. Exp. Med., (in press).
Shinohara, N., Taniguchi, M., and Kojima, M. : Mouse alloantibodies capable of blocking cytotoxic T cell function. 111. Studies on the Mechanism of blocking of CML by Anti-Lyt-2 antibodies. J. Immunol., (in press).
Wakabayashi, S., Taniguchi, M., Tokuhisa, T., Tomioka, H., and Okamoto, S.: Cytotoxic T lymphocytes induced by syngeneic mouse melanoma cells recognize human melanomas. Nature, (in press).
Gillis, S., Gillis, A.E., and Henney, C.S. : Monoclonal antibody directed against interleukin 2. I. Inhibition of T lymphocyte mitogenesis and the in vitro differentiation of a alloreactive cytotoxic T cells. J. Exp. Med., 154: 983, 1981.
Bhan, A.K., Nadler, L.M., Stashenko, P., and McClusky, R.T., Schlossman, S.F.: Stage of B cell differentiation in human lymphoid tissue. J. Exp. Med., 154: 737, 1981.
Bromberg, J.S., Benacerraf, B., Green, M.I.: Mechanisms of regulation of cell-mediated immunity. VII. Suppressor T cells induced by suboptimal doses of antigen plus an I-J specific allogeneic effect. J. Exp. Med., 153: 437, 1981.
Dietz, M.H., Sy, M-S, Benacerraf, B., Nisonoff, A., Greene, M.I., and Germain, R.N.: Antigen-and receptor-drived regulatory mechanisms VII. H-2-restricted anti-idiotypic suppressor factor from efferent suppressor T cells. J. Exp. Med., 153: 450, 1981.
Sy, M-S., Nisonoff, A., Germain, R.N., Benacerraf, B., and Greene, M.I.: Antigen- and receptor-drived regulatory mechanisms. VIII. Suppression of idiotype-negative, p-azobenzenear-sonate-specific T cells results from the interaction of an anti-idiotypic second-order T suppressor cell with a cross-reactive-idiotype-positive, p-azobenzene arsonate-primed T cell target. J. Exp. Med., 153: 1415, 1981.
III. TREATMENT
Proceedings of the United States-Japan Meeting on Drug Development and Cancer Treatment Research: in Cancer Treatment Symposia, published by NCI, 1982, (in press).
IV. INTERDISCIPLINARY PROGRAM AND COORDINATION
Miller, R.W., Gilman, P.A., and Sugano, H.: Meeting Highlights, Differences in Lymphocytic Diseases in the United States and Japan. J. Natl. Cancer Inst. (JNCI), Volume 67, No. 3, September 1981, pp. 739-740.
V. OTHER
U.S.-Japan Cooperative Cancer Research Program : Progress Report-April 1980 through March 1981. The National Cancer Institute (Bethesda, Maryland, U.S.A.) and the Japan Society for the Promotion of Science (Tokyo, Japan), 1981.