ETIOLOGY PROGRAM AREA
| Program Coordinators: | Dr. I. Bernard Weinstein, United States Dr. Takashi Sugimura, Japan |
| Principal Advisors: | United States Dr. Thomas L. Benjamin Dr. Hidesaburo Hanafusa Dr. Warren Nichols Dr. Robert Miller Japan Dr. Shozo Takayama Dr. Hiroto Shimojo Dr. Susumu Nishimura Dr. Takeshi Hirayama |
ADMINISTRATIVE REPORT
SEMINARS
| Seminar on "Biochemical Epidemiology" | ||
| Honolulu, Hawaii, February 10 to February 12, 1981 |
||
| Organizers: | Dr. Allan H. Conney Dr. Susumu Nishimura |
|
| Participants: | United States-8; Japan-15; United Kingdom-1 | |
| Seminar on "Interspecies Correlations in Chemical Carcinogenesis" | ||
| Tokyo, Japan, March 19 to March 21, 1981 |
||
| Organizers: | Dr. Shozo Takayama Dr. Curtis C. Harris |
|
| Participants: | United States-8; Japan-11; United Kingdom-1 | |
EXCHANGE OF SCIENTISTS
| Dr. Hirota Fujiki, National Cancer Center Research Institute, Section of Studies on Metastases, Tokyo |
||
| Dates: | February 8 to March 6, 1981 | |
| Host Scientist: | Dr. Richard E. Moore, Professor, Department of Chemistry University of Hawaii at Manoa, Honolulu, Hawaii |
|
| Subject: | Isolation and purification of a new potential tumor promoter Lyngbyatoxin A from the marine blue-green algae Lyngbya majuscula. |
|
| Dr. Yoshio Okada, Research Institute for Microbial Diseases, Osaka University, Osaka |
||
| Dates: | October 27 to November 22, 1980 | |
| Host Scientists: | Dr. Hidesaburo Hanafusa, Rockefeller University, New York, New York Dr. Thomas L. Benjamin, Department of Pathology, Harvard Medical School, Boston, Massachusetts |
|
| Subject: | Selective introduction of macromolecules into living mammalian cells via Sendai virus fusion. |
|
| Dr. Takemi Yanagimoto, The Institute of Statistical Mathematics, Ministry of Education, Science, and Culture, Tokyo | ||
| Dates: | September 15 to October 5, 1980 | |
| Host Scientist: | Dr. William J. Blot, National Cancer Institute, National Institutes of Health, Bethesda, Maryland |
|
| Subject: | Statistical methods for the bioassay for carcinogenicity of chemicals in the environment. |
|
| Dr. Hiroyuki Shimizu, Aichi Cancer Center Research Institute, Division of Epidemiology, Nagoya |
||
| Dates: | October 1, 1979 to September 30, 1980 | |
| Host Scientist: | Brian E. Henderson, M.D., Professor and Chairman, Department of Community and Family Medicine, University of Southern California, Los Angeles, California |
|
| Subjects: | Epidemiologic studies of lung cancers of specific histologic types; and a case-control study of prostate cancer in Japanese living in Los Angeles County. |
|
| Dr. Nobuo Yamaguchi, The Institute of Medical Science, University of Tokyo, Tokyo |
||
| Dates: | August 7 to October 18, 1980 |
|
| Host Scientists: | Dr. David M. Livingston, Division of Medical Oncology, Sidney Farber Cancer Institute, Boston, Massachusetts; Dr. Thomas L. Benjamin, Department of Pathology, Harvard Medical School, Boston, Massachusetts |
|
| Subject: | Construction of SV40 virus mutants with a deletion of a tandem repeat sequence. |
|
| Dr. Hiroshi Yasue, Laboratory of Viral Oncology, Aichi Cancer Center, Nagoya |
||
| Dates: | August 28 to November 27, 1980 |
|
| Host Scientist: | Dr. Eiichi Ohtsubo, Associate Professor, Department of Microbiology, School of Basic Health Sciences, State University of New York at Stonybrook, New York |
|
| Subject: | Studies on the amplification of adenovirus DNA after its integration into cellular DNA utilizing recombinant DNA techniques to clone the junction between viral and cellular DNA. |
|
| Dr. Thomas L. Benjamin, Department of Pathology, Harvard University School of Medicine Boston, Massachusetts |
||
| Dates: | June 3 to June 17, 1980 |
|
| Host Scientists: | Dr. Hiroto Shimojo, Institute of Medical Science, University of Tokyo, Tokyo Dr. Geuki Kimura, Kyushu University, Kyushu Dr. Yohei Ito, Kyoto University, Kyoto Dr. Yoshio Okada, Osaka University, Osaka |
|
| Subject: | Discussion of ongoing studies on various oncogenicviruses including adenovirus, human papovaviruses, SV40 virus, and Shope papilloma virus. |
|
| Dr. Dezider Grunberger, Division of Environmental Sciences and Institute of Cancer Research, Columbia University, New York, New York |
||
| Dates: | March 19 to March 29, 1981 | |
| Host Scientist: | Dr. Susumu Nishimura, National Cancer Research Institute, Tokyo |
|
| Subject: | Interactions of carcinogens with DNA and changes in the structure of phenylalanine tRNA in carcinogen-induced tumors. | |
EXCHANGE OF MATERIALS
Dr. Takashi Sugimura and his colleagues have continued to provide scientists in the United States with samples of very potent mutagens generated from the pyrolysates of amino acids. These have included two new highly potent mutagens, 2-amino 3-methyl-imidazo (4,5-f) quinoline (designated IQ) and 2-amino-3, 4-dimethylimidazo (4,5,f) quinoline (designated Me-IQ), which were found in broiled fish and fried ground beef. In addition, they have provided U.S. scientists with samples of a new class of tumor promoters which are indole alkaloids. These compounds include teleocidin, dihydroteleocidin, and Lyngbyatoxin. In the near future they will also be providing samples of debromoaplysiatoxin and radioactive teleocidin. All of these compounds are of considerable interest, are difficult to purify, and are not commercially available. Thus they represent invaluable materials for U. S. scientists engaged in carcinogenesis research.