AGENDA
SEMINAR ON HIGH LET RADIATION AND COMBINED MODALITIES
November 10 to November 12, 1980, Honolulu, Hawaii
| Monday, November 10, 1980 | ||
| 8:30am | Welcome and Opening Comments | Glenn Sheline |
| INTERCOMPARISON STUDIES ON HIGH ENERGY PROTON DOSIMETRY | ||
| Chairmen: Dr. Joseph Castro and Dr. Tetsuo Inada | ||
| 8:40- 8:55 | Results of Dosimetry Intercomparison Studies Performed on United States and Japan Proton Beams | Lynn Verhey |
| 9:00- 9:10 | Comments on the Physical Intercomparison Studies of High Energy Protons | Katsuhiro Kawashima Akira Ito |
| 9:20- 9:35 | Radiobiological Intercomparison of Harvard and NIRS Proton Beams | Muneyasu Urano |
| 9:40- 9:50 | Comments on the Radiobiological Intercomparison Studies of High Energy Protons | Hiroshi Ohara |
| 10:00 | COFFEE | |
| PHYSICAL STUDIES ON PARTICLE THERAPY | ||
| Chairman: Dr. Katsuhiro Kawashima | ||
| 10:15-10:35 | Preliminary Experiments of Three Dimensional Proton Spot Beam Scanning | Kiyomitsu Kawachi Tatsuaki Kanai Tetsuo Inada |
| 10:45-11:05 | Treatment Planning Developments Arising from Proton Therapy | Lynn Verhey Michael Goitein |
| 11:15-11:35 | Neutrons: Plans, Do and See | Akira Ito |
| 11:45-12:05pm | Cobalt Rad Equivalent Dose Distribution for Charged Particle Beams | John Lyman |
| 12:15- 1:15 | LUNCH | |
| 1:15-1:35 | Absorbed Dose Determinations for Clinical Pion Beams | Alfred Smith |
| 1:45- 2:05 | Dynamic Treatment with Pion Beams | Alfred Smith |
| BIOLOGICAL STUDIES ON PARTICLE THERAPY | ||
| Chairmen: Dr. Malcolm Bagshaw and Dr. Mitsuyuki Abe | ||
| 2:15- 2:35pm | Biological Effectiveness of the 70 MeV Protons at NIRS | Hiroshi Ohara |
| 2:45- 3:05 | Relative Biological Effectiveness for 160 MeV Proton Beams in Various Murine Tissues | Muneyasu Urano |
| 3:15 | COFFEE | |
| 3:30- 3:50 | Radiobiological Studies of Heavy Ions and Pions | Kiyohiko Sakamoto |
| 4:00- 4:20 | Update on Cellular Radiobiology of Heavy Ion Beams for Radiotherapy | Eleanor Blakely |
| 4:30- 4:50 | Prospects for Therapeutic Gains from Negative Pi Meson Beams | John Yuhas |
| 7:00 | RECEPTION and DINNER | |
| Tuesday, November 11, 1980 FUTURE PLANNING OF MEDICALLY DEDICATED ACCELERATORS |
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| Chairmen: Dr. Kiyohiko Sakamoto and Dr. Alfred Smith | ||
| 8:30- 8:50am | Report of the Japanese Committee on Medically Dedicated Accelerators: Design of Medically Dedicated Accelerators | Tadayoshi Fukumoto |
| 9:00- 9:20 | Design Studies of Medically Dedicated Heavy Ion Synchrotron | Yasuo Hirao (Reader: Dr. Fukumoto) |
| 9:30- 9:50 | Medical Proton Facilities in Tsukuba University | Tetsuo Inada |
| 10:00 | COFFEE | |
| 10:15-10:35 | Medical Electron Linear Accelerator for the Pion Generation | Kaneo Tsukada |
| 10:45-11:05 | Medically Dedicated Accelerators | Hermann Grunder |
| RADIATION SENSITIZERS AND PROTECTIVE AGENTS | ||
| Chairmen: Dr. William Dewey and Dr. Yuu Iino | ||
| 11:15-11:35am | Basic Rationale for the Use of Radio-sensitizers and the Development of Optimum Sensitizing Compounds in the united States | Theodore Phillips |
| 11:45-12:05pm | Protective Effects of WR-2721 and its Clinical Applications | Takamasa Tanaka |
| 12:15- 2:00 | LUNCH | |
| 2:00- 2:20 | Reduced Normal Tissue Toxicity as a Means of Improving the Therapy of Solid Tumors | John Yuhas |
| 2:30- 2:50 | Radioprotective Effects of Superoxide Dismutase: Fundamental and Clinical Studies | Mitsuyuki Abe |
| 3:00- 3:20 | High Dose Phase II Studies Using WR-2721 | Morton Kligerman |
| 3:30 | COFFEE | |
| 3:45- 4:05 | Phase I Clinical Study of the Hypoxic Cell Sensitizer, Misonidazole, in Japan | Yasuto Onoyama |
| 4:15- 4:35 | Clinical Trials with Hypoxic Cell Sensitizers in the RTOG | Theodore Phillips |
| 4:45- 5:05 | Combined Treatment of Lung Cancer with Ro-07-0582 and Radiation | Mitsuyuki Abe |
| Wednesday, November 12, 1980 HYPERTHERMIA |
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| Chairmen: Dr. Yasushi Shigematsu and Dr. John Yuhas | ||
| 8:30- 9:00am | Rationale for Hyperthermia in Radiation Therapy | William Dewey |
| 9:10- 9:30 | Effect of Elevated Temperature on Murine Tumors and Normal Tissue | Muneyasu Urano |
| 9:40- 10:00 | Clinical Experiences with Hyperthermia | Mitsuyuki Abe |
| 10:10 | COFFEE | |
| 10:35-10:50 | A Plan for the Hyperthermic Treatment of Cancer | Malcolm Bagshaw |
| CLINICAL TRIALS WITH PARTICLE THERAPY AND COMBINED MODALITIES | ||
| Chairmen: Dr. Theodore Phillips and Dr. Hiroshi Tsunemoto | ||
| 11:00- 11:20am | Scoring System for the Evaluation of Particle Therapy | Atsuo Akanuma |
| 11:30-11:50 | United States Scoring System for Neutron Therapy | David Hussey |
| 12:00 | LUNCH | |
| 1:00-1:20pm | Japanese Experiences with Neutron Clinical Trials | Hiroshi Tsunemoto Yuu Iino Shinroku Morita |
| 1:30- 1:50 | United States Experience with Neutron Clinical Trials | David Hussey |
| 2:00- 2:20 | Clinical Experience with Pions | Morton Kligerman |
| 2:30- 2:50 | Progress Report on Heavy Charged Particle Radiotherapy at Lawrence Berkeley Laboratory | Joseph Castro |
| 3:00 | COFFEE | |
| 3:15- 3:35 | Experimental Design Considerations in Combining Drugs and Irradiation | Stephen Carter |
| 3:45- 4:05 | Combined Treatment of Intraoral Carcinoma with Bleomycin and Radiation | Yasushi Shigematsu |
| 4:15- 4:35 | Results of Intraoperative Radiotherapy of Gastric Cancer | Mitsuyuki Abe |
| 4:45 | Closing Remarks | Yoichiro Umegaki Glenn Sheline |
| 7:00 | FAREWELL RECEPTION and DINNER | |
PARTICIPANTS
JAPAN
Mitsuyuki Abe, M.D.
Professor, Department of Radiology
Kyoto University
Sakyo-ku, Kyoto 606
Atsuo Akanuma, M.D.
Lecturer, Department of Radiology
University of Tokyo
Bunkyo-ku, Tokyo 113
Tadayoshi Fukumoto, Ph.D.
Professor, National Laboratory for High Energy Physics
Tsukuba, Ibaragi 300-32
Yuu Iino, M.D.
Associate Professor
Department of Radiology
Institute of Medical Sciences
University of Tokyo
Meguro-ku, Tokyo 108
Tetsuo Inada, Ph.D.
Professor
Department of Basic Radiology
Tsukuba University
Sakuramura, Ibaragi 305
Akira Ito, Ph.D.
Lecturer, Department of Radiology
Institute of Medical Sciences
University of Tokyo
Meguro-ku, Tokyo 108
Kiyomitsu Kawachi, Ph.D.
Chief, Division of Physics
National Institute of Radiological Sciences
Chiba, 260
Katsuhiro Kawashima, Ph.D.
Chief, Division of Physics
National Institute of Radiological Sciences
Chiba, 260
Shinroku Morita, M.D.
Chief, Hospital Division
National Institute of Radiological Sciences
Chiba, 260
Yasuto Onoyama, M.D.
Professor, Department of Radiology
Osaka City University
Abeno-ku, Osaka 545
Hiroshi Ohara, Ph.D.
Chief, Division of Physiology and Pathology
National Institute of Radiological Sciences
Chiba, 260
Kiyohiko Sakamoto, M.D.
Associate Professor
Department of Experimental Radiology
University of Tokyo
Bunkyo-ku, Tokyo 113
Yasushi Shigematsu, M.D.
Professor, Department of Radiology
Osaka University
Fukushima-ku, Osaka 553
Takamasa Tanaka, M.D.
Professor, Department of Radiology
Kansai Medical College
Moriguchi 570
Kaneo Tsukada, M.D.
Professor, College of Science and Technology
Nihon University
Surugadai, Kanda, Tokyo 101
Hiroshi Tsunemoto, M.D.
Head, Division of Clinical Research
National Institute of Radiological Sciences
Chiba, 260
Yoichiro Umegaki, M.D.
Head
Department of Radiology
Cancer Institute Hospital
Toshima-ku, Tokyo 170
UNITED STATES
Malcolm A. Bagshaw, M.D.
Professor and Chairman
Department of Radiology
Stanford University
Stanford, California 94305
Eleanor Blakely, Ph.D.
Biophysicist
Lawrence Berkeley Laboratory
Building 10, Room 209
University of California
Berkeley, California 94720
Carl W. Boyer, Jr., M.D.
Director
Department of Radiation Therapy
The Queens Medical Center
1301 Punchbowl Street
Honolulu, Hawaii 96813
*Steven Bush, M.D.
Cancer Research and Treatment Center
c/o LASL, MS-809
Los Alamos, New Mexico 87545
Stephen K. Carter, M.D.
Director
Northern California Cancer Program
1801 Page Mill Road
Building B, Suite 200
Palo Alto, California 94304
Joseph R. Castro, M.D.
Professor and Chief
Zellerbach-Saroni Tumor Institute
Mt. Zion Hospital
Post Office Box 7921
San Francisco, California 94120
William Dewey, Ph.D.
Professor
Department of Radiology and Radiation Biology
Colorado State University
Fort Collins, Colorado 80523
David Hussey, M.D.
Professor
Department of Radiotherapy
M.D. Anderson Hospital
6723 Bertner Drive
Houston, Texas 77030
Morton Kligerman, M.D.
Department of Radiation Therapy
Hospital of the University of Pennsylvania
3400 Spruce Street
Box 522
Philadelphia, Pennsylvania 19104
John Lynan, Ph.D.
Radiotherapy Section
Lawrence Berkeley Laboratory
Building 55, Room 127
University of California
Berkeley, California 94720
Theodore L. Phillips, M.D.
Professor and Chairman
Department of Radiation Oncology
University of California
330 Moffitt Hospital
San Francisco, California 94143
Glenn E. Sheline, M.D.
Professor and Vice Chairman
Department of Radiation Oncology
University of California
330 Moffitt Hospital
San Francisco, California 94143
Alfred R. Smith, Ph.D.
Clinical Physicist
Cancer Research and Treatment Center
c/o LASL, MS-809
Los Alamos, New Mexico 87545
Muneyasu Urano, M.D., Ph.D.
Department of Radiation Medicine
Massachusetts General Hospital
Boston, Massachusetts 02114
Lynn J. Verhey, M.D.
Radiation Biophysicist
Department of Radiation Medicine
Massachusetts General Hospital
Boston, Massachusetts 02114
John M. Yuhas, Ph.D.
Department of Radiation Therapy
Hospital of the University
of Pennsylvania
3400 Spruce Street
Philadelphia, Pennsylvania 19104
* Observer