AGENDA

SECOND JOINT IMMUNOLOGY AREA SEMINAR ON ANALYSIS OF THE MECHANISMS FOR INDUCTION OF TUMOR-SPECIFIC IMMUNITY AND EXPERIMENTAL APPROACHES FOR IMMUNOTHERAPY
Osaka, Japan, October 20 to October 22, 1980

Monday, October 20 1980
ANTIGENIC NATURE OF TUMOR CELLS
Detection of Tumor Associated Antigens
9:00- 9:40am Immunoglobulin Idiotype: A Tumor-Specific Antigen for Human B Cell Lymphomas Ronald Levy
9:40-10:10 Immunodiagnosis of Melanoma: Detection of Circulating Melanoma Antigen by Radioimmunoassay Yoshifumi Ishii


FUNDAMENTAL IMMUNOLOGIC PROCESS IN HOST RESPONSES TO TUMORS
Effector Mechanisms of Host Response
10:30-11:10 NK Cell Lines and their Specificity Christopher Henney
11:10-11:50 Role of Host Cellular Immunity in the Passive Immunization Against a Transplanted Gross-Positive Leukemia with Specific Antiserum Katsutoshi Komuro
11:50-12:30pm Ligand-Receptor Relationships in Tumor Immunity Mark Greene

Cellular Regulation of Host Immune Response
2:00- 2:40 Effects of UV Radiation on the Regulation of Host Immunity Frances Noonan
2:40- 3:20 The Role in Tumor of Antigen-Presenting Cells Immunity Mark Greene
3:30- 4:10 Abrogation of Adoptive Cellular Therapy of an Immunogenic Tumor by Suppressor T Cells Michael Berendt
7:00pm DINNER PARTY


Tuesday, October 21, 1980
FUNDAMENTAL IMMUNOLOGIC PROCESS IN HOST RESPONSE TO TUMORS (continued)
Molecular Regulation of Killer T Cell Induction
9:00- 9:40am Antigenic and Cellular Requirements of Interleukin-2 Production and its Role in Cytotoxic Responses Christopher Henney
9:40-10:10 Functional Characterization of the Killer Helper Factor Responsible for the Induction of Cytotoxic T Lynphocytes from Thynocytes Toshiyuki Hamaoka
10:l0-10:40 Production of TCGF and its Mediation for Establishment of Killer T Cell Lines Against Allogeneic and Tumor-associated Antigens Yoshiyuki Hashimoto

Host Immune Response to Tumor in Humans
10:50-11:30 T Cell Infiltration in Human Cancer Tissues and its Relevance to Clinical Status Kokichi Kikuchi
11:30-12:10pm Host Immune Responses to Leukemia Cell Surface Antigens by In Vitro Sensitization Kazumasa Yamada

NEW APPROACHES AND PRECLINICAL TRIALS FOR TUMOR PREVENTION
2:00- 2:40 Tumor Regression in Tumor-Bearing Mice by Inoculation of Immunogenic Somatic Hybrid Cells in Combination with Cyclophosphamide Takehiko Tachibana
2:40- 3:20 Extracorporeal Immunoadsorbents for Treatment of Neoplastic Disease David Terman
3:30- 4:10 Restrictions on the Immunologically Mediated Regression of Established Tumors with Endotoxin Michael Berendt
4:10- 4:50 Nonspecific Regional Immunotherapy of Autochthonous Murine Tumors Kosei Yasumoto


Wednesday, October 22, 1980
NEW APPROACHES AND PRECLINICAL TRIALS FOR TUMOR PREVENTION (continued)
9:00- 9:40am Effect of BCG-CWS and Nocardia Rubra-CWS on the Induction of Lung Cancer by Chemical Carcinogens in Rabbits and Mice Fumio Hirao
9:40-10:20 Analysis of Immunotherapeutic effect with Nocardio Rubra Cell Wall Skeleton in Preclinical and Clinical Immunotherapy Takeshi Ogura Yuichi Yamamura

OPEN DISCUSSION AND SUMMATION
10:40-12:00 Implications of Preclinical Tumor Immunology for Clinical Immunotherapy Yuichi Yamamura
Richard Hodes
PERSPECTIVES and SUMMATION William Terry


PARTICIPANTS

JAPAN

Dr. Toshiyuki Hamaoka
Principal Advisor
Professor, Institute for Cancer Research
Osaka University Medical School
Fukushima-ku, Osaka, 533

Dr. Yoshiyuki Hashimoto
Professor
Tohoku University Pharmaceutical School
Aza-Aoba Aramaki, Sendai, 980

Dr. Fumio Hirao
Lecturer
Osaka University Medical School
Fukushima-ku, Osaka, 553

Dr. Yoshifumi Ishii
Associate Professor
Sapporo Medical College
Minami 1-cho, Nishi 17 chome Chuo-ku, Sapporo, 060

Dr. Kokichi Kikuchi
Professor
Sapporo Medical College
Minami 1-cho, Nishi 17 chome Chuo-ku, Sapporo, 060

Dr. Katsutoshi Komuro
Associated Chief
Sapporo City General Hospital
Kita 1-jo, Nishi 9 chome Chuo-ku, Sapporo, 060

Dr. Takeshi Ogura
Lecturer
Osaka University Medical School
Fukushima-ku, Osaka, 553

Dr. Takehiko Tachibana
Professor
Tohoku University Medical School
4-1, Seiryocho, Sendai, 980

Dr. Kazumasa Yamada
Associate Professor
Nagoya University Medical School
65 Turumaicho Showa-ku, Nagoya, 466

Dr. Yuichi Yamamura
President, Osaka University
Yamadakami, Suita, Osaka

Dr. Kosei Yasumoto
Technical Staff of Ministry of Health and Welfare, Kyushu Cancer Center
595 Notame Minami-ku Fukuoka, 815


UNITED STATES

Dr. Michael Berendt
Trudeau Institute, Inc.
Medical Research Laboratories
Saranac Lake, New York 12983

Dr. Mark Greene
Assistant Professor
Harvard University School of Medicine
25 Shattuck
Boston, Massachusetts 02115

Dr. Christopher S. Henney
Head, Program Basic Immunology
Fred Hutchinson Cancer Research Center
1124 Columbia Street
Seattle, Washington 98104

Dr. Richard J. Hodes, Principal Advisor
Immunology Branch, DCBD
National Cancer Institute
Building 10, Room 4B17
Bethesda, Maryland 20205

Dr. Ronald Levy
Assistant Professor of Medicine
Division of Oncology, S025
Stanford University
Stanford, California 94305

Dr. Frances Noonan
Cancer Biology Program
Frederick Cancer Research Center
Post Office Box B
Frederick, Maryland 21701

Dr. David Terman
Associate Professor of Medicine
Baylor University College of Medicine
1200 Moursund
Houston, Texas 77030