SEMINAR AGENDA AND PARTICIPANTS
1) Seminar on “Gastrointestinal Tract Cancer”
Honolulu, Hawaii, March 3-6, 1980
AGENDA
| March 3 |
||
| 9:00-9:30 |
Dr. Sugimura | |
| New Direction of U.S.-Japan Cooperative Research Introductory Remarks: |
Dr. Piette Dr. Weisburger |
|
| I. Epidemiology (Dr. Sugimura, Chm.) | ||
| 9:30-9:35 | Opening Remarks | Dr. Sugimura |
| 9:35-10:05 | Current status of the epidemiology of stomach and colon cancer with special reference to life style risk factors. | Dr. Hirayama |
| 10:05-10:35 | Metabolic epidemiology of stomach and colon cancer. | Dr. Weisburger |
| 10:35-11:00 | (Coffee and General Discussion) | |
| 11:00-11:30 | The United States large bowel cancerproject Summary report of the current status 1979 | Dr. Copeland |
| 11:30-12:00 | From descriptive to analytic epidemiology of stomach and colon cancer. | Dr. Tominaga |
| 12:30-2:00 | (Lunch) | |
| II. Pathology, Pathogenesis, Precancerous Lesions (Dr. Wattenberg, Chm.) | ||
| 2:00-2:05 | Opening Remarks | Dr. Wattenberg |
| 2:05-2:35 | Histogenesis of human gastric carcinoma: Significance of adenoma and chronic gastritis as precancerous lesions. | Dr. Hirota |
| 2:35-3:05 | Gastric cancer in Hawaii Japanese | Dr. Stemmermann |
| 3:05-4:00 | (Coffee and General Discussion) | |
| 4:00-4:30 | Pathology of gastric cancer precursor lesions | Dr Correa |
| 4:30-5:00 | Comparative pathology of precancerous and cancerous lesions of colon. | Dr. Muto |
| 5:00-5:30 | lrreversible change in pepsinogen isozyme found during early stage of gastrocarcinogenesis by MNNG. | Dr. Furihata |
| March 4 | ||
| III. Experimental Models (Dr. Hirayama, Chm.) | ||
| 9:00-9:05 | Opening Remarks | Dr. Hirayama |
| 9:05-9:35 | Degraded careageenan colorectal carcinogenesis in rats. | Dr. Takayama |
| 9:35-10:05 | The role of fat and fiber as studied in experimental models for colon cancer. | Dr. Weisburger |
| 10:05-11:00 | (Coffee and General Discussion) | |
| 11:00-11:30 | Experimental model: Past and future | Dr. Sugimura |
| 11:30-12:00 | General Discussion | |
| 12:00-2:00 | (Lunch) | |
| IV. Genetic Background (Dr. Stemmermann, Chm.) | ||
| 2:00-2:05 | Opening Remarks | Dr. Stemmermann |
| 2:05-2:35 | Spontaneous development of forestomach papilloma and prepyloric ulcer in genetically mast cell depleted W/Wv and S1/S1d mice | Dr. Kitamura |
| 2:35-3:05 | Genetics as a determinant in colon cancer | Dr. Murata |
| 3:05-4:00 | (Coffee and General Discussion) | |
| 4:00-4:30 | Genetic diseases as an aid to pathogenesis studies | Dr. McKeen |
| 4:30-5:00 | Familial polyposis: New data | Dr. Lipkin |
| 5:00-5:30 | General Discussion | |
| March 5 | ||
| V. High Risk Human Population (Dr. Takayama, Chm.) | ||
| 9:00-9:05 | Opening Remarks | Dr. Takayama |
| 9:05 9:35 | Memorial Hospital registry of population groups at high risk for cancer of the large intestine | Dr. Lipkin |
| 9:35-10:05 | Intestinal metaplasia and its implications in human gastric cancer |
Dr. Matsukura |
| 10:05-11:00 | (Coffee and General Discussion) | |
| VI. Possible Carcinogens, Promoters, and Inhibitors (Dr. Correa, Chm.) | ||
| (Brief remarks and discussion) | ||
| 11:00-11:05 | Opening Remarks | Dr. Correa |
| A. Discussion on agents for colon cancer | ||
| 11:05-12:00 | Mutagens and nitrosamines in human feces | Dr. Bruce |
| Organization and in vivo production of a human fecal mutagen | Dr. Wilkins | |
| Fecal mutagens in Japanese living at high risk and at low risk | Dr. Mower | |
| Possible carcinogen in pyrolysis product | Dr. Takayama | |
| 12:00-2:00 | (Lunch) | |
| 2:00-3:15 | Mutagens and possible carcinogens in fried foods | Dr. Weisburger |
| The variable nature of the etiological factors in cancer of the intestinal tract | Dr. Nigro | |
| Our recent findings of mutagens in promoters in relation to experimental colon carcinogenesis | Dr. Furihata | |
| Inhibitors of large bowel carcinogenesis | Dr. Wattenberg | |
| 3:15-4:00 | (Coffee and General Discussion) | |
| B. Discussion on agents for gastric cancer | ||
| 4:00 – 5:15 | Gastric cancer mortality and dietary mutagenicity | Dr. Kamiyama |
| Gastric cancer | Dr. Tannenbaum | |
| Formation of methylnitrosourea in the rat stomach, and nitrosation-denitrosation of foodstuffs to produce alkylureas | Dr. Mirvish | |
| Nitrosation of fish: A source of gastric carcinogens | Dr. Weisburger | |
| Enhancing effects of sodium chloride on gastric carcinogenesis | Dr. Takahashi | |
| Do environmental chemicals exist in 3 dimensional spaces with axes of mutagenic, promotive and carcinogenic potentials: Possible new naturally occurring promoters | Dr. Sugimura | |
| 5:15-5:30 | (General Discussion) | |
| March 6 | ||
| VII. Intervention Study (Dr. Copeland, Chm.) | ||
| 9:00-9:05 | Opening Remarks | Dr. Copeland |
| 9:05 9:35 | An intervention study of the effect of ascorbate and alpha-tocopherol on recurrent polyps | Dr. Bruce |
| 9:35-10:05 | Animal model of chemotherapy and chemoprevention of colonic tumors | Dr. Narisawa |
| 10:05-10:30 | (Coffee and General Discussion) | |
| 10:30-11:00 | Report on a double-blind, randomized intervention trial of gastric cancer precursor lesions | Dr. Correa |
| 11:00-11:30 | Evaluation of intervention trials in stomach cancer | Dr. Oshima |
| 11:30-12:00 | (General Discussion) | |
| Closing Remarks: | Dr. Bruce Dr. Hirayama | |
PARTICIPANTS
United States
Dr. W. Robert Bruce
The Ontario Cancer Institute
The Princess Margaret Hospital
500 Sherbourne Street
Toronto, Canada M4X 1K9
Dr. Murray Copeland
University of Texas System Cancer Center
M.D. Anderson Hospital & Tumor Institute
Houston, Texas 77025
Dr. Pelayo Correa
Department of Pathology
Louisiana State University Medical Center
New Orleans, Louisiana 70112
Dr. Martin Lipkin
Memorial Sloan-Kettering Cancer Center
1275 York Avenue
New York, New York 10021
Dr. Elisabeth A. McKeen
C FSS
Landow Building Room A521
National Cancer Institute
Bethesda, Maryland 20205
Dr. Sidney S. Mirvish
Eppley Institute for Research in Cancer
University of Nebraska College of Medicine
42nd & Dewey Avenue
Omaha, Nebraska 68105
Dr. Howard F. Mower
Cancer Center of Hawaii
1236 Lauhala Street
Honolulu, Hawaii 96813
Dr. Norman D. Nigro
Wayne State University School of Medicine
540 West Canfield Avenue
Detroit, Michigan 48201
Dr. Lawrence H. Piette
Cancer Center of Hawaii
1236 Lauhala Street
Honolulu, Hawaii 96813
Dr. Grant N. Stemmerman
Kaukini Hospital
347 N. Kaukini Street
Honolulu, Hawaii 96817
Dr. Steven R. Tannenbaum
Department of Nutrition & Food Science
Massachusetts Institute of Technology
Cambridge, Massachusetts 02139
Dr. Lee W. Wattenberg
Department of Laboratory Medicine and Pathology
198 Jackson Hall
University of Minnesota Medical School
Minneapolis, Minnesota 55455
Dr. John H. Weisburger
Naylor Dana Institute for Disease Prevention
American Health Foundation
Dana Road
Valhalla, New York 10595
Dr. Tracy D. Wilkins
Anaerobe Laboratory
Virginia Polytechnic Institute & State University
Blacksburg, Virginia 24061
Japan
Dr. Chie Furihata
Tokyo University Institute of Medical Sciences
Tokyo, Japan
Dr. Takeshi Hirayama
National Cancer Center Research Institute
Tsukiji 5-chome, Chuo-ku, Tokyo Japan
Dr. Teruyuki Hirota
National Cancer Center Research Institute
5-1-1, Tsukiji, Chuo-ku, Tokyo Japan
Dr. S. Kamiyama
Akita University
Akita, Japan
Dr. Yukihiko Kitamura
Osaka University
Osaka, Japan
Dr. Norio Matsukura
National Cancer Center Research Institute
Tokyo, Japan
Dr. Motoi Murata
Institute of Radiation Medicine
Chiba, Japan
Dr. T. Muto
Department of Surgery
University of Tokyo
Tokyo, Japan
Dr. Tomio Narisawa
Akita University School of Medicine
1-1-1 Hondo, Akita 010, Japan
Dr. Akira Oshima
Adult Disease Center
Osaka, Japan
Dr. Michihito Takahashi
National Hygiene Laboratory
Tokyo 158, Japan
Dr. Shozo Takayama
Cancer Institute
Kami-Ikebukuro, 1-chome, Toshima-ku
Tokyo 170, Japan
Dr. Suketami Tominaga
Aichi Cancer Center Research Institute
Nagoya, Japan
Dr. Takashi Sugimura
National Cancer Center Research Institute
Tsukiji 5-chome, Chuo-ku, Tokyo Japan
2) Seminar on “Molecular Mechanism of DNA Synthesis in Cancer Cells”
International House, Tokyo, Japan, March 6-8, 1980
AGENDA
| Thursday, March 6 | ||
| 11:00-12:00 | Registration (Lunch) |
|
| 1:30-2:00 | Official Opening | Dr. Susumu Nishimura Dr. Katsuro Koike |
| Mechanism of Initiation of DNA Synthesis Chairperson: Dr. D. Korn | ||
| 2:00-2:40 | Studies on the In Vitro Replication of Adenoviral DNA | Dr. Jerard Hurwitz |
| 2:40-2:50 | Discussion | |
| 2:50-3:20 | (Coffee Break) | |
| 3:20-3:50 | Mapping of Initiation Sites of DNA Replication on Prokaryotic Genomes | Dr. Tsuneko Okazaki |
| 3:50-4:00 | Discussion | |
| 4:00-4:30 | Replication of Mitochondrial DNA: Nucleotide Sequence of the Origin and DNA-dependent ATPase | Dr. Katsuro Koike |
| 4:30-4:40 | Discussion | |
| Friday, March 7 DNA Polmerases and Their Reaction Mechanisms Chairpersons: Dr. J. Hurwitz Dr. K. Koike |
||
| 10:00-10:40 | Mechanisms of Catalysis of Human DNA Polymerases!! !and!! ! |
Dr. David Korn |
| 10:40-10:50 | Discussion | |
| 10:50-11:20 | (Coffee Break) | |
| 11:20-11:50 | DNA Polymerase!!!from Calf Thymus: Catalytic Properties and a Possible Cooperation with Terminal Deoxynucleotidyl Transferase |
Dr. Shonen Yoshida |
| 11:50-12:00 | Discussion (Lunch) |
|
| 11:30-2:10 | A Possible Role for DNA Polymerase! !! |
Dr. Arthur Weissbach |
| 2:10-2:20 | Discussion | |
| 2:20-2:50 | Dr. Akio Matsukage Difference in DNA Chain Elongation Mechanism of DNA Polymerases!!!,!!and!!! |
|
| 2:50-3:00 | Discussion |
|
| 3:00-3:30 | (Coffee Break) | |
| 3:30-4:00 | The Design, Synthesis and Inhibitory Effects of 2’-Deoxyribonucleosides 5’-triphosphate analogues on Eukaryotic DNA-dependent DNA Polymerases | Dr. Mineo Saneyoshi |
| 4:00-4:10 | Discussion | |
| 6:00-8:00 | Reception | |
| Saturday, March 8 DNA Repair and Enzymes Chairpersons: Dr. A. Weissbach Dr. M. Sekiguchi |
||
| 10:00-10:40 | Enzymology of DNA Repair | Dr. Lawrence Grossman |
| 10:40-10:50 | Discussion | |
| 10:50-11:20 | (Coffee Break) | |
| 11:20-11:50 | Mechanism of DNA Repair as Revealed by Artificial Introduction of Enzymes into Viable Cells | Dr. Mutsuo Sekiguchi |
| 11:50-12:00 | Discussion (Lunch) |
|
| 1:30-2:10 | Presence of Uracil in DNA of Cells Treated with Inhibitors of Thymidylate Synthetase | Dr. Mehren Goulian |
| 2:10-2:20 | Discussion | |
| 2:20-2:50 | Mouse FM3A Cell Mutants Resistant to Aphidicolin, an Inhibitor of DNA Polymerase!!! |
Dr. Takeshi Seno |
| 2:50-3:00 | Discussion | |
| 3:00-3:30 | (Coffee Break) | |
| 3:30-4:10 | The Structural and Functional Modification of DNA by Benzo(a)pyrene diol-epoxide I | Dr. Tsuyoshi Kakefuda |
| 4:10-4:20 | Discussion | |
| 4:20-4:50 | Involvement of DNA Polymerase!!!, in DNA Replication and Repair in HeLa Cells |
Dr. Fumio Hanaoka |
| 4:50-5:00 | Discussion | |
| 5:00-5:30 | Subcellular Action of Neocarzinostatin: Intracellular Incorporation, DNA Breakdown and Cytotoxicity | Dr. Hiroshi Maeda |
| 5:30-5:40 | Discussion | |
| 5:40-6:00 | Closing Remarks | Dr. David Korn |
PARTICIPANTS
United States
Dr. Mehren Goulian
Department of Medicine
University of California
San Diego, La Jolla, CA 92093
Dr. Lawrence Grossman
Department of Biochemistry
Johns Hopkins University
School of Hygine and Public Health
Baltimore, MD
Dr. Jerard Hurwitz
Department of Developmental Biology and Cancer
Albert Einstein College of Medicine
Bronx, New York, NY 10461
Dr. Tsuyoshi Kakefuda
Laboratory of Molecular Carcinogenesis
National Cancer Institute
National Institutes of Health
Bethesda, MD 20205
Dr. David Korn
Department of Pathology
Stanford University School of Medicine
Stanford, CA 94305
Dr. Arthur Weissbach
Roche Institute of Molecular Biology
Nutley, NJ 07110
(Observer)
Joh-ei Ikeda
Department of Developmental Biology and Cancer
Albert Einstein College of Medicine
Bronx, New York, NY 10461
Japan
Dr. Fumio Hanaoka
Physiological Chemistry
Faculty of Pharmaceutical Sciences
University of Tokyo
Hongo, Tokyo 113
Dr. Katsuro Koike
Department of Biochemistry Cancer Institute (JFCR)
Kami-Ikebukuro, Toshima-ku
Tokyo 170
Dr. Hiroshi Maeda
Department of Microbiology
Kumamoto University School of Medicine
Kumamoto 860
Dr. Akio Matsukage
Laboratory of Biochemistry
Aichi Cancer Center Research Institute
Chikusa-ku, Nagoya 464
Dr. Susumu Nishimura
Biology Division
National Cancer Center Research Institute
Tsukiji, Chuo-ku, Tokyo 104
Dr. Tsuneko Okazaki
Institute of Molecular Biology
Faculty of Science, Nagoya University
Nagoya 464
Dr. Mineo Saneyoshi
Faculty of Pharmaceutical Sciences
Hokkaido University
Kita-ku, Sapporo 060
Dr. Mutsuo Sekiguchi
Department of Biology
Faculty of Science, Kyushu University
Fukuoka 812
Dr. Takeshi Seno
Saitama Cancer Center Research Institute
Ina-machi, Saitama 362
Dr. Shonen Yoshida
Department of Biochemistry
Institute for Developmental Research
Aichi Prefecture Colony
Kasugai, Aichi 480-03
(Observers)
Dr. Dai Ayuzawa
Saitama Cancer Center Research Institute
Ina-machi, Saitama 362
Dr. Osamu Koiwai
Department of Biochemistry
Institute for Developmental Research
Aichi Prefecture Colony
Kasugai, Aichi 480-03
Dr. Chikao Nakayama
Faculty of Pharmaceutical Sciences
Hokkaido University
Kita-ku, Sapporo 060
Dr. To-ru Ogawa
Institute of Molecular Biology
Faculty of Science, Nagoya University
Nagoya 464
Dr. Tetsuo Ono
Tokyo Metropolitan Institute for Medical Sciences
Moto-Komagome, Bunkyo-ku, Tokyo 113
Dr. Shigeaki Sato
Biochemistry Division
National Cancer Center Research Institute
Tsukiji, Chuo-ku, Tokyo 104
Dr. Taijo Takahashi
Laboratory of Biochemistry
Aichi Cancer Center Research Institute
Chikusa-ku, Nagoya 464
Dr. Masa-atsu Yamada
Physiological Chemistry
Faculty of Pharmaceutical Sciences
University of Tokyo
Hongo, Tokyo 113
Dr. Michiyuki Yamada
Biochemistry Division
National Cancer Center Research Institute
Tsukiji, Chuo-ku, Tokyo 104