CANCER IMMUNOLOGY PROGRAM AREA REPORT
October 1, 1977 to September 30, 1978

Program Coordinators: Dr. Yohei Ito
Dr. Robert McAllister


Administrative Report
The joint efforts of American and Japanese scientists in the Cancer Immunology Program Area can be divided into three groups: Meetings, Seminars, and Conferences; the Exchange of Scientists; and the Exchange of Resources and Materials.
MEETINGS, SEMINARS, AND CONFERENCES
The Annual Meeting of this Program Area and a Symposium entitled "Immunology and Cancer" were held in Maui, Hawaii, on September 25 to 27, 1978. The agenda and lists of participants follow this Program Area Report.
A workshop on Immunological Xenogenization of Tumor Cells was held in Sapporo, Japan. The formal workshop was held on June 6 to 8, 1978, and Special Lectures on Cancer Research were presented on June 5 and June 9. This workshop, organized by Dr. Hiroshi Kobayashi, was partially supported with funds from the U.S. and was attended by 7 Americans, 35 Japanese, and 6 scientists from other countries. Although this workshop was not directhy under the auspices of the U.S.-Japan Cooperative Cancer Research Pro-gram, the American participation and support was facilitated by the U.S.-Japan Program. The agenda and list of participants follow this Program Area Report.

EXCHANGE OF SCIENTISTS
The name of each visiting scientist is followed by his address, the date of his visits, the names and addresses of all host scientists, and a brief description of techniques studied.
1. Takashi Mori, M.D.
Chief of the Second Department of Surgery
National Kinki Central Hospital for Chest Diseases
1180 Nagazone-Cho
Sakai City, Osaka 591, Japan
Dates: September 16-December 10, 1977
Hosts: Dr. Hiroshi Takita
Roswell Park Memorial Institute
Buffalo, New York 14203, U.S.A.
Dr. William Terry
National Cancer Institute
Bethesda, Maryland 20014, U.S.A.
Dr. Herbert Oettgen
Memorial Sloan-Kettering Cancer Center
1275 York Avenue New York, New York 10021, U.S.A.
Dr. Martin McKneally
Albany Medical College
Albany, New York 12208, U.S.A.
Dr. Michael Mastrangelo
American Oncologic Hospital
Fox Chase Cancer Center
Philadelphia, Pennsylvania 19111, U.S.A.
Dr. Evan Hersh M.D.
Anderson Hospital and Tumor Institute
University of Texas
Houston, Texas 77025, U.S.A.
Dr. E. Carmack Holmes
University of California at Los Angeles
Los Angeles, California 90024, U.S.A.
Dr. Mori visited various laboratories that were working in the field of immunotherapy of cancer and observed clinical techniques used in the ad-ministration of immunotherapeutic drugs in the treatment of cancer, particularly cancer of the lung.

2. Dr. Kosei Yasumoto
Department of Chest Surgery
Kyushu Cancer Institute Minamiku Fukuoka
595 Notame 815, Japan
Dates: March 1-31, 1978
Hosts: Dr. E. Carmack Holmes
University of California at Los Angeles
Los Angeles, California 90024, U.S.A.
Dr. Hiroshi Takita
Roswell Park Memorial Institute
Buffalo, New York 14263, U.S.A.
Dr. Martin McKneally
Albany Medical College
Albany, New York 12208, U.S.A.
Dr. James Holland
Mount Sinai School of Medicine
New York, New York 10029, U.S.A.
Dr. William Terry
National Cancer Institute
Bethesda, Maryland 20014, U.S.A.
Dr. Yasumoto visited various laboratories that are working in the field of immunology and immunotherapy of cancer and observed clinical techniques used in the administration of immunotherapeutic drugs in the treatment of cancer, particularly lung cancer.

3. Dr. Kazuhisa Sugimura
Postgraduate Student
The Third Department of Internal Medicine Osaka University Hospital
Fukushima-ku Osaka, Japan
Dates: April 1-December 31, 1978
Hosts: Dr. Harvey Cantor
Sidney Farber Cancer Center
Harvard Medical School
Boston, Massachusetts 02115, U.S.A.
Dr. Sugimura visited this laboratory and studied lymphocyte antigens.

4. Dr. H. Terry Wepsic
Staff Pathologist, VA Hospital
Assistant Professor in Residence
Department of Pathology
University of California San
Diego, California 92161, U.S.A.
Dates: July 1, 1978-June 30, 1979
Host: Dr. Hidematsu Hirai
University of Hokkaido School of Medicine
Sapporo, Japan
Dr. Wepsic studied tumor antigens of rat yolk-sac tumors. This one-year sabbatical was arranged under the auspices of the U.S.-Japan Cooperative Cancer Research Program. Its expenses, however, were not funded through this Program.

5. Dr. Hiromi Fujiwara
Institute for Cancer Research
Osaka University Medical School
Osaka, Japan
Dates: June 1, 1978-May 30, 1979
Host: Dr. William Terry
National Cancer Institute
Bethesda, Maryland 20014, U.S.A.
Dr. Fujiwara was a Visiting Fellow in the Fogarty International Program of the National Institutes of Health, Bethesda, Maryland. Although Dr. Fujiwara was not directly supported by the U.S.-Japan Program, his visit in the Immunology Branch of the National Cancer Institute was very much facilitated by the interactions between the late Dr. Masayasu Kitagawa and Dr. Terry that took place during the activities of the U.S.-Japan Cooperative Cancer Research Program.

EXCHANGE OF RESOURCES AND MATERIALS
Dr. Ichiro Azuma and Dr. Yuichi Yamamura sent 2 grams of the cell-wall skeletons of BCG and Nocardia rubra, of which 200 mg of each were distributed to Dr. Ronald Herberman of the National Cancer Institute, Bethesda, Maryland.

Scientific Summary of Program Area
The major accomplishments in this program area have been a consequence of the exchanges of information, reagents, and personnel.

INFORMATION EXCHANGE
Research Information.
Both countries are developing approaches to clinical immunotherapy. This information would usually not be in the literature for several years and would usually be presented at meetings not attended by scientists of both countries. The annual meetings and symposia have provided a forum for exchange of up-to-date information and this Information has modified activities. For example, reports on the use of intrapleural BCG cell-wall skeleton in Japan have stimulated interested scientists in the United States to clinical applications of this material. Similarly, reports of the use of intrapleural BCG in the treatment of stage I lung cancer in the U.S. have alerted Japanese clinicians to this clinical application. It is anticipated that trials presently under way in each country will lead to an opportunity to compare results within several years.
Application Information.
In both countries, clinical activities, either diagnostic or therapeutic, occasionally obtain unusual publicity and stimulate great public interest within the other country. The U.S.-Japan Cooperative Cancer Research Pro-gram has served as a clearinghouse for evaluation of these activities. This has been important in permitting rapid and accurate responses to the public inquiries about the real value of alleged diagnostic tests or treatments in a manner that would not be possible without this Program.

EXCHANGE OF RESOURCES AND MATERIALS
Exchange of reagents has involved derivatives of BCG organisms prepared in Japan and sent to the U.S. where studies of the activities of these materials in other immunotherapeutic models have been carried out. American scientists have supplied Japanese scientists with some inbred strains of animals not generally available.

EXCHANGE OF SCIENTISTS
The exchange of personnel has been facilitated by the Program. Contacts made at the annual meetings have led to a better understanding of the specific types of investigations being carried out in each laboratory, thus leading to a better placement of junior scientists in laboratories most appropriate to their research interests.

FUTURE OBJECTIVES
Experience to date makes it clear that a broadening of the Program into other areas of the biology of cancer — cell biology, molecular biology, and immunobiology — will be desirable. Many of the limitations in present approaches to immunotherapy and immunodiagnosis are due to our inadequate knowledge of the basic biology of the systems with which we deal. A collaborative pro-gram to widen knowledge in these areas can further benefit the scientists of both Japan and the United States.



SYMPOSIUM: IMMUNOLOGY AND CANCER
Maui, Hawaii
September 25 to 27, 1978

AGENDA
Monday, September 25
TUMOR ASSOCIATED IMMUNITY
8:45 a.m. Introductory Comments Yuichi Yamamura
William Terry
9:05 a.m. In Vitro Introduction of Tumor Specific Immunity Noel Warner
9:40 a.m. The Cellular Basis of Cytotoxic T Cell Responses to Tumors Chris Henney
10:15 a.m. Characterization of ADCC in Man Albert LoBuglio
10:50 a.m. COFFEE BREAK
11:05 a.m. Cell Mediated Cytotoxic Responses to Human Melanoma Target Cells Michael Bean
11:40 a.m. Serological Typing of Cell Surface Antigens of Human Malignant Melanoma Toshitada Takahashi
12:15 p.m. Serological Typing of Cell Surface Antigens of Human Renal Cancer and Astrocytoma Hiroshi Shiku
CHARACTERIZATION OF IMMUNE CELLS
7:30 p.m. Expression of I Region Gene Products on Accessory Cell Populations Richard Hodes
8:05 p.m. Distribution of T and B Cells in Cancer Tissues Kokichi Kikuchi
8:40 p.m. Characterization of Murine T and B Cell Lymphomas Through Quantitative Analysis of Cell Surface Marker Expression Noel Warner

Tuesday, September 26
SUPPRESSION OF IMMUNE RESPONSES
8:30 a.m. Selective Stimulation and Inactivation of Suppressor T Cells in Tumor Immunology Tomio Tada
9:05 a.m. Suppressor T Cells and Suppressor Macrophages: Their Induction and a Comparison of their Mechanism of Action Chris Henney
9:40 a.m. Suppressor Cells in Ultraviolet Carcinogenesis Richard Thorn
10:15 a.m. COFFEE BREAK
10:30 a.m. Restricted Suppressor T Cell Activity in the Blood of a Patient with Recurrent Bladder Carcinoma Michael Bean
11:05 a.m. Suppressor Cells in Tumor Bearing Individuals Ronald Herberman
MACROPHAGES
11:40 a.m. Studies on the Role of Oxidative Metabolism in the Tumor Cell Cytotoxicity of Activated Macrophages Carl Nathan
12:15 p.m. Activation of Tumoricidal Macrophages with Lymphokines Toru Tokunaga
NATURAL KILLER CELLS
7:30 p.m. Natural Killer Cells: Their Mechanism of Action and Possible Significance in Neoplasia Chris Henney
8:05 p.m. Natural Cell Mediated Cytotoxicity Against Tumors: Nature of Effector Cells and Factors Affecting Activity Ronald Herberman
8:40 p.m. Approaches to the Identification of the Natural Killer Cell and its Target Cell Specificity Noel Warner
9:15 p.m. Active Immunization With Xenogenized Tumor Cells Hiroshi Kobayashi

Wednesday, September 27
PRECLINICAL IMMUNOTHERAPY
8:30 a.m. Immunotherapy of Cancer With Nocardia Rubra Cell Wall Skeleton Yuichi Yamamura
9:05 a.m. Synthetic Immunotherapeutic Agents Ichiro Azuma
PRECLINICAL IMMUNOTHERAPY
9:40 a.m. Specific Immunotherapy of Established Visceral Micro-metastases by BCG Tumor Cell Michael Hanna
10:15 a.m. COFFEE BREAK
10:30 a.m. Experimental Immunotherapy of Cancer With Cell-Wall Skeletons of BCG and Nocardia Rubra Takeshi Ogura
11:05 a.m. Correlation Between Antigenicity of Cancer Cells and Therapeutic Effect of Immunopotentiators Yoshiyuki Hashimoto
11:40 a.m. Treatment of Established Micrometastases by Injection of Tumoricidal Macrophages
CLINICAL IMMUNOTHERAPY
1:30 p.m. The Immunotherapy of Acute Myelogenous Leukemia Using Cell-Wali Skeletons of BCG and Nocardia Rubra Kazuhisa Yamada
2:05 p.m. Preoperative Intralesional BCG Immunotherapy of Lung Cancer E. Carmack Holmes
2:40 p.m. Immunotherapy of Lung Cancer With the Cell-Wall Skeletons of BCG and Nocardia Rubra Kenji Sawamura

AMERICAN DELEGATION

Dr. William D. Terry, Chairman
Associate Director for Immunology
National Cancer Institute
Building 10, Room 4B17
Bethesda, Maryland, U.S.A.

Dr. Michael Bean
Virginia Mason Research Center
1000 Seneca Street
Seattle, Washington, U.S.A.

Dr. Isaiah J. Fidler
Head, Biology of Metastasis Section
Cancer Biology Program
Frederick Cancer Research Center
Post Office Box B
Frederick, Maryland, U.S.A.

Dr. Michael G. Hanna, Jr.
Director, Cancer Biology Program
Frederick Cancer Research Center
Post Office Box B
Frederick, Maryland, U.S.A.

Dr. Chris Henney
Head, Program Basic Immunology
Fred Hutchinson Cancer Research Center 1124
Columbia Street
Seattle, Washington, U.S.A.

Dr. Ronald Herberman
Chief, Laboratory of Immunodiagnosis
National Cancer Institute Building
10, Room 8B11
Bethesda, Maryland, U.S.A.

Dr. Richard Hodes
Head, Immunotherapy Section
Immunology Branch, DCBD
National Cancer Institute
Building 10, Room 4B17
Bethesda, Maryland, U.S.A.

Dr. E. Carmack Holmes
University of California
924 Westwood Boulevard, Suite 400
Los Angeles, California, U.S.A.

Dr. Albert LoBuglio
Director, Division of Hematology and Oncology
Division of Michigan
Simpson Memorial Research Institute
102 Observatory
Ann Arbor, Michigan, U.S.A.

Dr. Carl Nathan
Rockefeller University
1230 York Avenue
New York, New York, U.S.A.

Dr. Richard Thorn
Cancer Biology Program
Frederick Cancer Research Center
Post Office Box B
Frederick, Maryland, U.S.A.

Dr. Noel Warner
Surge Building
Departments of Pathology and Medicine
University of New Mexico
Albuquerque, New Mexico, U.S.A.

Dr. Hiroshi Shiku
Memorial Sloan Kettering Cancer Center
1275 York Avenue
New York, New York, U.S.A.


JAPANESE DELEGATION

Dr. Yuichi Yamamura. Chairman
Professor, Osaka University Medical School
Fukushima-ku
Osaka 553, Japan

Dr. Ichiro Azuma
Instructor, Osaka University Medical School
Fukushima-ku
Osaka 553, Japan

Dr. Yoshiyuki Hashimoto
Professor, Tohoku University
Pharmaceutical School
Aramaki, Sendai 980, Japan

Dr. Kokichi Kikuchi
Professor, Sapporo Medical College
Chuo-ku
Sapporo 060, Japan

Dr. Hiroshi Kobayashi
Professor, Institute for Cancer Research
Hokkaido University Medical School
Kita-ku
Sapporo 060, Japan

Dr. Takeshi Ogura
Instructor, Osaka University Medical School
Fukushima-ku
Osaka 553, Japan

Dr. Kenji Sawamura
Chief Surgeon National Kinki-Chuo Hospital
Sakai
Osaka 591, Japan

Dr. Tomio Tada
Professor, Chiba University Medical School
Inohana-cho
Chiba 280, Japan

Dr. Toshitada Takahashi
Chief, Research Institute
Aichi Cancer Center
Nagoya, Japan

Dr. Toru Tokunaga
Chief, National Institute of Health
Shinagawa-ku
Tokyo 141, Japan

Dr. Kazuhisa Yamada
Associate Professor
Nagoya University Medical School
Showa-ku
Nagoya 466, Japan


WORKSHOP ON IMMUNOLOGICAL XENOGENIZATION OF TUMOR CELLS
June 6-8, 1978
Park Hotel Sapporo, Japan

AGENDA
Tuesday, June 6
9:00 a.m. Opening Remarks H. Kobayashi
9:05 a.m. Opening Remarks C. W. Boone
Session 1A: Xenogenization with Virus
Co-chairmen: G. J. Svet-Moldavsky and J. Lindenmann
9:15 a.m. Xenogenization by Viruses: How Could it Work? J. Lindenmann
9:55 a.m. Augmented TATA Immunogenecity of Membranous and Soluble Extracts frorn Tumor Cells Infected with Surface Budding Virus C. W. Boone
10:35 a.m. COFFEE BREAK
10:50 a.m. Artificial Heterogenization (Xenogenization) of Tumors G. J.Svet-Moldavsky
11:30 a.m. Immunogenicity of Virus-Infected Xenogenized Tumor Cells H. Kobayashi and F. Sendo
12:10 p.m. Increased Immunogenicity of Rat Tumors After Infection With Endogenous Murine C-type Virus N. Kuzumaki and C. Klein
Session 1B: Xenogenization with Virus
Co-chairmen: C. W. Boone and H. Uetake
2:00 p.m. Stabilized Expression of Tumor-Associated Antigen in Xenogenized Tumor Cells to Complement Dependent Cytotoxicity E. Cotohda and T. Kodama
2:40 p.m. The Role of Virus-Associated Antigen on Xenogenized Tumor Cell Surface in Production of Antibody Against Tumor-Associated Antigen T. Moriuchi
3:10 p.m. Increased Immunosensitivity of Xenogenized Tumor Cells to Lymphocyte Cyiotoxicity M. Hosokawa
3:50 p.m. COFFEE BREAK
4:10 p.m. Induction of Immune resistance by HVJ-infected L1210 Cells K. Yamada
4:50 p.m. Decreased Transplantability of Cultured Tumor Cells Persistently Infected with Nononcogenic Viruses M. Hatano
5:20 p.m. Breakdown of MuL V-Induced Tolerance and Subsequent Regression of Xenogenized Tumors N. Takeichi

Wednesday, June 7
Session 2A: Xenogenization with Chemicals and Enzymes
Co-chairmen: C. M. Shearer and Y. Hashimoto
9:00 a.m. Enhanced Immunogenecity of Concanavalin A Coated Tumor Cells W. J. Martin
9:40 a.m. Induction of Immune Resistance to L1210 Murine Leukernia by Lectin-Bound Tumor Vaccine T. Kataoka
10:00 a.m. Induction of Immune Resistance Against Tumor in a Low Responsive Tumor-Host Combination by Immunization With Chemically Modified Tumor Cells in the Presence of the Chemicals-Reactive Helper T Cells T. Hamaoka
10:40 a.m. COFFEE BREAK
10:55 a.m. Induction of Immunity with Fluorescence-Haptenized Tumor Cells and Liposomes Y. Hashimoto
11:20 a.m. Immunoprophylaxis and Therapy With Lipid Conjugated Lymphoma Cells M. D. Prager
12:00 noon Alteration of Immunosensitivity in Nitrogen Mustard-Resistant Yoshida Sarcoma Cells S. Tsukagoshi
Session 2B: Recognition of Cell Surface Antigens Undergoing Xenogenization
Co-chairmen: N. A. Mitchison and T. Tada
2:00 p.m. Non-Enveloped Virus-Induced Specific Cell Surface Antigen(s) and Its Role in Cell-Mediated Immunity H. Uetake, T. Inada, and S. Hasegawa
2:30 p.m. Development and Alternate Changes of Surface Antigen in Adenovirus Type 12-Infected and Transformed Cells C. Hamada
2:50 p.m. MHC-Restriction of T-Cell Recognition R. M. Zinkcrnagel
3:30 p.m. COFFEE BREAK
3:45 p.m. Associate Recognition in the Response to Allo-Antigens (and Xenogenization of Allo-Antigens) N. A. Mitchison
4:25 p.m. Differential Recognition of Tumor Antigens by Cyto-toxic and Suppressor T Cells T. Tada
5:00 p.m. Recognition of RSV-Induced Tumor Cells in Syngeneic Mice and Semi-Syngeneic Reciprocal Hybrid Mice Takato Yoshida
5:20 p.m. Genetic Regulation of Immune Responses to TNP-Modified Cells C. M. Shearer

Thursday, June 8
Session 3A: Xenogenization by Cell-Hybridization
Co-chairmen: A. J. S. Davies and T. Tachibana
9:00 a.m. Antigenic Expression on Somatic Cell Hybrids in Relation to the Potential Use of Hybridization for Tumor Xenogenization C. Klein
9:40 a.m. Antigenic Expression on Mouse Hybrid Cells T. Tachibana
10:20 a.m. COFFEE BREAK
10:35 a.m. Immune Response to Hybrid Cells in Normal and Tumor-Bearing Mice T. Dei
11:15 a.m. Liposomal Fusion as a Means of Introducing Surface Antigens Into Living Cell Membranes A. J. S. Davies
11:55 a.m. Open Discussion
Session 3B: Application of Xenogenization to Human Cancer
Co-chairmen: G. Klein and T. Aoki
2:00 p.m. Melanoma Skin Test Antigens of Improved Sensitivity Prepared from Vesicular Stomatitis Virus-Infected Tumor Cells C. W. Boone
2:30 p.m. Vaccinia Virus Augmented Tumor Vaccine as a New Form of Immunotherapy. M. K. Wallack
3:00 p.m. COFFEE BREAK
3:15 p.m. Attempts at Virus-Associated Immunotherapy in Human Cancer J. Lindenmann
3:45 p.m. Oncotropic Viruses and Problems in Virotherapy A. J. Muceniece

SPECIAL LECTURES
Park Hotel Sapporo, Japan
Monday, June 5, 1978
Epstein-Barr Virus, Infectious Mononucleosis, Burkitt's Lymphoma and
Nasopharyngeal Carcinoma
Chairman: Toyoro Osata Speaker: George Klein

Thursday, June 8, 1978
Immunotherapy of Tumor with BCG and Nocardia Cell Wall Skeleton
Chairman: Hiroshi Kobayashi Speaker: Yuichi Yamamura


LECTURES ON CANCER RESEARCH
Centennial Hall Hokkaido University (Hokudai) Sapporo, Japan
Friday, June 9, 1978

10:00 a.m. Regulation of the Immune Response by la-Antigen Complexes Chairman: M. Aizawa
Speaker: N. A. Mitchison (UK)
10:40 a.m. Derepressed Histocompatibility Alloantigen on Transplacentally Induced Murine Lung Tumors Chairman: F. Sendo
Speaker: W. J. Martin (USA)
11:20 a.m. Long-Term Studies of the Lymphoid System of the Mouse Chairman: K. Kikuchi
Speaker: A. J. S. Davies (UK)
1:30 p.m. Immune Response, Protection and Autoimmunity Following Immunization of Mice With Modified Syngeneic Tumor Cells Chairman: H. Hosokawa
Speaker: M. D. Prager (USA)
2:10 p.m. Paradoxical Age-Dependent Features of Growth of Transplanted Fetal Tissues and Tumors Chairman: H. Kobayashi
Speaker: G. Svet-Modavsky (USSR)
2:50 p.m. Spontaneous Neoplastic Transformation in vitro and its Relationship to Plastic Film Tumorigenesis Chairman: M. Sasaki
Speaker: C. W. Boone (USA)
3:30 p.m. Oncolytic Enteroviruses in Experiment and Clinics Chairman: T. Kodama
Speaker: A. J. Muceniece (USSR)
4: 10 p.m. Adjuvant Therapy of Carcinoma of the Colon and Rectum with Vaccinia Oncolysates Chairman: T. Tanabe
Speaker: M. K. Wallack (USA)


PARTICIPANTS, SPEAKERS, AND MEMBERS OF THE COMMITTEE

Miki Aizawa
Professor, First Department of Pathology
Hokkaido University School of Medicine
Sapporo 060, Japan

Tadao Aoki
Head, Shinrakuen Hospital
Ariake, Niigata 950-21, Japan

Charles W. Boone
Head, Cell Biology Section
Laboratory of Viral Carcinogenesis
National Cancer Institute
National Institutes of Health
Bethesda, Maryland 20014, U.S.A.

Coro Chihara
Head, Department of Chemotherapy
National Cancer Center Institute
Tokyo 104, Japan

J. S. Davies
Professor, Division of Biology
Chester Beatty Research Institute
London SW3 6JB, England

Toshio Dei
Department of Immunology
Research Institute for Tuberculosis and Cancer,
Tohoku University
Sendai 980, Japan

Eiki Cotohda
Cell Biology Section
Laboratory of Viral Carcinogenesis
National Cancer Institute
National Institutes of Health
Bethesda, Maryland 20014, U.S.A.

Chuya Hamada
Professor, Department of Virology
Niigata University School of Medicine
Niigata 951, Japan

Toshiyuki Hamaoka
Associate Professor
Department of Oncogenesis
Institute for Cancer Research
Osaka University School of Medicine
Osaka 553, Japan

Yoshiyuki Hashimoto
Professor
Laboratory of Hygienic Chemistry
Tohoku University School of Pharmacology
Sendai 980, Japan

Motoichi Hatano
Professor, Department of Virology
Cancer Research Institute
Kanazawa University
Kanazawa 910, Japan

Hidematsu Hirai
Professor
First Department of Biochemistry
Hokkaido University School of Medicine
Sapporo 060, Japan

Masuo Hosokawa
Laboratory of Pathology
Cancer Institute
Hokkaido University School of Medicine
Sapporo 060, Japan

Katsuaki Itakura
Professor Second Department of Pathology
Asahikawa Medical College
Asahikawa 071-01, Japan

Tateshi Kataoka
Cancer Chemotherapy Center
Japanese Foundation for Cancer Research
Tokyo 170, Japan

Kokichi Kikuchi
Professor
First Department of Pathology
Sapporo Medical College Sapporo 060, Japan

George Klein
Professor, Department of Tumor Biology
Karolinska Institute
S-104 01, Stockholm 60, Sweden

Hiroshi Kobayashi
Director and Professor, Laboratory of Pathology
Cancer Institute
Hokkaido University School of Medicine
Sapporo 060, Japan

Takao Kodama
Associate Professor
Laboratory of Pathology, Cancer Institute
Hokkaido University School of Medicine
Sapporo 060, Japan

Noboru Kuzumaki
Department of Tumor Biology
Karolinska Institute
S-104 01, Stockholm 60, Sweden

Jean Lindenmann
Professor, Department of Microbiology
University of Zurich
Gloriastrasse 32, CH-8006 Zurich
Switzerland

W. John Martin
Head, Division of Virology
Bureau of Biologics
Bldg. 29A, Rm. 3B-13
National Institutes of Health
Bethesda, Maryland 20014, U.S.A.

N. Avrion Mitchison
Professor, University College London
Department of Zoology-Imperial Cancer
Research Fund
Gower Street, London WCIE 6BT
England

Denichi Mizuno
Professor, Department of Pharmacology
Faculty of Pharmaceutical Sciences
University of Tokyo
Tokyo 113, Japan

Tetsuya Moriuchi
Laboratory of Pathology
Cancer Institute
Hokkaido University School of Medicine
Sapporo 060, Japan

Aina J. Muceniece
Professor, Laboratory of Tumor Virotherapy
August Kirchenstien
Institute of Microbiology
Latvian Academy of Sciences
Kleisti, 226067 Riga, U.S.S.R.

Kusuya Nishioka
Deputy Director
Tokyo Metropolitan Institute of Medical Science
Tokyo 113, Japan

Kunzo Orita
Professor, First Department of Surgery
Okayama University School of Medicine
Okayama 700, Japan

Toyoro Osato
Professor, Laboratory of Virology
Cancer Institute
Hokkaido University School of Medicine
Sapporo 060, Japan

Morton D. Prager
Professor Departments of Surgery and Biochemistry
University of Texas
Health Science Center at Dallas
Dallas, Texas 75235, U.S.A.

Fujiro Sendo
Associate Professor, First Department of Pathology
Yamagata University School of Medicine
Yamagata 990-23, Japan

G. M. Shearer
Immunology Branch
Division of Cancer Biology and Diagnosis
National Cancer Institute
National Institutes of Health
Bethesda, Maryland 20014, U.S.A.

Ceorge J. Svet-Moldavsky
Visiting Professor from U.S.S.R.
Department of Neoplastic Diseases
Mount Sinai School of Medicine
The City University of New York
New York, N.Y. 10029, U.S.A.

Takehiko Tachibana
Professor, Department of Immunology
Research Institute for Tuberculosis and Cancer, Tohoku University
Sendai 980, Japan

Tomio Tada
Professor, Department of Immunology
Faculty of Medicine
University of Tokyo
Tokyo 113, Japan

Noritoshi Takeichi
Laboratory of Pathology
Cancer Institute
Hokkaido University School of Medicine
Sapporo 060, Japan

Kenii Takeya
Professor, Department of Bacteriology
Kyushu University School of Medicine
Fukuoka 812, Japan

Toru Tokunaga
Head, Department of Tuberculosis
National Institute of Health
Tokyo 141, Japan

Eiro Tsubura Professor, Internal Medicine
Tokushima University School of Medicine
Tokushima 770, Japan

Shigeru Tsukagoshi
Head, Cancer Chemotherapy Center
Japanese Foundation for Cancer Research
Tokyo 170, Japan

Hisao Uetake
Professor, Institute of Virus Research
Kyoto University
Kyoto 606, Japan

Ichiro Urushizaki
Professor, Internal Medicine
Cancer Institute
Sapporo Medical College
Sapporo 060, Japan

Takeo Wada
Professor
First Department of Internal Medicine
Sapporo Medical College
Sapporo 060, Japan

Mare K. Wallack
Head
Section of Surgical Oncology
Barnes and Wohl Hospitals
St. Louis Missouri 63110, U.S.A.

Kazumasa Yamada
Associate Professor
First Department of Internal Medicine
Nagoya University School of Medicine
Nagoya 466, Japan

Tadashi Yamamoto
Professor
Institute of Medical Science
University of Tokyo
Tokyo 108, Japan

Yuichi Yamamura
Professor
Third Department of Internal Medicine
Osaka University School of Medicine
Osaka 553, Japan

Takato Yoshida
Professor
Department of Microbiology
Hamamatsu Medical College
Hamamatsu 431-31, Japan

Rolf M. Zinkernagel
Head
Department of Immunopathology
Scripps Clinic and Research Foundation
La Jolla, California 92037, U.S.A.