LIST OF PARTICIPANTS AND PAPERS PRESENTED FOR SEMINARS

CHEMICAL CARCINOGENESIS

I. The Action of Protease Inhibitors and Carcinogenesis
March 1975, Hawaii
U.S.A.
1. Walter Troll
New York University
The inhibition of carcinogenesis by protease inhibitors: Assay of proteases with Protamine.
2. Mortimer Levitz
New York University
Activation of protease and plasminogen activator by Estradiol and progesterone: Modification of hormone Action by Leupeptin and Antipain.
3. Laszlo Lorand
Northwestern University
The cascade activation of proteases.
4. Edward Reich
Rockefeller University
Plasminogen activator: The characteristic enzyme of cancer.
5. Eliot Shaw
Brookhaven National Laboratory
Serine Proteases: Their action and site specific inhibitors.
6. Arthur Upton
State University of New York at Stony Brook
7. Bernard Weinstein
Columbia University
The mechanism of inhibition of carcinogenesis by dexamethasone: Inhibition of plasminogen activator excretion.
8. Lowell M. Breenbaum
Columbia University
Pepstatin inhibition of neoplastic ascites fluid accumulation.
JAPAN
1. Takashi Sugimura
National Cancer Center Research Institute
Past, present and future, Japanese cancer research using protease inhibitors.
2. Hamao Umezawa
Institute of Microbial Chemistry
Isolation and characterization of microbial protease inhibitors.
3. Setsuro Fujii
Tokushima University
Protease inhibitors and cellular proteases.
4. Takashi Kawachi
National Cancer Center Research Institute
Pepstatin, Leupeptin and stomach carcinogenesis of rat.
5. Yoshitaka Nagai
Tokyo Metropolitan Institute of Gerontology
Protease inhibitors and blast formation of lymphatic cells.
6. Shozo Takayama
Cancer Institute
Leupeptin and liver carcinogenesis.
7. Takaaki Aoyagi
Institute of Microbial Chemistry
Pepstatin inhibition of neoplastic ascites by SV 40 virus.
8. Taijiro Matsushima
The University of Tokyo
Microbial protease inhibitors and metastasis.
9. Motonori Hoshi
Hokkaido University
Effect of protease inhibitors on the fertilization of Sea Urchin.
10. Motoo Hozumi
National Cancer Center Research Institute
Leupeptin and in vitro carcinogenesis
11. Tadao Kakizoe
Tokyo Metropolitan Komagome Hospital
Leupeptin and bladder tumor of rats by N-Butyl-N-hydroxybutyl-nitrosamine.
12. Kazuko Hara
The University of Tokyo
Determination of Leupeptin in serum, urine and feces of rats.
II. Evaluation of Methods of Carcinogenesis Testing in Mammals
November 17-20, 1975, Hakone, Japan
U.S.A.
1. Umberto Saffiotti
National Cancer Institute
Principles of bioassays and priority for selecting test chemicals: Current bioassay approaches in the United States and Japan
2. Richard R. Bates
NCI Frederick Cancer Research Center
Principles of bioassays and priority for selecting test chemicals: General discussions on selecting test chemicals
3. Emmanuel Farber
University of Toronto
Principles of bioassays and priority for selecting test chemicals: Mutagenicity, chromosomal aberrations, and other short tests
4. Peter N. Magee
Middlesex Hospital Medical School
General discussions on evaluation of results: Problem of threshold
5. Norbert P. Page
National Cancer Institute
Current bioassay approaches in the United States and Japan: Selecting test chemicals: Condition of animal care and diet: Questions to the U.S. Guidelines
6. Robert A. Squire
National Cancer Institute
Pathology, appoaches and interpretation: Significance of histological diagnosis of tumors
7. John H. Weisburger
Naylor Dana Institute for Disease Prevention, American Health Foundation
Mutagenicity, chromosomal aberrations, and other short tests: General discussions on evaluation of results: Problem of threshold

JAPAN
1. Shigeyoshi Odashima
National Institute of Hygienic Sciences
Principles of bioassays and priority for selecting the test chemicals: General discussion of evaluation of results: Problem of weak carcinogens
2. Takashi Sugimura
National Cancer Center Research Institute
Principles of bioassays and priority for selecting test chemicals
3. Makoto Enomoto
St. Marianna University
Pathology, approaches and interpretation: Significance of histological diagnosis of tumors
4. Ryo Fukunishi
Ehime University
Condition of animal care and diet
5. Yoshiyuki Hashimoto
Tohoku University
6. Yuzo Hayashi
Hatano Institute, Food and Drug Safety Research Center
Spieces and strains used: Spontaneous tumors
7. Iwao Hirono
Gifu University
Spieces and strains used: Susceptibility
8. Yoshio Ikeda
National Institute of Hygienic Sciences
Spieces and strains used: Susceptibility
9. Hidehiko Isaka
Kagoshima University
10. Motoi Ishidate
National Institute of Hygienic Sciences
Principles of bioassays and priority for selecting test chemicals: Mutagenicity, chromosomal aberrations, and other short tests
11. Takatoshi Ishikawa
Cancer Institute
12. Nobuyuki Ito
Nagoya City University
Dose levels frequency, duration, route, and method of administration: Pathology, approaches and interpretation: Significance of histological diagnosis of tumors
13. Takashi Kawachi
National Cancer Center Research Institute
Mutagenicity, chromosomal aberrations, and other short tests
14. Akihiko Maekawa
National Institute of Hygienic Sciences
Spieces and strains used: Spontaneous tumors
15. Taijiro Matsushima
University of Tokyo
General discussions on evaluation of results: The Problem of threshold
16. Mutsushi Matsuyama
Aichi Cancer Center Research Institute
17. Masahiro Nakadate
National Institute of Hygienic Sciences
Principles of bioassays and priority for selecting test chemicals: General discussions on selecting test chemicals
18. Toshiaki Ogiu
National Institute of Hygienic, Sciences
Condition of animal care and diet
19, Shoji Tokuoka
Hiroshima University
20. Kenjiro Yokoro
Hiroshima University
Spieces and strains used: Susceptibility
III. Modified Cellular and Molecular Controls in Neoplasia
December 9-12, 1975, Hawaii
U.S.A.
1. Wayne E. Criss
Howard University
Regulation by the adenylate and guanylate energy charge in neoplastic liver.
2. Stuart A. Aaronson
National Cancer Institute
Cellular genetic controls in endogenous viral production
3. Henry C. Pitot, Jr.
University of Wisconsin
Intercellular membranes and post-transcriptional regulation in neoplasia
4. Russell Hilf
University of Rochester
Hormonal controls in mammary neoplasia
5. Francis Kenney
Oak Ridge National Laboratory
Glucocorticoid regulation in cultured hepatoma cells
6. Nelson Goldberg
University of Minnesota
Regulation of cyclic GMP and cyclic AMP
7. Chung Wu
University of Michigan
Hormonal regulation of some enzymes in amino acid metabolism
8. Rameshwar K. Sharma
University of Tennessee
Regulation of steroidogenesis in adrenal tumors
9. Marvin D. Siperstein
University of California, San Francisco
Regulation of cholesterol synthesis in neoplasia
10. John J. Voorhees
University of Michigan
Cyclic nucleotides in benign tumors
11. Kenneth S. McCarty
Duke University
Hormonal induction of neoplasia
12. Philip Coffino
University of California, San Francisco
Somatic genetic analysis of hormone action
13. Eugene DeSombre
University of Chicago
Steroid receptors in breast neoplasia
14. George Johnson
National Cancer Institute
Cyclic nucleotide regulation in normal and transformed cells
15. John J. Perkins
University of Colorado
Regulation of CAMP in malignant brain cells
16. Wesley D. Wicks
University of Colorado
Effects of cyclic AMP derivatives on tumor cells
17. A. W. Hsie
Oak Ridge National Laboratory
Action of cyclic AMP in Chinese hamster ovary cells
18. Harris Busch
Baylor College of Medicine
Nucleic acid metabolism in neoplasia
19. Sidney Weinhouse
Temple University
Isozyme composition and gene regulation in experimental hepatomas
20. S. Abraham
Bruce Lyon Memorial Research Laboratory, Oakland, Calif.
Lipids and lipogenesis in murine mammary neoplastic system
21. Arthur C. Upton
State University of New York at Stony Brook
22. Lawrence H. Piette
Cancer Center of Hawaii
23. J. C. Bartley
University of California, Oakland
24. Frederick Greenwood
Cancer Center of Hawaii
25. Tom Humpherys
Cancer Center of Hawaii
JAPAN
1. Tetsuo Ono
Cancer Institute, Japanese Foundation for Cancer Research
The mechanism of alkaline phosphatase induction in cultured mammary carcinoma cells
2. Takashi Sugimura
National Cancer Center Research Institute
Recent advances in studies on poly (ADP Ribose)
3. Hiroshi Terayama
The University of Tokyo
Epinephrine and corticoid receptors in plasma membranes of liver and hepatomas
4. Yasutomi Nishizuka
Kobe University
Protein phosphokinases and mode of action of cyclic GMP
5. Mitsuaki Yoshida
Cancer Institute, Japanese Foundation for Cancer Research
Adenylate cyclase activity in cells transformed by avian sarcoma viruses
6. Akira Ichihara
Tokushima University
Isozymes of cultured liver cells
7. Shigeru Tsuiki
Tohoku University
Neoplastic alterations and mechanisms of glucosamine 6-phosphate synthetase
8. Michihiko Kuwano
Kyushu University
Regulation of RNA metabolism in malignant cells
9. Hiroshi Kimura
Osaka University
Cyclic nucleotide in hepatoma
AUSTRALIA
1. John Sabine
University of Adelaide
Progressive loss of cellular metabolic controls during hepatic carcinogenesis
2. A. W. Murray
Flinders University
Effects of carcinogens and tumor promotors on epidermal cyclic nucleotide metabolism
3. F. J. Ballard
Division of Human Nutrition, C. S. I. R. O., Adelaide
Regulation of protein degradation in cultured hepatoma cells
4. J. J. Marchalonis
Walter and Eliza Hall Institute
Membrane immunoglobulins of neoplastic human and murine lymphocytes
5. J. F. Williams
Australian National University
The status of pyridine and adenine nucleotide ratios and of futile substrate cycling in the regulation of the energy metabolism and proposed hyperthermic regression of neoplasms
6. F. L. Bygrave
Australian National University
Mitochondrial calcium transport and the regulation of metabolism by calcium in tumor cells



CANCER VIROLOGY

I. Recent Advances in Tumor Virology
March 22-23, 1975, Hawaii
U.S.A.
1. Robert M. McAllister
Childrens Hospital of Los Angeles
RD-114 virus: a status report
2. Fred Rapp
The Pennsylvania State University
A quantitative focus assay for transformation by Herpes simplex virus.
3. J. T. August
Albert Einstein College of Medicine
Genetic expression of RNA tumor viruses
4. Robert Gallo
National Cancer Institute
Primate type-C viruses and leukemia.
5. Walter Eckhart
The Salk Institute for Biological Studies
Gene functions of polyoma virus
6. Murray Gardner
University of Southern California
Epidemiology and virology of naturally occurring cancer in wild mice.
JAPAN
1. Yohei Ito
Kyoto University
Shope papilloma-carcinoma complex as a prospective model for human cencer research
2. Hiroto Shimojo
The University of Tokyo
Analysis of cell transformation with temperature mutants of Simian virus 40
3. Toyoro Osato
Hokkaido University
Studies on the target cells for transformation by EB virus.
4. Kumao Toyoshima
Osaka University
Temperature dependent properties of the cells transformed by ts 121, a temperature sensitive mutant of polyoma virus.
5. Kei Fujinaga
Sapporo Medical College
Partial viral genome estimation: viral genome in adenovirus transformed cells.
6. Yoji Ikawa
Cancer Institute
Release of differentiation arrest in Friend virus-induced leukemia cells
7. Hiroshi Yoshikura
The University of Tokyo and Radium Institute, France
Host range determination of murine leukemia and sarcoma viruses
II. Viral Oncogenesis: Transmission, Persistence and Expression of Viral Genome.
March 26-27, 1976, Kyoto
U.S.A.
1. R. M. McAllister
University of Southern California and Childrens Hospital of Los Angeles
RD-114 virus: studies of the RNA of extracellular virus and the DNA of intracellular provirus.
2. W. Eckhart
The Salk Institute for Biological Studies
Polyoma virus and SV 40: viral gene functions and growth regulation.
3. R. Gallo
National Cancer Institute
The population of “Wolly Monkey (Simian) sarcoma viruses and type-C viruses from baboons and analyses of related viruses from man.
4. J. M. Bishop
University of California, San Francisco
Avian tumor viruses: transforming genes in normal avian cells.

5. P. K. Vogt
University of Southern California
Avian tumor viruses: gene physiology and gene mapping
6. M. Gardner
University of Southern California
Murine type-C viruses: pathogenesis of lymphoma and paralysis in wild mice.

7. J. Maizel
National Institute of Child Health, NIH
Human adenoviruses: early proteins.

JAPAN
1. Yohei Ito
Kyoto University
Establishment of epithelial cell lines with tumorigenic capacity from nasopharynageal carcinoma tissues.
2. Hiroto Shimojo
The University of Tokyo
Differentiation between T antigen and DNA binding protein in adenovirus 12-infected and transformed cells.
3. Tsutomu Miyamoto
Nagasaki University
Ecology of an avian tumor virus: Genetic conversion of Rous sarcoma virus.
4. Masahide Ishibashi
Aichi Cancer Center Research Institute
A search for virus-specific polypeptides in type 5 adenovirus-infected transformed cells.
5. Shiro Kato
Osaka University
Studies on Marek’s lymphoma cell lines with respect to their association with expressions of avian RNA tumor viruses
6. Akira Hakura
Osaka University
Polyoma virus: relation between viral gene functions and host cells.
7. Genki Kimura
Tottori University
Transformation system for polyoma virus SV 40 and adenovirus 1 2 using clonal cultures of a rat cell line.
8. Kumao Toyoshima
Osaka University
Control of chick helper factor in cells which lack natural group-specific antigen of avian leukosis.
9. Hiroshi Yoshikura
The University of Tokyo
Possible role of chemical carcinogen in the induction of mouse endogenous C-type virus.
10. Toyoro Osato
Hokkaido University
Type-C virus as a possible influencing factor of Epstein Barr virus expression.
11. Kei Fujinaga
Sapporo Medical College
Viral genome in adenovirus-transformed cells.
12. Sadaaki Kawai
The University of Tokyo
Recombination between a ts-mutant and a deletion mutant of Rous sarcoma virus.
13. Yorio Hinuma
Kumamoto University
14. Hisao Uetake
Kyoto University
15. Yoshikatsu Ozaki
Shiga Medical College
16. Kunihiro Notake
Aichi Medical College
17. Mitsuaki Yoshida
Cancer Institute, Japanese Foundation for Cancer Research
18. Katsuhiko Ono
Aichi Cancer Center
19. Akira Seto
Kyoto University
20. Masatoshi Owada
Osaka University
21. T. Niwa
Kyoto University


CANCER IMMUNOLOGY

I. Immunotherapy of Cancer and Its Fundamental Basis
March 13-15, 1 975, Hawaii
U.S.A.
1. William D. Terry
National Cancer Institute
2. Evan M. Hersh
M.D. Anderson Hospital, Univ. of Texas
Systemic use of BCG in man
3. E. Carmack Holmes
University of California, Los Angeles
Local and systemic use of BCG in man
4. Albert F. LoBuglio
Ohio State University
Transfer factor-characterization and immunotherapeutic trials
5. James F. Holland
Mount Sinai Hospital
Immunotherapy with neuraminidase treated cells
6. Herbert J. Rapp
National Cancer Institute
BCG and related products in immunotherapy of animal tumors
7. Steven A. Rosenberg
National Cancer Institute
8. Tadao Aoki
National Cancer Institute
Use of Strep. hemolyticus in the AKR spontaneous leukemia model
9. Herbert F. Oettgen
Memorial Sloan-Kettering Cancer Center
Therapeutic trials with C. parvum and other immunopotentiators
10. Dorothy B.Windhorst
National Cancer Institute
JAPAN
1. Yuichi Yamamura
Osaka University
In vitro adjuvant effect and antitumor activity of BCG cell wall skeleton
2. Ichiro Azuma
Osaka University
3. Hiroshi Kobayashi
Hokkaido University
Immunotherapy of tumor by allogeneic cells
4. Kokichi Kikuchi
Sapporo Medical College
In vitro blastogenesis and local response of lymphocytes to human autochthonous tumors
5. Masayasu Kitagawa
Osaka University
Cellular events of immunosuppression in tumor bearing host
6. Tadashi Yamamoto
The University of Tokyo capacity
Antitumor antibiotics carrying immunopotentiation
7. Tomiko Tanaka
National Cancer Center Research Institute
Effect of intratumor injection of live BCG on 3-methylcholanthrene-induced tumors of primary and early transplant generation in mice
II. Immunotherapy of Cancer and Its Fundamental Basis
March 16-20, 1976, Coronado, California
U.S.A.
1. William D. Terry
National Cancer Institute
Immunotherapy of malignant melanoma

2. J. George
Mt. Sinai School of Medicine
Bekesi Immunotherapy of AML

3. Evan M. Hersh
M. D. Anderson Hospital
1. Immunotherapy of breast cancer
1. Immunopotentiation by BCG
4. Richard J. Hodes
National Cancer Institute
In vitro studies in melanoma patients receiving immunotherapy
5. Albert LoBuglio
Ohio State University Hospital
Can non-specific immunotherapy affect human monocyte macrophage function ?

6. Donald Morton
California University
Immunotherapy of melanoma and sarcoma

7. Herbert F. Oettgen
Memorial Sloan-Kettering Cancer Center
Lysolecithin analogues as immunotherapeutic agents. Endotoxin-induced tumor necrosis factor
8. Herbert J. Rapp
National Cancer Institute
Immunotherapy of experimental cancer with BCG
9. Steven A. Rosenberg
National Cancer Institute
Immunologic studies on patients with sarcoma and melanoma

10. Dorothy B. Windhorst
National Cancer Institute
JAPAN
1. Yuichi Yamamura
Osaka University
Immunological and antitumor activities of Nocardia cell wall skeleton and synthetic peptidoglycan subunits
2. Kazumasa Yamada
Nagoya University
Therapy of patients with acute leukemia-immunotherapy with cell wall skeleton of BCG and chemotherapy

3. Susumu Kishimoto
Kumamoto University
Immunotherapy of leukemia with BCG cell wall skeleton
4. Kosei Yasumoto
Kyushu Cancer Center
Immunotherapy of human lung cancer with BCG cell wall skeleton
5. Yoshiyuki Hashimoto
Tohoku University
An approach to immunotherapy of urinary bladder cancer
6. Takato O. Yoshida
Hamamatsu University Medical School
Tumor-specific immune response and immuno-deficiency during development of autochthonous tumor
7. Kokichi Kikuchi
Sapporo Medical College
Role of T-cells in resistance against autochthonous tumors
8. Hiroshi Kobayashi
Hokkaido University
Xenogenization and its application to immunotherapy of cancer
9. Masayasu Kitagawa
Osaka University
T cell functions in resistance against cancer




CANCER CHEMOTHERAPY

I. Comparative Study on Cytosine Arabinoside and Cyclocytidine, Experimental and Clinical
February 13-14, 1975, Tokyo
U.S.A.
1. Stephen K. Carter
National Cancer Institute
Cytosine Arabinoside and Cyclocytidine as an example of the problem in analogue development.
An overview of the U.S. experience with Ara-C.
2. Abraham Goldin
National Cancer Institute
Cytosine Arabinoside and Cyclocytidine as example of the problem of schedule dependence testing.
Combination experimental studies with Cytosine Arabinoside and Cyclocytidine
3. Kenneth B. McCredie
M. D. Anderson Hospital, University of Texas
Clinical experience with Cyclocytidine in the U.S.
Cytosine Arabinoside alone and in combination in the treatment of acute adult leukemia
4. Dah H. Ho
M.D. Anderson Hospital, University of Texas
Pharmacologic studies with cyclocytidine in the U.S.
5. Irwin H. Krakoff
Memorial Sloan-Kettering Cancer Center
Development of and clinical experience with AAFC a fluorinated analogue of cyclocytidine

JAPAN
1. Yoshio Sakurai
Cancer Chemotherapy Center, Japanese Foundation for Cancer Research
2. Susumu Hibino
National Nagoya Hospital
3. Hachihiko Hirayama
Kohjin Co., Ltd.
4. Akio Hoshi
National Cancer Center Research Institute
Metabolism of cyclocytidine
5. Akira Hoshino
Cancer Chemotherapy Center, Japanese Foundation for Cancer Research
On the basis of experimental combination chemotherapy
6. Motonobu Ichino
Kojin Co., Ltd.
Pharmacology of cyclocytidine
7. Touru Ise
National Cancer Center Hospital
Clinical effects of cyclocytidine in the treatment of acute leukemia in children
8. Kiyoji Kimura
National Cancer Center Hospital
Cytocidal action of cyclocytidine in comparison of that of cytosine arabinoside.
An overview of the clinical effects of cyclocytidine in the treatment of acute leukemia in Japan.
The 6th National Hospital controlled cooperative studies of clinical effects of cyclocytidine alone and in combination in the treatment of acute leukemia
9. Kazuo Kuretani
National Cancer Center Research Institute
Metabolism of cyclocytidine
10. Toru Masaoka
Center for Adult Diseases, Osaka
On the decrease curve of leukemic cell in the treatment of acute leukemia with special reference to that of cyclocytidine
11. Toru Nakamura
Kyoto University
Mechanism of action of cyclocytidine in comparison of that of cytosine arabinoside
12. Makoto Ogawa
Aichi Cancer Center
Clinical effect of combination chemotherapy including cytosine arabinoside in the treatment of acute leukemia
13. Ryuzo Ohno
Nagoya University
Clinical effect of combination chemotherapy including cyclocytidine in the treatment of acute leukemia
14. Kazuo Oota
Aichi Cancer Center
Clinical effect of combination chemotherapy including cytosine arabinoside in the treatment of acute leukemia
15. Hiroshi Otsuki
National Cancer Center Hospital
Clinical effects of cyclocytidine in the treatment of acute leukemia in children
16. Yasunobu Sakai
National Cancer Center Hospital
Trial of new administration method of cyclocytidine and its clinical effects
17. Teruo Sakano
National Cancer Center Hospital
Trial of new administration method of cyclocytidine and its clinical effects
18. Nobuyuki Senda
Center for Adult Diseases, Osaka
On the decrease curve of leukemic cell in the treatment of acute leukemia with special reference to that of cyclocytidine
19. Shigeru Tsukagoshi
Cancer Chemotherapy Center, Japanese Foundation for Cancer Research
20. Hamao Umezawa
Institute of Microbial Chemistry
21. Gyoichi Wakisaka
Kyoto University
Mechanism of action of cyclocytidine in comparison of that of cytosine arabinoside
22. Kazumasa Yamada
Nagoya University
Clinical effect of combination chemotherapy including cyclocytidine in the treatment of acute leukemia
II. Phase I Study
February 14-15, 1975, Tokyo
U.S.A.
1. Stephen K. Carter
National Cancer Institute
NCI approach to clinical drug testing
2. Abraham Goldin
National Cancer Institute
The potential impact of experimental studies on the clinic
3. Kenneth B. McCredie
M. D. Anderson Hospital, University of Texas
Principles of Phase I Study evaluation
4. Dah H. Ho
M. D. Anderson Hospital, University of Texas
The interaction of the pharmacologist in clinical drug evaluation
5. Irwin H. Krakoff
Memorial Sloan-Kettering Cancer Center
Principles of Phase II Study evaluation
JAPAN
1. Yoshio Sakurai
Cancer Chemotherapy Center, Japanese Foundation for Cancer Research
2. Ichita Amaki
Nihon University
3. Hiroshi Fujita
Tsurumi University
Pharmacokinetics of anticancer agents for a clinical application
4. Hisashi Furue
Cancer Institute Hospital, Japanese Foundation for Cancer Research
5. Yoshio Hara
Niigata Cancer Center
6. Takao Hattori
Hiroshima University
7. Akira Hoshino
Cancer Chemotherapy Center, Japanese Foundation for Cancer Research
Evaluation of anticancer agents using L1210 mouse leukemia.
Phase I study of methyl-CCNU in Japan
8. Munemoto Ito
The Second National Hospital of Tokyo
9. Kiyoji Kimura
National Cancer Center Hospital
The in vitro screening and evaluation of anticancer agents.
Phase I study of ACNU 3-[(4-amino-2-methyl-5 pyrimidiny) methyl] -1-(2-chloroethyl)-I -nitrosourea hydrochloride
10. Tatsuhei Kondo
Nagoya University
11. Yoshiyuki Koyama
National Medical Center Hospital
Phase III Study of stomach cancer at National Hospital Chemotherapy Groups
12. Tadashi Maekawa
Gunma University
13. Hisashi Majima
Chiba Cancer Center
14. Hiroaki Nakazto
Aichi Cancer Center
Effects of mitomycin C as an adjuvant chemotherapy for the curative operation of stomach cancer
(Phase III study)
15. Hisanobu Niitani
National Cancer Center Hospital
16. Kazuo Oota
Aichi Cancer Center
17. Tatsuo Saito
Tohoku University
18. Hiroshi Sato
Sasaki Institute
Tumor spectrum of new anticancer agents using ascites hepatoma in rats
19. Nobuyuki Senda
Center for Adult Diseases, Osaka
20. Tetsuo Taguchi
Osaka University
21. Fujimaro Takaku
Jichi Medical School
22. Shigeru Tsukagoshi
Cancer Chemotherapy Center, Japanese Foundation for Cancer Research
23. Masanori Shimoyama
National Cancer Center Hospital
The in vitro screening and evaluation of anticancer agents
24. Hamao Umezawa
Institute of Microbial Chemistry
25. Gyoichi Wakisaka
Kyoto University
26. Yasunobu Sakai
National Cancer Center Hospital
Phase I Study of ACNU 3-[(4-amino-2-methyl-5 pyrimidinyl) methyl]-1-(2-chloroethyl)-1-nitrosourea hydrochloride
27. Kazumasa Yamada
Nagoya University
28. Kazuo Yunoki
Kagoshima University
III. Diagnosis and Treatment of Gastric Cancer
December 9, 1975, Tokyo
U.S.A.
1. Stephen K. Carter
National Cancer Institute
The current approach to gastrointestinal cancer therapy
2. Harry Handelman
National Cancer Institute
Review of other studies in gastric cancer
3. Edward D. Holyoke
State University of New York at Buffalo
Surgery of gastric cancer
4. Philip T.Lavin
State University of New York, Amherst
The role of the statistician in clinical trials with special emphasis on gastrointestinal cancer
5. Charles G. Moertel
University of Minnesota
Chemotherapy of gastric cancer
6. Philip S. Schein
Georgetown University
The gastrointestinal tumor study group -Structure and gastric cancer protocols
JAPAN
1. Yoshio Sakurai
Cancer Chemotherapy Center, Japanese Foundation for Cancer Research
2. Tamaki Kajitani
Cancer Institute Hospital, Japanese Foundation for Cancer Research
The present status of surgical role in treatment of gastric cancer in Cancer Institute
3. Kiyoji Kimura
National Cancer Center Hospital
4. Toshio Kurokawa
Cancer Institute Hospital, Japanese Foundation for Cancer Research
5. Hisashi Majima
Chiba Cancer Center
6. Kiyoshi Miwa
National Cancer Center Hospital
Statistical data of more than 10,000 stomach cancer patients treated in Japan
7. Toshifusa Nakajima
Cancer Institute Hospital, Japanese Foundation for Cancer Research
8. Kyoichi Nakamura
Tsukuba University
Diagnosis of early stomach cancer -Biopsy-
9. Hiroaki Nakazato
Aichi Cancer Center
Some additional presentations on the statistical investigation
10. Yanao Ogura
National Cancer Center Hospital
11. Tatsuo Saito
Tohoku University
The methods and results of chemotherapeutic treatment of gastric cancer by the protocols
12. Takao Sakita
Tsukuba University
Diagnosis of early stomach cancer -Endoscopy-
13. Hikoo Shirakabe
Juntendo University
Diagnosis of early stomach cancer -X-ray diagnosis-
14. Haruo Sugano
Cancer Institute, Japanese Foundation for Cancer Research
15. Takao Takekoshi
Cancer Institute Hospital, Japanese Foundation for Cancer Research
Diagnosis of early stomach cancer -Biopsy-
16. Shigeru Tsukagoshi
Cancer Chemotherapy Center, Japanese Foundation for Cancer Research
17. Hamao Umezawa
Institute of Microbial Chemistry
18. Teruo Sakano
National Cancer Center Hospital
IV. Comparative Studies of New Antitumor Agents and New Modality of Application - Symposium on the Nitrosoureas, Symposium on Bleomycin –
February 6-8, 1976, Hawaii
U.S.A.
1. Stephen K. Carter
National Cancer Institute
The Nitrosoureas-thoughts for the future-An overview of Bleomycin in U.S. clinical trials
2. Abraham Goldin
National Cancer Institute
Experimental studies with Bleomycin and their implication for clinical trial
3. Irwin Krakoff
Memorial Solan-Kettering Cancer Center
Studies with the Nitrosoureas at Memorial Hospital Bleomycin studies at the Memorial Sloan-Kettering Cancer Center
4. Robert Livingston
M.D. Anderson Hospital and Tumor Institute University of Texas
Combination chemotherapy approaches with the Nitrosoureas Bleomycin in combination chemotherapy regimens for solid tumors
5. Frank M. Schabel, Jr.
Southern Research Institute
Experimental tumor data with the Nitrosoureas and the implications for future analogue development
6. Philip Schein
Vincent T. Lombardi Cancer Research Center Gerogetown University
Streptozotocin - Current status and background and new analogues
7. Todd Wasserman
National Cancer Institute
An overview of the Nitrosoureas in U.S. clinical trials (BCNU, CCNU, MeCCNU) Bleomycin in combination chemotherapy Regimens for the malignant lymphomas
JAPAN
1. Yoshio Sakurai
Cancer Chemotherapy Center; Japanese Foundation for Cancer Research
Introduction of GANU
2. Ikuichiro Hiroto
Kyushu University
The effect of Bleomycin on the head and neck tumors

3. Tokuji Ichikawa
Tokyo University
Simultaneous combination with Bleomycin and radiation in the cancer therapy
4. Kaichi Isono
University of Chiba
Studies on the combined therapy with Bleornycin and radiation for esophageal carcinoma
5. Tatuo Saito
Tohoku University
An overview of Phase 11 Study of ACNU
6. Teruo Sakano
National Cancer Center Hospital
An overview of Phase I Study of ACNU
7. Yasushi Shigematsu
Osaka University
Present state of a controlled study of combined treatment with Bleomycin and radiation in Kyoto-Osaka-Kobe Area
8. Toyozo Terashima
National Institute of Radiological Sciences
Effect of Bleomycin on mammalian cells- The implication for tumor therapy
9. Hamao Umezawa
Institute of Microbial Chemistry
10. Masao Arakawa
Sankyo Pharmaceutical Co., Ltd.
Pharamacology of ACNU
11. Akira Matsuda
Nippon Kayaku Co.
Experimental chemotherapy of rat stomach cancer with Bleomycin




ANALYTICAL EPIDEMIOLOGY

I. Analytical Epidemiology of Cancer
December 2-5, 1 975, Orlando, Florida
U.S.A.
1. Robert W. Miller
National Cancer Institute
2. W. J. Schull
University of Texas
3. H. T. Lynch
Creighton University
4. A. M. DiGeorge
St. Christopher’s Hospital for Children, Philadelphia
5. J. J. Mulvihill
National Cancer Institute
6. J. F. Fraumeni
National Cancer Institute
7. W. E. Heston
National Cancer Institute
JAPAN
1. Takeshi Hirayama
National Cancer Center Research Institute
New horizon in cancer epidemiology
2. Noboru Kobayashi
The University of Tokyo
Precious cases in the epidemiology of childhood malignancies in Japan.

3. J. Utsunomiya
Tokyo Medical-Dental University
Approach to control familial polyposis in Japan. Gastric lesion in familial polyposis
4. M. Hitosugi
Kitasato University
New understanding of occupational cancer problems in Japan
5. K. Mabuchi
Johns Hopkins School of Public Health
An occupational study in progress
6. T. Yoshimura
Kyushu University
Epidemiological approach to PCB problems in Japan
7. K. Fukuda
Sapporo Medical College
Methodology in analytical epidemiology




LUNG CANCER

I. The Meeting for Morphology and Staging of Lung Cancer
March 26-28, 1975, Tokyo
U.S.A.
1. Clifton F. Mountain
M.D. Anderson Hospital and Tumor Institute University of Texas
Correlation between T. N M. to Prognosis
Correlation between Primary Variables of Staging to Survival
2. Mary Mattews
National Cancer Institute
Histological Classification in U.S.A. Selected Problems in Histology
JAPAN
1. Takeshi Hirayama
National Cancer Center Research Institute
2. Shichiro Ishikawa
National Cancer Center Hospital
Uniformity of T.N.M. classification between American and Japan Joint Committee
3. Yukio Shimosato
National Cancer Center Hospital
Histological classification by N.C.C.
4. Toshio Kitagawa
National Cancer Center Hospital
Radiotherapy
5. Hisanobu Niitani
National Cancer Center Hospital
6. Keiichi Suemasu
National Cancer Center Hospital
Co-ordinate staging carrying out at M.H. and N.C.C.
7. Yoshihiro Hayata
Tokyo Medical College
Surgical adjuvant chemotherapy
8. Shoji Hattori
Center for Adult Diseases, Osaka
E.M. findings of oat cell carcinoma chemotherapy
9. Yutaka Hayashi
Chiba University
10. Yutaka Yamaguchi
Chiba University
Surgical adjuvant chemotherapy
11. Yoshio Okada
Aichi Cancer Center
Surgical adjuvant chemotherapy
12. Iwao Kinoshita
Cancer Institute, Japanese Foundation for Cancer Research
Surgical adjuvant chemotherapy
13. Hiomi Homma
Juntendo University
Staging by J.L.C.S. chemotherapy
II. The Meeting for Detection of Early Lung Cancer
November 25-26, 1975, Tokyo
U.S.A.
1. Robert S. Fontana
Mayo Clinic
Mayo Lung Project and N.C.I. Project case presentation of early lung cancer - U.S. cases-
2. Morton L. Levin
Johns Hopkins University
Epidemiology in U.S. (Lung Cancer)
3. Geno Saccomanno
St. Mary’s Hospital
Cytology of sputum prior to the development of lung cancer
4. David R.Sanderson
Mayo Clinic
Current status of bronchoscopic findings of early lung cancer and newer development of bronchoscopic examination and endoscopic localization of early lung cancer
5. Lewis B. Woolner
Methodist Hospital and Mayo Clinic
Case presentation of early lung cancer -U.S. cases.
Cytopathologic aspects of early lung cancer
JAPAN
1. Takeshi Hirayama
National Cancer Center Research Institute
Epidemiology in Japan
2. Shigeto Ikeda
National Cancer Center Hospital
Japanese Lung Cancer Project for early detection Current status of bronchoscopic findings of early lung cancer
3. Shoji Hattori
Center for Adult Diseases, Osaka
Cytopathologic aspects of early lung cancer Difference between exfoliated cancer cells and well preserved cancer cells
4. Yoshihiro Hayata
Tokyo Medical College
Japanese Lung Cancer Project for therapy
5. Hiomi Honma
Juntendo Medical College
6. Shihei Horie
Dokkyo University
New technique for the examination of bronchoscopy
7. Iwao Kinoshita
Cancer Institute Hospital, Japanese Foundation for Cancer Research
8. Yuzuru Nishimura
Aichi Cancer Center
Case presentation of peripheral early lung cancer
9. Yukio Shimozato
National Cancer Center Hospital
Case presentation of early lung cancer Japanese cases - pathological report
10. Masanobu Takahashi
Kyorin Medical University
Cytology in early lung cancer of central type
11. Takashi Teramatsu
Kyoto University
Case presentation of early lung cancer
12. Hiroshi Yoshimatsu
Kitazato Institute Hospital
Japanese mediastinal diagnosis project



BREAST CANCER

I. Breast Cancer Planning Seminar
July 15-19, 1974, Bethesda, Maryland
U.S.A.
1. Nathaniel I. Berlin
National Cancer Institute
2. Gregory T. O’Conor
National Cancer Institute
3. Paul P. Carbone
National Cancer Institute
4. William McGuire
University of Texas, San Antonio
JAPAN
1. Haruo Sugano
Cancer Institute, Japanese Foundation for Cancer Research
2. Yoji Ikawa
Cancer Institute, Japanese Foundation for Cancer Research
3. Keijiro Kuno
Cancer Institute Hospital, Japanese Foundation for Cancer Research
II. U.S.-Japan Joint Seminar on Breast Cancer - Focusing Binational Efforts on Breast Cancer -
March 26-27, 1976, Tokyo
U.S.A.
1. Nathaniel I. Berlin
Northwestern University
The Breast Cancer Task Force of the National Cancer Institute - History and Development
2. William L. McGuire
University of Texas
Progesteron receptor of breast cancer and its correlation with clinical response
3. Guy R. Newell, Jr.
National Cancer Institute
Simultaneous occurrence of breast and other cancers
4. Robert R. Omata
National Cancer Institute
5. William Pomerance
National Cancer Institute
The possible contribution and limitations of the detection of early lesions to survival from breast cancer
6. Pietro M.Gullino
National Cancer Institute
Mammary tumor regression after hormonal deprivation of the host
7. Paul P. Carbone
National Cancer Institute
Changing roles of surgery, radiotherapy and chemotherapy in the treatment of primary breast cancer
8. Jeffrey Schlom
National Cancer Institute
Structural studies of the Mason - Pfizer Monkey viruses (tentative)
9. David Colcher
Meloy Laboratories, Inc.
10. Don Fine
NCI Frederick Cancer Research Center
JAPAN
1. Haruo Sugano
Cancer Institute, Japanese Foundation for Cancer Research
Histological features of breast cancer among Japanese female
2. Masao Fujimori
Saitama Cancer Center
Activities of Japanese Mammary Cancer Society
3. Takeshi Hirayama
National Cancer Center Research Institute
Socio-economical factors on breast cancer incidence
4. Yoji Ikawa
Cancer Institute, Japanese Foundation for Cancer Research
5. Masaru Izuo
Gunma University
Breast cancer cases in Japan - stage, treatment and the results
6. Soichi Kumaoka
National Cancer Center Research Institute
Possible etiological factors in breast cancer patients - analysis of hormones
7. Keijiro Kuno
Cancer Institute Hospital, Japanese Foundation for Cancer Research
Surgery of breast-cancer cases in Cancer Institute Hospital
8. Keishi Matsumoto
Osaka University
Estrogen receptors on breast cancer cells
9. Akio Matsuzawa
University of Tokyo
Pregnancy dependent virus-induced mammary tumor in DDD mice
10. Yasuaki Nishizuka
Aichi Cancer Center Research Institute
Experimental study of mammary cancer
11. Harutaka Tanaka
Kyoto University
Polypeptides and antigens of A and B particles of MTV
12. Shu Yuasa
The Institute of Public Health
Breast cancer incidence and menstruating period
13. Osahiko Abe
Keio University
14. Munemitsu Hoshino
Aichi Cancer Center Research Institute
15. Tamaki Kajitani
Cancer Institute Hospital, Japanese Foundation for Cancer Research
16. Junzo Kato
Teikyo University
17. Noboru Kurihara
Hiroshima University
18. Sotokichi Morii
Kansai Medical University
19. Nobuaki Sasano
Tohoku University
20. Eiichi Sato
Kagoshima University
21. Osamu Takatani
National Cancer Center Hospital
22. Hiroki Koyama
Center for Adult Diseases, Osaka
23. Hiroshi Yamamoto
National Cancer Center Hospital
24. Toshio Wagai
Juntendo University
A new echographic apparatus for mass-screening of breast cancer




URINARY BLADDER CANCER

I. Planning Seminar of Urinary Bladder Cancer
February 5-22, 1975, Madison, Wisconsin
U.S.A.
1. George T. Bryan
University of Wisconsin
2. Ryoichi Oyasu
Northwestern University
3. Walter Troll
New York University
4. Gilbert Friedell
St. Vincent Hospital
5. Joseph Leighton
The Medical College of Pennsylvania
JAPAN
1. O. Yoshida
Kyoto University
2. M. Okada
Tokyo Biochemical Research Institute
3. N. Ito
Nagoya City University
II. Experimental Models for Bladder Cancer
December 7-9, 1975, Hawaii
U.S.A.
1. George T. Bryan
University of Wisconsin
2. Ryoichi Oyasu
Northwestern University
Urinary bladder carcinogenesis in hamsters
3. Gilbert Friedell
St. Vincent Hospital
4. Joseph Leighton
The Medical College of Pennsylvania
Growth of normal and malignant bladder epithelium in vitro and as heterotopic implants
5. S. Cohen
Bladder cancer induced by FANFT
6. A. M. Pamukcu
University of Wisconsin
Bladder cancer in cattle and rats induced by bracken fern
7. C. Irving
VA Hospital Memphis
Biochemical mechanisms in experimental bladder cancer
8. R. E. Greenfield
St. Vincent Hospital
Review of other experimental studies in urinary bladder cancer in United States
9. M. S. Soloway
Bladder cancer in mice induced by FANFT
JAPAN
1. Osamu Yoshida
Kyoto University
Bladder cancer in rodents following intravesical foreign body implants relevance of experimental bladder carcinogenesis studies to humans
2. Nobuyuki Ito
Nagoya City University
Morphologic alterations of rodent urinary bladder by BBN
Review of other experimental studies in urinary bladder cancer in Japan
3. Masashi Okada
Tokyo Biochemical Research Institute
Rat urinary bladder cancer induced by butylhydroxybutylnitro samine (BBN)
4. Yoshiyuki Hashimoto
Tohoku University
In vitro bladder carcinogenesis
5. Hisashi Otsuka
Tokushima University
Bladder cancer in mice following BBN - cytoxan
6. Eigoro Okajima
Nara Medical University
Bladder cancer in dogs caused by BBN




HIGH LET RADIATION THERAPY

I. High LET Radiation Therapy Planning Seminar
August 16-18, 1975, Tokyo, Japan
U.S.A.
1. Glenn E. Sheline
National Cancer Institute
2. Francis J. Mahoney
National Cancer Institute
An overview of the U.S. National Cancer Institute high LET radiation therapy program
3. Herbert Attix
U.S. Naval Research Laboratory
The physics and doshnetry of fast neutrons for radiotherapy
4. Rodney Withers
M.D. Anderson Hospital
Radiobiology relevant to neutron radiotherapy
5. Robert Parker
University of Washington
The current status of fast neutron teletherapy of cancer in the United States
6. Gunter Seydel
American Oncologic Hospital
The clinical use of 252 -Californium sources and 252 -Californium Protocol (RTOG)
JAPAN
1. Akira Tsuya
Cancer Institute Hospital, Japanese Foundation for Cancer Research
Clinical experiences of Californium-252 therapy
2. Yoichiro Umegaki
National Institute of Radiological Sciences
Fast neutron therapy at NIRS Hospital
Proposal for the clinical trial of the fast neutron therapy in Japan
3. Tetsuji Nishikawa
National Laboratory of High Energy Physics
General status of accelerators in Japan possibly used for neutron applications
The KEK proton synchrotron and possibility of utilizing its booster beam for high LET radiation therapy
4. Tetsuo Inada
National Institute of Radiological Sciences
NIRS cyclotron facilities
NIRS proton therapy project
5. Akira Ito
Tokyo University Institute of Medical Sciences
TIMS cyclotron facilities
The fast neutron beam from the TIMS cyclotron
6. Hiroshi Hatanaka
Teikyo University
Slow neutron capture therapy
7. Haruma Yoshinaga
Kyushu University
Comparative studies on the effect of 14 MeV neutrons and X-rays on cultured mammalian cells (read by H. Sasaki)
8. Kiyohiko Sakamoto
University of Tokyo
9. Shigefumi Okada
University of Tokyo
Some comments on the radiobiological aspects of of high LET radiation therapy
10. Hiroshi Tsunemoto
National Institute of Radiological Sciences
Role of fractionation in fast neutron therapy Preliminary clinical trial with 2 MeV fast neutrons
11. Muneyasu Urano
National Institute of Radiological Sciences
Repair of potentially lethal radiation damage in animal tumors in vivo
12. Katsuhiro Kawashima
National Institute of Radiological Sciences
Neutron dosimetry in Japan
13. Akira Matsuyama
Institute of Physical and Chemical research
Studies on LET effects on different biological systems using charged particles accelerated in the IPCR cyclotron
14. Hisao Yamashita
Keio University
Preliminary studies on a remotely controlled afterloading equipment using high intensity sources of Californium-252
15. Hiroshi Iino
Institute of Medical Sciences, University of Tokyo
16. Koichi Kaneta
Cancer Institute Hospital, Japanese Foundation for Cancer Research
Clinical experiences with Californium-252 small sources
17. Yoshio Onai
Cancer Institute, Japanese Foundation for Cancer Research
18. Hiroshi Sasaki
Kyushu University
19. Eisei Tasaki
Tokyo Womens Medical College
20. Sinichi Okuyama
Tohoku University
21. Toshio Kitagawa
National Cancer Center Hospital
22. Hideo Niibe
Gunma University
23. Shozo Suzuki
Institute of Medical Sciences, University of Tokyo
24. Akiyoshi Kumazawa
Institute of Medical Sciences, University of Tokyo
25. Atuko Heshiki
Gunma University




CYTOLOGY

I. Automation of Cancer Cytology
February 20-21, 1975, Tokyo
U.S.A.
1. R. A. Malmgren
George Washington University
Overview of cytology automation
2. C. Herman
National Cancer Institute
Application of zero resolution flow analysis and sorters to cytology automation - Part I.
3. M. Melamed
Memorial Hospital for Cancer and Allied Diseases
Application of zero resolution flow analysis and sorters to cytology automation - Part II
4. J. Prewitt
National Institutes of Health
One score and four years of high resolution cytology automation
5. L. Wheeless
University of Rochester
Slit scan cytofluorometry as basis for an automated prescreening system
JAPAN
1. K. Kimura
National Cancer Center Hospital
2. S. Hattori
Center for Adult Diseases, Osaka
Soft ware of autoscreening system
3. Y.Hashimoto
College of Medical Technology Kansai
Hard ware of autoscreening system
4. Y. Kishigami
Center for Adult Diseases, Osaka
Soft ware of autoscreening system
5. I. Nishiya
Hokkaido University
Spectrophotometrical evaluation with prescreening scanning device utilizing glass fiber
6. I. Sawaragi
Kansai Medical University
Trials on autocytoscreener
7. M.Tajima
National Cancer Center
The results of mass screening of breast cancer
8. N. Tanaka
Chiba Cancer Center
Field test of automated cytoscreening system (Cybest)
9. Y.Tenjin
Kyoundo Hospital
Prescreening device utilizing 16mm roll film
10. Y. Uei
National Cancer Center Hospital
An attempt for automatic screening in uterin cancer cytology
II. Cancer Cytology
June 16-17, 1975, San Francisco, California
U.S.A.
1. R. A. Malmgren
George Washington University
2. P. Bartels
University of Arizona
Automated cytology - slide system (tentative)
3. W. Frable
Medical College of Virginia
Aspiration cytology
4. Chester Herman
National Cancer Institute
5. E. King
University of California
Specimen collection for automated cytology
6. M. Melamed
Memorial Hospital for Cancer and Allied Diseases
Investigative cytology - new fields
7. W. Pomerance
National Cancer Institute
8. J. Prewitt
National Cancer Institute
Computer program control for automatic cell identification and specimen classification
9. L. Wheeless
University of Rochester
Specimen preparation for automated cytology
10. J. Baccus
St. Luke’s Hospital
System evaluation and field testing
11. M.J. Fulwyler
Particle Technology, Inc.
Automated cytology - flow systems
JAPAN
1. K. Kimura
National Cancer Center Hospital
Investigative cytology using necleolar staining
2. Y. Hashimoto
College of Medical Technology Kansai
Autoscreener - slide system
3. S. Hattori
Center for Adult Diseases, Osaka
Specimen collection and field testing by autoscreener
4. M. Onoe
University of Tokyo
Automated on-line microscope
5. I. Sawaragi
Kansai Medical University
Cell identification on automated cytoscreening systems
6. M. Takahashi
Central Hospital, Japanese National Railway
Preparation of cervical specimen for cytology automation
A new approach to evaluate malignant cellular changes
7. N. Tanaka
Chiba Cancer Center
System evaluation and field testing on cybest
8. Y. Tenjin
Kyoundo Hospital
Cell fixation method on 16mm polyester film
Population screening by selfirrigation method




METASTASIS

I. Survey Seminar on Metastasis
March 4-11, 1975, Bethesda, Maryland
U.S.A.
1. Isaiah J. Fidler
University of Pennsylvania
2. Bernard Fisher
University of Pittsburgh
3. Pietro M. Gullino
National Cancer Institute
4. Robert R. Omata
National Cancer Institute
5. Philip G. Stansly
National Cancer Institute
JAPAN
1. Haruo Sato
Tohoku University
2. Eiro Tsubura
Tokushima University