1974 ACTIVITIES1975

ACTIVITIES OF THE U.S.-JAPAN COOPERATIVE CANCER RESEARCH PROGRAM
JAPANESE FY 75 (APRIL 1, 1975 - MARCH 31, 1976)

SCIENTIFIC SEMINARS

Eleven scientific seminars were supported by the program during the report period: 3 on the mainland U.S.A., 3 in Hawaii and 5 in Japan.

I. Chemical Carcinogenesis
	1.	Evaluation of Methods of Carcinogenesis in Mammals. Hakone, Japan November 17-20, 1975 (4 days)
		U.S.A.	7
		Japan	20

		Umberto Saffiotti	Division of Cancer Cause & Prevention, National Cancer Institute
		Shigeyoshi Odashima	Department of Chemical Pathology, National Institute of Hygienic Sciences

	2.	Modified Cellular and Molecular Controls in Neoplasia Hawaii December 9-1 2, 1975 (4 days)
		U.S.A.	15
		Japan	9
		(Australia	6)

		Wayne Criss	School of Medicine, University of Virginia
		Tetsuo Ono	Cancer Institute, Japanese Foundation for Cancer Research

II. Cancer Virology
	3.	Viral Oncogenesis: Transmission, Persistence and Expression of Viral Genome. Kyoto, Japan March 26-27, 1976 (2 days)
		U.S.A.	7
		Japan	22

		Robert M. McAllister	Childrens Hospital of Los Angeles
		Yohei Ito	School of Medicine, Kyoto University

III. Cancer Immunology
	4.	Immunotherapy of Cancer and Its Fundamental Basis Coronado, California March 16-20, 1976 (5 days)
		U.S.A.	10
		Japan	9

		William D. Terry	Division of Cancer Treatment, National Cancer Institute
		Yuichi Yamamura	National Cancer Institute School of Medicine, Osaka University

IV. Cancer Chemotherapy
	5.	Symposium on the Nitrosoureas and Bleomycin Kona, Hawaii February 6-8, 1976 (3 days)
		U.S.A.	7
		Japan	11

		Stephen K. Carter	Division of Cancer Treatment, National Cancer Institute
		Yoshio Sakurai	Cancer Chemotherapy Center, Japanese Foundation for Cancer Research

V. Analytical Epidemiology
	6.	Analytic Epidemiology of Cancer Orlando, Florida December 2-5, 1975 (4 days)
		U.S.A.	7
		Japan	7

		Robert W. Miller	Division of Cancer Cause and Prevention, National Cancer Institute
		Takeshi Hirayama	National Cancer Center Research Institute

VI. Breast Cancer
	7.	Current Status of Breast Cancer - Focusing on the Binational Efforts on Breast Cancer Tokyo March 26-27, 1976 (2 days) U.S.A. 10 Japan 24
		U.S.A.	10
		Japan	24

		Nathaniel I. Berlin	Comprehensive Cancer Center, Northwestern University Medical School
		Haruo Sugano	Cancer Institute, Japanese Foundation for Cancer Research

VII. Lung Cancer
	8.	Detection of Early Lung Cancer Tokyo November 25-26, 1975 (2 days)
		U.S.A.	5
		Japan	12

		Robert S. Fontana	Mayo Clinic and Mayo Foundation
		Shigeto Ikeda	National Cancer Center Hospital

VIII. Urinary Bladder Cancer
	9.	Experimental Models for Bladder Cancer Honolulu, Hawaii December 7-9, 1975 (3 days)
		U.S.A.	9
		Japan	9

		George T. Bryan	University Hospital, The University of Wisconsin,
		Osamu Yoshida	School of Medicine, Kyoto University

IX. High LET Radiation Therapy
	10.	Planning Seminar of High LET Radiation Therapy Tokyo July 16 -18, 1975 (3 days)
		U.S.A.	6
		Japan	25

		Glenn E. Sheline	Division of Cancer Research Resources and Centers, National Cancer Institute
		Akira Tsuya	Cancer Institute Hospital, Japanese Foundation for Cancer Research

X. Cytology
	11.	Automated Cytology and Cancer Cytology in General San Francisco, California June 16-17, 1975 (2 days)
		U.S.A.	11
		Japan	8

		Richard A. Malmgren	Cytopathology Service, George Washington University
		Kiyoji Kimura	National Cancer Center Hospital

Mainland U.S.A.			3
Hawaii			3
Japan			5
Total			11

EXCHANGE OF PERSONNEL

Fifteen Japanese scientists were supported by the program to conduct collaborative research in laboratories in the U.S.A. between April 1, 1975 and March 31, 1976. All or a portion of their visits which lasted between two weeks to one year (unless modified) took place within the above period.
The names, institutional affiliations of the scientists, the research subject, the host scientists and duration of the visits are given below. The date mentioned in parentheses is the extension of the visit supported by sources external to the program.

I. Chemical Carcinogenesis
	1.	Shozo Takayama	Cancer Institute, Japanese Foundation for Cancer Research
		Epithelial- and Mesenchymal Interactions in Carcinogenesis
		C. J. Dawe	National Cancer Institute
		November 24, 1975-December 14, 1975

II. Cancer Virology
	2.	Masahide Ishibashi	Aichi Cancer Center Research Institute
		Isolation of Proteins Specific for Virus-Induced Transformed Cells and Their Role
		J. V. Maizel	National Cancer Institute
		September 15, 1975-December 14, 1975

III. Cancer Immunology
	3.	Shaw Watanabe	School of Medicine, Keio University
		Lymphocyte Circulation and Morphology of the Antibody Forming Cells
		Costan Berard	National Cancer Institute
		September 5, 1975-March 4, 1976 (June 5, 1975-September 4, 1975: March 5, 1976-June 5, 1976)

	4.	Hiroshi Kobayashi	Cancer Institute, Hokkaido University
		Cancer Immunology
		William Terry	National Cancer Institute
		February 26, 1976-March 24, 1976

IV. Cancer Chemotherapy
	5.	Akio Hoshi	National Cancer Center Research Institute
		Mechanism of action of antitumor agents
		Abraham Goldin	National Cancer Institute
		June 15, 1975-November 30, 1975

	6.	Takeshi Kataoka	Cancer Institute, Japanese Foundation for Cancer Research
		Immunology and biology of cancer cells associated with immunotherapy of cancer
		D. Papahadjopoulos	Experimental Pathology, Roswell Park Memorial Institute
		March 10, 1976-June 9, 1976

	7.	Utako Mizoguchi	Cancer Institute, Japanese Foundation for Cancer Research
		Utilization of cancer and chemical data
		John Schneider	ICRDB Program, Office of International Affairs, National Cancer Institute
		Dale B. Baker	Chemical Abstracts Service
		April 2, 1975-April 15, 1975

V. Analytical Epidemiology
	8.	Katsuhiro Fukuda	Sapporo Medical College
		Cancer Epidemiology
		T. Hirohata	School of Public Health, University of Hawaii
		September 1, 1975-February 29, 1976

Vl. Breast Cancer
	9.	Keishi Matsumoto	School of Medicine, Osaka University
		Metabolism and action mechanism of steroid hormone
		E. Jensen	Ben May Laboratory of Cancer Research
		W. L. McGuire	University of Texas, San Antonio
		September 1, 1975-September 9, 1975 (July 13, 1975-August 31, 1975)

VII. Lung Cancer
	10.	Hisanobu Niitani	National Cancer Center Hospital
		Treatment of advanced lung cancer: role of lysosome in cancer chemotherapy Enzyme activities in lymphocytes and relationship to tumor immunology
		C. F. Mountain	M. D. Anderson Hospital
		Oleg Selawry	University of Miami
		William Terry	National Cancer Institute
		E. T. Frei	Sydney Farber Cancer Center
		O. Takita	Roswell Park Memorial Institute
		March 20, 1976 - April 24, 1976

VIII. Urinary Bladder Cancer
	11.	Masae Tatematsu	Nagoya City Higashi General Hospital
		Histopathological classification of human and experimental urinary bladder cancer
		Gilbert H. Friedell	St. Vincent Hospital, Worcester
		December 2, 1975-February 29, 1976

IX. High LET Radiation Therapy
	12.	Takeshi Hiraoka	Physics Division, National Institute of Radiological Sciences
		Radiation dosimetry for high LET radiations and associated problems with special interest in the use of paired ionization chamber method.
		P. R. Almond	M. D. Anderson Hospital
		January 16, 1976-March 31, 1976

X. Cytology
	13.	Yoshio Uei	National Cancer Center Hospital
		Cytopathology in the field of cancer and endocrine organs.
		M. R. Melamed	Memorial Hospital for Cancer and Allied Diseases
		September 2, 1975-October 31, 2975

	14.	Minoru Matsuda	The Center for Adult Diseases, Osaka
		Lung cancer and cytology
		M. R. Melamed	Memorial Hospital for Cancer and Allied Diseases
		R. A. Malmgren	The George Washington University
		L. Woolner	Mayo Clinic
		September 10, 1975-November 9, 1975

XI. Metastasis
	15.	Toshio Takahashi	Kyoto Prefectural University of Medicine
		Cencer metastasis, especially immunological aspect of lymphnodes in metastasis formation.
		B. Fisher	University of Pittsburgh
		January 3, 1976-March 31, 1976

long-term visit:	3
short-term visit:	12
Total	15

The below listed are the American scientists supported by the program to conduct collaborative researches in Japanese laboratories between April 1, 1975 and March 31, 1976. The names, institutional affiliations of the visiting and host scientists, duration of the visits and their research subjects are given below.

I. Chemical Carcinogenesis
	1.	Edith Yamazaki	University of California, Berkeley
		Takashi Sugimura	Institute of Medical Sciences, The University of Tokyo
		April 1, 1975-May 31, 1975 Salmonella/microsomal enzyme system.

	2.	Melvin Reuber	Consultant in Human and Experimental Pathology
		Shigeyoshi Odashima	Department of Chemical Pathology National Institute of Hygienic
		Sciences September 1, 1975-0ctober 31, 1975 Experiments on hepatocarcinogenesis and on more rapid means of screening chemicals for carcinogenecity.

II. Cancer Virology
	3.	Peter K. Vogt	University of Southern California
		Yohei Ito	Kyoto University
		March 20, 1976-April 5, 1976 Cancer Virology

	4.	Walter Eckhart	Salk Institute for Biological Studies
		Yohei Ito	Kyoto University
		March 20, 1976-April 5, 1976 Cancer Virology

III. Cancer Chemotherapy
	5.	Stephen K. Carter	Division of Cancer Treatment, National Cancer Institute
		Yoshio Sakurai	Cancer Chemotherapy Center, Japanese Foundation for Cancer Research
		December 7, 1975-December 14, 1975 A survey and in-depth study of gastric cancer therapy

	6.	Harry Handelsman	Division of Cancer Treatment, National Cancer Institute
		Yoshio Sakurai	Cancer Chemotherapy Center, Japanese Foundation for Cancer Research
		December 7, 1975-December 14, 1975 A survey and in-depth study of gastric cancer therapy

	7.	Edward D. Holyoke	Medical School, State University of New York at Buffalo
		Yoshio Sakurai	Cancer Chemotherapy Center, Japanese Foundation for Cancer Research
		December 7, 1975-December 14, 1975 A survey and in-depth study of gastric cancer therapy

	8.	Philip T. Lavin	Statistical Laboratory, State University of New York, Amherst
		Yoshio Sakurai	Cancer Chemotherapy Center, Japanese Foundation for Cancer Research
		December 7, 1975-December 14, 1975 A survey and in-depth study of gastric cancer therapy

	9.	Philip S. Schein	Vincent T. Lombardi Cancer Research Center, Georgetown University School of Medicine
		Yoshio Sakurai	Cancer Chemotherapy Center, Japanese Foundation for Cancer Research
		December 7, 1975-December 14, 1975 A survey and in-depth study of gastric cancer therapy

	10.	Charles G. Moertel	Mayo Medical School University of Minnesota
		Yoshio Sakurai	Cancer Chemotherapy Center, Japanese Foundation for Cancer Research
		December 7, 1975-December 14, 1975 A survey and in-depth study of gastric cancer therapy

IV. Analytical Epidemiology
	11.	William J. Blot	Division of Cancer Cause and Prevention, National Cancer Institute
		Takeshi Hirayama	Division of Epidemiology. National Cancer Center Research Institute
		October 1, 1975-0ctober 21, 1975 Detection of similarities and differences in demographic, occupational or environmental influences upon cancer mortality between the U.S.A. and Japan.

V. Breast Cancer
	12.	William McGuire	University of Texas, San Antonio
		Keishi Matsumoto	School of Medicine, Osaka University
		March 25, 1976-April 7, 1976 Estrogen receptors

	13.	Jeffery Schlom	National Cancer Institute
		Yoji Ikawa	Cancer Institute, Japanese Foundation for Cancer Research
		March 25, 1976-April 7, 1976 Virology

VI. High LET Radiation Therapy
	14.	Raymond U	Duke University
		Ikuo Watanabe	National Institute of Radiological Sciences
		March 1, 1976-May 31, 1976 Radiobiological measurements on the neutron beams planned for clinical use.

EXCHANGE OF MATERIALS AND INFORMATION

The following research materials were sent to the U.S.A. from Japan between April 1, 1975 and March 31, 1976 for the program areas mentioned.

I. Chemical Carcinogenesis

Chymostatin	200 g
Elastatinal	200 g

The following research materials were sent to Japan from the U.S.A. between April 1, 1975 and March 31, 1976.

I. Cancer Virology

Viruses:	AMV chicken plasma	2.0 g
	RLV JLSV-9 RLV culture fluid, concentrated	100 mg

Antisera against Viral Proteins:
	RLV p-30	10.0 ml
	FeLV p-30	10.0 ml
	RD-114 virus p-30	10.0 ml
	SSV-1 p-28	5.0 ml
	M-PMV p-27	5.0 ml
	Mouse MTV (RIII) gp.52	5.0 ml
	Mouse MTV (RIII) p-27	5.0 ml
	RLV reverse transcriptase	10.0 ml

II. Cancer Immunology

Dimethy1 Triazeno Imidazole Carboxamide (DTIC)
	100 mg/vial	980
	200 mg/vial	1000