1974 ACTIVITIES1974

ACTIVITIES OF THE U.S.-JAPAN COOPERATIVE CANCER RESEARCH PROGRAM
JAPANESE FY 74 (APRIL 1, 1974 - MARCH 31, 1975)

SCIENTIFIC SEMINARS

Nine scientific seminars were supported by the program during the report period: 3 on the mainland U.S.A., 3 in Hawaii and 3 in Japan. The seminars held are listed below according to the program areas previously described. For each seminar, the title, location, date, number of participants from each country and the names of organizers are given.

I. Chemical Carcinogenesis
	Action of Protease Inhibitors and Carcinogenesis Honolulu, Hawaii March 29-31, 1975 (3 days)
		U.S.A.	8
		Japan	12

		Walter Troll	Institute of Environmental Medicine, New York University Medical Center
		Takashi Sugimura	National Cancer Center Research Institute

II. Cancer Virology
	Recent Advances in Tumor Virology Hilo. Hawaii March 22-23, 1975 (2 days)
		U.S.A.	6
		Japan	7

		Robert M. McAllister	Childrens Hospital of Los Angeles
		Yohei Ito	School of Medicine, Kyoto University

III. Cancer Immunology
	Immunotherapy of Cancer and Its Fundamental Basis Honolulu Hawaii March 13-15, 1975 (3 days)
		U.S.A.	10
		Japan	7

		William Terry	Division of Cancer Biology and Diagnosis,
		Yuichi Yamamura	National Cancer Institute School of Medicine, Osaka University

IV. Cancer Chemotherapy
	Comparative Study on Cytosine Arabinoside and Cyclocytidine, Experimental and Clinical: Phase I study Tokyo February 13-15, 1975 (3 days)
		U.S.A.	5
		Japan	40

		Stephen K. Carter	Division of Cancer Treatment, National Cancer Institute
		Yoshio Sakurai	Cancer Chemotherapy Center, Japanese Foundation for Cancer Research

V. Breast Cancer
	Breast Cancer Planning Seminar Bethesda, Maryland July 15-19, 1974 (5 days)
		U.S.A.	4
		Japan	3

		Nathaniel I. Berlin	Division of Cancer Biology and Diagnosis, National Cancer Institute
		Haruo Sugano	Cancer Institute, Japanese Foundation for Cancer Research

VI. Lung Cancer
	Morphology and Staging of Lung Cancer Tokyo March 26-28, 1975 (3 days)
		U.S.A.	2
		Japan	13

		Clifton F. Mountain	M.D. Anderson Hospital
		Takeshi Hirayama	Epidemiology Division, National Cancer Center Research Institute

VII. Urinary Bladder Cancer
	Survey Seminar on Urinary Bladder Cancer Madison, Wisconsin February 5-22, 1975 (18 days)
		U.S.A.	5
		Japan	3

		George T. Bryan	University Hospital, The University of Wisconsin,
		Osamu Yoshida	School of Medicine, Kyoto University

VIII. Cytology
	Automation of Cancer Cytology Tokyo February 20-21, 1975 (2 days)
		U.S.A.	5
		Japan	10

		Richard A. Malmgren	School of Medicine, George Washington University
		Kiyoji Kimura	National Cancer Center Hospital

IX. Metastasis
	Cancer Metastasis Bethesda, Maryland March 3-10, 1975 (8 days)
		U.S.A.	5
		Japan	2

		Philip G. Stansly	Division of Cancer Research Resources and Centers, National Cancer Institute
		Haruo Sato	Research Institute for Tuberculosis, Leprosy and Cancer, Tohoku University

Mainland U.S.A.			3
Hawaii			3
Japan			3
Total			9

EXCHANGE OF PERSONNEL

Twenty-one Japanese scientists were supported by the Program to conduct collaborative research in laboratories in the U.S.A. between April 1, 1974 and March 31, 1975. All or a portion of their visits which lasted between two weeks to one year (unless modified) took place within this period. The names and institutional affiliations of the scientists, the research subjects, the host scientists and duration of the visits are given below. The date mentioned in parentheses is the extension of the visit supported by sources external to the program.

I. Chemical Carcinogenesis
	1.	Kun-Young Kang	Department of Medicine, National Kinki Central Hospital for Chest Diseases
		Asbestosis and neoplasia including lung cancer and malignant mesothelioma.
		Richard L. Naeye	The Milton S. Hershey Medical Center, The Pennsylvania State University
		Salvaggio	Louisiana State University
		September 15, 1974-March 13, 1975 (March 14, 1975-December 2, 1975)

	2.	Taijiro Matsushima	Institute of Medical Science, The University of Tokyo
		Relationship between carcinogenesis and mutagenesis
		Bruce N. Ames	University of California, Berkeley
		E. K. Weisburger	National Cancer Institute Walter Troll New York University
		S. Hakomori	University of Washington, Seattle
		H. Matsumoto	University of Hawaii
		February 13, 1975-April 2, 1975

II. Cancer Virology
	3.	Yoshikatsu Ozaki	School of Medicine, Kyoto University
		Studies on antigenic characterization of herpesviruses by neutralization kinetics: its application to the serological screening of unknown human oncogenic viruses
		J. L. Melnick	Baylor University College of Medicine
		January 10, 1975-March 10, 1975

	4.	Fumio Mizuno	Asahikawa Medical College
		Epstein-Barr virus carcinogenesis: dual infection and cocarcinogenesis by Epstein-Barr virus and type-C virus
		G. R. Pearson	National Cancer Institute
		M. Nonoyama	Ruth Presvitarian St. Luke’s Medical Center
		March 20, 1975-September 20, 1975 (September 21, 1975-March 20, 1976)

III. Cancer Immunology
	5.	Masuo Hosokawa	Cancer Institute, Hokkaido University
		Studies on immunotherapy of experimental tumors
		Richard L. Simmons	Department of Surgery, University of Minnesota
		November 20, 1974-January 20, 1975

	6.	Kunzo Orita	School of Medicine, Okayama University
		Studies on the cellular immunity of tumor bearing hosts including cancer patients.
		E. Klein Roswell	Park Memorial Institute
		J. E. Sokal	ditto
		January 6, 1975-March 31, 1975

	7.	Takeshi Ogura	School of Medicine, Osaka University
		Host defense mechanism against tumor metastasis: Immunology of lymph node metastasis with BCG.
		H. J. Rapp	National Cancer Institute
		B. Zbar	ditto
		February 1, 1975-June 30, 1975

IV. Cancer Chemotherapy
	8.	Masanori Shimoyama	Department of Internal Medicine, National Cancer Center Hospital
		In vitro test for immune response in cancer partients: Immunotherapy of cancer: Chemotherapy of hematological malignancies including supportive therapy (leucapheresis for granulocyto transfusion, HL-A typing, etc.)
		D.L. Morton	University of California School of Medicine, Los Angeles
		P. I. Terasaki	Center for Health Sciences, University of California, Los Angeles
		K. E. Hellstrom	Medical School, University of Washington, Seattle
		E. Freireich	M. D. Anderson Hospital
		S. Perry	National Cancer Institute
		L. J. Old	Sloan Kettering Institute for Cancer Research
		January 4, 1975-March 31, 1975

	9.	Toru Nakamura	School of Medicine, Kyoto University
		Mechanism of action of antileukemic agents in leukemic cells in relation with their clinical effects.
		D. Perry	National Cancer Institute
		J. H. Burchenal	Sloan Kettering Institute for Cancer Research
		Klein	Cancer Research Institute, San Francisco
		E. Frei	Children Cancer Institute, Boston
		E. J. Freireich	M. D. Anderson Hospital
		October 30, 1974-December 9, 1974

	10.	Shoji Okuma	Faculty of Pharmaceutical Sciences, The University of Tokyo
		Cancer chemotherapy by tumor immunity: Biochemistry of lysosome
		C. deDuve	The Rockefeller University
		March 26, 1975-March 25, 1976 (March 26, 1976-March 31, 1977)

	11.	Kazumasa Yamada	School of Medicine, Nagoya University
		Chemo-immunotherapy of leukemia
		L. J. Old	Sloan Kettering Institute for Cancer Research
		E. J. Freireich	M. D. Anderson Hospital
		January 13, 1975-February 11, 1975

V. Analytical Epidemiology
	12.	Keiko Omi	School of Medicine, The University of Tokyo
		Clinical oncology and hematology in pediatrics: Congenital anomalies and malignant neoplasm in childhood
		R. Miller	National Cancer Institute
		January 10, 1975-March 11, 1975

	13.	Takashi Kawana	School of Medicine, The University of Tokyo
		Virology and tumor immunology: HSV-II and uterine cancer
		L. Aurelian	The Johns Hopkins University
		A. Nahmias	Emory University
		February 12, 1975-August 13, 1975

VI. Breast Cancer
	14.	Keijiro Kuno	Department of Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research
		Therapy for breast cancer
		N. I. Berlin	National Cancer Institute
		February 1, 1975-February 16, 1975

	15.	Osahiko Abe	School of Medicine, Keio University
		Breast cancer and hormone
		N. I. Berlin	National Cancer Institute
		February 1, 1975-February 16, 1975

	16.	Masao Fujimori	Faculty of Medicine, Gunma University
		Therapy for breast cancer
		N. I. Berlin	National Cancer Institute
		February 1, 1975-February 16, 1975

	17.	Eiichi Sato	School of Medicine, Tohoku University
		Pathological and endocrinological study of human breast cancer.
		Peter Rosen	New York Memorial Hospital
		March 25, 1975-May 20, 1975

VII. Lung Cancer
	18.	Keiichi Suemasu	Division of Endoscopy, National Cancer Center Hospital
		Diagnosis and treatment of lung cancer: Metastasis and its inhibition of lung cancer: Clinical pathology of lung cancer
		O. Selawry	National Cancer Institute
		D. L. Paulson	Baylor University
		W. E. Neville	New Jersey University
		H. Takita	Roswell Park Memorial Institute
		E. J. Beattie	New York Memorial Sloan Kettering Institute for Cancer Research
		J. Leighton	Pittsburgh University
		December 6, 1974-February 5, 1975

VIII. Urinary Bladder Cancer
	19.	Takashi Harada	Department of Urology, Kansai Medical University
		Experimental studies on tumorigenesis of the urinary bladder
		G. T. Bryan	University of Wisconsin Medical School
		R. Oyasu	Northwestern University Medical School
		October 1, 1974-March 31, 1975

	20.	Yoshiyuki Hashimoto	Tokyo Biochemical Research Institute
		Tumor immunology and chemical carcinogenesis
		T. Aoki	National Cancer Institute
		March 2, 1975-March 30, 1975

IX. Cytology
	21.	Yoshio Hashimoto	Department of Medical Electronics, College of Medical Technology of Kansai
		Automation of cytology; Automatic cytological screening device and mass screening system for detection of uterine cancer
		Chester Herman	National Cancer Institute
		March 30, 1975-June 20, 1975

long-term visit:	6
short-term visit:	15
Total	21

EXCHANGE OF MATERIALS AND INFORMATION
The following materials were sent to the U.S.A. from Japan under this program between April 1, 1974 and March 31, 1975.

I. Chemical Carcinogenesis

Leupeptin	800 g
Antipain:	800 g
Pepstatin	500 g
Glucanolactom	600 g