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Report for JSPS Asian Science Seminar 2004
平成16年度日本学術振興会アジア学術セミナー実施報告書

Date: November 29, 2004

粘膜ワクチン開発へ向けて最近の展開:基礎から臨床まで

1.Title of Seminar
(in English)
2004 JSPS-KOSEF Asian Science Seminar
Development of Mucosal Vaccines: From Basic Research to
Clinical Application
(in Japanese)
粘膜ワクチン開発へ向けて最近の展開:基礎から臨床まで
2. Purpose of Seminar Infectious disease is still one of major life threaten problems in both industrialized and developing countries. For the control of emerging and re-emerging infectious diseases, one of most effective and beneficial strategies is of course the development of vaccine. Since the most of infectious microorganisms are invading the host via mucosal surface by the inhalation, digestion and sexual contact, it is logical to consider the use of the mucosal immune system to provide the first line of the defense in addition to the systemic immunity. Thus, mucosal immunization has been shown to be most effective vaccination regimen for the induction of both mucosal and systemic immune responses. While the injection type immunization, currently most commonly practiced method for vaccination induces mainly systemic, but not mucosal immunity. For the future development of vaccine, one has to consider the presence and use of the mucosal immune system. Taken account for these facts, a major task of this seminar was to provide young scientists including graduate students, postdoctoral fellows and research/clinical fellows from Asian countries an opportunity to expose the current knowledge of both basic and clinical aspects of the mucosal immunology for the development of mucosal vaccine. In addition, the seminar provided the scientific environment to create new platform for the exchange new idea and data relating to the understanding of the mucosal immune system for the development of new generation vaccine.
3. Period From Oct. 24, 2004    through Oct. 27, 2004    (4 days)
4. Program: Agenda, topics, related activities
(e.g., reception, excursion)
See attach (Please see the attached abstract book)
5. Venue International Vaccine Institute
San 4-8, Boncheon-7 dong, Kwanak-gu, Seoul 151-818, Korea
Tel: 82-2-881-1186    F: 82-2-881-1211
6. Organizer
1) Japan Side
Name in full
(in English) Hiroshi Kiyono, D.D.S., Ph. D
(in Japanese) 清野 宏
Affiliation and position
(in English) The University of Tokyo, Professor and Director
(in Japanese) 東京大学医科学研究所,教授
2) Korea Side
Name in full
Mi-Na Kweon, Ph. D.
Affiliation and position
(in English) International Vaccine Institute, Chief of Mucosal Immunology Section
(in Japanese) 国際ワクチン研究所,粘膜免疫部門 部長

7. Lecturers and Participants

1) Number of Persons

  Lecturers Participants Total
Japan side 12 4 16
Korea side 9 47 56
Third parties 2 27 29
Total 23 78 100

2) Lecturers

A.Please describe rationale for selecting lecturers, and the need for and role of their lectures in the seminar.
Of course, a first priority was the research activity of the candidate including the quality and productivity in the area of mucosal immunology, microbiology, infectious diseases, and vaccinology. Further, the effectiveness of presentation was another important aspect for the qualification of speakers. These criterions were essential for the planning of most effective and exciting program which would benefit the audience invited from different Asian countries. In addition, attractive communication ability was also another consideration for the selection of speakers, since it was important to create bi-directional interaction through the poster session as well as evening social get together for the one to one communication between the student and speaker. Because of the careful selection of highly talented speakers from Japan, Korea and Europe, individual lecturer did excellent presentation as well as individual base interaction with the seminar participants.

B.List

Name in full Institution/Affiliation/Position Nationality
- Japan side    
Taisuke HORIMOTO The University of Tokyo Japan
Hiromichi ISHIKAWA Keio University Japan
Hiroshi KIYONO The University of Tokyo Japan
Masayuki MIYASAKA Osaka University Japan
Chihiro SASAKAWA The University of Tokyo Japan
Masahiko SUGITA Osaka University Japan
Kiyoshi TAKATSU The University of Tokyo Japan
Kiyoshi TAKEDA Kyushu University Japan
Yoshifumi TAKEDA Jissen Women's University Japan
Masafumi YAMAMOTO Nihon University Japan
Tadashi YAMAMOTO The University of Tokyo Japan
Hisahiro YOSHIDA Riken Immunology and Allergy Research Center Japan
     
- Korea side    
John D. CLEMENS International Vaccine Institute Korea
Jacqueline DEEN International Vaccine Institute Korea
Ho Young KANG Pusan National University Korea
Mi-Na KWEON International Vaccine Institute Korea
Byoung S. KWON University of Ulsan Korea
Joon-Haeng RHEE Chonnam National University Medical School Korea
Lorenz von SEIDLEIN International Vaccine Institute Korea
Young Chul SUNG Pohang University of Sciences & Technology Korea
Aldo TAGLIABUE International Vaccine Institute Korea
     
- Third parties    
Martin LIPP Max-Delbruck-Center for Molecular Medicine Germany
Florence NIEDERGANG Institut Curie France

3) Participants

A.Please describe how you recruited participants and why they were selected.
Considering the era of IT technology, the announcement of the Asian Science Seminar was executed by the creation of web site. The web site containing the application form was connected via the Institute of Medical Science, the University of Tokyo, International Vaccine Institute and the related scientific society' site ( e.g., Japanese Society of Immunology Japanese Society of Vaccinology and etc.). Most of inquires and applications were obtained via the web. site announcement. The application contained the biographical sketch of the applicant, a short essay summarizing the applicant's desire to attend the seminar, the submission of poster presentation and the recommendation letter from the applicant's mentor or supervisor. Based on the information, a first priority was given to the qualified applicants with poster presentation. Further, regional distribution was also taken accounted for the selection of applicants. The committee also directly contacted to the applicant's mentor or supervisor in order to ensure his/her desire and commitment to the field of mucosal immunology and vaccine development. Based on the selection process, we were able to line up highly qualified and talented young scientists form Asia who were actively participated in the discussion of individual lecture as well as poster presentation.

B.List

Name in full Institution/Affiliation/Position Nationality
- Japan side    
Bagherichimeh ALIEZA University of Tsukuba Iran
Nam Ju KIM IMSUT
Korea
Tomonori NOCHI IMSUT
Japan
Naoko TAKAYAMA IMSUT Japan
     
- Korea Side    
Hey Ran CHA Sungkyunkwan University Korea
Jae-Hoon CHANG Seoul National University Korea
Sun-Young CHANG International Vaccine Institute Korea
Beom-Kyu CHOI University of Ulsan Korea
Jae-Hyeog CHOI University of Ulsan Korea
Yeonseok CHUNG Seoul National University Korea
Clark Changfa CUI International Vaccine Institute Korea
Seong-Kug EO Chonbuk National University Korea
Seung Hyun HAN International Vaccine Institute Korea
Sook-Kyoung HEO University of Ulsan Korea
Hyun JANG International Vaccine Institute Korea
Yong-Suk JANG Chonbuk National University Korea
Dan JIN Yonsei University Wonju College of Medicine Korea
In-Chol KANG Chonnam National University Dental School Korea
Sang-Wook KANG University of Ulsan Korea
Woo-Jin KANG University of Ulsan Korea
Byung-Seok KIM Seoul National University Korea
Chang-Han KIM University of Ulsan Korea
Dong-Hyeon KIM Seoul National University Korea
Hye-Jin KIM International Vaccine Institute Korea
Jin-Kyung KIM University of Ulsan Korea
Ju KIM Chonbuk National University Korea
Kwang-Hui KIM University of Ulsan Korea
Sam Woong KIM Pusan National University Korea
Soo Young KIM Chonnam National University Medical School Korea
Young Hee KIM Pusan National University Korea
Young-Ho KIM University of Ulsan Korea
Won-Young KIM University of Ulsan Korea
Sung Youl KO Seoul National University Korea
Ah Young LEE International Vaccine Institute Korea
Deong-Young LEE Seoul National University Korea
John Hwa LEE Chonbuk National University Korea
Kyung-Yeol LEE Chonbuk National University Korea
Sang-Chul LEE University of Ulsan Korea
Shee Eun LEE Chonnam National University Korea
Sun-Kyung LEE University of Ulsan Korea
Sun Hwa MOON Sungkyunkwan University Korea
Hee Sam NA Medical School of Chonnam National University Korea
Ju Youn PARK Yonsri University Wonju College of Medicine Korea
SungMoo PARK International Vaccine Institute Korea
Haryoung POO Korean Research Institute of Bioscience and Biotechnology Korea
Hyo-II SHIN University of Ulsan Korea
Jae Seung YANG International Vaccine Institute Korea
Ji Seon YANG Pusan National University Korea
Joo-Sung YANG Sungkyunkwan University Korea
Ah Young YOO Pusan National University Korea
Cheol H. YUN International Vaccine Institute Korea
     
- Third Parties    
Louis C. AJONUMA The Chinese University of Hong Kong Hong Kong
Jennifer B. BUNAGAN Polytechnic University of the Philippines, Manila Philippines
Rubelia A. BATERNA University of the Philippines, Manila Philippines
Jasmin AKTER ICDDR,B Bangladesh
Rashidul HAQUE ICDDR,B Bangladesh
Aliya NAHEED Centre for Health and Population Research Bangladesh
Syed Atif ALI Universiti Sains Malaysia Malaysia
Jittima CHATCHAWALSAISIN Chulaongkorn University Thailand
Parichat CHOMTO Silpakorn University Thailand
Attachai HOMHUAN Mahidol University Thailand
Wiwat PICHAYAKORN Chulalongkorn University Thailand
Srinuan SOMROOP Thammasat University Thailand
DELIMA Ministry of Health Indonesia
Whinnie LESTARI Ministry of Health Indonesia
Nguyen Thi Thu TRANG NIHE Vietnam
Luu Anh CHIEN National Institute of Hygiene and Epidemiology, Hanoi Vietnam
Nguyen Van CUONG National Institute of Hygiene and Epidemiology, Hanoi Vietnam
Gaurav GUPTA Biomed Pvt Ltd. India
Sanyukta Sen GUPTA All India Institute of Medical Sciences, India India
Shabirul HAQUE All India Institute of Medical Sciences, India India
Shazia Tabassum HAKIM Jinnah University for Women, Karachi Pakistan
M.Ahmed MESAIK University of Karachi Pakistan
Imran SHAHZAD UAAR Pakistan
Liao HEZHUANG GCDC P.R.China
Lin MEI GCDC P.R.China
Wang MINGLIU GCDC P.R.China
Mohammed ALALI TGAL Australia

8. Achievements

1) Upon what concept was the seminar planned and organized? (As reference, attach lecture summaries and other related documents.)
A major purpose of the seminar was to provide young scientists including graduate students, postdoctoral fellows and research/clinical fellows from Asian countries an opportunity to expose the current knowledge of both basic and clinical aspects of the mucosal immunology for the development of mucosal vaccine. However, the organizing committee felt strongly that it was very important to create bi-directional interaction between the lectures and audiences. Thus, the question and comment were permitted during the presentation and thus the student did not wait his/her questions till the end of the lecture. Of course, individual speaker presented a state of art lecture including the review of respective field and most recent finding from his/her research group. In result, very active question and answer period was held during the individual presentation. In order to further emphasize the importance of reciprocal interaction between speakers and students, the poster session and round table discussion were carried out during the seminar. In result, the seminar created very interactive environments for active discussion between the speakers and participants for the adaptation of basic knowledge of the mucosal immunity to vaccine development.

2) What results were achieved from an academic viewpoint? Please list them concretely.
It should be pointed out that the meeting focused on the basic and clinical aspects of mucosal immunology
with especially class/lecture type presentation was held at first time in the region of Asia. The meeting participants including graduate students, postdoctoral fellow and research and clinical fellows from Asian countries thus directly received a series of excellent presentation related to the uniqueness of the mucosal immune system and its potential application for the development of mucosal vaccine. The audience learned the basic concept and uniqueness of the mucosal immune system in comparison to the well known systemic immune system. In addition, the participants had an opportunity to experience a potential application of the system for the development of mucosal vaccine for the control of emerging and re-emerging infectious diseases.

3) What results were achieved in terms of international exchange and young researcher development?
The seminar accomplished to create the international environment where graduate students, postdoctoral fellow and research and clinical fellows were invited from ten different Asian countries in addition to Japan and Korea. Together with speakers from Japan, Korea and Europe, the flavor of the seminar was very internationally oriented. Thus, global scientific and social interaction was executed during the seminar by the meeting participants as well as speakers. To further enhance the international interaction, the student shared the hotel room with the other student from different country. The young scientists from Asian countries experienced the importance of the global network for the scientific activity.

9. What sort of specific activities may be expected of the seminar participants in the future?

Through this excellent scientific opportunity offered by the Asian Science Seminar, the participants from different Asian countries will have a chance to create their own international network to exchange their new knowledge and results among the students. Further, the students may also have an opportunity to seek their own scientific advancement with the speakers associated with various aspects of the mucosal immunology, microbiology, infectious diseases and vaccinology Since all of the invited speakers were considered highly respected scientist in these different areas, the participants may be able to extend their scientific experience in their laboratories.

10. Were the system and method of operating the seminar effective? Please note any specific suggestions your have for improving them?

Because of the effectiveness of the organizing committee as well as the secretarial and administrative supports from IVI and IMSUT, the operation of the seminar went very well. Thus, the committee and the secretarial/administrative personnel involved the organization of the seminar should be congratulated. Especially the supportive personnel from IVI made tremendous efforts for the smooth operation of this successful seminar.

11. Please describe any other effects of the seminar that deserve special mention.

It should be noted that the member of the organizing committee as well as secretarial/administrative personnel from IVI were key of the success of the seminar. As chairman of the organizing committee, I would like to express my sincere appreciation for the team of local organizing staff headed by my colleague Dr. Mi-Na Kweon. Without their hard work and self sacrifice since the beginning of and till the end of the seminar, we could not have such a successful seminar. They deserve most recognition for the success of this seminar. The seminar of course contributed for the establishment of platform for the scientific and social interaction among the meeting participants, invited speakers and IVI scientists for the understanding and use of the mucosal immune system for the development of new generation vaccine. In addition to the excellent seminar given by the invited speakers to the meeting participants, it was important to note that graduate students and young scientists associating with infectious diseases and vaccine from various Asian countries provided their thoughts and views for vaccine development to the invited speakers. Their comments and thoughts would influence on the invited speaker's scientific plan and protocol for their related research activities, when they returned to their laboratories .The purpose of this seminar was perfectly fit with the one of key missions of IVI which resulted in the creation of productive and simulative environment. Thus, the seminar mutually benefit to the IVI for the accomplishment of their mission. We thus learned from Dr. J. Clemens, Director of IVI that he would like to continuously involve future planning of the seminar.

<Impressions of Participants>

12. What sort of impressions or opinions was expressed by the lecturers?

The invited speakers felt strongly that the seminar provided very unique opportunity to create new platform for the scientific and social interaction with young talented scientists from different Asian countries. They enjoyed very much for their presentation because of active discussion with the students during the seminar. They were also impressed by the high quality of presentation as well as the meeting participants. Finally, most of the speakers expressed their willingness to participate one more time if such an opportunity arises in near future. This fact naturally speaks for the high standard of the seminar.

13. Did you have the participants carry out a questionnaire or assessment? If so, what results did you obtain?

Of course, the organizing committee felt strongly at the beginning of the planning of the seminar that it was important to obtain the feed back from the participants. Thus, the end of the seminar, the evaluation form was distributed to the seminar participants. We were able to recover a total of 53 evaluation forms from the meeting participants. As can be seen in the attached copy, we fortunately obtained very positive feed back. They express their desire to have a similar seminar annual base.

<Views and Comments on Program>

14. Please give us your comments and opinions on the seminar program itself. What did you think of JSPS's application recruitment period, timing of the selection notice, seminar funding by JSPS, method of seminar operation, or other elements of the program? Do you have any specific suggestions as to how any of these components can be improved?

A mission of the program is highly important for providing new opportunity to numerous numbers of talented graduate students, postdoctoral fellows and young research/clinical fellows from different Asian countries to experience most updated aspects of basic health science. Further, it creates new platform for global scientific interaction between the participants and speakers for the further advancement of knowledge and technology related to the development of mucosal vaccine for the prevention of infectious diseases. However, the operation system between the organizer's institution and JSPS need to be improved, especially the process of handling the budget and accounting. As the organizer, the most of headache was due to the restricted rule for the accounting associated with the seminar. It desires to have more flexibility and smoothness for the handling of the allocated budget from JSPS for the seminar. In stead of the transferring the support from JSPS to the host institute, it might be easier if JSPS is directly handling the budget and accounting together with the organizer. Thus, it will eliminate one layer of the complication associated with the handling the budget and accounting system under the accounting rule established by the administrative office of the individual host institute


2004 KOSEF-JSPS Asian Science Seminar
Development of Mucosal Vaccines
From Basic Research to Clinical Application
INTERNATIONAL VACCINE INSTITUTE (IVI), Seoul, Korea
October 24-27th, 2004

<AGENDA>

Sunday, 24th October, 2004
16.00 - 18.00 Registration (Novotel Hotel)
18.00 - 20.00 Welcome to participants (Novotel Hotel)
Monday, 25th October, 2004
09.00 - 09.30 Opening remarks
Tadashi Yamamoto (University of Tokyo, Japan)
John D. Clemens (IVI, Korea)
Officers from KOSEF and JSPS
SESSION I Basic Aspect of Mucosal Immune System
Chairperson : Tadashi Yamamoto (University of Tokyo, Japan)
09.30 - 10.00 Infectious diseases and their control: Past, present and future
Yoshifumi Takeda (Jissen Women's University, Japan)
10.00 - 11.00

Uniqueness of mucosal immune system
Hiroshi Kiyono (University of Tokyo, Japan)
11.00 - 12.00 Role of costimulation in immunity
Byoung S. Kwon (University of Ulsan, Korea)
12.00 - 13.00 Lunch
SESSION II Organogenesis of Mucosal Lymphoid Tissues
Chairperson : Byoung S. Kwon (University of Ulsan, Korea)
13.00 - 14.00 Lymphoid organogenesis
Martin Lipp (Max-Delbr-ck-Centre for Molecular Medicine, Germany)
14.00 - 15.00 Peyer's patch organogenesis
Hisahiro Yoshida (RIKEN, Japan)
15.00 - 15.30 Coffee break
15.30 - 16.30 Antigen sampling and uptake in the mucosal tissues
Florence Niedergang (Institute Curie, France)
16.30 - 17.30 Functional development of intestinal immune surveillance
Hiromichi Ishikawa (Keio University, Japan)
17.30 - 18.00 Tour of IVI (guide by Dr. Aldo Tagliabue)
18.00 - 20.00 Dinner - Korean Barbecue (IVI lobby)
Tuesday, 26th October, 2004
SESSION III Regulation of Mucosal Lymphocyte Homing
Chairperson : Masafumi Yamamoto (Nihon University, Japan)
09.00 - 10.00 Lymphocyte trafficking across high endothelial venules: dogmas and enigmas
Masayuki Miyasaka (Osaka University, Japan)
SESSION IV Innate and Acquired Immunity in Mucosal Tissues
Chairperson : Masayuki Miyasaka (Osaka University, Japan)
10.00 - 11.00 TLRs for the mucosal immunity
Kiyoshi Takeda (Kyushu University, Japan)
11.00 - 12.00 Role of GALT for mucosal IgA immunity
Masafumi Yamamoto (Nihon University, Japan)
12.00 - 13.30 Lunch & preparation for poster presentation
SESSION V Molecular and Cellular Aspect of Mucosal Infectious Diseases
Chairperson : Yoshifumi Takeda (Jissen Women's University, Japan)
13.30 - 14.30 Molecular mechanism of Shigella infection
Chihiro Sasakawa (University of Tokyo, Japan)
14.30 - 15.30 Mucosal invasion by Salmonella
Ho-Young Kang (Pusan National University, Korea)
15.30 - 16.00 Coffee break
16.00 - 17.00 Molecular aspects of influenza virus: exploiting genome packaging to develop
vaccines by reverse genetics
Taisuke Horimoto (University of Tokyo, Japan)
17.00 - 18.00 Perspectives of AIDS vaccine development
Young-Chul Sung (Pohang University of Science & Technology, Korea)
18.00 - 20.00 Poster Presentation (IVI lobby)
Wednesday, 27th October, 2004
SESSION VI New Trends in Mucosal Vaccine Development
Chairperson : Hiroshi Kiyono (University of Tokyo, Japan)
08.30 - 09.30 New TB vaccine strategies by the use of CD1 immunity
Masahiko Sugita (Kyoto University, Japan)
09.30 - 10.30 TB derived peptide 25 as a new immunomodulator
Kiyoshi Takatsu (University of Tokyo, Japan)
10.30 - 10.45 Coffee break
10.45 - 11.30 Bacterial enterotoxins as mucosal adjuvants
Mi-Na Kweon (IVI, Korea)
11.30 - 12.30 TLR-targeted mucosal adjuvant
Joon-Haeng Rhee (Chonnam National University, Korea)
12.30 - 13.30 Lunch
SESSION VII From Laboratory Research to Field Trials
Chairperson : John D. Clemens (IVI, Korea)
13.30 - 14.00 From bench to bedside
John D. Clemens (IVI, Korea)
14.00 - 14.30 Field studies of the oral Cholera vaccine
Jacqueline Deen (IVI, Korea)
14.30 - 15.00 Role of field studies in developing Shigella vaccines
Lorenz von Seidlein (IVI, Korea)
15.00 - 15.30 Clinical trial of oral vaccine for Salmonella typhi
Aldo Tagliabue (IVI, Korea)
15.30 - 16.00 Coffee break
16.00 - 17.30 Round Table or Panel Discussion "How can we bridge between the basic science in mucosal immunology and translational research for field trials"
Chairperson :
John D. Clemens (IVI, Korea)
Hiroshi Kiyono (University of Tokyo, Japan)
17.30 - 18.00 Summary and Conclusion