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Date: November 29, 2004
1.Title of Seminar |
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2. Purpose of Seminar | Infectious disease is still one of major life threaten problems in both industrialized and developing countries. For the control of emerging and re-emerging infectious diseases, one of most effective and beneficial strategies is of course the development of vaccine. Since the most of infectious microorganisms are invading the host via mucosal surface by the inhalation, digestion and sexual contact, it is logical to consider the use of the mucosal immune system to provide the first line of the defense in addition to the systemic immunity. Thus, mucosal immunization has been shown to be most effective vaccination regimen for the induction of both mucosal and systemic immune responses. While the injection type immunization, currently most commonly practiced method for vaccination induces mainly systemic, but not mucosal immunity. For the future development of vaccine, one has to consider the presence and use of the mucosal immune system. Taken account for these facts, a major task of this seminar was to provide young scientists including graduate students, postdoctoral fellows and research/clinical fellows from Asian countries an opportunity to expose the current knowledge of both basic and clinical aspects of the mucosal immunology for the development of mucosal vaccine. In addition, the seminar provided the scientific environment to create new platform for the exchange new idea and data relating to the understanding of the mucosal immune system for the development of new generation vaccine. |
3. Period | From Oct. 24, 2004 through Oct. 27, 2004 (4 days) |
4. Program: Agenda, topics, related activities (e.g., reception, excursion) |
See attach (Please see the attached abstract book) |
5. Venue | International Vaccine Institute San 4-8, Boncheon-7 dong, Kwanak-gu, Seoul 151-818, Korea Tel: 82-2-881-1186 F: 82-2-881-1211 |
6. Organizer |
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7. Lecturers and Participants
1) Number of Persons
Lecturers | Participants | Total | |
---|---|---|---|
Japan side | 12 | 4 | 16 |
Korea side | 9 | 47 | 56 |
Third parties | 2 | 27 | 29 |
Total | 23 | 78 | 100 |
2) Lecturers
A.Please describe rationale for selecting lecturers, and the need for and role of their lectures in the seminar.
Of course, a first priority was the research activity of the candidate including the quality and productivity in the area of mucosal immunology, microbiology, infectious diseases, and vaccinology. Further, the effectiveness of presentation was another important aspect for the qualification of speakers. These criterions were essential for the planning of most effective and exciting program which would benefit the audience invited from different Asian countries. In addition, attractive communication ability was also another consideration for the selection of speakers, since it was important to create bi-directional interaction through the poster session as well as evening social get together for the one to one communication between the student and speaker. Because of the careful selection of highly talented speakers from Japan, Korea and Europe, individual lecturer did excellent presentation as well as individual base interaction with the seminar participants.
B.List
Name in full | Institution/Affiliation/Position | Nationality |
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- Japan side | ||
Taisuke HORIMOTO | The University of Tokyo | Japan |
Hiromichi ISHIKAWA | Keio University | Japan |
Hiroshi KIYONO | The University of Tokyo | Japan |
Masayuki MIYASAKA | Osaka University | Japan |
Chihiro SASAKAWA | The University of Tokyo | Japan |
Masahiko SUGITA | Osaka University | Japan |
Kiyoshi TAKATSU | The University of Tokyo | Japan |
Kiyoshi TAKEDA | Kyushu University | Japan |
Yoshifumi TAKEDA | Jissen Women's University | Japan |
Masafumi YAMAMOTO | Nihon University | Japan |
Tadashi YAMAMOTO | The University of Tokyo | Japan |
Hisahiro YOSHIDA | Riken Immunology and Allergy Research Center | Japan |
- Korea side | ||
John D. CLEMENS | International Vaccine Institute | Korea |
Jacqueline DEEN | International Vaccine Institute | Korea |
Ho Young KANG | Pusan National University | Korea |
Mi-Na KWEON | International Vaccine Institute | Korea |
Byoung S. KWON | University of Ulsan | Korea |
Joon-Haeng RHEE | Chonnam National University Medical School | Korea |
Lorenz von SEIDLEIN | International Vaccine Institute | Korea |
Young Chul SUNG | Pohang University of Sciences & Technology | Korea |
Aldo TAGLIABUE | International Vaccine Institute | Korea |
- Third parties | ||
Martin LIPP | Max-Delbruck-Center for Molecular Medicine | Germany |
Florence NIEDERGANG | Institut Curie | France |
3) Participants
A.Please describe how you recruited participants and why they were selected.
Considering the era of IT technology, the announcement of the Asian Science Seminar was executed by the creation of web site. The web site containing the application form was connected via the Institute of Medical Science, the University of Tokyo, International Vaccine Institute and the related scientific society' site ( e.g., Japanese Society of Immunology Japanese Society of Vaccinology and etc.). Most of inquires and applications were obtained via the web. site announcement. The application contained the biographical sketch of the applicant, a short essay summarizing the applicant's desire to attend the seminar, the submission of poster presentation and the recommendation letter from the applicant's mentor or supervisor. Based on the information, a first priority was given to the qualified applicants with poster presentation. Further, regional distribution was also taken accounted for the selection of applicants. The committee also directly contacted to the applicant's mentor or supervisor in order to ensure his/her desire and commitment to the field of mucosal immunology and vaccine development. Based on the selection process, we were able to line up highly qualified and talented young scientists form Asia who were actively participated in the discussion of individual lecture as well as poster presentation.
B.List
Name in full | Institution/Affiliation/Position | Nationality |
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- Japan side | ||
Bagherichimeh ALIEZA | University of Tsukuba | Iran |
Nam Ju KIM | IMSUT |
Korea |
Tomonori NOCHI | IMSUT |
Japan |
Naoko TAKAYAMA | IMSUT | Japan |
- Korea Side | ||
Hey Ran CHA | Sungkyunkwan University | Korea |
Jae-Hoon CHANG | Seoul National University | Korea |
Sun-Young CHANG | International Vaccine Institute | Korea |
Beom-Kyu CHOI | University of Ulsan | Korea |
Jae-Hyeog CHOI | University of Ulsan | Korea |
Yeonseok CHUNG | Seoul National University | Korea |
Clark Changfa CUI | International Vaccine Institute | Korea |
Seong-Kug EO | Chonbuk National University | Korea |
Seung Hyun HAN | International Vaccine Institute | Korea |
Sook-Kyoung HEO | University of Ulsan | Korea |
Hyun JANG | International Vaccine Institute | Korea |
Yong-Suk JANG | Chonbuk National University | Korea |
Dan JIN | Yonsei University Wonju College of Medicine | Korea |
In-Chol KANG | Chonnam National University Dental School | Korea |
Sang-Wook KANG | University of Ulsan | Korea |
Woo-Jin KANG | University of Ulsan | Korea |
Byung-Seok KIM | Seoul National University | Korea |
Chang-Han KIM | University of Ulsan | Korea |
Dong-Hyeon KIM | Seoul National University | Korea |
Hye-Jin KIM | International Vaccine Institute | Korea |
Jin-Kyung KIM | University of Ulsan | Korea |
Ju KIM | Chonbuk National University | Korea |
Kwang-Hui KIM | University of Ulsan | Korea |
Sam Woong KIM | Pusan National University | Korea |
Soo Young KIM | Chonnam National University Medical School | Korea |
Young Hee KIM | Pusan National University | Korea |
Young-Ho KIM | University of Ulsan | Korea |
Won-Young KIM | University of Ulsan | Korea |
Sung Youl KO | Seoul National University | Korea |
Ah Young LEE | International Vaccine Institute | Korea |
Deong-Young LEE | Seoul National University | Korea |
John Hwa LEE | Chonbuk National University | Korea |
Kyung-Yeol LEE | Chonbuk National University | Korea |
Sang-Chul LEE | University of Ulsan | Korea |
Shee Eun LEE | Chonnam National University | Korea |
Sun-Kyung LEE | University of Ulsan | Korea |
Sun Hwa MOON | Sungkyunkwan University | Korea |
Hee Sam NA | Medical School of Chonnam National University | Korea |
Ju Youn PARK | Yonsri University Wonju College of Medicine | Korea |
SungMoo PARK | International Vaccine Institute | Korea |
Haryoung POO | Korean Research Institute of Bioscience and Biotechnology | Korea |
Hyo-II SHIN | University of Ulsan | Korea |
Jae Seung YANG | International Vaccine Institute | Korea |
Ji Seon YANG | Pusan National University | Korea |
Joo-Sung YANG | Sungkyunkwan University | Korea |
Ah Young YOO | Pusan National University | Korea |
Cheol H. YUN | International Vaccine Institute | Korea |
- Third Parties | ||
Louis C. AJONUMA | The Chinese University of Hong Kong | Hong Kong |
Jennifer B. BUNAGAN | Polytechnic University of the Philippines, Manila | Philippines |
Rubelia A. BATERNA | University of the Philippines, Manila | Philippines |
Jasmin AKTER | ICDDR,B | Bangladesh |
Rashidul HAQUE | ICDDR,B | Bangladesh |
Aliya NAHEED | Centre for Health and Population Research | Bangladesh |
Syed Atif ALI | Universiti Sains Malaysia | Malaysia |
Jittima CHATCHAWALSAISIN | Chulaongkorn University | Thailand |
Parichat CHOMTO | Silpakorn University | Thailand |
Attachai HOMHUAN | Mahidol University | Thailand |
Wiwat PICHAYAKORN | Chulalongkorn University | Thailand |
Srinuan SOMROOP | Thammasat University | Thailand |
DELIMA | Ministry of Health | Indonesia |
Whinnie LESTARI | Ministry of Health | Indonesia |
Nguyen Thi Thu TRANG | NIHE | Vietnam |
Luu Anh CHIEN | National Institute of Hygiene and Epidemiology, Hanoi | Vietnam |
Nguyen Van CUONG | National Institute of Hygiene and Epidemiology, Hanoi | Vietnam |
Gaurav GUPTA | Biomed Pvt Ltd. | India |
Sanyukta Sen GUPTA | All India Institute of Medical Sciences, India | India |
Shabirul HAQUE | All India Institute of Medical Sciences, India | India |
Shazia Tabassum HAKIM | Jinnah University for Women, Karachi | Pakistan |
M.Ahmed MESAIK | University of Karachi | Pakistan |
Imran SHAHZAD | UAAR | Pakistan |
Liao HEZHUANG | GCDC | P.R.China |
Lin MEI | GCDC | P.R.China |
Wang MINGLIU | GCDC | P.R.China |
Mohammed ALALI | TGAL | Australia |
8. Achievements
1) Upon what concept was the seminar planned and organized? (As reference, attach lecture summaries and other related documents.)
A major purpose of the seminar was to provide young scientists including graduate students, postdoctoral fellows and research/clinical fellows from Asian countries an opportunity to expose the current knowledge of both basic and clinical aspects of the mucosal immunology for the development of mucosal vaccine. However, the organizing committee felt strongly that it was very important to create bi-directional interaction between the lectures and audiences. Thus, the question and comment were permitted during the presentation and thus the student did not wait his/her questions till the end of the lecture. Of course, individual speaker presented a state of art lecture including the review of respective field and most recent finding from his/her research group. In result, very active question and answer period was held during the individual presentation. In order to further emphasize the importance of reciprocal interaction between speakers and students, the poster session and round table discussion were carried out during the seminar. In result, the seminar created very interactive environments for active discussion between the speakers and participants for the adaptation of basic knowledge of the mucosal immunity to vaccine development.
2) What results were achieved from an academic viewpoint? Please list them concretely.
It should be pointed out that the meeting focused on the basic and clinical aspects of mucosal immunology
with especially class/lecture type presentation was held at first time in the region of Asia. The meeting participants including graduate students, postdoctoral fellow and research and clinical fellows from Asian countries thus directly received a series of excellent presentation related to the uniqueness of the mucosal immune system and its potential application for the development of mucosal vaccine. The audience learned the basic concept and uniqueness of the mucosal immune system in comparison to the well known systemic immune system. In addition, the participants had an opportunity to experience a potential application of the system for the development of mucosal vaccine for the control of emerging and re-emerging infectious diseases.
3) What results were achieved in terms of international exchange and young researcher development?
The seminar accomplished to create the international environment where graduate students, postdoctoral fellow and research and clinical fellows were invited from ten different Asian countries in addition to Japan and Korea. Together with speakers from Japan, Korea and Europe, the flavor of the seminar was very internationally oriented. Thus, global scientific and social interaction was executed during the seminar by the meeting participants as well as speakers. To further enhance the international interaction, the student shared the hotel room with the other student from different country. The young scientists from Asian countries experienced the importance of the global network for the scientific activity.
9. What sort of specific activities may be expected of the seminar participants in the future?
Through this excellent scientific opportunity offered by the Asian Science Seminar, the participants from different Asian countries will have a chance to create their own international network to exchange their new knowledge and results among the students. Further, the students may also have an opportunity to seek their own scientific advancement with the speakers associated with various aspects of the mucosal immunology, microbiology, infectious diseases and vaccinology Since all of the invited speakers were considered highly respected scientist in these different areas, the participants may be able to extend their scientific experience in their laboratories.
10. Were the system and method of operating the seminar effective? Please note any specific suggestions your have for improving them?
Because of the effectiveness of the organizing committee as well as the secretarial and administrative supports from IVI and IMSUT, the operation of the seminar went very well. Thus, the committee and the secretarial/administrative personnel involved the organization of the seminar should be congratulated. Especially the supportive personnel from IVI made tremendous efforts for the smooth operation of this successful seminar.
11. Please describe any other effects of the seminar that deserve special mention.
It should be noted that the member of the organizing committee as well as secretarial/administrative personnel from IVI were key of the success of the seminar. As chairman of the organizing committee, I would like to express my sincere appreciation for the team of local organizing staff headed by my colleague Dr. Mi-Na Kweon. Without their hard work and self sacrifice since the beginning of and till the end of the seminar, we could not have such a successful seminar. They deserve most recognition for the success of this seminar. The seminar of course contributed for the establishment of platform for the scientific and social interaction among the meeting participants, invited speakers and IVI scientists for the understanding and use of the mucosal immune system for the development of new generation vaccine. In addition to the excellent seminar given by the invited speakers to the meeting participants, it was important to note that graduate students and young scientists associating with infectious diseases and vaccine from various Asian countries provided their thoughts and views for vaccine development to the invited speakers. Their comments and thoughts would influence on the invited speaker's scientific plan and protocol for their related research activities, when they returned to their laboratories .The purpose of this seminar was perfectly fit with the one of key missions of IVI which resulted in the creation of productive and simulative environment. Thus, the seminar mutually benefit to the IVI for the accomplishment of their mission. We thus learned from Dr. J. Clemens, Director of IVI that he would like to continuously involve future planning of the seminar.
<Impressions of Participants>
12. What sort of impressions or opinions was expressed by the lecturers?
The invited speakers felt strongly that the seminar provided very unique opportunity to create new platform for the scientific and social interaction with young talented scientists from different Asian countries. They enjoyed very much for their presentation because of active discussion with the students during the seminar. They were also impressed by the high quality of presentation as well as the meeting participants. Finally, most of the speakers expressed their willingness to participate one more time if such an opportunity arises in near future. This fact naturally speaks for the high standard of the seminar.
13. Did you have the participants carry out a questionnaire or assessment? If so, what results did you obtain?
Of course, the organizing committee felt strongly at the beginning of the planning of the seminar that it was important to obtain the feed back from the participants. Thus, the end of the seminar, the evaluation form was distributed to the seminar participants. We were able to recover a total of 53 evaluation forms from the meeting participants. As can be seen in the attached copy, we fortunately obtained very positive feed back. They express their desire to have a similar seminar annual base.
<Views and Comments on Program>
14. Please give us your comments and opinions on the seminar program itself. What did you think of JSPS's application recruitment period, timing of the selection notice, seminar funding by JSPS, method of seminar operation, or other elements of the program? Do you have any specific suggestions as to how any of these components can be improved?
A mission of the program is highly important for providing new opportunity to numerous numbers of talented graduate students, postdoctoral fellows and young research/clinical fellows from different Asian countries to experience most updated aspects of basic health science. Further, it creates new platform for global scientific interaction between the participants and speakers for the further advancement of knowledge and technology related to the development of mucosal vaccine for the prevention of infectious diseases. However, the operation system between the organizer's institution and JSPS need to be improved, especially the process of handling the budget and accounting. As the organizer, the most of headache was due to the restricted rule for the accounting associated with the seminar. It desires to have more flexibility and smoothness for the handling of the allocated budget from JSPS for the seminar. In stead of the transferring the support from JSPS to the host institute, it might be easier if JSPS is directly handling the budget and accounting together with the organizer. Thus, it will eliminate one layer of the complication associated with the handling the budget and accounting system under the accounting rule established by the administrative office of the individual host institute
<AGENDA>
16.00 - 18.00 | Registration (Novotel Hotel) |
18.00 - 20.00 | Welcome to participants (Novotel Hotel) |
09.00 - 09.30 | Opening remarks Tadashi Yamamoto (University of Tokyo, Japan) John D. Clemens (IVI, Korea) Officers from KOSEF and JSPS |
SESSION I | Basic Aspect of Mucosal Immune System Chairperson : Tadashi Yamamoto (University of Tokyo, Japan) |
09.30 - 10.00 | Infectious diseases and their control: Past, present and future Yoshifumi Takeda (Jissen Women's University, Japan) |
10.00 - 11.00 |
Uniqueness of mucosal immune system Hiroshi Kiyono (University of Tokyo, Japan) |
11.00 - 12.00 | Role of costimulation in immunity Byoung S. Kwon (University of Ulsan, Korea) |
12.00 - 13.00 | Lunch |
SESSION II | Organogenesis of Mucosal Lymphoid Tissues Chairperson : Byoung S. Kwon (University of Ulsan, Korea) |
13.00 - 14.00 | Lymphoid organogenesis Martin Lipp (Max-Delbr-ck-Centre for Molecular Medicine, Germany) |
14.00 - 15.00 | Peyer's patch organogenesis Hisahiro Yoshida (RIKEN, Japan) |
15.00 - 15.30 | Coffee break |
15.30 - 16.30 | Antigen sampling and uptake in the mucosal tissues Florence Niedergang (Institute Curie, France) |
16.30 - 17.30 | Functional development of intestinal immune surveillance Hiromichi Ishikawa (Keio University, Japan) |
17.30 - 18.00 | Tour of IVI (guide by Dr. Aldo Tagliabue) |
18.00 - 20.00 | Dinner - Korean Barbecue (IVI lobby) |
SESSION III | Regulation of Mucosal Lymphocyte Homing Chairperson : Masafumi Yamamoto (Nihon University, Japan) |
09.00 - 10.00 | Lymphocyte trafficking across high endothelial venules: dogmas and enigmas Masayuki Miyasaka (Osaka University, Japan) |
SESSION IV | Innate and Acquired Immunity in Mucosal Tissues Chairperson : Masayuki Miyasaka (Osaka University, Japan) |
10.00 - 11.00 | TLRs for the mucosal immunity Kiyoshi Takeda (Kyushu University, Japan) |
11.00 - 12.00 | Role of GALT for mucosal IgA immunity Masafumi Yamamoto (Nihon University, Japan) |
12.00 - 13.30 | Lunch & preparation for poster presentation |
SESSION V | Molecular and Cellular Aspect of Mucosal Infectious Diseases Chairperson : Yoshifumi Takeda (Jissen Women's University, Japan) |
13.30 - 14.30 | Molecular mechanism of Shigella infection Chihiro Sasakawa (University of Tokyo, Japan) |
14.30 - 15.30 | Mucosal invasion by Salmonella Ho-Young Kang (Pusan National University, Korea) |
15.30 - 16.00 | Coffee break |
16.00 - 17.00 | Molecular aspects of influenza virus: exploiting genome packaging to develop vaccines by reverse genetics Taisuke Horimoto (University of Tokyo, Japan) |
17.00 - 18.00 | Perspectives of AIDS vaccine development Young-Chul Sung (Pohang University of Science & Technology, Korea) |
18.00 - 20.00 | Poster Presentation (IVI lobby) |
SESSION VI | New Trends in Mucosal Vaccine Development Chairperson : Hiroshi Kiyono (University of Tokyo, Japan) |
08.30 - 09.30 | New TB vaccine strategies by the use of CD1 immunity Masahiko Sugita (Kyoto University, Japan) |
09.30 - 10.30 | TB derived peptide 25 as a new immunomodulator Kiyoshi Takatsu (University of Tokyo, Japan) |
10.30 - 10.45 | Coffee break |
10.45 - 11.30 | Bacterial enterotoxins as mucosal adjuvants Mi-Na Kweon (IVI, Korea) |
11.30 - 12.30 | TLR-targeted mucosal adjuvant Joon-Haeng Rhee (Chonnam National University, Korea) |
12.30 - 13.30 | Lunch |
SESSION VII | From Laboratory Research to Field Trials Chairperson : John D. Clemens (IVI, Korea) |
13.30 - 14.00 | From bench to bedside John D. Clemens (IVI, Korea) |
14.00 - 14.30 | Field studies of the oral Cholera vaccine Jacqueline Deen (IVI, Korea) |
14.30 - 15.00 | Role of field studies in developing Shigella vaccines Lorenz von Seidlein (IVI, Korea) |
15.00 - 15.30 | Clinical trial of oral vaccine for Salmonella typhi Aldo Tagliabue (IVI, Korea) |
15.30 - 16.00 | Coffee break |
16.00 - 17.30 | Round Table or Panel Discussion "How can we bridge between the basic science in mucosal immunology and translational research for field trials"
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17.30 - 18.00 | Summary and Conclusion |