A brief report on the activity of 2004 in Nagoya University of the JSPS
Invitation Award for Eminent Scientist, Prof. Louis J Ignarro

Akihisa Iguchi, Professor,
Toshio Hayashi, Assistant Professor and Lecturer,
Department of Geriatrics, NagoyaUniversityGraduateSchool of Medicine

NagoyaUniversity invited Professor Louis J. Ignarro (Department of Medical and Molecular Pharmacology, UCLA school of medicine, Novel Laureate 1998) between May 20th and June 1st 2004 for the JSPS Invitation Award for Eminent Scientists supported by the Japan Society for the Promotion of Science.This is 5th visit supported by this Award (2002-2004).The outlines of educative activities, academic exchanges and cooperative researches are as follows.

(1) Educative activities within the university

An educative lecture was held for the graduate students and teaching staffs of the Faculty of Medicine on May 24 th.The title was gRole of arginine-citrulline cycle in vascular systemh, where Prof. Ignarro introduced his recent research after getting Novel Prize on 1998.Participants were impressed by his interesting talk about his active and novel research.

It was very much appreciated that he had attended the round table discussion held on May.23rd and 24th.Although the objectives of these meetings were the promotion of the collaborate research with UCLA and the laboratory of Department of Geriatrics, they were held at Kakuyuu Kaikan (alumni hall in medical faculty) and open for any scientists.He gave his valuable opinion and advice, especially to graduate students on the progress of their researches and courses of research in the future.

Preceded the lecture and meetings, a commendation ceremony for his activity and instruction for NagoyaUniversity was held at the administrative office of NagoyaUniversity (Higashiyama District).Prof. Hirano, president of NagoyaUniversity, representing NagoyaUniversity, made public recognition of the activities by him in the medical field and granted the honorable doctorate to him.This doctorate is 12th honorable one in one hundred history of NagoyaUniversity.

(2) Academic exchanges with other Universities and laboratories

Prof. Ignarro gave lecture for The 3rd international meeting on the biology, chemistry and therapeutic application of Nitric Oxide and simultaneous meeting of 4th annual scientific meeting of the Nitric Oxide society in Japan.Prof. Ignarro combined two separate international meeting related to Nitric Oxide at 2000, and became a founder the meeting.This international meeting held from May 24th to 28th at Nara Centennial Hall. His plenary session was held on May 25th, for over 1000 scientists from not only Japan but also many places all over the world. The title is gThe unique role of nitric oxide as a signaling molecule in the cardiovascular systemh and his one-hour lecture held the audiences spellbound.He will visit Japan on this October, and the lectures in TokyoUniversity and KumamotoUniversity are also planned.

He will visit Japan on this October, and the lectures in TokyoUniversity and KumamotoUniversity are also planned.

(3) Collaborative researches

The collaborative research titled on gDevelopment of new treatment tool to regress advanced atherosclerosis- The comparison between NO donor targeted to artery and in vivo gene transfer of NO synthaseh was conducted with emphasis on the analysis of the effects of endothelial function and signaling molecule.

This research is now being conducted by postdoctoral researcher, Packiasamy AR Juliet, Quang Fang Ding and Mitsuo Kodama and graduate students, Masako Oosawa, Asaka Miyazaki, Akiko Fukatsu, Hisako Matsui-Hirai and Jun Funami, and Daigo Sumi, postdoctoral fellow in Ignarro lab. who graduated from our department also took part in the program. Based on exciting discussion and accurate protocol suggested by Prof. Ignarro, we submitted several papers in last two years during this award and four papers are already accepted (at August 11, 2004). Associate Professor, Hiroshi Watanabe, Department of Clinical Pharmacology also did collaborate research with him about gEndothelial myosin kinaseh (Cadriovasc. Res. 2004). Professor, Yoshito Kumagai, Graduate School of doctoral program in medical sciences, University of Tsukuba also plan to do collaborate research with him The topic is gThe relation between NO and arsenic contained in drinking water in chinah. The novel researches between Professor Ignarro and many Japanese scientists related to NO be expecting widely progressed more and more.


1: Packiasamy ARJ , Hayashi T, Sumi D, Matsui-Hirai H, Miyazaki A, Fukatsu A, Funami J, Ignarro L.J, Iguchi A. Combined effect of Testosterone and apocynin on nitric oxide and superoxide production in PMA differentiated THP-1 cells. BBA Molecular Cell Research (in press)

2. Takeuchi K, Watanabe H, Tran QK, Ozeki M, Sumi D, Hayashi T, Iguchi A, Ignarro LJ, Ohashi K, Hayashi H,
Nitric oxide: inhibitory effects on endothelial cell calcium signaling, prostaglandin I2 production and nitric oxide synthase expression.
Cardiovasc Res. 2004 ;62:194-201.

3:Hayashi T, Sumi D, Juliet PA, Matsui-Hirai H, Asai-Tanaka Y, Kano H, Fukatsu A, Tsunekawa T, Miyazaki A, Ignarro LJ, Iguchi A,.
Gene transfer of endothelial NO synthase, but not eNOS plus inducible NOS, regressed atherosclerosis in rabbits.
Cardiovasc Res. 2004 ;61:339-51.

4: Juliet PA, Hayashi T, Ignarro LJ. Iguchi A.
Concomitant production of nitric oxide and superoxide in human macrophages.
Biochem Biophys Res Commun. 2003;310:367-70.

5: Sumi D, Hayashi T, Matsui-Hirai H, Jacobs AT, Ignarro LJ, Iguchi A.
17beta-estradiol inhibits NADPH oxidase activity through the regulation of p47phox mRNA and protein expression in THP-1 cells.
Biochim Biophys Acta. 2003;1640:113-8.